Öz
Biostatistics which is the application of statistics in the field of health and biology; provides powerful tools for creating questions, designing studies, developing measurements, and analyzing data and has an important place in determining the efficacy and safety of products such as drugs and vaccines. The impact of statistical sciences on medical and biological sciences has increased rapidly during the last few decades. Clinicians need to understand statistics well enough to follow up and evaluate empirical studies that provide an evidence base for clinical practice. Recent advances in biomedical research have created both new challenges and opportunities for statisticians and data scientists. Big data analytics, precision medicine, artificial intelligence, causal inference, and other new research resources inspire data scientists to develop modern statistical methods and innovative inference procedures. Therefore new philosophies such as causal models and prediction, new models such as graphical chain models and random effects models, faster computers and new clever algorithms for integration and maximization are needed. Without adequate investment in biostatistics, all medical research is at a significant risk of “drowning in data, but starving for knowledge”.
Anahtar Kelimeler
Kaynakça
- Diggle PJ, Chetwynd AG. Statistics and scientific method: An introduction for students and researchers. 1st ed. New York: Oxford University Press; 2011.
- Barkan H. Statistics in clinical research: Important considerations. Ann Card Anaesth. 2015;18(1):74-82.
- Lee KJ, Moreno-Betancur M, Kasza J, Marschner IC, Barnett AG, Carlin JB. Biostatistics: a fundamental discipline at the core of modern health data science. Med J Aust. 2019;211(10):444-6.e1.
- O'Neill RT. FDA's critical path initiative: a perspective on contributions of biostatistics. Biom J. 2006;48(4):559-64.
- Molenberghs G. Biometry, biometrics, biostatistics, bioinformatics,..., bio-X. Biometrics. 2005;61(1):1-9.
- Welty LJ, Carter RE, Finkelstein DM, Harrell FE Jr, Lindsell CJ, Macaluso M, et al; Biostatistics, Epidemiology, and Research Design Key Function Committee of the Clinical and Translational Science Award Consortium. Strategies for developing biostatistics resources in an academic health center. Acad Med. 2013;88(4):454-60.
- Khurshid A, Ageel MI, Anwer S. Evolution of (bio)statistics in medical research: Fifty eight years of “Numbering Off”. Int J Crit Stat. 2013;4(1):5-17.
- Chiang CL. What is biostatistics? Biometrics. 1985;41(3):771-5.
- Kotz S, Read CB, David L. Biostatistics. In: Kotz S, Balakrishnan N, Read CB, Vidakovic B, editors. 2nd ed. New Jersey: John Wiley & Sons; 2005. p. 551-63.
- Morgan PP. What are my chances of understanding biostatistics? CMAJ. 1986;134(10):1105-6.
- Weisberg HI. Statistics and clinical trials: Past, present and future. In: JSM Proceedings, Section on Statistical Education. Alexandria, VA: American Statistical Association; 2011. p. 1547-61.
- Biduchak A, Grytsiuk M, Chornenka Z, Domanchuk T. History of formation and development of biostatistics. Current Issues of Social Studies and History of Medicine. 2020;2(26):84-90.
- Öğüş E. To be together medicine and biostatistics in history: Review. Turkiye Klinikleri J Biostat. 2017;9(1):74-83.
- Zhao Y, Abebe A, Qi L, Zhang M, Zhang X. New advances in biostatistics. J Probab Stat. 2019;Special Issue:1352310.
- van Houwelingen HC. The future of biostatistics: expecting the unexpected. Stat Med. 1997;16(24):2773-84.
- Akdeniz F. New trends and developments in statistics. Soc Sci Res J. 2015;4(4):1-11.
- Fan J, Lin X, Liu JS. New developments in biostatistics and bioinformatics. New Jersey: Higher Education Press; 2009.
- Sathian B, Sreedharan J. Importance of biostatistics to improve the quality of medical journals. WebmedCentral BIOSTATISTICS. 2012;3(5):WMC003332.
- Schork NJ. Randomized clinical trials and personalized medicine: A commentary on deaton and cartwright. Soc Sci Med. 2018;210:71-73.
Öz
İstatistiğin sağlık ve biyoloji alanındaki uygulaması olan biyoistatistik; soru oluşturma, çalışma tasarlama, ölçüm geliştirme ve verilerin analizi için güçlü araçlar sağlar ve ilaç, aşı gibi ürünlerin etkinlik ve güvenliğinin belirlenmesinde önemli bir yere sahiptir. İstatistik biliminin tıp ve biyolojik bilimler üzerindeki etkisi son yıllarda hızla artmıştır. Klinisyenlerin, klinik uygulama için kanıtlar sağlayan deneysel çalışmaları izlemek ve değerlendirmek için istatistiği yeterince iyi anlamaları gerekir. Biyomedikal araştırmalardaki son gelişmeler, istatistikçiler ve veri bilimcileri için hem yeni zorluklar hem de fırsatlar yaratmıştır. Büyük veri analitiği, hassas (kişiselleştirilmiş) tıp, yapay zeka, nedensel çıkarım ve diğer yeni araştırma kaynakları; veri bilimcilerine modern istatistiksel teknikler ve yenilikçi çıkarım yöntemleri geliştirme konusunda ilham vermektedir. Bu nedenle; nedensel modeller ve tahmin gibi yeni felsefelere, grafik zincir ve rastgele etki gibi yeni modellere, daha hızlı bilgisayarlara, entegrasyon ve maksimizasyon için yeni akıllı algoritmalara ihtiyaç vardır. Biyoistatistiğe yeterli yatırım yapılmazsa, tüm sağlık araştırmaları önemli bir “veride boğulma, ancak bilgi açlığından ölme” riski altındadır.
Anahtar Kelimeler
Kaynakça
- Diggle PJ, Chetwynd AG. Statistics and scientific method: An introduction for students and researchers. 1st ed. New York: Oxford University Press; 2011.
- Barkan H. Statistics in clinical research: Important considerations. Ann Card Anaesth. 2015;18(1):74-82.
- Lee KJ, Moreno-Betancur M, Kasza J, Marschner IC, Barnett AG, Carlin JB. Biostatistics: a fundamental discipline at the core of modern health data science. Med J Aust. 2019;211(10):444-6.e1.
- O'Neill RT. FDA's critical path initiative: a perspective on contributions of biostatistics. Biom J. 2006;48(4):559-64.
- Molenberghs G. Biometry, biometrics, biostatistics, bioinformatics,..., bio-X. Biometrics. 2005;61(1):1-9.
- Welty LJ, Carter RE, Finkelstein DM, Harrell FE Jr, Lindsell CJ, Macaluso M, et al; Biostatistics, Epidemiology, and Research Design Key Function Committee of the Clinical and Translational Science Award Consortium. Strategies for developing biostatistics resources in an academic health center. Acad Med. 2013;88(4):454-60.
- Khurshid A, Ageel MI, Anwer S. Evolution of (bio)statistics in medical research: Fifty eight years of “Numbering Off”. Int J Crit Stat. 2013;4(1):5-17.
- Chiang CL. What is biostatistics? Biometrics. 1985;41(3):771-5.
- Kotz S, Read CB, David L. Biostatistics. In: Kotz S, Balakrishnan N, Read CB, Vidakovic B, editors. 2nd ed. New Jersey: John Wiley & Sons; 2005. p. 551-63.
- Morgan PP. What are my chances of understanding biostatistics? CMAJ. 1986;134(10):1105-6.
- Weisberg HI. Statistics and clinical trials: Past, present and future. In: JSM Proceedings, Section on Statistical Education. Alexandria, VA: American Statistical Association; 2011. p. 1547-61.
- Biduchak A, Grytsiuk M, Chornenka Z, Domanchuk T. History of formation and development of biostatistics. Current Issues of Social Studies and History of Medicine. 2020;2(26):84-90.
- Öğüş E. To be together medicine and biostatistics in history: Review. Turkiye Klinikleri J Biostat. 2017;9(1):74-83.
- Zhao Y, Abebe A, Qi L, Zhang M, Zhang X. New advances in biostatistics. J Probab Stat. 2019;Special Issue:1352310.
- van Houwelingen HC. The future of biostatistics: expecting the unexpected. Stat Med. 1997;16(24):2773-84.
- Akdeniz F. New trends and developments in statistics. Soc Sci Res J. 2015;4(4):1-11.
- Fan J, Lin X, Liu JS. New developments in biostatistics and bioinformatics. New Jersey: Higher Education Press; 2009.
- Sathian B, Sreedharan J. Importance of biostatistics to improve the quality of medical journals. WebmedCentral BIOSTATISTICS. 2012;3(5):WMC003332.
- Schork NJ. Randomized clinical trials and personalized medicine: A commentary on deaton and cartwright. Soc Sci Med. 2018;210:71-73.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Davetli Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Aralık 2021 |
| Gönderilme Tarihi | 23 Eylül 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 23 Sayı: 3 |
Kaynak Göster
Cited By
Düzce Tıp Fakültesi Dergisi Creative Commons Atıf-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.