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Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications

Yıl 2020, Cilt: 22 Sayı: 1, 67 - 70, 30.04.2020

Gökhan Aytekin Fatih Çölkesen Eray Yıldız Hacı Esen Şevket Arslan

https://doi.org/10.18678/dtfd.693297

Öz

Common variable immune deficiency (CVID) is a rare primary immunodeficiency disorder that is characterized by defective antibody production and inadequate B cell differentiation. While frequently recurrent respiratory tract infections are the most prominent clinical feature in CVID patients, CVID is a heterogeneous immune deficiency disorder that involves many systems and organs such as lymphoid hyperplasia, autoimmune cytopenia, chronic lung diseases, granulomatous diseases and susceptibility to malignancy. This may lead to delay in diagnosis and immunoglobulin replacement therapy, not being able to receive antibiotics at the appropriate dose and time, chronic inflammation, and therefore secondary amyloidosis. In this case report it is aimed to present a CVID patient with autoimmune complications and developing renal amyloidosis during follow-up.

Anahtar Kelimeler

Common Variable Immune Deficiency renal amyloidosis chronic inflamation

Destekleyen Kurum

none

Proje Numarası

-

Teşekkür

-

Kaynakça

  • Hermaszewski RA, Webster AD. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med. 1993;86(1):31-42.
  • Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92(1):34-48.
  • Spickett GP, Farrant J, North ME, Zhang JG, Morgan L, Webster AD. Common variable immunodeficiency: how many diseases? Immunol Today. 1997;18(7):325-8.
  • Lachmann HJ, Hawkins PN. Systemic amyloidosis. Curr Opin Pharmacol. 2006;6(2):214-20.
  • Strachan RW, Gillanders LA. A case of primary acquired hypogammaglobulinaemia with pernicious anaemia and amyloidosis: demonstrated at the Postgraduate Medical School of London. Br Med J. 1965;1(5426):35-8.
  • Gaffney EF, Lee JC. Systemic amyloidosis and hypogammaglobulinemia. Arch Pathol Lab Med. 1978;102(11):558-9.
  • Borte S, Celiksoy MH, Menzel V, Ozkaya O, Ozen FZ, Hammarström L, et al. Novel NLRP12 mutations associated with intestinal amyloidosis in a patient diagnosed with common variable immunodeficiency. Clin Immunol. 2014;154(2):105-11.
  • Lederman HM, Winkelstein JA. X-linked agammaglobulinemia: an analysis of 96 patients. Medicine (Baltimore). 1985;64(3):145-56.
  • Aytekin G, Çölkesen F, Yıldız E, Arslan S. Risk factors of bronchiectasis in adult patients with common variable immunodeficiency. Asthma Allergy Immunol. 2019;17(3):160-5.
  • Urschel S, Kayikci L, Wintergerst U, Notheis G, Jansson A, Belohradsky BH. Common variable immunodeficiency disorders in children: delayed diagnosis despite typical clinical presentation. J Pediatr. 2009;154(6):888-94.
  • Esenboga S, Çagdas Ayvaz D, Saglam Ayhan A, Peynircioglu B, Sanal O, Tezcan I. CVID associated with systemic amyloidosis. Case Reports Immunol. 2015;2015:879179.
  • Arslan S, Ucar R, Yavsan DM, Esen H, Maden E, Reisli I, et al. Common variable immunodeficiency and pulmonary amyloidosis: a case report. J Clin Immunol. 2015;35(4):344-7.
  • Aydin Z, Gursu M, Ozturk S, Kilicaslan I, Kazancioglu R. A case of primary immune deficiency presenting with nephrotic syndrome. NDT Plus. 2010;3(5):456-8.
  • Turkmen K, Anil M, Solak Y, Atalay H, Esen H, Tonbul HZ. A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency. Ann Saudi Med. 2010;30(5):401-3.
  • Kadiroğlu AK, Yıldırım Y, Yılmaz Z, Kayabaşı H, Avcı Y, Yıldırım MS, et al. A rare cause of secondary amyloidosis: common variable immunodeficiency disease. Case Rep Nephrol. 2012;2012:860208.
  • Meysman M, Debeuckelaer S, Reynaert H, Schoors DF, Dehou MF, Van Camp B. Systemic amyloidosis-induced diarrhea in sex-linked agammaglobulinemia. Am J Gastroenterol. 1993;88(8):1275-7.
  • Kotilainen P, Vuori K, Kainulainen L, Aho H, Saario R, Asola M, et al. Systemic amyloidosis in a patient with hypogammaglobulinaemia. J Intern Med. 1996;240(2):103-6.
  • Aytekin G, Çölkesen F, Ardeniz O, Çalışkaner A. Successful immunoglobulin replacement with subcutaneous immunoglobulin therapy in a patient with primary intestinal lymphangiectasia. Asthma Allergy Immunol. 2019;17(1):57-60.
  • Esteve V, Almirall J, Ponz E, García N, Ribera L, Larrosa M, et al. [Renal involvement in amyloidosis. Clinical outcomes, evolution and survival]. Nefrologia. 2006;26(2):212-7.
  • Balwani MR, Kute VB, Shah PR, Wakhare P, Trivedi HL. Secondary renal amyloidosis in a patient of pulmonary tuberculosis and common variable immunodeficiency. J Nephropharmacol. 2015;4(2):69-71.

Otoimmun Komplikasyonlarla Seyreden Yaygın Değişken İmmün Yetmezlik Hastasında Renal Amiloidoz

Yıl 2020, Cilt: 22 Sayı: 1, 67 - 70, 30.04.2020

Gökhan Aytekin Fatih Çölkesen Eray Yıldız Hacı Esen Şevket Arslan

https://doi.org/10.18678/dtfd.693297

Öz

Yaygın değişken immün yetmezlik (YDIY), bozulmuş antikor üretimi ve yetersiz B hücresi farklılaşması ile karakterize nadir görülen bir birincil immün yetmezlik tablosudur. Her ne kadar YDIY hastalarında sık tekrarlayan solunum yolu enfeksiyonları en belirgin klinik durum olsa da; YDIY, lenfoid hiperplazi, otoimmün sitopeni, kronik akciğer hastalıkları, granülomatöz hastalıklar ve maligniteye yatkınlık gibi birçok sistem ve organı etkileyen heterojen bir immün sistem bozukluğudur. Bu durum, tanı ve immünoglobulin replasman tedavisinde gecikmeye, uygun dozda ve zamanda antibiyotik alınamamasına, kronik inflamasyona ve dolayısıyla sekonder amiloidoza yol açabilir. Bu vaka sunumunda, otoimmün komplikasyonla seyreden bir YDIY olgusu ve takip sırasında gelişen renal amiloidoz tablosunun sunulması amaçlanmıştır.

Anahtar Kelimeler

Yaygın değişken immün yetmezlik renal amiloidoz kronik enflamasyon

Proje Numarası

-

Kaynakça

  • Hermaszewski RA, Webster AD. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med. 1993;86(1):31-42.
  • Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92(1):34-48.
  • Spickett GP, Farrant J, North ME, Zhang JG, Morgan L, Webster AD. Common variable immunodeficiency: how many diseases? Immunol Today. 1997;18(7):325-8.
  • Lachmann HJ, Hawkins PN. Systemic amyloidosis. Curr Opin Pharmacol. 2006;6(2):214-20.
  • Strachan RW, Gillanders LA. A case of primary acquired hypogammaglobulinaemia with pernicious anaemia and amyloidosis: demonstrated at the Postgraduate Medical School of London. Br Med J. 1965;1(5426):35-8.
  • Gaffney EF, Lee JC. Systemic amyloidosis and hypogammaglobulinemia. Arch Pathol Lab Med. 1978;102(11):558-9.
  • Borte S, Celiksoy MH, Menzel V, Ozkaya O, Ozen FZ, Hammarström L, et al. Novel NLRP12 mutations associated with intestinal amyloidosis in a patient diagnosed with common variable immunodeficiency. Clin Immunol. 2014;154(2):105-11.
  • Lederman HM, Winkelstein JA. X-linked agammaglobulinemia: an analysis of 96 patients. Medicine (Baltimore). 1985;64(3):145-56.
  • Aytekin G, Çölkesen F, Yıldız E, Arslan S. Risk factors of bronchiectasis in adult patients with common variable immunodeficiency. Asthma Allergy Immunol. 2019;17(3):160-5.
  • Urschel S, Kayikci L, Wintergerst U, Notheis G, Jansson A, Belohradsky BH. Common variable immunodeficiency disorders in children: delayed diagnosis despite typical clinical presentation. J Pediatr. 2009;154(6):888-94.
  • Esenboga S, Çagdas Ayvaz D, Saglam Ayhan A, Peynircioglu B, Sanal O, Tezcan I. CVID associated with systemic amyloidosis. Case Reports Immunol. 2015;2015:879179.
  • Arslan S, Ucar R, Yavsan DM, Esen H, Maden E, Reisli I, et al. Common variable immunodeficiency and pulmonary amyloidosis: a case report. J Clin Immunol. 2015;35(4):344-7.
  • Aydin Z, Gursu M, Ozturk S, Kilicaslan I, Kazancioglu R. A case of primary immune deficiency presenting with nephrotic syndrome. NDT Plus. 2010;3(5):456-8.
  • Turkmen K, Anil M, Solak Y, Atalay H, Esen H, Tonbul HZ. A hepatitis C-positive patient with new onset of nephrotic syndrome and systemic amyloidosis secondary to common variable immunodeficiency. Ann Saudi Med. 2010;30(5):401-3.
  • Kadiroğlu AK, Yıldırım Y, Yılmaz Z, Kayabaşı H, Avcı Y, Yıldırım MS, et al. A rare cause of secondary amyloidosis: common variable immunodeficiency disease. Case Rep Nephrol. 2012;2012:860208.
  • Meysman M, Debeuckelaer S, Reynaert H, Schoors DF, Dehou MF, Van Camp B. Systemic amyloidosis-induced diarrhea in sex-linked agammaglobulinemia. Am J Gastroenterol. 1993;88(8):1275-7.
  • Kotilainen P, Vuori K, Kainulainen L, Aho H, Saario R, Asola M, et al. Systemic amyloidosis in a patient with hypogammaglobulinaemia. J Intern Med. 1996;240(2):103-6.
  • Aytekin G, Çölkesen F, Ardeniz O, Çalışkaner A. Successful immunoglobulin replacement with subcutaneous immunoglobulin therapy in a patient with primary intestinal lymphangiectasia. Asthma Allergy Immunol. 2019;17(1):57-60.
  • Esteve V, Almirall J, Ponz E, García N, Ribera L, Larrosa M, et al. [Renal involvement in amyloidosis. Clinical outcomes, evolution and survival]. Nefrologia. 2006;26(2):212-7.
  • Balwani MR, Kute VB, Shah PR, Wakhare P, Trivedi HL. Secondary renal amyloidosis in a patient of pulmonary tuberculosis and common variable immunodeficiency. J Nephropharmacol. 2015;4(2):69-71.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Olgu Sunumu
Yazarlar

Gökhan Aytekin 0000-0002-9089-5914

Fatih Çölkesen Bu kişi benim 0000-0002-9596-1773

Eray Yıldız Bu kişi benim 0000-0002-9596-1773

Hacı Esen 0000-0002-8559-2476

Şevket Arslan Bu kişi benim 0000-0002-0343-0159

Proje Numarası -
Yayımlanma Tarihi 30 Nisan 2020
Gönderilme Tarihi 24 Şubat 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 22 Sayı: 1

Kaynak Göster

APA Aytekin, G., Çölkesen, F., Yıldız, E., Esen, H., vd. (2020). Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications. Duzce Medical Journal, 22(1), 67-70. https://doi.org/10.18678/dtfd.693297
AMA Aytekin G, Çölkesen F, Yıldız E, Esen H, Arslan Ş. Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications. Duzce Med J. Nisan 2020;22(1):67-70. doi:10.18678/dtfd.693297
Chicago Aytekin, Gökhan, Fatih Çölkesen, Eray Yıldız, Hacı Esen, ve Şevket Arslan. “Renal Amyloidosis in a Common Variable Immune Deficiency Patient With Autoimmune Complications”. Duzce Medical Journal 22, sy. 1 (Nisan 2020): 67-70. https://doi.org/10.18678/dtfd.693297.
EndNote Aytekin G, Çölkesen F, Yıldız E, Esen H, Arslan Ş (01 Nisan 2020) Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications. Duzce Medical Journal 22 1 67–70.
IEEE G. Aytekin, F. Çölkesen, E. Yıldız, H. Esen, ve Ş. Arslan, “Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications”, Duzce Med J, c. 22, sy. 1, ss. 67–70, 2020, doi: 10.18678/dtfd.693297.
ISNAD Aytekin, Gökhan vd. “Renal Amyloidosis in a Common Variable Immune Deficiency Patient With Autoimmune Complications”. Duzce Medical Journal 22/1 (Nisan 2020), 67-70. https://doi.org/10.18678/dtfd.693297.
JAMA Aytekin G, Çölkesen F, Yıldız E, Esen H, Arslan Ş. Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications. Duzce Med J. 2020;22:67–70.
MLA Aytekin, Gökhan vd. “Renal Amyloidosis in a Common Variable Immune Deficiency Patient With Autoimmune Complications”. Duzce Medical Journal, c. 22, sy. 1, 2020, ss. 67-70, doi:10.18678/dtfd.693297.
Vancouver Aytekin G, Çölkesen F, Yıldız E, Esen H, Arslan Ş. Renal Amyloidosis in a Common Variable Immune Deficiency Patient with Autoimmune Complications. Duzce Med J. 2020;22(1):67-70.
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