Araştırma Makalesi
BibTex RIS Kaynak Göster

Alopesi areata’da IL - 6 Promotör Polimorfizmi

Yıl 2016, Cilt: 43 Sayı: 4, 484 - 489, 25.12.2016

Öz


Amaç: Alopesi areata (AA), T- hücre aracılı otoimmün
bir hastalıktır ve sitokinler bu hastalığın gelişiminde önemli rol
oynamaktadırlar. Önceki çalışmalar AA’lı hastaların serumlarında
proinflamatuar bir sitokin olan IL–6’nın serum seviyesinin kontrol
grubuna göre anlamlı düzeyde yüksek olduğunu göstermiştir. IL–6 geninin
promotör bölgesinde bulunan -174 G/C polimorfizmi IL–6’nın serum
seviyesini etkilemektedir. Sunulan bu çalışmanın amacı IL–6 -174 G/C
promotör polimorfizmi ile AA’nın ilişkisinin olup olmadığını
değerlendirmekti.


Yöntemler: Bu çalışmaya 146 AA’lı hasta ve 133
sağlıklı birey dahil edildi. IL–6 geni -174 G/C polimorfizminin
genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon
Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.


Bulgular: Hasta ve kontrol grupları arasında IL–6 geni
-174 G/C promotör polimorfizminin genotip ve allel frekanslarının
dağılımı istatistiksel olarak anlamlı bulunmadı (sırasıyla, p=0.749 ve
p=0.228).


Sonuç: Bu çalışma, IL–6 -174G/C polimorfizminin AA için bir yatkınlık faktörü olmadığını göstermektedir.

Kaynakça

  • 1. Seok H, Suh DW, Jo B, Lee HB, Jang HM, Park HK. Association between TLR1 polymorphisms and alopecia areata. Autoimmunity 2014;1–6.
  • 2. Kim SK, Park HJ, Chung JH, et al. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans.
  • Journal Of Interferon & Cytokıne Research 2014;34.
  • 3. Jabbari A, Petukhova L, Cabral RM, et al. Genetic basis of alopecia areata: A roadmap for translational research. Dermatol Clin. 2013;31:109–17.
  • 4. CorkMJ, Crane AM, Duff GW. Genetic control of cytokines. Cytokine gene polymorphisms in alopecia areata. Dermatol
  • Clin. 1996;14:671-8.
  • 5. de Andrade M, Jackow CM, Dahm N, et al. Alopecia areata in families: association with the HLA locus. J Investig Dermatol Symp Proc. 1999;4:220–3.
  • 6. Rodriguez TA, Fernandes KE, Dresser KL, Duvic M. National Alopecia Areata Registry. Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors. J Am Acad Dermatol 2010;62:525-7.
  • 7. Sundberg JP, Silva KA, Li R, et al. Adult Onset Alopecia Areata Is a Complex Polygenic Trait in the C3H/HeJ Mouse Model. J
  • Invest Dermatol 2004;123:294–7.
  • 8. Blaumeiser B, Goot Ineke van der, Fimmers R, et al. Familial aggregation of alopecia areata. J Am A cad Dermatol 2006;54:627-32.
  • 9. Wang E, McElwee KJ. Etiopathogenesis of alopecia areata: Why do our patients get it? Dermatologic Therapy 2011;24:337–47.
  • 10. Ito T, Tokura Y. The role of cytokines and chemokines in the Tcellmediated autoimmune process in alopecia areata. Experimental Dermatology 2014;23:787–91.
  • 11. Kalkan G, Karakus N, Baş Y, et al. The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population. Gene 2013;527:565–9.
  • 12. Uçmak D, B alcı G, Harman M. Evaluation of interleukin 2 and tumor necrosis factorα levels in patients with lichen planus. Dicle Med J. 2012;39:6-8.
  • 13. Sımpson RJ, Hammacher A, Smıth DK, Matthews JM, Ward LD. Interleukin 6: Structure function relationships. Protein Science 1997;6929-55.
  • 14. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol. 1998;16:249–84.
  • 15. Wang HY, Zhang JJ, Zheng XY, et al. Association between IL6 Gene (− 174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk. Pathol. Oncol. Res. DOI 10.1007/s12253-016-0073-6.
  • 16. Belluco C, Olivieri F, Bonafe M, et al. 174G/C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res. 2003;9:2173–6.
  • 17. Bilgic O, Sivrikaya A, Unlu A, Altinyazar HC. Serum cytokine and chemokine profiles in patients with alopecia areata. J Dermatolog Treat. 2015;Oct 7:1-4.
  • 18. Atwa MA, Youssef N, Bayoumy NM. Thelper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factora) in patients with alopecia areata: association with clinical type and severity. International Journal of Dermatology 2016;55:666–72.
  • 19. Cussigh A, Falleti E, Fabris C, et al. Interleukin 6 promoter polymorphisms influence the outcome of chronic hepatitis C. Immunogenetics 2011;63:33–41.
  • 20. Pekiner FN, Aytugar E, Demirel GY, Borahan MO. Interleukin2, interleukin 6 and T regulatory cells in peripheral blood of patients with Behc ̧et’s disease and recurrent aphthous ulcerations. J Oral Pathol Med. 2012;41:73–79.
  • 21. Demirturk F, Ates O, Gunal O, et al. IL-6 gene promoter polymorphisms: genetic susceptibility to recurrent pregnancy loss. Bratisl Lek Listy 2014;115:479–82.
  • 22. AlBanna N, Raghupathy R, Albert MJ. Correlation of Proinflammatory and AntiInflammatory Cytokine Levels with Histopathological Changes in an Adult Mouse Lung Model of Campylobacter jejuni Infection. Clınıcal And Vaccıne Immunology, Dec. 2008;1780–7.
  • 23. Bodemer C, Peuchmaur M, Fraitaig S, et al. Role of Cytotoxic T Cellsin Chronic Alopecia Areata. J Invest Dermatol 2000;114:112–6.
  • 24. Gregoriou S, Papafragkaki D, Kontochris GT, et al. Cytokines and Other Mediators in Alopecia Areata. Hindawi Publishing
  • Corporation Mediators of Inflammation, 2010;5.
  • 25. Brull DJ, Montgomery HE, Sanders J, et al. Interleukin6 gene 174g > c and -572g > c promoter polymorphisms are strong redictors of plasma interleukin6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol. 2001;21:1458–63
Yıl 2016, Cilt: 43 Sayı: 4, 484 - 489, 25.12.2016

Öz

Kaynakça

  • 1. Seok H, Suh DW, Jo B, Lee HB, Jang HM, Park HK. Association between TLR1 polymorphisms and alopecia areata. Autoimmunity 2014;1–6.
  • 2. Kim SK, Park HJ, Chung JH, et al. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans.
  • Journal Of Interferon & Cytokıne Research 2014;34.
  • 3. Jabbari A, Petukhova L, Cabral RM, et al. Genetic basis of alopecia areata: A roadmap for translational research. Dermatol Clin. 2013;31:109–17.
  • 4. CorkMJ, Crane AM, Duff GW. Genetic control of cytokines. Cytokine gene polymorphisms in alopecia areata. Dermatol
  • Clin. 1996;14:671-8.
  • 5. de Andrade M, Jackow CM, Dahm N, et al. Alopecia areata in families: association with the HLA locus. J Investig Dermatol Symp Proc. 1999;4:220–3.
  • 6. Rodriguez TA, Fernandes KE, Dresser KL, Duvic M. National Alopecia Areata Registry. Concordance rate of alopecia areata in identical twins supports both genetic and environmental factors. J Am Acad Dermatol 2010;62:525-7.
  • 7. Sundberg JP, Silva KA, Li R, et al. Adult Onset Alopecia Areata Is a Complex Polygenic Trait in the C3H/HeJ Mouse Model. J
  • Invest Dermatol 2004;123:294–7.
  • 8. Blaumeiser B, Goot Ineke van der, Fimmers R, et al. Familial aggregation of alopecia areata. J Am A cad Dermatol 2006;54:627-32.
  • 9. Wang E, McElwee KJ. Etiopathogenesis of alopecia areata: Why do our patients get it? Dermatologic Therapy 2011;24:337–47.
  • 10. Ito T, Tokura Y. The role of cytokines and chemokines in the Tcellmediated autoimmune process in alopecia areata. Experimental Dermatology 2014;23:787–91.
  • 11. Kalkan G, Karakus N, Baş Y, et al. The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population. Gene 2013;527:565–9.
  • 12. Uçmak D, B alcı G, Harman M. Evaluation of interleukin 2 and tumor necrosis factorα levels in patients with lichen planus. Dicle Med J. 2012;39:6-8.
  • 13. Sımpson RJ, Hammacher A, Smıth DK, Matthews JM, Ward LD. Interleukin 6: Structure function relationships. Protein Science 1997;6929-55.
  • 14. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol. 1998;16:249–84.
  • 15. Wang HY, Zhang JJ, Zheng XY, et al. Association between IL6 Gene (− 174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk. Pathol. Oncol. Res. DOI 10.1007/s12253-016-0073-6.
  • 16. Belluco C, Olivieri F, Bonafe M, et al. 174G/C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res. 2003;9:2173–6.
  • 17. Bilgic O, Sivrikaya A, Unlu A, Altinyazar HC. Serum cytokine and chemokine profiles in patients with alopecia areata. J Dermatolog Treat. 2015;Oct 7:1-4.
  • 18. Atwa MA, Youssef N, Bayoumy NM. Thelper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factora) in patients with alopecia areata: association with clinical type and severity. International Journal of Dermatology 2016;55:666–72.
  • 19. Cussigh A, Falleti E, Fabris C, et al. Interleukin 6 promoter polymorphisms influence the outcome of chronic hepatitis C. Immunogenetics 2011;63:33–41.
  • 20. Pekiner FN, Aytugar E, Demirel GY, Borahan MO. Interleukin2, interleukin 6 and T regulatory cells in peripheral blood of patients with Behc ̧et’s disease and recurrent aphthous ulcerations. J Oral Pathol Med. 2012;41:73–79.
  • 21. Demirturk F, Ates O, Gunal O, et al. IL-6 gene promoter polymorphisms: genetic susceptibility to recurrent pregnancy loss. Bratisl Lek Listy 2014;115:479–82.
  • 22. AlBanna N, Raghupathy R, Albert MJ. Correlation of Proinflammatory and AntiInflammatory Cytokine Levels with Histopathological Changes in an Adult Mouse Lung Model of Campylobacter jejuni Infection. Clınıcal And Vaccıne Immunology, Dec. 2008;1780–7.
  • 23. Bodemer C, Peuchmaur M, Fraitaig S, et al. Role of Cytotoxic T Cellsin Chronic Alopecia Areata. J Invest Dermatol 2000;114:112–6.
  • 24. Gregoriou S, Papafragkaki D, Kontochris GT, et al. Cytokines and Other Mediators in Alopecia Areata. Hindawi Publishing
  • Corporation Mediators of Inflammation, 2010;5.
  • 25. Brull DJ, Montgomery HE, Sanders J, et al. Interleukin6 gene 174g > c and -572g > c promoter polymorphisms are strong redictors of plasma interleukin6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol. 2001;21:1458–63
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırma Yazıları
Yazarlar

Hacı Ömer Ateş

Yayımlanma Tarihi 25 Aralık 2016
Gönderilme Tarihi 11 Ocak 2017
Yayımlandığı Sayı Yıl 2016 Cilt: 43 Sayı: 4

Kaynak Göster

APA Ateş, H. . Ö. (2016). Alopesi areata’da IL - 6 Promotör Polimorfizmi. Dicle Tıp Dergisi, 43(4), 484-489.
AMA Ateş HÖ. Alopesi areata’da IL - 6 Promotör Polimorfizmi. diclemedj. Aralık 2016;43(4):484-489.
Chicago Ateş, Hacı Ömer. “Alopesi areata’da IL - 6 Promotör Polimorfizmi”. Dicle Tıp Dergisi 43, sy. 4 (Aralık 2016): 484-89.
EndNote Ateş HÖ (01 Aralık 2016) Alopesi areata’da IL - 6 Promotör Polimorfizmi. Dicle Tıp Dergisi 43 4 484–489.
IEEE H. . Ö. Ateş, “Alopesi areata’da IL - 6 Promotör Polimorfizmi”, diclemedj, c. 43, sy. 4, ss. 484–489, 2016.
ISNAD Ateş, Hacı Ömer. “Alopesi areata’da IL - 6 Promotör Polimorfizmi”. Dicle Tıp Dergisi 43/4 (Aralık 2016), 484-489.
JAMA Ateş HÖ. Alopesi areata’da IL - 6 Promotör Polimorfizmi. diclemedj. 2016;43:484–489.
MLA Ateş, Hacı Ömer. “Alopesi areata’da IL - 6 Promotör Polimorfizmi”. Dicle Tıp Dergisi, c. 43, sy. 4, 2016, ss. 484-9.
Vancouver Ateş HÖ. Alopesi areata’da IL - 6 Promotör Polimorfizmi. diclemedj. 2016;43(4):484-9.