Öz
Kaynakça
- Crișu G, Balaban V, Gaman L, Jinga M, Marin F, Stoian I, Atanasiu V. Early risk stratification in acute pancreatitis: the role of biochemical and hematological parameters. Internal Medicine. 2020; 17(3): 11-18. doi: 10.2478/inmed-2020-0113
- Tenner S, Baillie J, Dewitt J, Vege SS. American college of gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013 Sep;108(9):1400-15. doi: 10.1038/ajg.2013.218.
- Greenberg JA, Hsu J, Bawazeer M, et al. Clinical practice guideline: management of acute pancreatitis. Can J Surg. 2016; 59(2): 128-140. doi: 10.1503/cjs.015015
- Larvin M, McMahon MJ. APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet. 1989;2(8656):201-205. doi:10.1016/s0140-6736(89)90381-4
- van Grinsven J, van Vugt JLA, Gharbharan A, et al. The Association of Computed Tomography-Assessed Body Composition with Mortality in Patients with Necrotizing Pancreatitis. J Gastrointest Surg. 2017;21(6):1000-1008. doi:10.1007/s11605-016-3352-3
- O’Leary DP, O'Neill D, McLaughlin P, et al. Effects of abdominal fat distribution parameters on severity of acute pancreatitis. World J Surg 2012; 36: 1679–1685.doi: 10.1007/s00268-011-1414-y
- Kuan LL, Dennison AR, Garcea G. Association of visceral adipose tissue on the incidence and severity of acute pancreatitis: A systematic review. Pancreatology. 2020;20(6):1056-1061. doi:10.1016/j.pan.2020.05.027
- Trikudanathan G, Vantanasiri K, Faizi N, et al. Decreased skeletal muscle density is an independent predictor of mortality in necrotizing pancreatitis- A single tertiary center experience in 507 patients [published online ahead of print, 2021 May 15]. Pancreatology. 2021;S1424-3903(21)00160-5. doi:10.1016/j.pan.2021.05.010
- Aubrey J, Esfandiari N, Baracos VE, et al. Measurement of skeletal muscle radiation attenuation and basis of its biological variation. Acta Physiol (Oxf). 2014;210(3):489-497. doi:10.1111/apha.12224
- Yoon SB, Choi MH, Lee IS, et al. Impact of body fat and muscle distribution on severity of acute pancreatitis. Pancreatology. 2017;17(2):188-193. doi:10.1016/j.pan.2017.02.002
- Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102-111. doi:10.1136/gutjnl-2012-302779
- Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-495. doi:10.1016/S1470-2045(10)70218-7
- Sternby H, Mahle M, Linder N, et al. Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue. United European Gastroenterol J. 2019;7(10):1312-1320. doi:10.1177/2050640619882520
- Patel K, Trivedi RN, Durgampudi C, et al. Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation. Am J Pathol. 2015;185(3):808-819. doi:10.1016/j.ajpath.2014.11.019
- Beydogan E, Gulle S, Gezer C, Boyuk B. Effect of abdominal fat distribution on severity of acute pancreatitis. Clin Exp Hepatol. 2021;7(3):264-269. doi:10.5114/ceh.2021.109345
Öz
Objective: Predicting the clinical course of acute pancreatitis has been discussed previously on the basis of visceral adipose tissue. This study was conducted to determine the relationship between clinical outcomes of acute pancreatitis and changes in skeletal muscle parameters.
Method: This is a single-center, cross-sectional, retrospective study. Patients who were diagnosed with acute pancreatitis between 01-28 February 2019 and had abdominal computed tomography (CT) taken in the first week of their hospitalization were included in the study. L3 level of abdominal CT images were used to evaluate skeletal muscle parameters.
Results: During the hospital database scanning, 127 patients newly diagnosed with acute pancreatitis were included in the study. The median age was 50 (18-88) years, 47% were male, and 53% were female. The median body mass index (BMI) was 26,42 (19.4-46.8) kg/m2. Fifty-one % of patients were diagnosed with biliary acute pancreatitis, and 48.8% were diagnosed with non-biliary acute pancreatitis. At the same time, acute pancreatitis severity was classified according to revised Atlanta criteria, 67.7% were mild (n = 86), 28.3% were moderate (n = 36) and 5 (3.9%) patients were severe. Skeletal muscle mass was evaluated using the total psoas index (TPI) and, skeletal muscle density calculated by HU. Median TPI was 6.3 (2.5-13.7). The median of Hounsfield Unit (HU) average calculation was 18.9 (3.8-28.5) (Table 1). There were no statistically significant differences on sex, age, BMI, skeletal muscle parameters, and acute pancreatitis clinical outcome (Table 2).
Conclusion: Skeletal muscle parameters determined by TPI and HU were not a predictor of the clinical course, and viewing them always cannot effectively investigate their effect on acute pathologies. So, this way couldn't be proposed as a perfect method for predicting the clinical outcome of acute pancreatitis.
Anahtar Kelimeler
skeletal muscle parameters pancreatitis computed tomography L3 level
Kaynakça
- Crișu G, Balaban V, Gaman L, Jinga M, Marin F, Stoian I, Atanasiu V. Early risk stratification in acute pancreatitis: the role of biochemical and hematological parameters. Internal Medicine. 2020; 17(3): 11-18. doi: 10.2478/inmed-2020-0113
- Tenner S, Baillie J, Dewitt J, Vege SS. American college of gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013 Sep;108(9):1400-15. doi: 10.1038/ajg.2013.218.
- Greenberg JA, Hsu J, Bawazeer M, et al. Clinical practice guideline: management of acute pancreatitis. Can J Surg. 2016; 59(2): 128-140. doi: 10.1503/cjs.015015
- Larvin M, McMahon MJ. APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet. 1989;2(8656):201-205. doi:10.1016/s0140-6736(89)90381-4
- van Grinsven J, van Vugt JLA, Gharbharan A, et al. The Association of Computed Tomography-Assessed Body Composition with Mortality in Patients with Necrotizing Pancreatitis. J Gastrointest Surg. 2017;21(6):1000-1008. doi:10.1007/s11605-016-3352-3
- O’Leary DP, O'Neill D, McLaughlin P, et al. Effects of abdominal fat distribution parameters on severity of acute pancreatitis. World J Surg 2012; 36: 1679–1685.doi: 10.1007/s00268-011-1414-y
- Kuan LL, Dennison AR, Garcea G. Association of visceral adipose tissue on the incidence and severity of acute pancreatitis: A systematic review. Pancreatology. 2020;20(6):1056-1061. doi:10.1016/j.pan.2020.05.027
- Trikudanathan G, Vantanasiri K, Faizi N, et al. Decreased skeletal muscle density is an independent predictor of mortality in necrotizing pancreatitis- A single tertiary center experience in 507 patients [published online ahead of print, 2021 May 15]. Pancreatology. 2021;S1424-3903(21)00160-5. doi:10.1016/j.pan.2021.05.010
- Aubrey J, Esfandiari N, Baracos VE, et al. Measurement of skeletal muscle radiation attenuation and basis of its biological variation. Acta Physiol (Oxf). 2014;210(3):489-497. doi:10.1111/apha.12224
- Yoon SB, Choi MH, Lee IS, et al. Impact of body fat and muscle distribution on severity of acute pancreatitis. Pancreatology. 2017;17(2):188-193. doi:10.1016/j.pan.2017.02.002
- Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102-111. doi:10.1136/gutjnl-2012-302779
- Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-495. doi:10.1016/S1470-2045(10)70218-7
- Sternby H, Mahle M, Linder N, et al. Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue. United European Gastroenterol J. 2019;7(10):1312-1320. doi:10.1177/2050640619882520
- Patel K, Trivedi RN, Durgampudi C, et al. Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation. Am J Pathol. 2015;185(3):808-819. doi:10.1016/j.ajpath.2014.11.019
- Beydogan E, Gulle S, Gezer C, Boyuk B. Effect of abdominal fat distribution on severity of acute pancreatitis. Clin Exp Hepatol. 2021;7(3):264-269. doi:10.5114/ceh.2021.109345
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Research Articles |
| Yazarlar | |
| Erken Görünüm Tarihi | 28 Nisan 2023 |
| Yayımlanma Tarihi | 29 Nisan 2023 |
| Gönderilme Tarihi | 1 Şubat 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 3 Sayı: 2 |
