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Corpus Callosum Volume in Patients with First-Episode Psychosis

Yıl 2022, Cilt: 12 Sayı: 2, 331 - 336, 30.06.2022

Onur Ağdanlı Ahmet Topuzoglu Nuri Karabay Köksal Alptekin

https://doi.org/10.33808/clinexphealthsci.789999

Öz

Objective In first-episode psychosis, a relationship may exist between disruption communication between two brain hemispheres and psychosis symptomatology. We aimed to investigate the relationship between corpus callosum (CC) volume and psychosis symptomatology in patients with first-episode psychosis.
Methods This is a retrospective case-control study wherein first-episode psychosis cases and healthy controls were included from inpatient unit archives of the Department of Psychiatry and Department of Radiology, Dokuz Eylül University School of Medicine. Psychosis symptoms were assessed using the positive and negative syndrome scale (PANSS). The CC, the chief connection between two brain hemispheres, was examined using magnetic resonance imaging (MRI); 27 patients with first-episode psychosis and 29 healthy volunteers were evaluated via 1.5-T MR. MRI findings of CC volumes of the two groups were compared. Correlations between PANSS scores and CC volume were also evaluated.
Results The CC volume was lower in patients with first-episode psychosis than in healthy controls. Moreover, we observed a significant negative correlation between the CC volume and emotional withdrawal scores, and a significant positive correlation between the CC volume and hallucinations.
Conclusions The CC is a vital structure that connects two frontal lobes of the brain. There may be CC abnormalities in first-episode psychosis. Emotional withdrawal is associated with decreased CC volume, whereas hallucinations are associated with increased CC volume. The development of these symptoms may be associated with changes in CC connections.

Anahtar Kelimeler

First-episode psychosis corpus callosum emotional withdrawal hallucinations

Kaynakça

  • [1] Andreasen NC. Neuroimaging. Teaching and learning about schizophrenia. Module 2, 10-19.WPA, 1994.
  • [2] Pearlson G. D., Marsh L., Magnetic resonance imaging in psychiatry. Review of Psychiatry 1993; 12 (13): 347-381.
  • [3] Bachmann S, Pantel J, Flender A, Bottmer C. Corpus callosum in first-episode patients with schizophrenia a magnetic resonance imaging study. Psychol. Med. 2003; 33:1019-1027.
  • [4] Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. J Neurol Neurosurg Psychiatry 2002; 72:757-760.
  • [5] Ross C. A, Pearlson G. D., Schizophrenia, The heteromodal association neocortex and development: potential for a neurogenetic approach. Trends in Neurosci. 1996; 19:171-176.
  • [6] Hofer S, Frahm J. Topography of the human corpus callosum revisited: comprehensive lif tractrography using diffusion tensor magnetic resonance imaging. NeuroImage 2006; 32: 989-994.
  • [7] Taylor WD, Hsu E, Krishnan KR, MacFall JR. Diffusion tensor imaging: background, potential and utility in psychiatric research. Biol Psychiatry 2004; 55:201-207.
  • [8] Camchong J, Lim KO, Sponheim SR, MacDonald III AW. Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients’ nonpsychotic relatives. Front. Hum. Neurosci. Vol;3 Article 35, 1-6.
  • [9] Francis AN, Mothi SS, Mathew IT, Tandon N, Clementz B, Pearlson GD. Callosal abnormalities across the psychosis dimension: bipolar schizophrenia network on intermediate phenotypes. Biol. Psychiatry 2016;80 (8), 627–635.
  • [10] Mäkinen J, Miettunen J, Isohanni M, Koponen H. Negative symptoms in schizophrenia—A review. Nord. J. Psychiatry 2008;62;5:334-340.
  • [11] Arnone D, McIntosh AM, Tan GM, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia. Schizophr. Res. 2008; 101: 124-132.
  • [12] Brewer W, Wood S, Phillips L, Francey MS, Pantelis C, Yung AR. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophr Bull. 2006; 32:538-555.
  • [13] Christensen J, Holcomb J, Garver DL. State-related changes in cerebral white matter may underlie psychosis exacerbation. Psychiatry Res. 2004; 130: 71-78.
  • [14] Okugawa G, Nobuhara K, Takase K, Saito Y, Yoshimura M, Toshikiko K. Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophrenia. Neuropsychobiology 2007; 55: 43-46.
  • [15] Bartzokis G, Lu PH, Nuechterlein KH, Gitlin M, Doi J, Edwards N. Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia. Schizophr. Res. 2007; 93: 13-22.
  • [16] Karp BI, Garvey M, Jacobsen LK, Frazier JA, Hamburger SD, Bedwell JS. Abnormal neurologic maturation in adolescents with early-onset schizophrenia. Am. J. Psychiatry 2001; 158: 118-122.
  • [17] Vourdas A, Pipe R, Corrigall R, Frangou S. Increased developmental deviance and premorbid dysfunction in early onset schizophrenia. Schizophr. Res. 2003; 62: 13-22.
  • [18] Pujol J, Vendrell P, Junque C, Martí-Vilalta JL, Capdevila A. When does human brain development end? Evidence of corpus callosum growth up to adulthood. Ann. Neurol. 1993; 34: 71-75.
  • [19] McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA. MRI anatomy of schizophrenia. Biol. Psychiatry 1999; 45: 1099-1119.
  • [20] Woodruff P, McManus I, David A. Meta-analysis of corpus callosum size in schizophrenia. J Neurol Neurosurg Psychiatry 1995; 58: 457-461.
  • [21] Li T, Wang Q, Zhang J, Rolls ET, Yang W, Palaniyappan L. Brain-wide analysis of functional connectivity in first episode and chronic stages of schizophrenia. Schizophr Bull. 2017;43(2):436-448.
  • [22] Crow, TJ. Schizophrenia is a transcallosal misconnection syndrome. Schizophr. Res. 1998; 30: 111-114.
  • [23] Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposa concerning the genetic basis of the disease. Arch. Gen. Psychiatry 1989; 46: 1145-1150.
  • [24] Rossell SL, Shapleske J, Fukuda R, Woodruff PW, Simmons A, David AS. Corpus callosum area and functioning in schizophrenic patients with auditory-verbal hallucinations. Schizophr Res. 2001; 50: 9-17.
  • [25] Hoff AL, Neal C, Kushner M, DeLisi LE. Gender differences in corpus callosum size in first-episode schizophrenics. Biol. Psychiatry 1994; 35: 913-919.
  • [26] DeQuardo JR, Keshavan MS, Bookstein FL, Bagwell WW, Green WD, Sweeney JA, et al. Landmark-based morphometric analysis of first-episode schizophrenia. Biol. Psychiatry 1999; 45: 1321-1328.
  • [27] Foong, J., Maier, M., Clark, C. A., Barker GJ, Miller DH, Ron MA. Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2000; 68: 242–244.
  • [28] Koutsouleris N, Gaser C, Jäger M, Bottlender R, Frodl T, Holzinger S. Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study. NeuroImage 2008; 39: 1600–1612.
  • [29] Walterfang M, Wood A, Reutens D, Wood SJ, Chen J, Velakoulis D. Morphology of the corpus callosum at different stages of schizophrenia: a cross-sectional study in first-episode and chronic illness. Br J Psychiatry. 2008; 192: 429–434.
  • [30] Downhill Jr J.E, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, et al. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr. Res. 2000; 42: 193–208.
  • [31] Rotarska-Jagiela A, Schönmeyer R, Oertel V, Haenschel C, Vogeley K, Linden DE.. The corpus callosum in schizophrenia volume and connectivity changes affect specific regions. NeuroImage 2008; 39: 1522–1532.
  • [32] Whitford TJ, Kubicki M, Schneiderman JS, O’Donnell LJ, King R, Alvarado JL, et al. Corpus Callosum Abnormalities and their Association with Psychotic Symptoms in Patients with Schizophrenia. Biol. Psychiatry. 2010; 68:70–77

Yıl 2022, Cilt: 12 Sayı: 2, 331 - 336, 30.06.2022

Onur Ağdanlı Ahmet Topuzoglu Nuri Karabay Köksal Alptekin

https://doi.org/10.33808/clinexphealthsci.789999

Öz

Kaynakça

  • [1] Andreasen NC. Neuroimaging. Teaching and learning about schizophrenia. Module 2, 10-19.WPA, 1994.
  • [2] Pearlson G. D., Marsh L., Magnetic resonance imaging in psychiatry. Review of Psychiatry 1993; 12 (13): 347-381.
  • [3] Bachmann S, Pantel J, Flender A, Bottmer C. Corpus callosum in first-episode patients with schizophrenia a magnetic resonance imaging study. Psychol. Med. 2003; 33:1019-1027.
  • [4] Keshavan MS, Diwadkar VA, Harenski K, Rosenberg DR, Sweeney JA, Pettegrew JW. Abnormalities of the corpus callosum in first episode, treatment naive schizophrenia. J Neurol Neurosurg Psychiatry 2002; 72:757-760.
  • [5] Ross C. A, Pearlson G. D., Schizophrenia, The heteromodal association neocortex and development: potential for a neurogenetic approach. Trends in Neurosci. 1996; 19:171-176.
  • [6] Hofer S, Frahm J. Topography of the human corpus callosum revisited: comprehensive lif tractrography using diffusion tensor magnetic resonance imaging. NeuroImage 2006; 32: 989-994.
  • [7] Taylor WD, Hsu E, Krishnan KR, MacFall JR. Diffusion tensor imaging: background, potential and utility in psychiatric research. Biol Psychiatry 2004; 55:201-207.
  • [8] Camchong J, Lim KO, Sponheim SR, MacDonald III AW. Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients’ nonpsychotic relatives. Front. Hum. Neurosci. Vol;3 Article 35, 1-6.
  • [9] Francis AN, Mothi SS, Mathew IT, Tandon N, Clementz B, Pearlson GD. Callosal abnormalities across the psychosis dimension: bipolar schizophrenia network on intermediate phenotypes. Biol. Psychiatry 2016;80 (8), 627–635.
  • [10] Mäkinen J, Miettunen J, Isohanni M, Koponen H. Negative symptoms in schizophrenia—A review. Nord. J. Psychiatry 2008;62;5:334-340.
  • [11] Arnone D, McIntosh AM, Tan GM, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia. Schizophr. Res. 2008; 101: 124-132.
  • [12] Brewer W, Wood S, Phillips L, Francey MS, Pantelis C, Yung AR. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophr Bull. 2006; 32:538-555.
  • [13] Christensen J, Holcomb J, Garver DL. State-related changes in cerebral white matter may underlie psychosis exacerbation. Psychiatry Res. 2004; 130: 71-78.
  • [14] Okugawa G, Nobuhara K, Takase K, Saito Y, Yoshimura M, Toshikiko K. Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophrenia. Neuropsychobiology 2007; 55: 43-46.
  • [15] Bartzokis G, Lu PH, Nuechterlein KH, Gitlin M, Doi J, Edwards N. Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia. Schizophr. Res. 2007; 93: 13-22.
  • [16] Karp BI, Garvey M, Jacobsen LK, Frazier JA, Hamburger SD, Bedwell JS. Abnormal neurologic maturation in adolescents with early-onset schizophrenia. Am. J. Psychiatry 2001; 158: 118-122.
  • [17] Vourdas A, Pipe R, Corrigall R, Frangou S. Increased developmental deviance and premorbid dysfunction in early onset schizophrenia. Schizophr. Res. 2003; 62: 13-22.
  • [18] Pujol J, Vendrell P, Junque C, Martí-Vilalta JL, Capdevila A. When does human brain development end? Evidence of corpus callosum growth up to adulthood. Ann. Neurol. 1993; 34: 71-75.
  • [19] McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA. MRI anatomy of schizophrenia. Biol. Psychiatry 1999; 45: 1099-1119.
  • [20] Woodruff P, McManus I, David A. Meta-analysis of corpus callosum size in schizophrenia. J Neurol Neurosurg Psychiatry 1995; 58: 457-461.
  • [21] Li T, Wang Q, Zhang J, Rolls ET, Yang W, Palaniyappan L. Brain-wide analysis of functional connectivity in first episode and chronic stages of schizophrenia. Schizophr Bull. 2017;43(2):436-448.
  • [22] Crow, TJ. Schizophrenia is a transcallosal misconnection syndrome. Schizophr. Res. 1998; 30: 111-114.
  • [23] Crow TJ, Ball J, Bloom SR, Brown R, Bruton CJ, Colter N. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposa concerning the genetic basis of the disease. Arch. Gen. Psychiatry 1989; 46: 1145-1150.
  • [24] Rossell SL, Shapleske J, Fukuda R, Woodruff PW, Simmons A, David AS. Corpus callosum area and functioning in schizophrenic patients with auditory-verbal hallucinations. Schizophr Res. 2001; 50: 9-17.
  • [25] Hoff AL, Neal C, Kushner M, DeLisi LE. Gender differences in corpus callosum size in first-episode schizophrenics. Biol. Psychiatry 1994; 35: 913-919.
  • [26] DeQuardo JR, Keshavan MS, Bookstein FL, Bagwell WW, Green WD, Sweeney JA, et al. Landmark-based morphometric analysis of first-episode schizophrenia. Biol. Psychiatry 1999; 45: 1321-1328.
  • [27] Foong, J., Maier, M., Clark, C. A., Barker GJ, Miller DH, Ron MA. Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2000; 68: 242–244.
  • [28] Koutsouleris N, Gaser C, Jäger M, Bottlender R, Frodl T, Holzinger S. Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study. NeuroImage 2008; 39: 1600–1612.
  • [29] Walterfang M, Wood A, Reutens D, Wood SJ, Chen J, Velakoulis D. Morphology of the corpus callosum at different stages of schizophrenia: a cross-sectional study in first-episode and chronic illness. Br J Psychiatry. 2008; 192: 429–434.
  • [30] Downhill Jr J.E, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, et al. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr. Res. 2000; 42: 193–208.
  • [31] Rotarska-Jagiela A, Schönmeyer R, Oertel V, Haenschel C, Vogeley K, Linden DE.. The corpus callosum in schizophrenia volume and connectivity changes affect specific regions. NeuroImage 2008; 39: 1522–1532.
  • [32] Whitford TJ, Kubicki M, Schneiderman JS, O’Donnell LJ, King R, Alvarado JL, et al. Corpus Callosum Abnormalities and their Association with Psychotic Symptoms in Patients with Schizophrenia. Biol. Psychiatry. 2010; 68:70–77
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Articles
Yazarlar

Onur Ağdanlı Bu kişi benim 0000-0002-6630-1098

Ahmet Topuzoglu 0000-0002-7497-548X

Nuri Karabay 0000-0002-1059-5517

Köksal Alptekin Bu kişi benim 0000-0002-7601-9002

Yayımlanma Tarihi 30 Haziran 2022
Gönderilme Tarihi 8 Eylül 2020
Yayımlandığı Sayı Yıl 2022 Cilt: 12 Sayı: 2

Kaynak Göster

APA Ağdanlı, O., Topuzoglu, A., Karabay, N., Alptekin, K. (2022). Corpus Callosum Volume in Patients with First-Episode Psychosis. Clinical and Experimental Health Sciences, 12(2), 331-336. https://doi.org/10.33808/clinexphealthsci.789999
AMA Ağdanlı O, Topuzoglu A, Karabay N, Alptekin K. Corpus Callosum Volume in Patients with First-Episode Psychosis. Clinical and Experimental Health Sciences. Haziran 2022;12(2):331-336. doi:10.33808/clinexphealthsci.789999
Chicago Ağdanlı, Onur, Ahmet Topuzoglu, Nuri Karabay, ve Köksal Alptekin. “Corpus Callosum Volume in Patients With First-Episode Psychosis”. Clinical and Experimental Health Sciences 12, sy. 2 (Haziran 2022): 331-36. https://doi.org/10.33808/clinexphealthsci.789999.
EndNote Ağdanlı O, Topuzoglu A, Karabay N, Alptekin K (01 Haziran 2022) Corpus Callosum Volume in Patients with First-Episode Psychosis. Clinical and Experimental Health Sciences 12 2 331–336.
IEEE O. Ağdanlı, A. Topuzoglu, N. Karabay, ve K. Alptekin, “Corpus Callosum Volume in Patients with First-Episode Psychosis”, Clinical and Experimental Health Sciences, c. 12, sy. 2, ss. 331–336, 2022, doi: 10.33808/clinexphealthsci.789999.
ISNAD Ağdanlı, Onur vd. “Corpus Callosum Volume in Patients With First-Episode Psychosis”. Clinical and Experimental Health Sciences 12/2 (Haziran 2022), 331-336. https://doi.org/10.33808/clinexphealthsci.789999.
JAMA Ağdanlı O, Topuzoglu A, Karabay N, Alptekin K. Corpus Callosum Volume in Patients with First-Episode Psychosis. Clinical and Experimental Health Sciences. 2022;12:331–336.
MLA Ağdanlı, Onur vd. “Corpus Callosum Volume in Patients With First-Episode Psychosis”. Clinical and Experimental Health Sciences, c. 12, sy. 2, 2022, ss. 331-6, doi:10.33808/clinexphealthsci.789999.
Vancouver Ağdanlı O, Topuzoglu A, Karabay N, Alptekin K. Corpus Callosum Volume in Patients with First-Episode Psychosis. Clinical and Experimental Health Sciences. 2022;12(2):331-6.
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