Derleme
ENDOMETRIALHYPERPLASIA AND ITS RELATIONSHIP WITH P16 STROMAL EXPRESSION OF ENDOMETRIAL POLYPS: REVIEW
Öz
Recently, p16 stromal expression has been reported in the examination of endometrial serous adenocarcinomas associated with endometrial polyps. Therefore, endometrial polyps are defined as preneoplastic formations in some textbooks. Due to these different expressions of stromal cells in endometrial polyps, we wanted to present the place of p16 expressions in stromal tissue in endometrial hyperplasia and endometrial polyps in the differential diagnosis in our review article.
Anahtar Kelimeler
Kaynakça
- Allison, K. H., Reed, S.D., Voigt, L.F., et al (2008). Diagnosing endometrial hyperplasia: why is it so difficult to agree? Am J Surg Pathol, 32:691–698.
- Carlson, J. W., Mutter, G.L. (2008). Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change. Histopathology, 53:325–332 .
- Chiesa-Vottero, A., Malpica, A., Deavers, M.T., Broaddus, R., Nuovo, G.J., & Silva EG (2007).
- Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. Int J Gynecol Pathol, 26:328–333 .
- Cin, P. D., Wanschura, S., Kazmierczak, B. et al. (1998). Amplification and expression of the HMGIC gene in a benign endometrial polyp. Genes Chrom Cancer, 22:95–99.
- D’Angelo, E., Prat, J. (2010). Uterine sarcomas: a review. Gynecol Oncol, 116:131–139 .
- Fletcher, J. A., Pinkus, J. L., Lage, J. M. et al. (1992). Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chrom Cancer, 5:260–263.
- Gannon, B. R., Manduch, M., Childs, T. J. (2007). Differential immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants. Int J Gynecol Pathol, 27:68–73.
- Horree, N., Heintz, A. P. M., Sie-Go, DMDS et al. (2007). p16 is consistently expressed in endometrial tubal metaplasia. Cell Oncol, 29:37–45.
- Huang, E., Hornstein, M. D., Stewart, E. A., et al. (2011). Evaluation of the cyclic endometrium and benign endometrial disorders. In: Crum CP, Nucci MR, Lee KR (eds) Diagnostic gynecologic and obstetric pathology, 2nd edn. Elsevier Saunders, Philadelphia, pp 407–456.
- Keating, J. T., Cviko, A., Riethdorf, S., et al. (2001). Ki-67, Cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol, 25:884–891.
- Kim, K. R., Peng, R., Ro, J. Y., et al. (2004). A diagnostically useful histopathologic feature of endometrial polyp. The long axis of endometrial glands arranged parallel to surface epithelium. Am J Surg Pathol, 28:1057–1062
- Klaes, R., Friedrich, T., Ridder, R., et al. (2002). p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol, 26:1389–1399.
- Mai, K. T., Teo, I., Moghrabi, H. A., et al. (2008). Calretinin and CD34 immunoreactivity of the endometrial stroma in normal endometrium and change of the immunoreactivity in dysfunctional uterine bleeding with evidence of ‘disordered endometrial stroma’. Pathology, 40:493–499.
- Malpica, A., Deavers, M. T., & Euscher, E. (2010). Benign endometrial conditions. In: Malpica A, Deavers MT, Euscher E (eds) Biopsy interpretation of the uterine cervix and corpus. Lippincott Williams & Wilkins, Philadelphia, pp 117–144.
- Marotti, J. D., Glatz, K., Parkash, V., Hecht, J. L. (2011). International internet-based assessment of observer variability for diagnostically challenging endometrial biopsies. Arch Pathol Lab Med, 135:464– 470.
- McCluggage, W.G. (2011). Benign diseases of the endometrium. In: Kurmann RJ, Ellenson LH, Ronnett BM (eds) Blaustein’s pathology of the female genital tract, 6th edn. Springer, New York, pp 307–358.
- Michaloglou , C., Vredeveld, L. C. W., Soengas, M. S., et al. (2005). BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436:720–724.
- Moghrabi, H. A., Elkeilani, A., Thomas, J. M., et al. (2007). Calretinin: an immunohistochemical marker for the normal functional endometrial stroma and alterations of the immunoreactivity in dysfunctional uterine bleeding. Path Res Pract, 203:79–83.
- Munger, K., Werness, B. A., Dyson, N., et al. (1989). Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J, 4099–4105.
- O’Neill, C. J., McCluggage, W. G. (2006). p16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol, 13:8–15.
- Reslová, T., Tosner, J., Resl, M., et al. (1999). Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet, 262:133–139.
- Romagosa, C., Simonetti, S., López-Vincente, L., et al. (2011). p16Ink-4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors. Oncogene, 30:2087–2097.
- Sabah, M., Cummins, R., Leader, M., et al. (2006). Loss of p16(INK4A) expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors. Appl Immunohistochem Mol Morphol, 14:97–102.
- Schwartz, B., Avivi-Green, C., & Polak-Charcon, S., (1998) Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells. Mol Cell Biochem, 188:21–30. Serrano, M. (1997). The tumor suppressor protein p16INK4a. Exp Cell Res. 237:7–13.
- Silverberg, S.G. (1992). Endometrial polyp and hyperplasias. In: Silverberg SG, Kurman RJ (eds) Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of tumor pathology. Third series. Fascicle 3. Armed Forces Institute of Pathology, Washington, pp 15–45.
- Silverberg, S. G. (2000). Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. Mod Pathol, 13:309–327.
- Winkler, B., Alvarez, S., Richart, R. M., et al. (1984). Pitfalls in the diagnosis of endometrial hyperplasia. Obstet Gynecol, 64:185–193.
- Yemelyanova, A., Ji, H., Shih, J. M., et al. (2009). Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas. Immunohistochemical analysis of 201 cases. Am J Surg Pathol. 33:1504–1514.
Yıl 2022,
Cilt: 9 Sayı: 2, 168 - 174, 31.12.2022
Öz
Son zamanlarda endometriyal poliplerle ilişkili endometriyal seröz adenokarsinomların incelenmesinde p16 stromal ekspresyonu bildirilmiştir. Bu nedenle endometrial polipler bazı kaynaklarfa preneoplastik oluşumlar olarak tanımlanmaktadır. Endometrial poliplerdeki bu farklı stromal hücre ekspresyonları nedeniyle, derleme yazımızda endometrial hiperplazi ve endometrial poliplerde stromal dokudaki p16 ekspresyonlarının ayırıcı tanıdaki yerini sunmak istedik.
Anahtar Kelimeler
Kaynakça
- Allison, K. H., Reed, S.D., Voigt, L.F., et al (2008). Diagnosing endometrial hyperplasia: why is it so difficult to agree? Am J Surg Pathol, 32:691–698.
- Carlson, J. W., Mutter, G.L. (2008). Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change. Histopathology, 53:325–332 .
- Chiesa-Vottero, A., Malpica, A., Deavers, M.T., Broaddus, R., Nuovo, G.J., & Silva EG (2007).
- Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. Int J Gynecol Pathol, 26:328–333 .
- Cin, P. D., Wanschura, S., Kazmierczak, B. et al. (1998). Amplification and expression of the HMGIC gene in a benign endometrial polyp. Genes Chrom Cancer, 22:95–99.
- D’Angelo, E., Prat, J. (2010). Uterine sarcomas: a review. Gynecol Oncol, 116:131–139 .
- Fletcher, J. A., Pinkus, J. L., Lage, J. M. et al. (1992). Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp. Genes Chrom Cancer, 5:260–263.
- Gannon, B. R., Manduch, M., Childs, T. J. (2007). Differential immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants. Int J Gynecol Pathol, 27:68–73.
- Horree, N., Heintz, A. P. M., Sie-Go, DMDS et al. (2007). p16 is consistently expressed in endometrial tubal metaplasia. Cell Oncol, 29:37–45.
- Huang, E., Hornstein, M. D., Stewart, E. A., et al. (2011). Evaluation of the cyclic endometrium and benign endometrial disorders. In: Crum CP, Nucci MR, Lee KR (eds) Diagnostic gynecologic and obstetric pathology, 2nd edn. Elsevier Saunders, Philadelphia, pp 407–456.
- Keating, J. T., Cviko, A., Riethdorf, S., et al. (2001). Ki-67, Cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol, 25:884–891.
- Kim, K. R., Peng, R., Ro, J. Y., et al. (2004). A diagnostically useful histopathologic feature of endometrial polyp. The long axis of endometrial glands arranged parallel to surface epithelium. Am J Surg Pathol, 28:1057–1062
- Klaes, R., Friedrich, T., Ridder, R., et al. (2002). p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol, 26:1389–1399.
- Mai, K. T., Teo, I., Moghrabi, H. A., et al. (2008). Calretinin and CD34 immunoreactivity of the endometrial stroma in normal endometrium and change of the immunoreactivity in dysfunctional uterine bleeding with evidence of ‘disordered endometrial stroma’. Pathology, 40:493–499.
- Malpica, A., Deavers, M. T., & Euscher, E. (2010). Benign endometrial conditions. In: Malpica A, Deavers MT, Euscher E (eds) Biopsy interpretation of the uterine cervix and corpus. Lippincott Williams & Wilkins, Philadelphia, pp 117–144.
- Marotti, J. D., Glatz, K., Parkash, V., Hecht, J. L. (2011). International internet-based assessment of observer variability for diagnostically challenging endometrial biopsies. Arch Pathol Lab Med, 135:464– 470.
- McCluggage, W.G. (2011). Benign diseases of the endometrium. In: Kurmann RJ, Ellenson LH, Ronnett BM (eds) Blaustein’s pathology of the female genital tract, 6th edn. Springer, New York, pp 307–358.
- Michaloglou , C., Vredeveld, L. C. W., Soengas, M. S., et al. (2005). BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436:720–724.
- Moghrabi, H. A., Elkeilani, A., Thomas, J. M., et al. (2007). Calretinin: an immunohistochemical marker for the normal functional endometrial stroma and alterations of the immunoreactivity in dysfunctional uterine bleeding. Path Res Pract, 203:79–83.
- Munger, K., Werness, B. A., Dyson, N., et al. (1989). Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J, 4099–4105.
- O’Neill, C. J., McCluggage, W. G. (2006). p16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol, 13:8–15.
- Reslová, T., Tosner, J., Resl, M., et al. (1999). Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet, 262:133–139.
- Romagosa, C., Simonetti, S., López-Vincente, L., et al. (2011). p16Ink-4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors. Oncogene, 30:2087–2097.
- Sabah, M., Cummins, R., Leader, M., et al. (2006). Loss of p16(INK4A) expression is associated with allelic imbalance/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors. Appl Immunohistochem Mol Morphol, 14:97–102.
- Schwartz, B., Avivi-Green, C., & Polak-Charcon, S., (1998) Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells. Mol Cell Biochem, 188:21–30. Serrano, M. (1997). The tumor suppressor protein p16INK4a. Exp Cell Res. 237:7–13.
- Silverberg, S.G. (1992). Endometrial polyp and hyperplasias. In: Silverberg SG, Kurman RJ (eds) Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of tumor pathology. Third series. Fascicle 3. Armed Forces Institute of Pathology, Washington, pp 15–45.
- Silverberg, S. G. (2000). Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. Mod Pathol, 13:309–327.
- Winkler, B., Alvarez, S., Richart, R. M., et al. (1984). Pitfalls in the diagnosis of endometrial hyperplasia. Obstet Gynecol, 64:185–193.
- Yemelyanova, A., Ji, H., Shih, J. M., et al. (2009). Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas. Immunohistochemical analysis of 201 cases. Am J Surg Pathol. 33:1504–1514.
Toplam 29 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Çevre Bilimleri |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2022 |
| Gönderilme Tarihi | 14 Aralık 2022 |
| Kabul Tarihi | 26 Aralık 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 9 Sayı: 2 |
