Araştırma Makalesi
BibTex RIS Kaynak Göster

Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia

Yıl 2022, Cilt: 9 Sayı: 1, 99 - 105, 31.03.2022
https://doi.org/10.34087/cbusbed.1002485

Öz

Objective: Preeclampsia is a pregnancy-specific disease with hypertension, proteinuria, and/or organ damage. This study aimed to investigate whether preeclampsia is predictable or not based on some hematological parameters at primary care units step where routine follow-ups are made during the pregnancy.
Materials and methods: In this retrospective study, 58 pregnant women with preeclampsia and 116 healthy pregnant women were included. Two different hemogram results belonging to the time of diagnosis and 2-6 weeks before diagnosis in the preeclampsia group; and two different hemogram results belonging to the time of delivery and 2-6 weeks before delivery for the control group were included in the study.
Results: It was determined that MPV levels were higher; platelet count, NLR, and PLR levels were lower in the second hemogram results compared with the first hemogram results of the preeclampsia group. The ROC analysis result, it was revealed that the sensitivity and specificity of MPV for predicting preeclampsia were 75,9% and 33,3%, respectively, when the cut-off value of MPV was accepted as 8,95 (fL).
Conclusion: When we compared the results of our study with the literature, it was evaluated that MPV, NLR, and PLR data could be used for the prediction of preeclampsia patients. It has been required for a long duration of studies
that need a large number of patients to use the tendency in an increase of MPV and the decrease of NLR and PLR for prediction of preeclampsia.

Kaynakça

  • Lee, G, Schafer, A.I, Arterial hypertension. Goldman-Cecil Medicine, 2016, 381-97.
  • Chen, Y.T, Lin, T.Y, Cheng, P.J, Chan, K.S, Huang, H.Y, Shaw, S.W, Taiwanese new direction in prediction of early pregnancy preeclampsia, Taiwanese Journal of Obstetrics & Gynecology, 2021, 60(1), 66-9.
  • Eiland, E, Nzerue, C, Faulkner, M. Preeclampsia, 2012, Journal of Pregnancy, 2012.
  • Moussa, H.N, Arian, S.E, Sibai, B.M, Management of hypertensive disorders in pregnancy, Women’s Health (London, England), 2014,10(04), 385-404.
  • Taravati, A, Tohidi, F, Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia, Taiwanese Journal of Obstetrics & Gynecology, 2018, 57, 779-90.
  • Osungbade, K.O, Ige, O.K, Public health perspectives of preeclampsia in developing countries: implication for health system strengthening, Journal of Pregnancy, 2011.
  • Mannaerts, D, Heyvaert, S, Cordt, C.D, Macken, C, Loos, C, Jacquemyn, Y, Are neutrophil / lymphocyteratio (NLR), platelet / lymphocyteratio (PLR), and / or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? Journal of Maternal-Fetal and Neonatal Medicine, 2019, 32(9), 1412-9.
  • Monteith, C, Egan, K, O’Connor, H, Maguire, P, Kevane, B, Szklanna, P.B, et al, Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study, Journal of Perinatal Medicine, 2018, 46(9), 1010-5.
  • Kirbas, A, Ersoy, A.O, Daglar, K, Dikici, T, Biberoglu, E.H, Kirbas, O, et al., Prediction of preeclampsia by first trimester combined test and simple complete blood count parameters, Journal of Clinical & Diagnostic Research, 2015, 9(11), 20-3.
  • Roberts, J.M, August, P.A, Bakris, G, Barton, J.R, Bernstein, I.M, Druzin, M, et al., Report of the American College of Obstetricians and Gynecologists’ task force on hypertension in pregnancy, Obstetrics and Gynecology, 2013, 122(5), 1122-31.
  • Nooh, A.M, Abdeldayem, H.M, Changes in platelet indices during pregnancy as potential markers for prediction of preeclampsia development, Journal of Obstetrics and Gynecology, 2015, 5, 703-12.
  • Pickel, K.M, Stern, C, Eberhard, K, Lang, U, Obermayer- Pietsch, B, Cervar- Zivkovic, M, Comparison of mean platelet volume (MPV) and sFlt-1/PlGF ratio as predictive markers for preeclampsia, Journal of Maternal-Fetal and Neonatal Medicine, 2019, 34(9), 1407-14.
  • Rezk, M, Gaber, W, Shaheen, A, Nofal, A, Emara, M, Gamal, A, et al., First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk, Hypertension in Pregnancy, 2018, 37(3), 111-7.
  • Gezer, C, Ekin, A, Özeren, M, Taner, C.E, Avcı, M.E, Doğan, A, Erken ve geç preeklampside birinci trimester inflamasyon belirteçlerinin yeri, Perinatoloji Dergisi, 2014, 22(3), 128-32.
  • Han, L, Liu, X, Li, H, Zou, J, Yang, Z, Han, J, et al., Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia, PLoS ONE, 2014, 9(12).
  • Pektas, M.K, Yesildager, U, Tuncer, N, Arioz, D.T, Nadirgil-Koken, N, Yilmazer, M, Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia? Journal of Obstetrics and Gynaecology Research, 2014, 40(7), 1840-5.
  • Sitotawa, C, Asrie, F, Melku, M, Evaluation of platelet and white cell parameters among pregnant women with preeclampsia in Gondar, Northwest Ethiopia: A comparative cross-sectional study, Pregnancy Hypertension, 2018, 13, 242-7.
  • Koltan, S.O, Ulkumen, B.A, Pala, H.G, Preeklampsinin ağırlığı ile ortalama trombosit hacmi ve trombosit dağılım genişliği ilişkisi, Perinatoloji Dergisi, 2016, 24(3), 162-5.
  • Vilchez, G, Lagos, M, Kumar, K, Argoti, P, Is mean platelet volume a better biomarker in pre-eclampsia? Journal of Obstetrics and Gynaecology Research, 2017, 43(6), 982-90.
  • Yavuzcan, A, Caglar, M, Ustun, Y, Dilbaz, S, Ozdemir, I, Yildiz, E, et al., Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia, Ginekologia Polska, 2014, 85(3), 197-203.
  • AlSheeha, M.A, Alaboudi, R.S, Alghasham, M.A, Iqbal, J, Adam, I, Platelet count and platelet indices in women with preeclampsia, Vascular Health and Risk Management, 2016, 12, 477-80.
  • Kim, M.A, Han, G.H, Kwon, J.Y, Kim, Y.H, Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia, American Journal of Reproductive Immunology, 2018, 80(1), 1-6.
  • Sezer, S.D, Kucuk, M, Yuksel, H, Odabasi, A.R, Preeklamptik gebelerde trombosit parametreleri, Pamukkale Tıp Dergisi, 2011, 4(2), 66-7.

Preeklampsi Olgularında Ortalama Trombosit Hacmi ve Trombosit Düzeylerinin İncelenmesi

Yıl 2022, Cilt: 9 Sayı: 1, 99 - 105, 31.03.2022
https://doi.org/10.34087/cbusbed.1002485

Öz

Giriş ve Amaç: Preeklampsi; hipertansiyon, proteinüri ve/veya organ hasarı ile seyreden gebeliğe özgü bir hastalıktır. Bu çalışmada, gebelikte rutin takiplerin yapıldığı birinci basamakta bazı hematolojik parametrelere göre preeklampsinin öngörülebilir olup olmadığının araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Bu retrospektif çalışmaya 58 preeklampsili gebe ve 116 sağlıklı gebe dahil edildi. Preeklampsi grubunda tanı anına ve tanıdan 2-6 hafta öncesine ait iki farklı hemogram sonucu; kontrol grubu için doğum zamanı ve doğumdan 2-6 hafta öncesine ait iki farklı hemogram sonucu çalışmaya dahil edildi.
Bulgular: Preeklampsi grubunun ikinci hemogram sonuçlarında trombosit sayısı, NLR ve PLR düzeyleri ilk hemogram sonuçlarına göre daha düşük, MPV düzeyleri daha yüksek olarak bulundu. ROC analizi sonucu, MPV’nin 8.95 (fL) kabul edildiği cut-off değerinde preeklampsiyi öngörmedeki duyarlılığı %75,9 ve özgüllüğü %33,3 olarak saptandı.
Sonuç: Çalışmamızın sonuçlarını literatürle karşılaştırdığımızda MPV, NLR ve PLR verilerinin preeklampsi tanılı hastaları öngörmede kullanılabilir olduğu değerlendirildi. MPV’de yükselme, NLR ve PLR’de düşme eğiliminin preeklampsiyi öngörmede kullanılabilmesi için daha fazla hasta sayılı ve uzun süreli çalışmalara ihtiyaç duyulmaktadır.

Kaynakça

  • Lee, G, Schafer, A.I, Arterial hypertension. Goldman-Cecil Medicine, 2016, 381-97.
  • Chen, Y.T, Lin, T.Y, Cheng, P.J, Chan, K.S, Huang, H.Y, Shaw, S.W, Taiwanese new direction in prediction of early pregnancy preeclampsia, Taiwanese Journal of Obstetrics & Gynecology, 2021, 60(1), 66-9.
  • Eiland, E, Nzerue, C, Faulkner, M. Preeclampsia, 2012, Journal of Pregnancy, 2012.
  • Moussa, H.N, Arian, S.E, Sibai, B.M, Management of hypertensive disorders in pregnancy, Women’s Health (London, England), 2014,10(04), 385-404.
  • Taravati, A, Tohidi, F, Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia, Taiwanese Journal of Obstetrics & Gynecology, 2018, 57, 779-90.
  • Osungbade, K.O, Ige, O.K, Public health perspectives of preeclampsia in developing countries: implication for health system strengthening, Journal of Pregnancy, 2011.
  • Mannaerts, D, Heyvaert, S, Cordt, C.D, Macken, C, Loos, C, Jacquemyn, Y, Are neutrophil / lymphocyteratio (NLR), platelet / lymphocyteratio (PLR), and / or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia? Journal of Maternal-Fetal and Neonatal Medicine, 2019, 32(9), 1412-9.
  • Monteith, C, Egan, K, O’Connor, H, Maguire, P, Kevane, B, Szklanna, P.B, et al, Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study, Journal of Perinatal Medicine, 2018, 46(9), 1010-5.
  • Kirbas, A, Ersoy, A.O, Daglar, K, Dikici, T, Biberoglu, E.H, Kirbas, O, et al., Prediction of preeclampsia by first trimester combined test and simple complete blood count parameters, Journal of Clinical & Diagnostic Research, 2015, 9(11), 20-3.
  • Roberts, J.M, August, P.A, Bakris, G, Barton, J.R, Bernstein, I.M, Druzin, M, et al., Report of the American College of Obstetricians and Gynecologists’ task force on hypertension in pregnancy, Obstetrics and Gynecology, 2013, 122(5), 1122-31.
  • Nooh, A.M, Abdeldayem, H.M, Changes in platelet indices during pregnancy as potential markers for prediction of preeclampsia development, Journal of Obstetrics and Gynecology, 2015, 5, 703-12.
  • Pickel, K.M, Stern, C, Eberhard, K, Lang, U, Obermayer- Pietsch, B, Cervar- Zivkovic, M, Comparison of mean platelet volume (MPV) and sFlt-1/PlGF ratio as predictive markers for preeclampsia, Journal of Maternal-Fetal and Neonatal Medicine, 2019, 34(9), 1407-14.
  • Rezk, M, Gaber, W, Shaheen, A, Nofal, A, Emara, M, Gamal, A, et al., First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk, Hypertension in Pregnancy, 2018, 37(3), 111-7.
  • Gezer, C, Ekin, A, Özeren, M, Taner, C.E, Avcı, M.E, Doğan, A, Erken ve geç preeklampside birinci trimester inflamasyon belirteçlerinin yeri, Perinatoloji Dergisi, 2014, 22(3), 128-32.
  • Han, L, Liu, X, Li, H, Zou, J, Yang, Z, Han, J, et al., Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia, PLoS ONE, 2014, 9(12).
  • Pektas, M.K, Yesildager, U, Tuncer, N, Arioz, D.T, Nadirgil-Koken, N, Yilmazer, M, Could mean platelet volume in late first trimester of pregnancy predict intrauterine growth restriction and pre-eclampsia? Journal of Obstetrics and Gynaecology Research, 2014, 40(7), 1840-5.
  • Sitotawa, C, Asrie, F, Melku, M, Evaluation of platelet and white cell parameters among pregnant women with preeclampsia in Gondar, Northwest Ethiopia: A comparative cross-sectional study, Pregnancy Hypertension, 2018, 13, 242-7.
  • Koltan, S.O, Ulkumen, B.A, Pala, H.G, Preeklampsinin ağırlığı ile ortalama trombosit hacmi ve trombosit dağılım genişliği ilişkisi, Perinatoloji Dergisi, 2016, 24(3), 162-5.
  • Vilchez, G, Lagos, M, Kumar, K, Argoti, P, Is mean platelet volume a better biomarker in pre-eclampsia? Journal of Obstetrics and Gynaecology Research, 2017, 43(6), 982-90.
  • Yavuzcan, A, Caglar, M, Ustun, Y, Dilbaz, S, Ozdemir, I, Yildiz, E, et al., Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia, Ginekologia Polska, 2014, 85(3), 197-203.
  • AlSheeha, M.A, Alaboudi, R.S, Alghasham, M.A, Iqbal, J, Adam, I, Platelet count and platelet indices in women with preeclampsia, Vascular Health and Risk Management, 2016, 12, 477-80.
  • Kim, M.A, Han, G.H, Kwon, J.Y, Kim, Y.H, Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia, American Journal of Reproductive Immunology, 2018, 80(1), 1-6.
  • Sezer, S.D, Kucuk, M, Yuksel, H, Odabasi, A.R, Preeklamptik gebelerde trombosit parametreleri, Pamukkale Tıp Dergisi, 2011, 4(2), 66-7.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Hilal İkbal Damar 0000-0003-0515-7659

Hüseyin Elbi 0000-0002-2955-5400

Fatih Ozcan 0000-0001-9380-5227

Yayımlanma Tarihi 31 Mart 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 9 Sayı: 1

Kaynak Göster

APA Damar, H. İ., Elbi, H., & Ozcan, F. (2022). Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 9(1), 99-105. https://doi.org/10.34087/cbusbed.1002485
AMA Damar Hİ, Elbi H, Ozcan F. Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia. CBU-SBED. Mart 2022;9(1):99-105. doi:10.34087/cbusbed.1002485
Chicago Damar, Hilal İkbal, Hüseyin Elbi, ve Fatih Ozcan. “Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9, sy. 1 (Mart 2022): 99-105. https://doi.org/10.34087/cbusbed.1002485.
EndNote Damar Hİ, Elbi H, Ozcan F (01 Mart 2022) Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9 1 99–105.
IEEE H. İ. Damar, H. Elbi, ve F. Ozcan, “Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia”, CBU-SBED, c. 9, sy. 1, ss. 99–105, 2022, doi: 10.34087/cbusbed.1002485.
ISNAD Damar, Hilal İkbal vd. “Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 9/1 (Mart 2022), 99-105. https://doi.org/10.34087/cbusbed.1002485.
JAMA Damar Hİ, Elbi H, Ozcan F. Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia. CBU-SBED. 2022;9:99–105.
MLA Damar, Hilal İkbal vd. “Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia”. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, c. 9, sy. 1, 2022, ss. 99-105, doi:10.34087/cbusbed.1002485.
Vancouver Damar Hİ, Elbi H, Ozcan F. Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia. CBU-SBED. 2022;9(1):99-105.