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Yıl 2023, Cilt: 1 Sayı: 1, 26 - 32, 01.01.2023

Tuba Ersal Fatma Laika Karabulut

Öz

Kaynakça

  • Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2(9):533-43 DOI: 10.1016/s1470-2045(01)00486-7.
  • McMahon BJ, Alberts SR, Wainwright RB, Bulkow L, Lanier AP. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med. 1990;150(5):1051-4 DOI: 10.1001/archinte.150.5.1051.
  • Sugano S, Miyoshi K, Suzuki T, Kawafune T, Kubota M. Intrahepatic arteriovenous shunting due to hepatocellular carcinoma and cirrhosis, and its change by transcatheter arterial embolization. Am J Gastroenterol. 1994;89(2):184-8 https://pubmed.ncbi.nlm.nih.gov/8304300/
  • MC. K. Tumors of the liver. In: Zakim D. BT, editor. HEPATOLOGY: A TEXTBOOK OF THE LİVER DİSEASE. PHILADELPHIA: WB Saunders Company; 1996. p. 1513.
  • Lai CL, Ng RP, Lok AS. The diagnostic value of the ratio of serum gamma-glutamyl transpeptidase to alkaline phosphatase in alcoholic liver disease. Scand J Gastroenterol. 1982;17(1):41-7 DOI: 10.3109/00365528209181042.
  • Yoon KT, Kim JK, Kim DY, Ahn SH, Lee JD, Yun M, et al. Role of <sup>18</sup>FFluorodeoxyglucose Positron Emission Tomography in Detecting Extrahepatic Metastasis in Pretreatment Staging of Hepatocellular Carcinoma. Oncology. 2007;72(suppl 1)(Suppl. 1):10410 DOI: 10.1159/000111715.
  • Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y. Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer. 1990;66(10):2174-9 DOI: 10.1002/1097 0142(19901115)66:10<2174::aidcncr2820661022>3.0.co;2-a.
  • Kew MC, Dos Santos HA, Sherlock S. Diagnosis of primary cancer of the liver. Br Med J. 1971;4(5784):408-11 DOI: 10.1136/bmj.4.5784.408.
  • Llovet JM, Bustamante J, Castells A, Vilana R, Ayuso Mdel C, Sala M, et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 1999;29(1):62-7 DOI: 10.1002/hep.510290145.
  • A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. 1998;28(3):751-5 DOI: 10.1002/hep.510280322.
  • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42(5):1208-36 DOI: 10.1002/hep.20933.
  • Gogel BM, Goldstein RM, Kuhn JA, McCarty TM, Donahoe A, Glastad K. Diagnostic evaluation of hepatocellular carcinoma in a cirrhotic liver. Oncology (Williston Park). 2000;14(6 Suppl 3):15-20
  • Wu JT. Serum alpha-fetoprotein and its lectin reactivity in liver diseases: a review. Ann Clin Lab Sci. 1990;20(2):98-105 https://pubmed.ncbi.nlm.nih.gov/1691611/
  • Collier J, Sherman M. Screening for hepatocellular carcinoma. Hepatology. 1998;27(1):273-8 DOI: 10.1002/hep.510270140.
  • Lok AS, Lai CL. alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology. 1989;9(1):110-5 DOI: 10.1002/hep.1840090119.
  • Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer. 1985;56(4):918-28 DOI: 10.1002/1097-0142(19850815)56:4<918::aidcncr2820560437>3.0.co;2-e.
  • Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. The Cancer of the Liver Italian Program (CLIP) Investigators. Hepatology. 2000;31(4):840-5 DOI: 10.1053/he.2000.5628.
  • Primack A, Vogel CL, Kyalwazi SK, Ziegler JL, Simon R, Anthony PP. A staging system for hepatocellular carcinoma: prognostic factors in Ugandan patients. Cancer. 1975;35(5):135764 DOI: 10.1002/1097-0142(197505)35:5<1357::aid-cncr2820350518>3.0.co;2-8.
  • Lai CL, Lam KC, Wong KP, Wu PC, Todd D. Clinical features of hepatocellular carcinoma: review of 211 patients in Hong Kong. Cancer. 1981;47(11):2746-55 DOI: 10.1002/10970142(19810601)47:11<2746::aid-cncr2820471134>3.0.co;2-k.
  • Okuda K. Natural history of hepatocellular carcinoma including fibrolamellar and hepatocholangiocarcinoma variants. J Gastroenterol Hepatol. 2002;17(4):401-5 DOI: 10.1046/j.14401746.2002.02734.x.
  • Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19(3):329-38 DOI: 10.1055/s-2007-1007122.
  • Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred fortyseven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 2000;191(1):38-46 DOI: 10.1016/s1072-7515(00)00261-1.
  • Bralet MP, Régimbeau JM, Pineau P, Dubois S, Loas G, Degos F, et al. Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology. 2000;32(2):200-4 DOI: 10.1053/jhep.2000.9033.
  • Hasegawa S, Yamasaki N, Hiwaki T, Sako K, Komorizono Y, Baba Y, et al. Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection. Cancer. 1999;86(9):1682-90 DOI: 10.1002/(sici)10970142(19991101)86:9<1682::aid-cncr9>3.0.co;2-6.
  • Shiina S, Tagawa K, Niwa Y, Unuma T, Komatsu Y, Yoshiura K, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma: results in 146 patients. AJR Am J Roentgenol. 1993;160(5):1023-8 DOI: 10.2214/ajr.160.5.7682378.
  • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology. 2003;37(2):429-42 DOI: 10.1053/jhep.2003.50047.
  • Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol. 2004;5(7):40918 DOI: 10.1016/s1470-2045(04)01508-6.
  • Mathurin P, Rixe O, Carbonell N, Bernard B, Cluzel P, Bellin MF, et al. Review article: Overview of medical treatments in unresectable hepatocellular carcinoma--an impossible metaanalysis? Aliment Pharmacol Ther. 1998;12(2):111-26 DOI: 10.1046/j.13652036.1998.00286.x.
  • Okuda K KM, Okuda H. Neoplasms of the liver. In: Schiff L SE, editor. Diseases of the Liver. 7 ed. Philadelphia, PA: JB Lippincott Co; 1993. p. 1236-96.
  • El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med. 2000;160(21):3227-30 DOI: 10.1001/archinte.160.21.3227.
  • HBV genome integration and genetic instability in HBsAg-negative and anti-HCV-positive hepatocellular carcinoma in Japan. Cancer Letters. 1997;119(1):53-61 DOI: https://doi.org/10.1016/S0304-3835(97)00249-8.
  • Özdemir S ST, Şentürk H. Primary liver tumors. Turkish Gastroenterology. 1993(4):398401
  • Caturelli E, Solmi L, Anti M, Fusilli S, Roselli P, Andriulli A, et al. Ultrasound guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study. Gut. 2004;53(9):1356-62 DOI: 10.1136/gut.2003.032359.
  • Bruix J, Barrera JM, Calvet X, Ercilla G, Costa J, Sanchez-Tapias JM, et al. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989;2(8670):1004-6 DOI: 10.1016/s0140-6736(89)91015-5.

Demographic, etiological, clinical features, and laboratory features of hepatocellular carcinoma; a single center experience

Yıl 2023, Cilt: 1 Sayı: 1, 26 - 32, 01.01.2023

Tuba Ersal Fatma Laika Karabulut

Öz

Objective: Hepatocellular carcinoma (HCC) is our country's most commonly encountered cancer. This study examined demographic, etiologic, clinical characteristics, and biochemical and serological findings of patients with HCC.
Methods: We retrospectively analyzed 207 HCC patients followed by gastroenterology and medical oncology departments.
Results: It was established that, in the demographic analysis, HCC was more common in the elderly population, especially in men. The positive hepatitis B virus surface antigen rate was 65.5%, anti-delta was 2%, and hepatitis C virus antibody was determined to be 15%. The rate of alcohol users was 11.1%, and that of tobacco users was 68.2%. Serum alkaline phosphatase, gamma-glutamyl transferase, and serum alpha-fetoprotein (AFP) levels were above average in 75.6%, 86.3%, and 72.6% of patients, respectively. Approximately 63% of patients had cirrhosis at presentation. Ultrasonography (USG) was the primary diagnostic method in 57% of the patients. Histopathological diagnosis was made by ultrasound-guided biopsy in 67.6% of the patients.
Conclusion: Chronic hepatitis B was the most common etiological factor for HCC, and chronic hepatitis C was observed at a significant rate of %15. The majority of the patients developed HCC on the cirrhotic ground. Most of the patients had high levels of AFP. In 58% of patients, the tumor was located in the right lobe. Routine liver tests and clinical findings varied. Radiologically, it was concluded that USG, computed tomography, and magnetic resonance imaging techniques were complementary and equivalent methods in terms of tumor diameter.

Anahtar Kelimeler

Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Alpha-fetoprotein

Kaynakça

  • Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2(9):533-43 DOI: 10.1016/s1470-2045(01)00486-7.
  • McMahon BJ, Alberts SR, Wainwright RB, Bulkow L, Lanier AP. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med. 1990;150(5):1051-4 DOI: 10.1001/archinte.150.5.1051.
  • Sugano S, Miyoshi K, Suzuki T, Kawafune T, Kubota M. Intrahepatic arteriovenous shunting due to hepatocellular carcinoma and cirrhosis, and its change by transcatheter arterial embolization. Am J Gastroenterol. 1994;89(2):184-8 https://pubmed.ncbi.nlm.nih.gov/8304300/
  • MC. K. Tumors of the liver. In: Zakim D. BT, editor. HEPATOLOGY: A TEXTBOOK OF THE LİVER DİSEASE. PHILADELPHIA: WB Saunders Company; 1996. p. 1513.
  • Lai CL, Ng RP, Lok AS. The diagnostic value of the ratio of serum gamma-glutamyl transpeptidase to alkaline phosphatase in alcoholic liver disease. Scand J Gastroenterol. 1982;17(1):41-7 DOI: 10.3109/00365528209181042.
  • Yoon KT, Kim JK, Kim DY, Ahn SH, Lee JD, Yun M, et al. Role of <sup>18</sup>FFluorodeoxyglucose Positron Emission Tomography in Detecting Extrahepatic Metastasis in Pretreatment Staging of Hepatocellular Carcinoma. Oncology. 2007;72(suppl 1)(Suppl. 1):10410 DOI: 10.1159/000111715.
  • Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y. Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer. 1990;66(10):2174-9 DOI: 10.1002/1097 0142(19901115)66:10<2174::aidcncr2820661022>3.0.co;2-a.
  • Kew MC, Dos Santos HA, Sherlock S. Diagnosis of primary cancer of the liver. Br Med J. 1971;4(5784):408-11 DOI: 10.1136/bmj.4.5784.408.
  • Llovet JM, Bustamante J, Castells A, Vilana R, Ayuso Mdel C, Sala M, et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology. 1999;29(1):62-7 DOI: 10.1002/hep.510290145.
  • A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology. 1998;28(3):751-5 DOI: 10.1002/hep.510280322.
  • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42(5):1208-36 DOI: 10.1002/hep.20933.
  • Gogel BM, Goldstein RM, Kuhn JA, McCarty TM, Donahoe A, Glastad K. Diagnostic evaluation of hepatocellular carcinoma in a cirrhotic liver. Oncology (Williston Park). 2000;14(6 Suppl 3):15-20
  • Wu JT. Serum alpha-fetoprotein and its lectin reactivity in liver diseases: a review. Ann Clin Lab Sci. 1990;20(2):98-105 https://pubmed.ncbi.nlm.nih.gov/1691611/
  • Collier J, Sherman M. Screening for hepatocellular carcinoma. Hepatology. 1998;27(1):273-8 DOI: 10.1002/hep.510270140.
  • Lok AS, Lai CL. alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology. 1989;9(1):110-5 DOI: 10.1002/hep.1840090119.
  • Okuda K, Ohtsuki T, Obata H, Tomimatsu M, Okazaki N, Hasegawa H, et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients. Cancer. 1985;56(4):918-28 DOI: 10.1002/1097-0142(19850815)56:4<918::aidcncr2820560437>3.0.co;2-e.
  • Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. The Cancer of the Liver Italian Program (CLIP) Investigators. Hepatology. 2000;31(4):840-5 DOI: 10.1053/he.2000.5628.
  • Primack A, Vogel CL, Kyalwazi SK, Ziegler JL, Simon R, Anthony PP. A staging system for hepatocellular carcinoma: prognostic factors in Ugandan patients. Cancer. 1975;35(5):135764 DOI: 10.1002/1097-0142(197505)35:5<1357::aid-cncr2820350518>3.0.co;2-8.
  • Lai CL, Lam KC, Wong KP, Wu PC, Todd D. Clinical features of hepatocellular carcinoma: review of 211 patients in Hong Kong. Cancer. 1981;47(11):2746-55 DOI: 10.1002/10970142(19810601)47:11<2746::aid-cncr2820471134>3.0.co;2-k.
  • Okuda K. Natural history of hepatocellular carcinoma including fibrolamellar and hepatocholangiocarcinoma variants. J Gastroenterol Hepatol. 2002;17(4):401-5 DOI: 10.1046/j.14401746.2002.02734.x.
  • Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19(3):329-38 DOI: 10.1055/s-2007-1007122.
  • Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred fortyseven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 2000;191(1):38-46 DOI: 10.1016/s1072-7515(00)00261-1.
  • Bralet MP, Régimbeau JM, Pineau P, Dubois S, Loas G, Degos F, et al. Hepatocellular carcinoma occurring in nonfibrotic liver: epidemiologic and histopathologic analysis of 80 French cases. Hepatology. 2000;32(2):200-4 DOI: 10.1053/jhep.2000.9033.
  • Hasegawa S, Yamasaki N, Hiwaki T, Sako K, Komorizono Y, Baba Y, et al. Factors that predict intrahepatic recurrence of hepatocellular carcinoma in 81 patients initially treated by percutaneous ethanol injection. Cancer. 1999;86(9):1682-90 DOI: 10.1002/(sici)10970142(19991101)86:9<1682::aid-cncr9>3.0.co;2-6.
  • Shiina S, Tagawa K, Niwa Y, Unuma T, Komatsu Y, Yoshiura K, et al. Percutaneous ethanol injection therapy for hepatocellular carcinoma: results in 146 patients. AJR Am J Roentgenol. 1993;160(5):1023-8 DOI: 10.2214/ajr.160.5.7682378.
  • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology. 2003;37(2):429-42 DOI: 10.1053/jhep.2003.50047.
  • Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol. 2004;5(7):40918 DOI: 10.1016/s1470-2045(04)01508-6.
  • Mathurin P, Rixe O, Carbonell N, Bernard B, Cluzel P, Bellin MF, et al. Review article: Overview of medical treatments in unresectable hepatocellular carcinoma--an impossible metaanalysis? Aliment Pharmacol Ther. 1998;12(2):111-26 DOI: 10.1046/j.13652036.1998.00286.x.
  • Okuda K KM, Okuda H. Neoplasms of the liver. In: Schiff L SE, editor. Diseases of the Liver. 7 ed. Philadelphia, PA: JB Lippincott Co; 1993. p. 1236-96.
  • El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med. 2000;160(21):3227-30 DOI: 10.1001/archinte.160.21.3227.
  • HBV genome integration and genetic instability in HBsAg-negative and anti-HCV-positive hepatocellular carcinoma in Japan. Cancer Letters. 1997;119(1):53-61 DOI: https://doi.org/10.1016/S0304-3835(97)00249-8.
  • Özdemir S ST, Şentürk H. Primary liver tumors. Turkish Gastroenterology. 1993(4):398401
  • Caturelli E, Solmi L, Anti M, Fusilli S, Roselli P, Andriulli A, et al. Ultrasound guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study. Gut. 2004;53(9):1356-62 DOI: 10.1136/gut.2003.032359.
  • Bruix J, Barrera JM, Calvet X, Ercilla G, Costa J, Sanchez-Tapias JM, et al. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989;2(8670):1004-6 DOI: 10.1016/s0140-6736(89)91015-5.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Research Articles
Yazarlar

Tuba Ersal 0000-0001-5419-3221

Fatma Laika Karabulut 0000-0002-1435-3400

Yayımlanma Tarihi 1 Ocak 2023
Gönderilme Tarihi 30 Kasım 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 1 Sayı: 1

Kaynak Göster

EndNote Ersal T, Karabulut FL (01 Ocak 2023) Demographic, etiological, clinical features, and laboratory features of hepatocellular carcinoma; a single center experience. Journal of Bursa Faculty of Medicine 1 1 26–32.
 Kapak Resmi İndir

Journal of Bursa Faculty of Medicine, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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