Derleme
BibTex RIS Kaynak Göster

Yıl 2020, Cilt: 9 Sayı: 1, 168 - 175, 30.06.2020

Sümeyye Güzel Nucan Yabancı Ayhan

Öz

Kaynakça

  • Aeberli, I., Biebinger, R., Lehmann, R., L’allemand, D., Spinas, G.A., Zimmermann, M.B. 2007. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab; 92: 4359-4365.
  • Alkhouri, N., Lopez, R., Berk, M., Feldstein, A.E. 2009. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol; 43: 985-989.
  • Bar-El Dadon, S., Reifen, R. 2017. Vitamin A and the epigenome. Crit Rev Food Sci Nutr; 57: 2404-2411.
  • Bellovino, D., Lanyau, Y., Garaguso, I., Amicone, L., Cavallari, C., Tripodi, M., Gaetani, S. 1999. MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol. J Cell Physiol; 181: 24-32.
  • Bitetto, D., Bortolotti, N., Falleti, E., Vescovo, S., Fabris, C., Fattovich, G., Cussigh, A., Cmet, S., Fornasiere, E., Ceriani, E., Pirisi, M., Toniutto, P. 2013. Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy. Hepatology; 57: 925-933.
  • Blomhoff, R., Blomhoff, H.K. 2006. Overview of retinoid metabolism and function. J. Neurobiol; 66: 606-630.
  • Bono, M.R., Tejon, G., Flores-Santibañez, F., Fernandez, D., Rosemblatt, M., Sauma, D. 2016. Retinoic Acid as a Modulator of T Cell Immunity. Nutrients; 8(6):349.
  • Botella-Carretero, J.I., Balsa, J.A., Vázquez, C., Peromingo, R., Díaz-Enriquez, M., Escobar-Morreale, H.F. 2010. Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. Obes Surg; 20: 69-76.
  • Chaves, G.V., Pereira, S.E., Saboya, C.J., Spitz, D., Rodrigues, C.S., Ramalho, A. 2014. Association between liver vitamin A reserves and severity of nonalcoholic fatty liver disease in the class III obese following bariatric surgery. Obes Surg; 24: 219-224.
  • Clemente, C., Elba, S., Buongiorno, G., Berloco, P., Guerra, V., Di Leo, A. 2002. Serum retinol and risk of hepatocellular carcinoma in patients with child-Pugh class A cirrhosis. Cancer Lett; 178: 123-129.
  • Comerford, K.B., Buchan,W., Karakas, S.E. 2014. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res; 46: 224-231.
  • During, A., Harrison, E.H. 2007. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res; 48: 2283-2294.
  • Dünya Sağlık Örgütü, https://www.who.int/nutrition/publications/micronutrients/vitamin_a_deficiency/WHO_NUT_96.10/en/, Erişim Tarihi: 15.06.2019.
  • Erikstrup, C., Mortensen, O.H., Nielsen, A.R., Fischer, C.P., Plomgaard, P., Petersen, A.M., Krogh-Madsen, R., Lindegaard, B., Erhardt, J.G., Ullum, H., et al. 2009. RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes. Diabetes Obes Metab; 11: 204-212.
  • Godala, M.M., Materek-Kusmierkiewicz, I., Moczulski, D., Rutkowski, M., Szatko, F., Gaszynska, E., Tokarski, S., Kowalski, J. 2017. The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study. Adv Clin Exp Med; 26(4):581-586.
  • Hannah, W.N., Harrison, S.A. 2016. Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease. Dig Dis Sci;61: 1365-1374.
  • Huang, P., Chandra, V., Rastinejad, F. 2014. Retinoic acid actions through mammalian nuclear receptors. Chem Rev; 114: 233-254.
  • Hussain, M.M. 2000. A proposed model for the assembly of chylomicrons. Atherosclerosis; 148: 1-15.
  • Ishibashi, S., Perrey, S., Chen, Z., Osuga, J., Shimada, M., Ohashi, K., Harada, K., Yazaki, Y., Yamada, N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem; 271: 22422-22427.
  • Kanaka-Gantenbein, C., Margeli, A., Pervanidou, P., Sakka, S., Mastorakos, G., Chrousos, G.P., Papassotiriou, I. 2008. Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: When children are not just “small adults”. Clin Chem; 54: 1176-1182.
  • Kim, H. Lee, K.-W., Lee, K., Seo, S., Park, M.-Y., Ahn, S.W., Hong, S.K., Yoon, K.C., Kim, H.-S., Choi, Y., et al. 2018. Effect of PNPLA3 I148M polymorphism on histologically proven non-alcoholic fatty liver disease in liver transplant recipients. Hepatol Res; 48(3): E162-E171.
  • Krawczyk, M., Jiménez-Agüero, R., Alustiza, J.M., Emparanza, J.I., Perugorria, M.J., Bujanda, L., Lammert, F., Banales, J.M. 2016. PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery. Surg Obes Relat Dis; 12: 1838-1846.
  • Linke, T., Dawson, H., Harrison, E.H. 2005. Isolation and characterization of a microsomal acid retinyl ester hydrolase. J Biol Chem; 280: 23287-23294.
  • Liu, Y., Chen, H., Mu, D., Fan, J. Song, J., Zhong, Y., Li, D., Xia, M. 2016. Circulating Retinoic Acid Levels and the Development of Metabolic Syndrome. J Clin Endocrinol Metab; 101: 1686-1692.
  • Liu, Y., Chen, H., Wang, J., Zhou,W., Sun, R., Xia, M. 2015. Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease. Am J Clin Nutr; 102: 130-137.
  • Malik, N.A. 2016. Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: A Review. Appl Biochem Biotechnol; 179: 179-201.
  • Mello, T., Nakatsuka, A., Fears, S. Davis, W., Tsukamoto, H., Bosron, W.F., Sanghani, S.P. 2008. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochem Biophys Res Commun; 374: 460-464.
  • Mills, J.P., Furr, H.C., Tanumihardjo, S.A. 2008. Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Exp Biol Med; 233: 1255-1261.
  • Mondul, A., Mancina, R.M., Merlo, A., Dongiovanni, P., Rametta, R., Montalcini, T., Valenti, L., Albanes, D., Romeo, S. 2015. PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity. J Nutr; 145: 1687-1691.
  • Newsome, P.N., Beldon, I., Moussa, Y., Delahooke, T.E., Poulopoulos, G., Hayes, P.C., Plevris, J.N. 2000. Low serum retinol levels are associated with hepatocellular carcinoma in patients with chronic liver disease. Aliment Pharmacol Ther; 14: 1295-1301.
  • Nguyen, V., George, J. 2015. Nonalcoholic Fatty Liver Disease Management: Dietary and Lifestyle Modifications. Semin. Liver Dis; 35: 318-337.
  • Pang, W., Zhang, Y., Wang, S., Jia, A., Dong, W., Cai, C., Hua, Z., Zhang, J. 2011. The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. J Lipid Res; 52: 934-941.
  • Pirazzi, C., Valenti, L., Motta, B.M., Pingitore, P., Hedfalk, K., Mancina, R.M., Burza, M.A., Indiveri, C., Ferro, Y. Montalcini, T., et al. 2014. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum Mol Genet; 23: 4077-4085.
  • Reinehr, T., Stoffel-Wagner, B., Roth, C.L. 2008. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab; 93: 2287-2293.
  • Saeed, A., Dullaart, R.P.F., Schreuder, T.C.M.A., Blokzill, H., Faber, K.N. 2018. Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients; 10(1).
  • Saeed, A., Hoekstra, M., Hoeke, M.O., Heegsma, J., Faber, K.N. 2017. The interrelationship between bile acid and vitamin A homeostasis. Biochim Biophys Acta; 1862: 496-512.
  • Suano de Souza, F.I., Silverio Amancio, O.M., Saccardo Sarni, R.O., Sacchi Pitta, T., Fernandes, A.P., Affonso Fonseca, F.L., Hix, S., Ramalho, R.A. 2008. Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels. Int J Vitam Nutr Res; 78: 27-32.
  • Tajtáková, M., Semanová, Z., Ivancová, G., Petrovicová, J., Donicová, V., Zemberová, E. 2007. Serum level of retinol-binding protein 4 in obese patients with insulin resistance and in patients with type 2 diabetes treated with metformin. Vnitr Lek; 53: 960-963.
  • Tanumihardjo, S.A., Russell, R.M., Stephensen, C.B., Gannon, B.M., Craft, N.E., Haskell, M.J., Lietz, G., Schulze, K., Raiten, D.J. 2016. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr; 146: 1816-1848.
  • Taschler, U., Schreiber, R., Chitraju, C., Grabner, G.F., Romauch, M., Wolinski, H., Haemmerle, G., Breinbauer, R., Zechner, R. Lass, A., Zimmermann, R. 2015. Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells. Biochim Biophys Acta; 1851: 937-945.
  • Teske, M., Melges, A.P., de Souza, F.I., Fonseca, F.L., Sarni, R.O. 2014. Plasma concentrations of retinol in obese children and adolescents: Relationship to metabolic syndrome components. Rev Paul Pediatr; 32: 50-54.
  • Trasino, S.E., Tang, X.-H., Jessurun, J., Gudas, L.J. 2015. Obesity Leads to Tissue, but not Serum Vitamin A Deficiency. Sci Rep; 5: 15893.
  • Ulgen, F., Herder, C., Kühn, M.C.,Willenberg, H.S., Schott, M., Scherbaum,W.A., Schinner, S. 2010. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem; 116: 57-62.
  • Van den Berg, E.H., Amini, M., Schreuder, T.C., Dullaart, R.P., Faber, K.N., Alizadeh, B.Z., Blokzijl, H. 2017. Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort. PLoS ONE; 12: e0171502.
  • Weber, D., Grune, T. 2012. The contribution of β-carotene to vitamin A supply of humans. Mol Nutr Food Res; 56: 251-258.
  • Wei, X., Peng, R., Cao, J., Kang, Y., Qu, P., Liu, Y., Xiao, X., Li, T. 2016. Serum vitamin A status is associated with obesity and the metabolic syndrome among school-age children in Chongqing, China. Asia Pac. J Clin Nutr; 25: 563-570.
  • Wolf, E., Utech, M., Stehle, P., Büsing, M., Stoffel-Wagner, B., Ellinger, S. 2015. Preoperative micronutrient status in morbidly obese patients before undergoing bariatric surgery: Results of a cross-sectional study. Surg. Obes Relat Dis; 11: 1157-1163.
  • Xia, M.-F., Ling, Y. Bian, H., Lin, H.-D., Yan, H.-M., Chang, X.-X., Li, X.-M., Ma, H., Wang, D., Zhang, L.-S., et al. 2016. I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders. Aliment Pharmacol Ther; 43,:631-642.
  • Yanagitani, A., Yamada, S., Yasui, S., Shimomura, T., Murai, R., Murawaki, Y., Hashiguchi, K., Kanbe, T., Saeki, T., Ichiba, M., et al. 2004. Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice. Hepatology; 40: 366-375.
  • Zhang, R., Wang, Y., Li, R., Chen, G. 2015. Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. Int J Mol Sci; 16: 14210-14244.

A VİTAMİNİNİN NON-ALKOLİK YAĞLI KARACİĞER HASTALIĞINDAKİ ROLÜ

Yıl 2020, Cilt: 9 Sayı: 1, 168 - 175, 30.06.2020

Sümeyye Güzel Nucan Yabancı Ayhan

Öz

Temel
bir mikro besin ögesi olan A vitamini, karaciğerdeki glukoz ve lipid
homeostazının düzenlenmesi dahil olmak üzere çeşitli fizyolojik fonksiyonlarda
kritik rol oynamaktadır. A vitamini vücutta temel olarak karaciğerdeki pasif hepatik
yıldız hücrelerde (HYH) depolanır. Hepatositler A vitaminini metabolize eder ve
A vitamini metabolitlerine yanıt olarak glukoz ve lipid metabolizması değişikliğinde
rol oynar. Ancak aktif hale getirilmiş HYH'ler A vitamini içeriklerini kaybeder
ve karaciğer yağlanmasının alkol tüketimine bağlı olmayan türü olan non-alkolik
yağlı karaciğer hastalığı (NAYKH) gelişmesine neden olur. Bu derlemede, NAYKH 'de
A vitamini metabolizması ve karaciğer hastalığının ilerlemesindeki olası rolü
ile birlikte A vitamini metabolitlerinin terapötik potansiyelinin
değerlendirmesi amaçlanmıştır. 

Anahtar Kelimeler

A vitamini non-alkolik yağlı karaciğer hastalığı retinol retinoik asit

Kaynakça

  • Aeberli, I., Biebinger, R., Lehmann, R., L’allemand, D., Spinas, G.A., Zimmermann, M.B. 2007. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab; 92: 4359-4365.
  • Alkhouri, N., Lopez, R., Berk, M., Feldstein, A.E. 2009. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol; 43: 985-989.
  • Bar-El Dadon, S., Reifen, R. 2017. Vitamin A and the epigenome. Crit Rev Food Sci Nutr; 57: 2404-2411.
  • Bellovino, D., Lanyau, Y., Garaguso, I., Amicone, L., Cavallari, C., Tripodi, M., Gaetani, S. 1999. MMH cells: An in vitro model for the study of retinol-binding protein secretion regulated by retinol. J Cell Physiol; 181: 24-32.
  • Bitetto, D., Bortolotti, N., Falleti, E., Vescovo, S., Fabris, C., Fattovich, G., Cussigh, A., Cmet, S., Fornasiere, E., Ceriani, E., Pirisi, M., Toniutto, P. 2013. Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy. Hepatology; 57: 925-933.
  • Blomhoff, R., Blomhoff, H.K. 2006. Overview of retinoid metabolism and function. J. Neurobiol; 66: 606-630.
  • Bono, M.R., Tejon, G., Flores-Santibañez, F., Fernandez, D., Rosemblatt, M., Sauma, D. 2016. Retinoic Acid as a Modulator of T Cell Immunity. Nutrients; 8(6):349.
  • Botella-Carretero, J.I., Balsa, J.A., Vázquez, C., Peromingo, R., Díaz-Enriquez, M., Escobar-Morreale, H.F. 2010. Retinol and alpha-tocopherol in morbid obesity and nonalcoholic fatty liver disease. Obes Surg; 20: 69-76.
  • Chaves, G.V., Pereira, S.E., Saboya, C.J., Spitz, D., Rodrigues, C.S., Ramalho, A. 2014. Association between liver vitamin A reserves and severity of nonalcoholic fatty liver disease in the class III obese following bariatric surgery. Obes Surg; 24: 219-224.
  • Clemente, C., Elba, S., Buongiorno, G., Berloco, P., Guerra, V., Di Leo, A. 2002. Serum retinol and risk of hepatocellular carcinoma in patients with child-Pugh class A cirrhosis. Cancer Lett; 178: 123-129.
  • Comerford, K.B., Buchan,W., Karakas, S.E. 2014. The effects of weight loss on FABP4 and RBP4 in obese women with metabolic syndrome. Horm Metab Res; 46: 224-231.
  • During, A., Harrison, E.H. 2007. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res; 48: 2283-2294.
  • Dünya Sağlık Örgütü, https://www.who.int/nutrition/publications/micronutrients/vitamin_a_deficiency/WHO_NUT_96.10/en/, Erişim Tarihi: 15.06.2019.
  • Erikstrup, C., Mortensen, O.H., Nielsen, A.R., Fischer, C.P., Plomgaard, P., Petersen, A.M., Krogh-Madsen, R., Lindegaard, B., Erhardt, J.G., Ullum, H., et al. 2009. RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes. Diabetes Obes Metab; 11: 204-212.
  • Godala, M.M., Materek-Kusmierkiewicz, I., Moczulski, D., Rutkowski, M., Szatko, F., Gaszynska, E., Tokarski, S., Kowalski, J. 2017. The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study. Adv Clin Exp Med; 26(4):581-586.
  • Hannah, W.N., Harrison, S.A. 2016. Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease. Dig Dis Sci;61: 1365-1374.
  • Huang, P., Chandra, V., Rastinejad, F. 2014. Retinoic acid actions through mammalian nuclear receptors. Chem Rev; 114: 233-254.
  • Hussain, M.M. 2000. A proposed model for the assembly of chylomicrons. Atherosclerosis; 148: 1-15.
  • Ishibashi, S., Perrey, S., Chen, Z., Osuga, J., Shimada, M., Ohashi, K., Harada, K., Yazaki, Y., Yamada, N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem; 271: 22422-22427.
  • Kanaka-Gantenbein, C., Margeli, A., Pervanidou, P., Sakka, S., Mastorakos, G., Chrousos, G.P., Papassotiriou, I. 2008. Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: When children are not just “small adults”. Clin Chem; 54: 1176-1182.
  • Kim, H. Lee, K.-W., Lee, K., Seo, S., Park, M.-Y., Ahn, S.W., Hong, S.K., Yoon, K.C., Kim, H.-S., Choi, Y., et al. 2018. Effect of PNPLA3 I148M polymorphism on histologically proven non-alcoholic fatty liver disease in liver transplant recipients. Hepatol Res; 48(3): E162-E171.
  • Krawczyk, M., Jiménez-Agüero, R., Alustiza, J.M., Emparanza, J.I., Perugorria, M.J., Bujanda, L., Lammert, F., Banales, J.M. 2016. PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery. Surg Obes Relat Dis; 12: 1838-1846.
  • Linke, T., Dawson, H., Harrison, E.H. 2005. Isolation and characterization of a microsomal acid retinyl ester hydrolase. J Biol Chem; 280: 23287-23294.
  • Liu, Y., Chen, H., Mu, D., Fan, J. Song, J., Zhong, Y., Li, D., Xia, M. 2016. Circulating Retinoic Acid Levels and the Development of Metabolic Syndrome. J Clin Endocrinol Metab; 101: 1686-1692.
  • Liu, Y., Chen, H., Wang, J., Zhou,W., Sun, R., Xia, M. 2015. Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease. Am J Clin Nutr; 102: 130-137.
  • Malik, N.A. 2016. Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: A Review. Appl Biochem Biotechnol; 179: 179-201.
  • Mello, T., Nakatsuka, A., Fears, S. Davis, W., Tsukamoto, H., Bosron, W.F., Sanghani, S.P. 2008. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochem Biophys Res Commun; 374: 460-464.
  • Mills, J.P., Furr, H.C., Tanumihardjo, S.A. 2008. Retinol to retinol-binding protein (RBP) is low in obese adults due to elevated apo-RBP. Exp Biol Med; 233: 1255-1261.
  • Mondul, A., Mancina, R.M., Merlo, A., Dongiovanni, P., Rametta, R., Montalcini, T., Valenti, L., Albanes, D., Romeo, S. 2015. PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity. J Nutr; 145: 1687-1691.
  • Newsome, P.N., Beldon, I., Moussa, Y., Delahooke, T.E., Poulopoulos, G., Hayes, P.C., Plevris, J.N. 2000. Low serum retinol levels are associated with hepatocellular carcinoma in patients with chronic liver disease. Aliment Pharmacol Ther; 14: 1295-1301.
  • Nguyen, V., George, J. 2015. Nonalcoholic Fatty Liver Disease Management: Dietary and Lifestyle Modifications. Semin. Liver Dis; 35: 318-337.
  • Pang, W., Zhang, Y., Wang, S., Jia, A., Dong, W., Cai, C., Hua, Z., Zhang, J. 2011. The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. J Lipid Res; 52: 934-941.
  • Pirazzi, C., Valenti, L., Motta, B.M., Pingitore, P., Hedfalk, K., Mancina, R.M., Burza, M.A., Indiveri, C., Ferro, Y. Montalcini, T., et al. 2014. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum Mol Genet; 23: 4077-4085.
  • Reinehr, T., Stoffel-Wagner, B., Roth, C.L. 2008. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab; 93: 2287-2293.
  • Saeed, A., Dullaart, R.P.F., Schreuder, T.C.M.A., Blokzill, H., Faber, K.N. 2018. Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). Nutrients; 10(1).
  • Saeed, A., Hoekstra, M., Hoeke, M.O., Heegsma, J., Faber, K.N. 2017. The interrelationship between bile acid and vitamin A homeostasis. Biochim Biophys Acta; 1862: 496-512.
  • Suano de Souza, F.I., Silverio Amancio, O.M., Saccardo Sarni, R.O., Sacchi Pitta, T., Fernandes, A.P., Affonso Fonseca, F.L., Hix, S., Ramalho, R.A. 2008. Non-alcoholic fatty liver disease in overweight children and its relationship with retinol serum levels. Int J Vitam Nutr Res; 78: 27-32.
  • Tajtáková, M., Semanová, Z., Ivancová, G., Petrovicová, J., Donicová, V., Zemberová, E. 2007. Serum level of retinol-binding protein 4 in obese patients with insulin resistance and in patients with type 2 diabetes treated with metformin. Vnitr Lek; 53: 960-963.
  • Tanumihardjo, S.A., Russell, R.M., Stephensen, C.B., Gannon, B.M., Craft, N.E., Haskell, M.J., Lietz, G., Schulze, K., Raiten, D.J. 2016. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr; 146: 1816-1848.
  • Taschler, U., Schreiber, R., Chitraju, C., Grabner, G.F., Romauch, M., Wolinski, H., Haemmerle, G., Breinbauer, R., Zechner, R. Lass, A., Zimmermann, R. 2015. Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells. Biochim Biophys Acta; 1851: 937-945.
  • Teske, M., Melges, A.P., de Souza, F.I., Fonseca, F.L., Sarni, R.O. 2014. Plasma concentrations of retinol in obese children and adolescents: Relationship to metabolic syndrome components. Rev Paul Pediatr; 32: 50-54.
  • Trasino, S.E., Tang, X.-H., Jessurun, J., Gudas, L.J. 2015. Obesity Leads to Tissue, but not Serum Vitamin A Deficiency. Sci Rep; 5: 15893.
  • Ulgen, F., Herder, C., Kühn, M.C.,Willenberg, H.S., Schott, M., Scherbaum,W.A., Schinner, S. 2010. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem; 116: 57-62.
  • Van den Berg, E.H., Amini, M., Schreuder, T.C., Dullaart, R.P., Faber, K.N., Alizadeh, B.Z., Blokzijl, H. 2017. Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort. PLoS ONE; 12: e0171502.
  • Weber, D., Grune, T. 2012. The contribution of β-carotene to vitamin A supply of humans. Mol Nutr Food Res; 56: 251-258.
  • Wei, X., Peng, R., Cao, J., Kang, Y., Qu, P., Liu, Y., Xiao, X., Li, T. 2016. Serum vitamin A status is associated with obesity and the metabolic syndrome among school-age children in Chongqing, China. Asia Pac. J Clin Nutr; 25: 563-570.
  • Wolf, E., Utech, M., Stehle, P., Büsing, M., Stoffel-Wagner, B., Ellinger, S. 2015. Preoperative micronutrient status in morbidly obese patients before undergoing bariatric surgery: Results of a cross-sectional study. Surg. Obes Relat Dis; 11: 1157-1163.
  • Xia, M.-F., Ling, Y. Bian, H., Lin, H.-D., Yan, H.-M., Chang, X.-X., Li, X.-M., Ma, H., Wang, D., Zhang, L.-S., et al. 2016. I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders. Aliment Pharmacol Ther; 43,:631-642.
  • Yanagitani, A., Yamada, S., Yasui, S., Shimomura, T., Murai, R., Murawaki, Y., Hashiguchi, K., Kanbe, T., Saeki, T., Ichiba, M., et al. 2004. Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice. Hepatology; 40: 366-375.
  • Zhang, R., Wang, Y., Li, R., Chen, G. 2015. Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism. Int J Mol Sci; 16: 14210-14244.
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Sümeyye Güzel

Nucan Yabancı Ayhan

Yayımlanma Tarihi 30 Haziran 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 9 Sayı: 1

Kaynak Göster

APA Güzel, S., & Yabancı Ayhan, N. (2020). A VİTAMİNİNİN NON-ALKOLİK YAĞLI KARACİĞER HASTALIĞINDAKİ ROLÜ. Ankara Sağlık Bilimleri Dergisi, 9(1), 168-175.