Öz
Larenks karsinomları baş boyun karsinomlarının yaklaşık yarısından sorumlu iken glottik lezyonlar larenks karsinomlarınn %60 ını oluşturur. Glottik karsinomlar daha çok lokalize kalma eğiliminde olsalarda ileri evrelerde subglottik yayılımla birlikte paratrakeal lenf nodlarına da metastaz yaparlar. Bu metastaz oranı %12 gibi düşük seviyelerde olmakla birlikte görüntüleme yöntemleri ile ortaya koymakta kolay değildir. Preoperatif görüntüleme yöntemleri ile N0 olarak değerlendirilen ve postoperatif dönemde paratrakeal lenf nodu metastazı saptanan glottik squamoz hücreli karsinom olgusu literatür eşliğinde tartışılmıştır.
Anahtar Kelimeler
larenks karsinomu glottik karsinom paratrakeal lenfadenopati
Kaynakça
- 1. American Cancer Society. Laryngeal and Hypopharyngeal Cancers What is cancer ? What are laryngeal and hypopharyngeal cancers ? Published online 2014:1-10.
- 2. Mendenhall WM, Hinerman RW, Amdur RJ, Mancuso AA, Villaret DB, Robbins KT. Larynx. In: Perez CA, Brady L, Halperin E, Schmidt-Ullrich R, eds. Principles and Practice of Radiation Oncology. 4th editio. Lippincott Williams&Wilkins; 2016:928.
- 3. National Cancer Institute. Cancer Stat Facts: Laryngeal Cancer.
- 4. Kowalski LP, Franco EL, de Andrade Sobrinho J. Factors influencing regional lymph node metastasis from laryngeal carcinoma. Ann Otol Rhinol Laryngol. Published online 1995. doi:10.1177/000348949510400605
- 5. Lingen M. Head and Neck. In: Kumar V, Abbas A, Aster J, eds. Robbins&Cotran Pathologic Basis of Disease. 9th ed. Elsevier Saunders; 2015:738-741.
- 6. Thompson L. Malign Neoplasms of the Larynx, Hypopharynx and Trachea. In: Thompson L, Goldblum J, eds. Head and Neck Pathology. 2nd ed. Elsevier Saunders; 2012:144-179.
- 7. Etil D. Larinks ve Hipofarinks. In: Sarioglu S, ed. Baş Boyun Patolojisi. 1st ed. O’Tıp Kitabevi; 2014:199-226.
- 8. Maier H, Tisch M. Epidemiology of laryngeal cancer: Results of the Heidelberg case- control study. Acta Oto-Laryngologica, Suppl. Published online 1997. doi:10.3109/00016489709124063
- 9. Nguyen C, Naghibzadeh B, Black MJ, Rochon L, Shenouda G. Glottic microinvasive carcinoma: Is it different from carcinoma in situ? J Otolaryngol. Published online 1996.
- 10. Bryne M, Jenssen N, Boysen M. Histological grading in the deep invasive front of T1 and T2 glottic squamous cell carcinomas has high prognostic value. Virchows Arch. Published online 1995. doi:10.1007/BF00203395
- 11. Futrell JW, Bennet SH, Hoye RC, Roth JA, Ketcham AS. Predicting survival in cancer of the larynx or hypopharynx. Am J Surg. 1971;4(122):451-457. doi:10.1016/0002-9610(71)90467-3
- 12. Damiani J, Damiani KK, Hauck K, Hyams VJ. Mucoepidermoid-adenosquamous carcinoma of the larynx and hypopharynx: A report of 21 cases and a review of the literature. Otolaryngol - Head Neck Surg. Published online 1981. doi:10.1177/019459988108900218
- 13. Krȩcicki T, Jeleń M, Zalesska-Krȩcicka M, Szkudlarek T. Ki-67 immunostaining and prognosis in laryngeal cancer. Clin Otolaryngol Allied Sci. Published online 1998. doi:10.1046/j.1365-2273.1998.2360539.x
- 14. Spector JG, Sessions DG, Haughey BH, et al. Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx. Laryngoscope. Published online 2001. doi:10.1097/00005537-200106000-00028
- 15. Lam KY, Lo CY, Liu MC. Primary squamous cell carcinoma of the thyroid gland: An entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles. Histopathology. Published online 2001. doi:10.1046/j.1365-2559.2001.01207.x
- 16. Korovin GS, Cho HT, Kuriloff DB, Sobol SM. Squamous cell carcinoma of the thyroid: A diagnostic dilemma. Ann Otol Rhinol Laryngol. Published online 1989. doi:10.1177/000348948909800113
- 17. Cho JK, Woo SH, Park J, Kim MJ, Jeong HS. Primary squamous cell carcinomas in the thyroid gland: An individual participant data meta-analysis. Cancer Med. Published online 2014. doi:10.1002/cam4.287
- 18. Makay O, Kaya T, Ertan Y, et al. Primary squamous cell carcinoma of the thyroid: Report of three cases. Endocr J. Published online 2008. doi:10.1507/endocrj.K07E-102
- 19. Sparano A, Chernock R, Laccourreye O, Weinstein G, Feldman M. Predictors of thyroid gland invasion in glottic squamous cell carcinoma. Laryngoscope. Published online 2005. doi:10.1097/01.MLG.0000165454.75480.EA
- 20. Thaler ER, Montone K, Tucker J, Weinstein GS. Delphian lymph node in laryngeal carcinoma: A whole organ study. Laryngoscope. Published online 1997. doi:10.1097/00005537-199703000-00010
- 21. Lucioni M, D’Ascanio L, De Nardi E, Lionello M, Bertolin A, Rizzotto G. Management of paratracheal lymph nodes in laryngeal cancer with subglottic involvement. Head Neck. Published online 2018. doi:10.1002/hed.24905
- 22. Kaya S. Larenks Hastalıkları. Bilimsel Tıp Kitabevi; 2002.
- 23. Ferlito A, Robbins KT, Shaha AR, et al. Current considerations in neck dissection. Acta Otolaryngol. Published online 2002. doi:10.1080/000164802753648259
- 24. Welsh LW. L: The normal human laryngeal lymphatics. Ann Otol Rhinol Laryngol. Published online 1964. doi:10.1177/000348946407300301
Öz
While laryngeal carcinomas are responsible for about half of head and neck carcinomas, glottic lesions constitute 60% of laryngeal carcinomas. Although glottic carcinomas tend to remain more localized, they also metastasize to paratracheal lymph nodes with subglottic spread in advanced stages. Although this metastasis rate is as low as 12%, it is not easy to reveal it with imaging methods. A case of glottic squamous cell carcinoma, which was evaluated as N0 by preoperative imaging and found to have paratracheal lymph node metastasis in the postoperative period, is presented along with the literature.
Anahtar Kelimeler
Larenx Carsinoma glottic carsinoma paratracheal lymphadenopathy
Kaynakça
- 1. American Cancer Society. Laryngeal and Hypopharyngeal Cancers What is cancer ? What are laryngeal and hypopharyngeal cancers ? Published online 2014:1-10.
- 2. Mendenhall WM, Hinerman RW, Amdur RJ, Mancuso AA, Villaret DB, Robbins KT. Larynx. In: Perez CA, Brady L, Halperin E, Schmidt-Ullrich R, eds. Principles and Practice of Radiation Oncology. 4th editio. Lippincott Williams&Wilkins; 2016:928.
- 3. National Cancer Institute. Cancer Stat Facts: Laryngeal Cancer.
- 4. Kowalski LP, Franco EL, de Andrade Sobrinho J. Factors influencing regional lymph node metastasis from laryngeal carcinoma. Ann Otol Rhinol Laryngol. Published online 1995. doi:10.1177/000348949510400605
- 5. Lingen M. Head and Neck. In: Kumar V, Abbas A, Aster J, eds. Robbins&Cotran Pathologic Basis of Disease. 9th ed. Elsevier Saunders; 2015:738-741.
- 6. Thompson L. Malign Neoplasms of the Larynx, Hypopharynx and Trachea. In: Thompson L, Goldblum J, eds. Head and Neck Pathology. 2nd ed. Elsevier Saunders; 2012:144-179.
- 7. Etil D. Larinks ve Hipofarinks. In: Sarioglu S, ed. Baş Boyun Patolojisi. 1st ed. O’Tıp Kitabevi; 2014:199-226.
- 8. Maier H, Tisch M. Epidemiology of laryngeal cancer: Results of the Heidelberg case- control study. Acta Oto-Laryngologica, Suppl. Published online 1997. doi:10.3109/00016489709124063
- 9. Nguyen C, Naghibzadeh B, Black MJ, Rochon L, Shenouda G. Glottic microinvasive carcinoma: Is it different from carcinoma in situ? J Otolaryngol. Published online 1996.
- 10. Bryne M, Jenssen N, Boysen M. Histological grading in the deep invasive front of T1 and T2 glottic squamous cell carcinomas has high prognostic value. Virchows Arch. Published online 1995. doi:10.1007/BF00203395
- 11. Futrell JW, Bennet SH, Hoye RC, Roth JA, Ketcham AS. Predicting survival in cancer of the larynx or hypopharynx. Am J Surg. 1971;4(122):451-457. doi:10.1016/0002-9610(71)90467-3
- 12. Damiani J, Damiani KK, Hauck K, Hyams VJ. Mucoepidermoid-adenosquamous carcinoma of the larynx and hypopharynx: A report of 21 cases and a review of the literature. Otolaryngol - Head Neck Surg. Published online 1981. doi:10.1177/019459988108900218
- 13. Krȩcicki T, Jeleń M, Zalesska-Krȩcicka M, Szkudlarek T. Ki-67 immunostaining and prognosis in laryngeal cancer. Clin Otolaryngol Allied Sci. Published online 1998. doi:10.1046/j.1365-2273.1998.2360539.x
- 14. Spector JG, Sessions DG, Haughey BH, et al. Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx. Laryngoscope. Published online 2001. doi:10.1097/00005537-200106000-00028
- 15. Lam KY, Lo CY, Liu MC. Primary squamous cell carcinoma of the thyroid gland: An entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles. Histopathology. Published online 2001. doi:10.1046/j.1365-2559.2001.01207.x
- 16. Korovin GS, Cho HT, Kuriloff DB, Sobol SM. Squamous cell carcinoma of the thyroid: A diagnostic dilemma. Ann Otol Rhinol Laryngol. Published online 1989. doi:10.1177/000348948909800113
- 17. Cho JK, Woo SH, Park J, Kim MJ, Jeong HS. Primary squamous cell carcinomas in the thyroid gland: An individual participant data meta-analysis. Cancer Med. Published online 2014. doi:10.1002/cam4.287
- 18. Makay O, Kaya T, Ertan Y, et al. Primary squamous cell carcinoma of the thyroid: Report of three cases. Endocr J. Published online 2008. doi:10.1507/endocrj.K07E-102
- 19. Sparano A, Chernock R, Laccourreye O, Weinstein G, Feldman M. Predictors of thyroid gland invasion in glottic squamous cell carcinoma. Laryngoscope. Published online 2005. doi:10.1097/01.MLG.0000165454.75480.EA
- 20. Thaler ER, Montone K, Tucker J, Weinstein GS. Delphian lymph node in laryngeal carcinoma: A whole organ study. Laryngoscope. Published online 1997. doi:10.1097/00005537-199703000-00010
- 21. Lucioni M, D’Ascanio L, De Nardi E, Lionello M, Bertolin A, Rizzotto G. Management of paratracheal lymph nodes in laryngeal cancer with subglottic involvement. Head Neck. Published online 2018. doi:10.1002/hed.24905
- 22. Kaya S. Larenks Hastalıkları. Bilimsel Tıp Kitabevi; 2002.
- 23. Ferlito A, Robbins KT, Shaha AR, et al. Current considerations in neck dissection. Acta Otolaryngol. Published online 2002. doi:10.1080/000164802753648259
- 24. Welsh LW. L: The normal human laryngeal lymphatics. Ann Otol Rhinol Laryngol. Published online 1964. doi:10.1177/000348946407300301
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Olgu sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2021 |
| Kabul Tarihi | 4 Mayıs 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 4 Sayı: 2 |
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