Comparison of Clinic and Demographic Characteristics of Children with Laboratory-Confirmed and Suspected COVID-19 who Admitted to Pediatric Emergency Clinic
Öz
Aim: To determine the frequency of COVID-19 infection in children and to compare the parameters of laboratory-confirmed and suspected cases.
Material and Methods: Medical records collected with a prospective design of 1300 pediatric patients who applied to COVID-19 triage of pediatric emergency service. Clinic and demographic characteristics of children with laboratory-confirmed and suspected COVID-19 were compared. Nasopharyngeal swab sample was taken from all pediatric patients in accordance with the possible case definition determined by the national Ministry of Health.
Results: The COVID-19 test was found positive in 94 (7.2%) children. Of those, 34.5% children had a history of contact, and 31.9% of all cases were asymptomatic. The mean age of children who were positive for COVID-19 was higher than those who were negative (p <0.001). COVID-19 positive cases had a higher domestic contact history than those who were negative (79.8% and 31%, respectively, p <0.001). The mean WBC, platelet, neutrophil, RDW, procalcitonin, CRP, LDH and total bilirubin values of COVID-19 positive patients were found as significantly lower than COVID-19 negative patients (p <0.05).
Conclusion: We found that there was a statistically significant difference between COVID-19 positive and negative patients in terms of age and laboratory parameters. We have shown that most patients with positive COVID-19 test are asymptomatic, have a high rate of contact history and require hospitalization.
Anahtar Kelimeler
COVID-19 children emergency clinical course laboratory transmission
Proje Numarası
Yok
Kaynakça
- Zhu NA, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 7
- World Health Organization. Novel coronavirus (2019-nCoV). Situation report-22 [Internet]. Geneva (Switzerland): World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/ default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.
- Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Apr 14: doi: 10.1111/apa.15270.
- Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223): 514-523.
- Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1371.
- Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-132.
- Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020;39(5):355-368.
- Republic of Turkey Ministry COVID-19 Information Page. https://covid19.saglik.gov.tr/TR-66301/covid-19-rehberi.html.
- Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702.
- Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020;53(3):371-372.
- Mania A, Mazur-Melewska K, Lubarski K, Kuczma-Napierała J, Mazurek J, Jończyk-Potoczna K, et al. Wide spectrum of clinical picture of COVID-19 in children - from mild to severe disease. J Infect Public Health. 2021;14(3):374-379.
- Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020 Jul 28;71(15):853-857.
- Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 23;382(17):1663-1665.
- Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-673.
- Martins MM, Prata-Barbosa A, da Cunha AJLA. Update on SARS-CoV-2 infection in children. Paediatr Int Child Health. 2021;41(1):56-64.
- Bozlu G, Ozgokce Ozmen B, Akca M, Durak F, Kuyucu N. The Role of Immature Granulocytes Percentage to Predict Severe COVID-19 in Children. Kuwait Medical Journal, (In press).
- Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020;58(7):1135-1138.
Çocuk Acil Kliniğine Başvuran Laboratuvarca Doğrulanmış ve Şüpheli COVID-19 Çocukların Klinik ve Demografik Özelliklerinin Karşılaştırılması
Öz
Amaç: Çocuklarda COVID-19 enfeksiyonu sıklığını belirlemek ve laboratuvarca doğrulanmış ve şüpheli vakaların parametrelerini karşılaştırmak.
Gereç ve Yöntemler: Çocuk acil servisinin COVID-19 triyajına başvuran 1300 pediatrik hastadan prospektif bir tasarımla toplanan tıbbi kayıtlar alındı. Laboratuvarca doğrulanmış ve COVID-19 şüphesi olan çocukların klinik ve demografik özellikleri karşılaştırıldı. Sağlık Bakanlığı tarafından belirlenen olası vaka tanımına göre tüm pediatrik hastalardan nazofaringeal sürüntü örneği alındı.
Bulgular: 94 (%7,2) çocukta COVID-19 testi pozitif bulundu. Bunların %34,5'inde çocukların temas öyküsü vardı ve tüm vakaların %31,9'u asemptomatiktir. COVID-19 pozitif olan çocukların yaş ortalaması negatif olanlardan daha yüksekti (p <0.001). COVID-19 pozitif vakaların, negatif olanlara göre daha yüksek ev içi temas öyküsü vardı (sırasıyla %79,8 ve %31, p <0,001). COVID 19 pozitif çocuklarda ortalama beyaz kan hücresi, trombosit, nötrofil, kırmızı kan hücresi dağılım genişliği, prokalsitonin, C-reaktif protein, laktat dehidrogenaz ve total bilirubin değerleri istatistiksel olarak anlamlıydı (p <0.05).
Sonuç: Çocuklarda COVID-19 enfeksiyonu oranı nispeten düşüktür ve COVID-19 ile ilişkili bildirilen vaka serileri de pediatrik grupta erişkinlere göre daha azdır. COVID-19'un çocuklarda epidemiyolojik özellikleri ve bulaşma yolları ile ilgili önemli sayıda vaka içeren çalışmalardan biri olduğunu ve bundan sonraki çalışmalara ışık tutacağını düşünüyoruz.
Anahtar Kelimeler
COVID-19 çocuklar acil durum klinik kursu laboratuvar bulaşma
Destekleyen Kurum
Yok
Proje Numarası
Yok
Teşekkür
Yok
Kaynakça
- Zhu NA, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 7
- World Health Organization. Novel coronavirus (2019-nCoV). Situation report-22 [Internet]. Geneva (Switzerland): World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/ default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.
- Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Apr 14: doi: 10.1111/apa.15270.
- Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223): 514-523.
- Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1371.
- Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-132.
- Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020;39(5):355-368.
- Republic of Turkey Ministry COVID-19 Information Page. https://covid19.saglik.gov.tr/TR-66301/covid-19-rehberi.html.
- Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702.
- Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020;53(3):371-372.
- Mania A, Mazur-Melewska K, Lubarski K, Kuczma-Napierała J, Mazurek J, Jończyk-Potoczna K, et al. Wide spectrum of clinical picture of COVID-19 in children - from mild to severe disease. J Infect Public Health. 2021;14(3):374-379.
- Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020 Jul 28;71(15):853-857.
- Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 23;382(17):1663-1665.
- Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-673.
- Martins MM, Prata-Barbosa A, da Cunha AJLA. Update on SARS-CoV-2 infection in children. Paediatr Int Child Health. 2021;41(1):56-64.
- Bozlu G, Ozgokce Ozmen B, Akca M, Durak F, Kuyucu N. The Role of Immature Granulocytes Percentage to Predict Severe COVID-19 in Children. Kuwait Medical Journal, (In press).
- Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020;58(7):1135-1138.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Orijinal Çalışma |
| Yazarlar | |
| Proje Numarası | Yok |
| Erken Görünüm Tarihi | 29 Aralık 2023 |
| Yayımlanma Tarihi | 29 Aralık 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 6 Sayı: 4 |
