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Vitamin D and Its Anticarcinogenic Effects

Yıl 2021, Cilt: 5 Sayı: 1, 136 - 146, 31.01.2021

Murat Arı

https://doi.org/10.46237/amusbfd.740270

Öz

Vitamin D is identified as a hormon-like group of sterols, dissolved in oil and organic solvents, but do not dissolve in water act as hormones, because it reaches every organ and tissue through their receptors and perform important tasks. It plays a fundamental role in maintaining calcium and phosphorus metabolism. Many studies have revealed that the active form of vitamin D (1,25-(OH)2D3) has also cell proliferation, apoptotic and antioxidant effects. The purpose of this review is to highlight the major role of vitamin D and its metabolites, as well as cancer and their relation to autoimmune diseases, immune system.

Anahtar Kelimeler

Vitamin D Antioxidants Cancer

Kaynakça

  • 1. Hochberg, Z. (2004). Requirements for vitamin D in an indoors culture. Highlights, 12, 19-23.
  • 2. Rusinska, A., Pludowski, P., Walczak, M., Borszewska-Kornacka, M., Bossowski, A., & Chalebna-Sokol, D. (2018). Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland-Recomendations of the Polish society of pediatric endocrinology and diabetes and the expert panel with the participation of the national specialist consultans and representatives of scientific societies-2018 update. Frontiers in Endocrinology, 9, 246.
  • 3. Dittmer, K. E., & Thompson, K. G. (2011). Vitamin D metabolism and rickets in domestic animals: A review. Veterinary Pathology, 48(2), 389-407.
  • 4. Montgomery, R., Conway, T. W., Spector, A.A. (2000). Biyokimya olgu sunumlu yaklaşım. Ankara: Palme Yayıncılık.
  • 5. Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-81.
  • 6. Gow, A. G., Else, R., Evans, H., Berry, J. L., Herrtage M. E., & Mellany, R.J. (2011). Hypovitaminosis D in dogs with inflammatory bowel disease and hypoalbuminaemia. Journal of Small Animal Practice, 52,411-418.
  • 7. Potts J. T. (2005). Parathyroid hormone: pastandpresent . J. Endocrinol, 187(3), 311-325.
  • 8. Human, K.L., & Lane, N.E. (2006). Parathyroid hormone update. Rheum Dis Clin North Am, 32, 703-19.
  • 9. Rubin, M. R. (2002). “The anabolic effects of parathyroid hormone” Osteoporos Int, 13, 267-77.
  • 10. Kimball, S., Fuleihan, G. H., & Vieth, R. (2008). Vitamin D. A growing perspective. Crit Rev Clin Lab Sci, 45(4), 339-414.
  • 11. Akbel, E. (2005). Yüksek protein içeren diyetle beslenen sıçanlara atkestanesi ekstresi verilmesinin kemik ve kalsiyum metabolizmasına etkileri. (Yayımlanmamış Doktora Tezi) Afyonkarahisar Kocatepe Üniversitesi, Afyonkarahisar, Türkiye.
  • 12. Dawson-Hughes, B., Dallal, G. E., Kral, E.A., Haris, S., Sokol, L. J., & Falconer, G. (1991). Effect of vitamin D supplementation on winter time and overall bone loss in healthy postmenopausal women. Ann Int Med, 115, 505-12.
  • 13. Tezcan, I. (2012). D Vitamini ve immün sistem. Türkiye Klinikleri, 8(2), 66-8.
  • 14. Bikle, D. (2009). Nonclassic actions of vitamin D. J Clin Endocrinol Metab, 94(1), 2634.
  • 15. Yang, S., Li, A., Wang, J., Liu, J., Han, Y., Zhamg, W., et al. (2018). Vitamin D receptor: A novel therapeutic target for kidney diseases. Curr Med Chem. 25, 3256-3271.
  • 16. Fleet, J. C., De Smet, M., Johnson, R., & Li, Y. (2012). Vitamin D and cancer: A review of molecular mechanisms. Biocherm, 441-6176.
  • 17. Chesney, W.R. (2010). Vitamin D and magic mountain: The anti infectious role of vitamin. J. Pediatr, 156(5), 698-703.
  • 18. Mokhtari, Z., Hekmatdoost, A., & Nourian, M. (2017). Antioxidant efficacy of vitamin D. Journal of Parathyroid Disease, 5(1), 11-6.
  • 19. Murray, A., Madden, S. F., Synnott, N., Klinger, R., O’Connor, D., O’Donnovan, N., et al. (2017). Vitamin D receptor as a target for breast cancer therapy. Society for Endocrinology, ERC-16-0463.
  • 20. Apperly F.L. (1941). The relation of solar radiation to cancer mortality in North America. Cancer Research, 1, 191-195.
  • 21. Manson, J. E., Mayne, S. T., & Clinton, S. K. (2011). Vitamin D and prevention of cancer-ready for prime time? (perspective). N. Engl j Med, 364,1385-1387.
  • 22. Deeb, K. K., Trump, D. L., Johnson, C. S. (2007). Vitamin D signaling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer, 7, 684–700
  • 23. Buras, R. R., Schumaker, L. M., Davoodi, F., Brenner, R. V., Shabahang, M., Nauta, R. J., et al. (1994). Vitamin D receptors in breast cancer cells. Breast Cancer Research and Treatment, 31, 191-202.
  • 24. Brenner, R. V., Shabahang, M., Schumaker, L. M., Nauta, R. J., Uskokovic, M. R., Evans, S. R., et al. (1995). The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Letters, 92, 77-82.
  • 25. Campbell, M. S., Narvaez, C. J., Tenniswood, M., & Welsh, J. (1996). 1,25-Dihidroksivitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. Journal of Steroid Biochemistry and Molecular Bioogy, 58(4), 367-376.
  • 26. Saraçligil, B., Ozturk, B., Unlu, A., Abusoglu, S., & Tekin, G. (2017). The effect of vitamin D on MCF breast cancer cell metabolism. Bratislava Medical Journal, 118(2), 101- 106.
  • 27. Murray, A., Madden, S. F., Synnott, N., Klinger, R., O’Connor, D., O’Donnovan, N., et al. (2017). Vitamin D receptor as a target for breast cancer therapy. Society for Endocrinology, ERC-16-0463.
  • 28. Arı, M., Karul, A., & Sakarya, S. (2018). Investigation of antiproliferative, apoptotic and antioxidant effects of oleuropein and vitamin D on breast cancer cell lines (MCF-7). MDPI. Proceedings, 2, 1534; doi:10.3390/proceedings2251534
  • 29. Segovia-Mendoza, M., Diaz, L., Gonzalez-Gonzalez, M. E, Martínez-Reza, I., García-Quiroz, J., Prado-Garcia, H., et al. (2015). Calcitriol and its analogues enhance the antiproliferative activity of gefi-tinib in breast cancer cells. The Journal Steroid Biocheistry and Molecular Biology, 148, 122-131.
  • 30. Rosen, C. J., Adams, J. S., Bikle, D. D., Black, D. M., Demay, M. B., Manson, J. E, et al. (2012). The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocrine Reviews, 33(3), 456-492.
  • 31. Zgaga, L., Theodoratou, E., Farrington S. M., Din, F. V., Ooi, L. Y., Glodzik, D., et al. (2014). Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer. Journal of Clinical Oncology, 32 (23), 2430–2439.
  • 32. Spina, C. (2005). Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs. J Steroid Biochem Mol Biol, 97(1-2), 111-120.
  • 33. Leyssens, C., Marien, E., Verlinden, L., Derua, R., Waelkens, E., Swinnen, J. V., et al. (2015). Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs. The Journal of Steroid Biochemistry and Molecular Biology, 148, 172-178
  • 34. Feldman, D., Krishnan, A. V., Swami, S., Giovannucci, E., & Feldman, B. J. (2014). The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer, 14(5), 342-357.
  • 35. Tangpricha, V., Spina, C., Yao, M., Chen T. C., Wolfe, M. M., & Holick, M. F. (2005). Vitamin D deficiency enhances the growth of MC-26 colon cancer xenograftsin Balb/c mice. J Nutr, 135, 2350-2354.
  • 36. Washington, M. N., & Weigel, N. L. (2010). 1α-25-dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene-fusion. Endocrinology, 151, 1409–1417.
  • 37. Nair-Shalliker, V., Clements, M., Fenech, M., & Armstrong, B. K. (2012). Personal sun exposure and serum 25-hydroxy vitamin D concentrations. Photochem Photobiol, 89: 208–14.
  • 38. Feskanich, D., Ma, J., Fuchs, C. S., Kirkner, G. J., Hankinson, S. E., Hollis, B. W., et al. (2004). Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev, 13, 1502–8.
  • 39. Schwartz, Z., Graham, E. J., Wang, L., Lossdörfer, S., Gay, I., Johnson‐Pais, T. L., et al. (2005). Phospholipase A2 activating protein (PLAA) is reuired for 1alpha,25(OH)2D3 signaling in gowth plate chondrocytes. J Cell Physiol, 203, 54-70.
  • 40. Liu, G., Wilding, G., Staab, M. J. Horvath, D., Miller, K., Dresen, A., et al. (2003). Phase II study of 1alphahydroxyvitamin D(2) in the treatment of advanced androgenindependent prostate cancer. Clin Cancer Res, 9(11), 4077–83.
  • 41. Wactavski-Wende, J., Kotchen, J. M, Anderson, G. L., Assaf, A. R., Brunner, R. L., O'sullivan, M. J., et al. (2006). Women’s health initiative investigators. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med, 354(7), 684–96.
  • 42. Trivedi, D. P, Doll, R., & Khaw, K. T. (2003). Effect of four-monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ, 326, 469.
  • 43. Anderson, L. N., Cotterchio M., Vieth R., & Knight J. A. (2010). Vitamin D and calcium intakes and breast cancer risk in pre-and postmenopausal women. Am J Clin Nutr, 91, 1699-1707.
  • 44. Helzlsouer, K. J, & VDPP Steering Committee. (2010). Overview of the cohort consortium vitamin D pooling project of rarer cancers. American journal of epidemiology, 172(1), 4-9.
  • 45. Kıdır, M. (2013). D vitamininin immun sistem, deri ve kanser ilişkisi. S.D.Ü Tıp Fak. Derg, 20(4), 158-161.
  • 46. Sintov, A. C., Yarmolinski, L., Dahan, A., & Ben-Shabat, S. (2014). Pharmacological effects of vitamin D and its analogs: recent developments. Drug Discovery Today, 19(11), 1769-1774.
  • 47. Berkovich, L., Ben-Shabat, S., & Sintov, A. C. (2010) Induction of apoptosis and inhibition of prostate and breast cancer growth by BGP-15, a new calcipotriene-derived vitamin D3 analog. Anticancer Drugs, 21, 609–618.
  • 48. Hossein-Nezhad, A., & Holick, M. F. (2013). Vitamin D for health: A global perspective. In: Mayo Clinic Proceedings. 88 (7), 720-55.
  • 49. Sarı, E., Bülbül, L., Bencer, M., Akçay, T., Özkul Sağlam, T., & Hatipoğlu, S. (2014). Yüksek doz D vitamini alımı sonucu hiperkalsemi gelişen olguda pamidronat tedavisi. Şişli Etfal Hastanesi Tıp Bülteni, 48(4),322-324.
  • 50. Balkan, F & Ünal, O. K. (2013). D vitamini intoksikasyonu. Balkan ve Ünal Genel Tıp Derg. 23(3), 90-2.
  • 51. Holick, M. F. (2009). Vitamin D Status: Measurement, Interpretation, and Clinical Application. Annals of Epidemiology, 19(2),73-8.
  • 52. Hossein-Nezhad, A., & Holick, M. F. (2013). Vitamin D for health: A global perspective. In: Mayo Clinic Proceedings, 88 (7); 720-55.
  • 53. Pérez-Barrios, C., Hernández-Álvarez, E., Blanco-Navarro, I., Pérez-Sacristán, B., & Granado-Lorencio, F. (2016). Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. Clin Nutr. 35(6): 1354-1358.
  • 54. Aydın, A. E, & Dokuzlar, E. (2018). Geriatrik bir olguda D vitamini intoksikasyonuna bağlı gelişen akut mental değişiklik. Geriatrik Bilimler Dergisi, 1(2), 73-78.
  • 55. Buluş, D., İnan, Y., Demet, E., & Andıran, N. (2016). D Vitamini intoksikasyonuna bağlı hiperkalsemi: Olgu Sunumu. Türkiye Çocuk Hastalıkları Dergisi. 4, 277-279.
  • 56. Alikasifoglu, A. (2008). Çocukluk yaş grubunda D vitamini intoksikasyonu. Danone Enstitüsü Beslenme Serileri, 2, 57-61.
  • 57. Mesa, J. M., Sanmartí, A. S., Obiols, G. A., Lucas, A. M., Garciá, F. B., Ribera, E. P., et al. (1983). Vitamin D intoxication in 3 cases of hypothyroidism. Rev Clin Esp, 171(4), 297-299

Vitamin D ve Antikanserojenik Etkileri

Yıl 2021, Cilt: 5 Sayı: 1, 136 - 146, 31.01.2021

Murat Arı

https://doi.org/10.46237/amusbfd.740270

Öz

Vitamin D, yağda ve organik çözücülerde çözünen, fakat suda çözünmeyen, sahip olduğu reseptörleri aracılığıyla her organ ve dokuya ulaşıp önemli görevler yapması sebebiyle hormon benzeri görev yapan bir grup sterol olarak ifade edilir. Kalsiyum ve fosfor metabolizmasının devamlılığının sağlanmasında majör rol oynar. Yapılan pek çok çalışmada, D vitamininin aktif formu olan 1,25-OH2D3’ün aynı zamanda hücre proliferasyonu, apoptotik ve antioksidan etkilerinin de olduğu ortaya çıkarılmıştır. Bu derlemenin amacı, vitamin D ve metabolitlerinin herkes tarafından bilinen majör rolünün yanı sıra kanser ve buna bağlı olarak otoimmun hastalıklar, bağışıklık sistemi ile ilgili ilişkilerini vurgulamaktır.

Anahtar Kelimeler

Vitamin D Antioksidanlar Kanser

Kaynakça

  • 1. Hochberg, Z. (2004). Requirements for vitamin D in an indoors culture. Highlights, 12, 19-23.
  • 2. Rusinska, A., Pludowski, P., Walczak, M., Borszewska-Kornacka, M., Bossowski, A., & Chalebna-Sokol, D. (2018). Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland-Recomendations of the Polish society of pediatric endocrinology and diabetes and the expert panel with the participation of the national specialist consultans and representatives of scientific societies-2018 update. Frontiers in Endocrinology, 9, 246.
  • 3. Dittmer, K. E., & Thompson, K. G. (2011). Vitamin D metabolism and rickets in domestic animals: A review. Veterinary Pathology, 48(2), 389-407.
  • 4. Montgomery, R., Conway, T. W., Spector, A.A. (2000). Biyokimya olgu sunumlu yaklaşım. Ankara: Palme Yayıncılık.
  • 5. Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-81.
  • 6. Gow, A. G., Else, R., Evans, H., Berry, J. L., Herrtage M. E., & Mellany, R.J. (2011). Hypovitaminosis D in dogs with inflammatory bowel disease and hypoalbuminaemia. Journal of Small Animal Practice, 52,411-418.
  • 7. Potts J. T. (2005). Parathyroid hormone: pastandpresent . J. Endocrinol, 187(3), 311-325.
  • 8. Human, K.L., & Lane, N.E. (2006). Parathyroid hormone update. Rheum Dis Clin North Am, 32, 703-19.
  • 9. Rubin, M. R. (2002). “The anabolic effects of parathyroid hormone” Osteoporos Int, 13, 267-77.
  • 10. Kimball, S., Fuleihan, G. H., & Vieth, R. (2008). Vitamin D. A growing perspective. Crit Rev Clin Lab Sci, 45(4), 339-414.
  • 11. Akbel, E. (2005). Yüksek protein içeren diyetle beslenen sıçanlara atkestanesi ekstresi verilmesinin kemik ve kalsiyum metabolizmasına etkileri. (Yayımlanmamış Doktora Tezi) Afyonkarahisar Kocatepe Üniversitesi, Afyonkarahisar, Türkiye.
  • 12. Dawson-Hughes, B., Dallal, G. E., Kral, E.A., Haris, S., Sokol, L. J., & Falconer, G. (1991). Effect of vitamin D supplementation on winter time and overall bone loss in healthy postmenopausal women. Ann Int Med, 115, 505-12.
  • 13. Tezcan, I. (2012). D Vitamini ve immün sistem. Türkiye Klinikleri, 8(2), 66-8.
  • 14. Bikle, D. (2009). Nonclassic actions of vitamin D. J Clin Endocrinol Metab, 94(1), 2634.
  • 15. Yang, S., Li, A., Wang, J., Liu, J., Han, Y., Zhamg, W., et al. (2018). Vitamin D receptor: A novel therapeutic target for kidney diseases. Curr Med Chem. 25, 3256-3271.
  • 16. Fleet, J. C., De Smet, M., Johnson, R., & Li, Y. (2012). Vitamin D and cancer: A review of molecular mechanisms. Biocherm, 441-6176.
  • 17. Chesney, W.R. (2010). Vitamin D and magic mountain: The anti infectious role of vitamin. J. Pediatr, 156(5), 698-703.
  • 18. Mokhtari, Z., Hekmatdoost, A., & Nourian, M. (2017). Antioxidant efficacy of vitamin D. Journal of Parathyroid Disease, 5(1), 11-6.
  • 19. Murray, A., Madden, S. F., Synnott, N., Klinger, R., O’Connor, D., O’Donnovan, N., et al. (2017). Vitamin D receptor as a target for breast cancer therapy. Society for Endocrinology, ERC-16-0463.
  • 20. Apperly F.L. (1941). The relation of solar radiation to cancer mortality in North America. Cancer Research, 1, 191-195.
  • 21. Manson, J. E., Mayne, S. T., & Clinton, S. K. (2011). Vitamin D and prevention of cancer-ready for prime time? (perspective). N. Engl j Med, 364,1385-1387.
  • 22. Deeb, K. K., Trump, D. L., Johnson, C. S. (2007). Vitamin D signaling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer, 7, 684–700
  • 23. Buras, R. R., Schumaker, L. M., Davoodi, F., Brenner, R. V., Shabahang, M., Nauta, R. J., et al. (1994). Vitamin D receptors in breast cancer cells. Breast Cancer Research and Treatment, 31, 191-202.
  • 24. Brenner, R. V., Shabahang, M., Schumaker, L. M., Nauta, R. J., Uskokovic, M. R., Evans, S. R., et al. (1995). The antiproliferative effect of vitamin D analogs on MCF-7 human breast cancer cells. Cancer Letters, 92, 77-82.
  • 25. Campbell, M. S., Narvaez, C. J., Tenniswood, M., & Welsh, J. (1996). 1,25-Dihidroksivitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells. Journal of Steroid Biochemistry and Molecular Bioogy, 58(4), 367-376.
  • 26. Saraçligil, B., Ozturk, B., Unlu, A., Abusoglu, S., & Tekin, G. (2017). The effect of vitamin D on MCF breast cancer cell metabolism. Bratislava Medical Journal, 118(2), 101- 106.
  • 27. Murray, A., Madden, S. F., Synnott, N., Klinger, R., O’Connor, D., O’Donnovan, N., et al. (2017). Vitamin D receptor as a target for breast cancer therapy. Society for Endocrinology, ERC-16-0463.
  • 28. Arı, M., Karul, A., & Sakarya, S. (2018). Investigation of antiproliferative, apoptotic and antioxidant effects of oleuropein and vitamin D on breast cancer cell lines (MCF-7). MDPI. Proceedings, 2, 1534; doi:10.3390/proceedings2251534
  • 29. Segovia-Mendoza, M., Diaz, L., Gonzalez-Gonzalez, M. E, Martínez-Reza, I., García-Quiroz, J., Prado-Garcia, H., et al. (2015). Calcitriol and its analogues enhance the antiproliferative activity of gefi-tinib in breast cancer cells. The Journal Steroid Biocheistry and Molecular Biology, 148, 122-131.
  • 30. Rosen, C. J., Adams, J. S., Bikle, D. D., Black, D. M., Demay, M. B., Manson, J. E, et al. (2012). The nonskeletal effects of vitamin D: An endocrine society scientific statement. Endocrine Reviews, 33(3), 456-492.
  • 31. Zgaga, L., Theodoratou, E., Farrington S. M., Din, F. V., Ooi, L. Y., Glodzik, D., et al. (2014). Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer. Journal of Clinical Oncology, 32 (23), 2430–2439.
  • 32. Spina, C. (2005). Colon cancer and solar ultraviolet B radiation and prevention and treatment of colon cancer in mice with vitamin D and its Gemini analogs. J Steroid Biochem Mol Biol, 97(1-2), 111-120.
  • 33. Leyssens, C., Marien, E., Verlinden, L., Derua, R., Waelkens, E., Swinnen, J. V., et al. (2015). Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs. The Journal of Steroid Biochemistry and Molecular Biology, 148, 172-178
  • 34. Feldman, D., Krishnan, A. V., Swami, S., Giovannucci, E., & Feldman, B. J. (2014). The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer, 14(5), 342-357.
  • 35. Tangpricha, V., Spina, C., Yao, M., Chen T. C., Wolfe, M. M., & Holick, M. F. (2005). Vitamin D deficiency enhances the growth of MC-26 colon cancer xenograftsin Balb/c mice. J Nutr, 135, 2350-2354.
  • 36. Washington, M. N., & Weigel, N. L. (2010). 1α-25-dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene-fusion. Endocrinology, 151, 1409–1417.
  • 37. Nair-Shalliker, V., Clements, M., Fenech, M., & Armstrong, B. K. (2012). Personal sun exposure and serum 25-hydroxy vitamin D concentrations. Photochem Photobiol, 89: 208–14.
  • 38. Feskanich, D., Ma, J., Fuchs, C. S., Kirkner, G. J., Hankinson, S. E., Hollis, B. W., et al. (2004). Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev, 13, 1502–8.
  • 39. Schwartz, Z., Graham, E. J., Wang, L., Lossdörfer, S., Gay, I., Johnson‐Pais, T. L., et al. (2005). Phospholipase A2 activating protein (PLAA) is reuired for 1alpha,25(OH)2D3 signaling in gowth plate chondrocytes. J Cell Physiol, 203, 54-70.
  • 40. Liu, G., Wilding, G., Staab, M. J. Horvath, D., Miller, K., Dresen, A., et al. (2003). Phase II study of 1alphahydroxyvitamin D(2) in the treatment of advanced androgenindependent prostate cancer. Clin Cancer Res, 9(11), 4077–83.
  • 41. Wactavski-Wende, J., Kotchen, J. M, Anderson, G. L., Assaf, A. R., Brunner, R. L., O'sullivan, M. J., et al. (2006). Women’s health initiative investigators. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med, 354(7), 684–96.
  • 42. Trivedi, D. P, Doll, R., & Khaw, K. T. (2003). Effect of four-monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ, 326, 469.
  • 43. Anderson, L. N., Cotterchio M., Vieth R., & Knight J. A. (2010). Vitamin D and calcium intakes and breast cancer risk in pre-and postmenopausal women. Am J Clin Nutr, 91, 1699-1707.
  • 44. Helzlsouer, K. J, & VDPP Steering Committee. (2010). Overview of the cohort consortium vitamin D pooling project of rarer cancers. American journal of epidemiology, 172(1), 4-9.
  • 45. Kıdır, M. (2013). D vitamininin immun sistem, deri ve kanser ilişkisi. S.D.Ü Tıp Fak. Derg, 20(4), 158-161.
  • 46. Sintov, A. C., Yarmolinski, L., Dahan, A., & Ben-Shabat, S. (2014). Pharmacological effects of vitamin D and its analogs: recent developments. Drug Discovery Today, 19(11), 1769-1774.
  • 47. Berkovich, L., Ben-Shabat, S., & Sintov, A. C. (2010) Induction of apoptosis and inhibition of prostate and breast cancer growth by BGP-15, a new calcipotriene-derived vitamin D3 analog. Anticancer Drugs, 21, 609–618.
  • 48. Hossein-Nezhad, A., & Holick, M. F. (2013). Vitamin D for health: A global perspective. In: Mayo Clinic Proceedings. 88 (7), 720-55.
  • 49. Sarı, E., Bülbül, L., Bencer, M., Akçay, T., Özkul Sağlam, T., & Hatipoğlu, S. (2014). Yüksek doz D vitamini alımı sonucu hiperkalsemi gelişen olguda pamidronat tedavisi. Şişli Etfal Hastanesi Tıp Bülteni, 48(4),322-324.
  • 50. Balkan, F & Ünal, O. K. (2013). D vitamini intoksikasyonu. Balkan ve Ünal Genel Tıp Derg. 23(3), 90-2.
  • 51. Holick, M. F. (2009). Vitamin D Status: Measurement, Interpretation, and Clinical Application. Annals of Epidemiology, 19(2),73-8.
  • 52. Hossein-Nezhad, A., & Holick, M. F. (2013). Vitamin D for health: A global perspective. In: Mayo Clinic Proceedings, 88 (7); 720-55.
  • 53. Pérez-Barrios, C., Hernández-Álvarez, E., Blanco-Navarro, I., Pérez-Sacristán, B., & Granado-Lorencio, F. (2016). Prevalence of hypercalcemia related to hypervitaminosis D in clinical practice. Clin Nutr. 35(6): 1354-1358.
  • 54. Aydın, A. E, & Dokuzlar, E. (2018). Geriatrik bir olguda D vitamini intoksikasyonuna bağlı gelişen akut mental değişiklik. Geriatrik Bilimler Dergisi, 1(2), 73-78.
  • 55. Buluş, D., İnan, Y., Demet, E., & Andıran, N. (2016). D Vitamini intoksikasyonuna bağlı hiperkalsemi: Olgu Sunumu. Türkiye Çocuk Hastalıkları Dergisi. 4, 277-279.
  • 56. Alikasifoglu, A. (2008). Çocukluk yaş grubunda D vitamini intoksikasyonu. Danone Enstitüsü Beslenme Serileri, 2, 57-61.
  • 57. Mesa, J. M., Sanmartí, A. S., Obiols, G. A., Lucas, A. M., Garciá, F. B., Ribera, E. P., et al. (1983). Vitamin D intoxication in 3 cases of hypothyroidism. Rev Clin Esp, 171(4), 297-299
Toplam 57 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme Makaleler
Yazarlar

Murat Arı 0000-0002-1504-7050

Yayımlanma Tarihi 31 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 1

Kaynak Göster

APA Arı, M. (2021). Vitamin D ve Antikanserojenik Etkileri. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 5(1), 136-146. https://doi.org/10.46237/amusbfd.740270

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