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Titanyum Dioksitin Yavru Sıçanlarda Glikoz Metabolizması Üzerine Etkisi

Yıl 2023, Sayı: 5, 10 - 16, 31.03.2023

Öz

Amaç: Gıda katkı maddesi olarak kullanılan titanyum diokside en çok çocukluk ve ergenlik dönemlerinde maruz kalınmaktadır. Titanyum dioksidin metabolizmaya olumsuz etkileriyle ilgili çalışmalar halen netlik kazanmamıştır. Bu çalışmada çocukluk ve ergenlik dönemindeki sıçanlarda titanyum dioksidin glikoz metabolizması üzerine etkilerini araştırmak amaçlanmıştır.
Gereç ve Yöntem: Çalışmada 20 adet 3 haftalık dişi Sprague-Dawley sıçan kullanılmıştır. Sıçanlar deney ve kontrol grubu olarak her grupta 10 sıçan olacak şekilde ikiye ayrılmıştır. Deney grubuna 6 hafta boyunca 5 gün 140 mg/kg titanium dioksit oral gavajla verilmiştir. Deney süresince her hafta ağırlık değişimi, 2. ve 6. haftalarda kan glikoz düzeyi, deney sonunda ise trigliserit düzeyleri ölçülmüş ve bu ölçümlerle trigliserit glikoz indeksi hesaplanmıştır.
Bulgular: Deney boyunca vücut ağırlık artışında gruplar arasında anlamlı fark görülmedi (p=0,796). 2. ve 6. haftalarda kan glikoz düzeyi ölçülmüş ve 2. haftaya göre 6. haftadaki yüzde artış miktarı arasında anlamlı fark görülmedi (0,604). Deney sonunda gruplar arasındaki kan glikozu ve trigliserit düzeyleri arasında anlamlı fark bulunmadı (p=0,315, p=0,633). TyG indeksi hesaplaması sonucu gruplar arasında fark saptanmadı (p=0,274). Ayrıca deney ve kontrol grubunda ağırlık artışı, glikoz düzeyi ve trigliserit düzeyleri arasında anlamlı ilişki yoktu.
Sonuç: İnce partiküllü titanyum dioksidin çocukluk ve ergenlik dönemindeki sıçanlarda glikoz metabolizması üzerine olumsuz bir etki oluşturmadığı söylenebilir. Daha net etki gözleyebilmek için ince partiküllü titanyum dioksit ile yapılan ilave çalışmalara ihtiyaç vardır.

Destekleyen Kurum

Sağlık Bilimleri Üniversitesi BAP Birimi

Proje Numarası

2021/127

Kaynakça

  • Bettini, S., Boutet-Robinet, E., Cartier, C., Coméra, C., Gaultier, E., Dupuy, J., ... & Houdeau, E. (2017). Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Scientific reports, 7(1), 1-13.
  • Bischoff, N. S., de Kok, T. M., Sijm, D. T., van Breda, S. G., Briedé, J. J., Castenmiller, J. J., ... & Van Loveren, H. (2020). Possible adverse effects of food additive E171 (titanium dioxide) related to particle specific human toxicity, including the immune system. International journal of molecular sciences, 22(1), 207.
  • Carocho, M., Barreiro, M. F., Morales, P., & Ferreira, I. C. (2014). Adding molecules to food, pros and cons: A review on synthetic and natural food additives. Comprehensive reviews in food science and food safety, 13(4), 377-399.
  • Chen, Z., Han, S., Zheng, P., Zhou, D., Zhou, S., & Jia, G. (2020). Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats. Nanoscale, 12(10), 5973-5986.
  • Chen, Z., Wang, Y., Wang, X., Zhuo, L., Chen, S., Tang, S., ... & Jia, G. (2018). Effect of titanium dioxide nanoparticles on glucose homeostasis after oral administration. Journal of Applied Toxicology, 38(6), 810-823.
  • Chen, Z., Wang, Y., Zhuo, L., Chen, S., Zhao, L., Luan, X., ... & Jia, G. (2015). Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration. Toxicology letters, 239(2), 123-130.
  • Dorier, M., Béal, D., Marie-Desvergne, C., Dubosson, M., Barreau, F., Houdeau, E., ... & Carriere, M. (2017). Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress. Nanotoxicology, 11(6), 751-761.
  • Grande, F., & Tucci, P. (2016). Titanium dioxide nanoparticles: a risk for human health?. Mini reviews in medicinal chemistry, 16(9), 762-769.
  • Gu, N., Hu, H., Guo, Q., Jin, S., Wang, C., Oh, Y., ... & Wu, Q. (2015). Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food and Chemical Toxicology, 86, 124-131.
  • Hong, F., Zhou, Y., Zhao, X., Sheng, L., & Wang, L. (2017). Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice. International journal of nanomedicine, 12, 6197.
  • Hu, H., Li, L., Guo, Q., Zong, H., Yan, Y., Yin, Y., ... & Gu, N. (2018). RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 12(4), 341-356.
  • Hu, H., Zhang, B., Li, L., Guo, Q., Yang, D., Wei, X., ... & Gu, N. (2020). The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environmental toxicology, 35(4), 443-456.
  • Janus, M. (Ed.). (2017). Application of titanium dioxide. BoD–Books on Demand. sf: 24.
  • Li, C., Zhang, R., Ma, C., Shang, H., McClements, D. J., White, J. C., & Xing, B. (2021). Food-grade titanium dioxide particles decreased the bioaccessibility of vitamin d3 in the simulated human gastrointestinal tract. Journal of Agricultural and Food Chemistry, 69(9), 2855-2863.
  • Mao, Z., Li, Y., Dong, T., Zhang, L., Zhang, Y., Li, S., ... & Xia, Y. (2019). Exposure to titanium dioxide nanoparticles during pregnancy changed maternal gut microbiota and increased blood glucose of rat. Nanoscale research letters, 14(1), 1-8.
  • Mohammadipour, A., Fazel, A., Haghir, H., Motejaded, F., Rafatpanah, H., Zabihi, H., ... & Bideskan, A. E. (2014). Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring. Environmental toxicology and pharmacology, 37(2), 617-625.
  • Parhofer, K. G. (2015). Interaction between glucose and lipid metabolism: more than diabetic dyslipidemia. Diabetes & metabolism journal, 39(5), 353-362.
  • Proquin, H., Rodríguez-Ibarra, C., Moonen, C. G., Urrutia Ortega, I. M., Briedé, J. J., de Kok, T. M., ... & Chirino, Y. I. (2017). Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions. Mutagenesis, 32(1), 139-149.
  • Shukla, R. K., Kumar, A., Vallabani, N. V. S., Pandey, A. K., & Dhawan, A. (2014). Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine, 9(9), 1423-1434.
  • Warheit, D. B., Brown, S. C., & Donner, E. M. (2015). Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles. Food and Chemical Toxicology, 84, 208-224.
  • Winkler, H. C., Notter, T., Meyer, U., & Naegeli, H. (2018). Critical review of the safety assessment of titanium dioxide additives in food. Journal of nanobiotechnology, 16(1), 1-19.
  • Ze, Y., Sheng, L., Zhao, X., Hong, J., Ze, X., Yu, X., ... & Hong, F. (2014). TiO2 nanoparticles induced hippocampal neuroinflammation in mice. PloS one, 9(3), e92230.

Effect of Titanium Dioxide on Glucose Metabolism in Young Rats

Yıl 2023, Sayı: 5, 10 - 16, 31.03.2023

Öz

Proje Numarası

2021/127

Kaynakça

  • Bettini, S., Boutet-Robinet, E., Cartier, C., Coméra, C., Gaultier, E., Dupuy, J., ... & Houdeau, E. (2017). Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Scientific reports, 7(1), 1-13.
  • Bischoff, N. S., de Kok, T. M., Sijm, D. T., van Breda, S. G., Briedé, J. J., Castenmiller, J. J., ... & Van Loveren, H. (2020). Possible adverse effects of food additive E171 (titanium dioxide) related to particle specific human toxicity, including the immune system. International journal of molecular sciences, 22(1), 207.
  • Carocho, M., Barreiro, M. F., Morales, P., & Ferreira, I. C. (2014). Adding molecules to food, pros and cons: A review on synthetic and natural food additives. Comprehensive reviews in food science and food safety, 13(4), 377-399.
  • Chen, Z., Han, S., Zheng, P., Zhou, D., Zhou, S., & Jia, G. (2020). Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats. Nanoscale, 12(10), 5973-5986.
  • Chen, Z., Wang, Y., Wang, X., Zhuo, L., Chen, S., Tang, S., ... & Jia, G. (2018). Effect of titanium dioxide nanoparticles on glucose homeostasis after oral administration. Journal of Applied Toxicology, 38(6), 810-823.
  • Chen, Z., Wang, Y., Zhuo, L., Chen, S., Zhao, L., Luan, X., ... & Jia, G. (2015). Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration. Toxicology letters, 239(2), 123-130.
  • Dorier, M., Béal, D., Marie-Desvergne, C., Dubosson, M., Barreau, F., Houdeau, E., ... & Carriere, M. (2017). Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress. Nanotoxicology, 11(6), 751-761.
  • Grande, F., & Tucci, P. (2016). Titanium dioxide nanoparticles: a risk for human health?. Mini reviews in medicinal chemistry, 16(9), 762-769.
  • Gu, N., Hu, H., Guo, Q., Jin, S., Wang, C., Oh, Y., ... & Wu, Q. (2015). Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food and Chemical Toxicology, 86, 124-131.
  • Hong, F., Zhou, Y., Zhao, X., Sheng, L., & Wang, L. (2017). Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice. International journal of nanomedicine, 12, 6197.
  • Hu, H., Li, L., Guo, Q., Zong, H., Yan, Y., Yin, Y., ... & Gu, N. (2018). RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice. Nanotoxicology, 12(4), 341-356.
  • Hu, H., Zhang, B., Li, L., Guo, Q., Yang, D., Wei, X., ... & Gu, N. (2020). The toxic effects of titanium dioxide nanoparticles on plasma glucose metabolism are more severe in developing mice than in adult mice. Environmental toxicology, 35(4), 443-456.
  • Janus, M. (Ed.). (2017). Application of titanium dioxide. BoD–Books on Demand. sf: 24.
  • Li, C., Zhang, R., Ma, C., Shang, H., McClements, D. J., White, J. C., & Xing, B. (2021). Food-grade titanium dioxide particles decreased the bioaccessibility of vitamin d3 in the simulated human gastrointestinal tract. Journal of Agricultural and Food Chemistry, 69(9), 2855-2863.
  • Mao, Z., Li, Y., Dong, T., Zhang, L., Zhang, Y., Li, S., ... & Xia, Y. (2019). Exposure to titanium dioxide nanoparticles during pregnancy changed maternal gut microbiota and increased blood glucose of rat. Nanoscale research letters, 14(1), 1-8.
  • Mohammadipour, A., Fazel, A., Haghir, H., Motejaded, F., Rafatpanah, H., Zabihi, H., ... & Bideskan, A. E. (2014). Maternal exposure to titanium dioxide nanoparticles during pregnancy; impaired memory and decreased hippocampal cell proliferation in rat offspring. Environmental toxicology and pharmacology, 37(2), 617-625.
  • Parhofer, K. G. (2015). Interaction between glucose and lipid metabolism: more than diabetic dyslipidemia. Diabetes & metabolism journal, 39(5), 353-362.
  • Proquin, H., Rodríguez-Ibarra, C., Moonen, C. G., Urrutia Ortega, I. M., Briedé, J. J., de Kok, T. M., ... & Chirino, Y. I. (2017). Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions. Mutagenesis, 32(1), 139-149.
  • Shukla, R. K., Kumar, A., Vallabani, N. V. S., Pandey, A. K., & Dhawan, A. (2014). Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine, 9(9), 1423-1434.
  • Warheit, D. B., Brown, S. C., & Donner, E. M. (2015). Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles. Food and Chemical Toxicology, 84, 208-224.
  • Winkler, H. C., Notter, T., Meyer, U., & Naegeli, H. (2018). Critical review of the safety assessment of titanium dioxide additives in food. Journal of nanobiotechnology, 16(1), 1-19.
  • Ze, Y., Sheng, L., Zhao, X., Hong, J., Ze, X., Yu, X., ... & Hong, F. (2014). TiO2 nanoparticles induced hippocampal neuroinflammation in mice. PloS one, 9(3), e92230.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Biyokimya ve Hücre Biyolojisi (Diğer), Beslenme ve Diyetetik, Halk Sağlığı, Çevre Sağlığı
Bölüm Araştırma Makaleleri
Yazarlar

Kübra İzler 0000-0001-6031-6638

Fatih Gültekin 0000-0003-2888-3215

Kursad Baydili 0000-0002-2785-0406

Eray Metin Güler 0000-0003-4351-1719

Proje Numarası 2021/127
Erken Görünüm Tarihi 31 Mart 2023
Yayımlanma Tarihi 31 Mart 2023
Gönderilme Tarihi 19 Temmuz 2022
Yayımlandığı Sayı Yıl 2023 Sayı: 5

Kaynak Göster

APA İzler, K., Gültekin, F., Baydili, K., Güler, E. M. (2023). Titanyum Dioksitin Yavru Sıçanlarda Glikoz Metabolizması Üzerine Etkisi. Akademik Et Ve Süt Kurumu Dergisi(5), 10-16.