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Enfeksiyon Hastalıklarında Ferroptozun Rolü

Year 2023, Volume: 49 Issue: 3, 425 - 438, 31.12.2023

Ali Eren İskin Ferah Budak

https://doi.org/10.32708/uutfd.1337979

Abstract

Glutatyon (GSH) ve glutatyon peroksidaz 4 (Glutathione peroxidase 4; GPX4) gibi lipid onarım sistemleriyle kontrol edilen ve çoklu doymamış yağ asidi (polyunsaturated fatty acids; PUFA) biyosentezini de kapsayan, bir dizi enzimatik reaksiyon ile korele olan ölüm tipine ferroptoz adı verilir. Ferroptoz aynı zamanda, ferröz (Fe+2) demire bağımlı hücre ölüm tipi olarak tanımlanmıştır. Apoptoz, piroptoz, otofaji gibi diğer hücre ölüm yollarından farklı özellikler gösterir. Ferroptoz sırasında gözlemlenen en önemli morfolojik özellikler; mitokondride gözlenen küçülme ve membran yoğunluğudur. Biyokimyasal özellikler ise, hücre içi serbest demir miktarındaki artış ve lipid peroksidasyonudur. Ferroptoz, nörodejeneratif hastalıklar ve kanser gibi hastalıkların ortaya çıkmasında ve gelişiminde önemli rol oynaması nedeniyle çok sayıda araştırmanın odak noktası haline gelmiştir. Bu hastalıkların yanı sıra; GPX4, GSH aktivitesinde azalma ve ortamda reaktif oksijen türlerinin (ROT) birikimi gibi olaylar ile birçok enfeksiyon hastalığında da ferroptoz süreci görülebilmektedir.

Keywords

Ferroptoz Demir Lipid peroksidasyonu GPX4 Enfeksiyon

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Ferroptosis in Infectious Diseases

Year 2023, Volume: 49 Issue: 3, 425 - 438, 31.12.2023

Ali Eren İskin Ferah Budak

https://doi.org/10.32708/uutfd.1337979

Abstract

The type of death that is controlled by lipid repair systems such as glutathione (GSH) and glutathione peroxidase 4 (GPX4) and correlates with a series of enzymatic reactions, including polyunsaturated fatty acids (PUFA) biosynthesis, is called ferroptosis. Ferroptosis has also been defined as a ferrous (Fe+2) iron-dependent type of cell death. It shows different features from other cell death pathways such as apoptosis, pyroptosis, autophagy. The most important morphological features observed during ferroptosis; shrinkage and membrane density observed in mitochondria. Biochemical features are the increase in the amount of intracellular free iron and lipid peroxidation. Ferroptosis has become the focus of numerous studies because it plays an important role in the emergence and development of diseases such as neurodegenerative diseases and cancer. Besides these diseases; Ferroptosis process can be seen in many infectious diseases with events such as decrease in GPX4, GSH activity and accumulation of reactive oxygen species (ROS) in the environment.

Keywords

Ferroptosis Iron Lipid peroxidation GPX4 Infection

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There are 126 citations in total.

Details

Primary Language Turkish
Subjects Immunology (Other), Infectious Diseases
Journal Section Review Articles
Authors

Ali Eren İskin 0009-0005-2987-3475

Ferah Budak 0000-0001-7625-9148

Publication Date December 31, 2023
Acceptance Date November 28, 2023
Published in Issue Year 2023 Volume: 49 Issue: 3

Cite

APA İskin, A. E., & Budak, F. (2023). Enfeksiyon Hastalıklarında Ferroptozun Rolü. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 49(3), 425-438. https://doi.org/10.32708/uutfd.1337979
AMA İskin AE, Budak F. Enfeksiyon Hastalıklarında Ferroptozun Rolü. Uludağ Tıp Derg. December 2023;49(3):425-438. doi:10.32708/uutfd.1337979
Chicago İskin, Ali Eren, and Ferah Budak. “Enfeksiyon Hastalıklarında Ferroptozun Rolü”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 49, no. 3 (December 2023): 425-38. https://doi.org/10.32708/uutfd.1337979.
EndNote İskin AE, Budak F (December 1, 2023) Enfeksiyon Hastalıklarında Ferroptozun Rolü. Uludağ Üniversitesi Tıp Fakültesi Dergisi 49 3 425–438.
IEEE A. E. İskin and F. Budak, “Enfeksiyon Hastalıklarında Ferroptozun Rolü”, Uludağ Tıp Derg, vol. 49, no. 3, pp. 425–438, 2023, doi: 10.32708/uutfd.1337979.
ISNAD İskin, Ali Eren - Budak, Ferah. “Enfeksiyon Hastalıklarında Ferroptozun Rolü”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 49/3 (December 2023), 425-438. https://doi.org/10.32708/uutfd.1337979.
JAMA İskin AE, Budak F. Enfeksiyon Hastalıklarında Ferroptozun Rolü. Uludağ Tıp Derg. 2023;49:425–438.
MLA İskin, Ali Eren and Ferah Budak. “Enfeksiyon Hastalıklarında Ferroptozun Rolü”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol. 49, no. 3, 2023, pp. 425-38, doi:10.32708/uutfd.1337979.
Vancouver İskin AE, Budak F. Enfeksiyon Hastalıklarında Ferroptozun Rolü. Uludağ Tıp Derg. 2023;49(3):425-38.
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