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Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.

Year 2023, Volume: 5 Issue: 1, 1 - 10, 30.06.2023

Zehra Can Elif Ayazoglu Demir Zeynep Akar Yakup Kara Betül Gıdık

https://doi.org/10.51435/turkjac.1246389

Abstract

The study aims to investigated the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhbition and cytotoxic effects of two different of Artemisia spp. (Artemisia dracunculus L. and Artemisia dracunculoides Pursh) cultivated in Turkey organically, for the first time. Total phenolic, total flavonoid contents of the plants determined spectrophotometrically while antioxidant activity DPPH, CUPRAC, and FRAP was determined using colorimetric method. And also acetylcholinesterase enzyme inhibition activity and anti-cancer activity in-vitro aganist human melanoma (VMM917, CRL-3232), lung carcinoma (A549, CCL-185) and, normal human fibroblast (hGF, PCS-201-018) cells were studied. Total phenolic (225-324 mgGAE/g sample) and total flavonoid contents (0.066-0.085 mgQAE/g sample), antioxidant activity (DPPH (1.371-1.655 mg/mL), CUPRAC (0.246-0.344 µM CTEAC) and FRAP (462.133-726.661 µM CTEAC)). A. dracunculus and A. dracunculoides extracts inhibited 40.09±0.65%, and 39.48±3.68% of acetylcholinesterase activity. It was determined that demonstrated the selective effect of A. dracunculus and A. dracunculoides on the cytotoxicity of A549 and hGF cells.

Keywords

Artemisia dracunculus Artemisia dracunculoides acetylcholinesterase lung carcinoma human melanoma

Supporting Institution

Bayburt University

Project Number

BAP-AGAM project No. 2021/69001-01-06

References

  • [1] M. Willcox, Artemisia species: from traditional medicines to modern antimalarials-and back again J Altern Complem Med, 15, 2009, 101–109.
  • [2] B. Koul, P, Taak, The Artemisia genus: a review on traditional uses, phytochemical constituents, pharmacological properties and germplasm conservation. JGL. 7(1):1000142. 2017.
  • [3] H. Ekiert, J. Swiatkowska, E. Knut, P. Klin, A. Rzepiela, M. Tomczyk, A. Szopa, Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Frontiers in Pharacol, 14. 2021.
  • [4] R. Phillips, N. Foy, Herbs. Pan Books Ltd., London, pp. 1990, 171–178.
  • [5] G. Haghi, F. Ghasian, J. Safaei-Ghomi, Determination of the essential oil from root and aerial parts of Artemisia dracunculus L. cultivated in central Iran, J Essential Oil Res, 22, 2010, 294–296.
  • [6] E.M. Suleimenov, A.V. Tkachev, S.M. Adekenov, Essential oil from Kazakhstan Artemisia species. Chem, Nat Compd, 46(1), 2010, 135–139.
  • [7] I. Tak, D. Mohiuddin, B.A. Ganai, M.Z. Chishti, F. Ahmad, J.S. Dar, Phytochemical studies on the extract and essential oils of Artemisia dracunculus L. (tarragon), Afr J Plant Sci, 8(10), 2014, 72–75.
  • [8] S. Weinoehrl, B. Feistel, I. Pischel, B. Kopp, V. Butterweck, Comparative evaluation of two different Artemisia dracunculus L. cultivars for blood sugar lowering effects in rats, Phytother Res, 26, 2012, 625–629.
  • [9] T. Daly, M.A. Jiwan, N.M. O’Brien, S.A. Aherne, Carotenoid content of commonly consumed herbs and assessment of their bioaccessibility using an in vitro digestion model, Plant Food Hum Nutr, 65, 2010, 164–169.
  • [10] D. Obolskiy, I. Pischel, B. Feistel, N. Glotov, M. Heinrich, Artemisia dracunculus L. (tarragon): A critical review of its traditional use, chemical composition, pharmacology, and safety, J Agric Food Chem, 59, 2011, 11367–11384.
  • [11] G. ZawiĞlak, K. Dzida, Composition of essentials oils and content of macronutrients in herbage of tarragon (Artemisia dracunculus L.) grown in south-eastern Poland, J Elementol, 4, 2012, 721–729.
  • [12] A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, M.J. Thun, Cancer Statistics, CA Cancer J Clin, 58(2), 2008, 71–96.
  • [13] R.T. Skeel, Handbook of cancer chemotherapy. Lippincott Williams and Wilkins, Philadelphia, 2003.
  • [14] S. Duangmano, P. Sae-Lim, A. Suksamrarn, F.E. Domann, P. Patmasiriwat, B. Cucurbitacin, Inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation, BMC Complement Medicine Ther, 12, 2012,185.
  • [15] A. Trendafilova, L.M. Moujir, P.M.C. Sousa, A.M.L. Seca, Research advances on health effects of edible Artemisia species and some sesquiterpene lactones constituents, Foods, 10(1),2021,65.
  • [16] K. Slinkard, V.L. Singleton, Total phenol analysis: Automation and comparison with manual methods, Am J Enol Vitic, 28, 1997,49–55.
  • [17] L.R. Fukumoto, G. Mazza, Assessing antioxidant and prooxidant activities of phenolic compounds, J Agric Food Chem, 48, 2000, 3597–3604.
  • [18] W. Brand-Williams, M.E. Cuvelier, C. Berset, Use of a free radical method to evaluate antioxidant activity, LWT-Food Sci Technol, 28,1995,25–30.
  • [19] Z. Akar, M. Kucuk, H. Doğan, A new colorimetric DPPH• scavenging activity method with no need for a spectrophotometer applied on synthetic and natural antioxidants and medicinal herbs, J Enzyme Inhib Med Chem, 32 (1), 2017, 640–47.
  • [20] Z. Iskefiyeli, PhD. Thesis, Karadeniz Technical University, The Graduate School of Natural and Applied Sciences, Chemistry Graduate Program, Trabzon, Türkiye. 2014.
  • [21] I.F.F. Benzie, J.J. Strain, The ferric reducing ability of plasma (FRAP) as a measure of ‘’antioxidant power’’: The FRAP assay, Anal Biochem, 239, 1996,70–6.
  • [22] R. Apak, K. Guclu, M. Ozyurek, S.E. Karademir, Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method, J Agric Food Chem, 52, 2004,7970–81.
  • [23] Z. Akar, Chemical compositions by using LC–MS/MS and GC–MS and antioxidant activities of methanolic extracts from leaf and flower parts of Scabiosa columbaria subsp. columbaria var. columbaria L., Saudi J Biol Sci, 28(11), 2021, 6639–6644.
  • [24] Z. Can, N. Baltas, Bioactivity and enzyme inhibition properties of Stevia rebaudiana, Current Enzyme Inhib, 12(2), 2016, 188–194.
  • [25] G.L. Ellman, K.D. Courtney, JrV. Andres, R.M. Featherstone. A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol, 7(2), 1961, 88–95.
  • [26] N. Baltas, O. Yildiz, S. Kolayli, Inhibition properties of propolis extracts to some clinically important enzymes, J Enzyme Inhib Med Chem, 31(sup1), 2016, 52–55.
  • [27] E. Demir-Ayazoğlu, S. Demir, Y. Aliyazicioğlu, In vitro Cytotoxic Effect of Ethanol and Dimethyl Sulfoxide on Various. Human Cell Lines, KSU J Agric Natur, 23(5): p. 2020, 1119–1124.
  • [28] E. Demir-Ayazoğlu, A. Colak, S. Celik-Uzuner, O. Bekircan, 2021. Cytotoxic effect of a 3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazole derivative compound in human melanoma cells, Inter J Biol Chem, 14, (1), 2021, 139–48.
  • [29] T. Mosmann, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65(1–2), 1983, 55–63.
  • [30] M.J. Abad, L.M. Bedoya, L. Apaza, P. Bermejo, The Artemisia L. genus: a review of bioactive essential oils, Molecules, 17(3), 2012, 2542–2566.
  • [31] T.S. Cid-Pérez, R. Ávila-Sosa, C.E. Ochoa-Velasco, B.E. RiveraChavira, G.V. Nevárez-Moorillón, Antioxidant and antimicrobial activity of mexican oregano (Poliomintha longiflora) essential oil, hydrosol and extracts fromwaste solid residues, Plants 8 (1),2019.
  • [32] J. Arias, J. Mejía, Y. Córdoba, J.R. Martínez, E. Stashenko, J.M. del Valle, Optimization of flavonoids extraction from Lippia graveolens and Lippia origanoides chemotypes with ethanol-modified supercritical CO2 after steam distillation, Ind Crops Prod, 146, 2020, 112170.
  • [33] I. Bautista-Hernández, C.N. Aguilar, G.C. Martínez-Ávila, A. Ilina, C. Torres-León, D.K. Verma, M.L. Chávez-González, Phenolic compounds and antioxidant activity of Lippia graveolens Kunth residual leaves fermented by two filamentous fungal strains in solid-state process, Food Bioprod Process, 136, 2022, 24–35.
  • [34] H. Mumivand, M. Babalar, L. Tabrizi, L.E. Craker, M. Shokrpour, J. Hadian, Antioxidant properties and principal phenolic phytochemicals of Iranian tarragon (Artemisia dracunculus L.) accessions, Hortic Environ Biote, 58(4), 2017,414–422.
  • [35] A. Ismail, E.S. Abdalla, F.A. Khalil, E.M. El-Hadidy, Effect of Tarragon (Artemisia dracunculus L.) and its ethanolic extracts on chronic liver disease in male albino rats. Inter J Food Sci, 4(2), 2021, 46–59.
  • [36] Z. Akar, N.A. Burnaz, A new colorimetric method for CUPRAC assay with using of TLC plate, LWT - Food Sci Technol, 112,2019, 108212.
  • [37] B.A. Behbahani, F. Shahidi, F.T. Yazdi, S.A. Mortazavi, M. Mohebbi, Antioxidant activity and antimicrobial effect of tarragon (Artemisia dracunculus) extract and chemical composition of its essential oil, J Food Meas Charact, 11(2), 2017, 847–863.
  • [38] N. Sahakyan, P. Andreoletti, M. Cherkaoui‐Malki, M. Petrosyan, A. Trchounian, Artemisia dracunculus L. essential oil phytochemical components trigger the activity of cellular antioxidant enzymes, J Food Biochem, 45(4) 2021, e13691.
  • [39] I.S. Carvalho, T. Cavaco, M. Brodelius, Phenolic composition and antioxidant capacity of six Artemisia species, Ind Crop Prod, 33(2), 2011, 382–388.
  • [40] J.A. Ross, C.M. Kasum, Dietary flavonoids: Bioavailability, metabolic effects, and safety, Annu Rev Nutr, 22, 2002,19–34.
  • [41] B. Deng, S. Fang, X. Shang, X. Fu, W.Yang, Influence of genotypes and environmental factors on leaf triterpenoid content and growth of Cyclocarya paliurus, J Forest Res, 30 (3), 2019, 789–798.
  • [42] S. Logendra, D.M. Ribnicky, H. Yang, A. Poulev, Ma J. E.J. Kennelly, I. Raskın, Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus, Phytochem, 67(14), 2006, 1539-1546.
  • [43] D. Govorko, S. Logendra, Y. Wang, D. Esposito, S. Komarnytsky, D. Ribnicky, A. Poulev, Z. Wang, T.C. William, I. Raskin, Polyphenolic compounds fromArtemisia dracunculus L.inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line, Am J Physiol Endocrinol, 293 (6), 2007, E1503–E1510.
  • [44] L.Z. Lin, J.M. Harnly, LC-PDA-ESI/MS Identification of the phenolic components of three compositae spices: Chamomile, tarragon, and mexican arnica, Nat Prod Commun, 7(6), 2012,749-752.
  • [45] Y.J. Lee, M. Thiruvengadam, I.M. Chung, P. Nagella, Polyphenol composition and antioxidant activity from the vegetable plant Artemisia absinthium L, Aust J Crop Sci, 7(12), 2013,1921-1926.
  • [46] D. Melguizo, E. Diaz-de-Cerio, R. Quirantes-Piné, J. Švarc-Gajić, A. Segura-Carretero, The potential of Artemisia vulgaris leaves as a source of antioxidant phenolic compounds, J Funct Foods, 2014,192-200.
  • [47] A. Farah, M. Monteiro, C.M. Donangelo, S. Lafay, Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans, J Nutr, 138(12), 2008, 2309-2315.
  • [48] C.A. Curcio, T. Kemper, Nucleus rape dorsalis in dementia of the Alzheimer type: Neurofibrillary changes and neuronal packing density, J Neuropathol Exp, 43 (4),1984, 359–368.
  • [49] G. Orhan, I. Orhan, B. Sener, Recent developments in natural and synthetic drug research for Alzheimer's disease, Lett Drug Des Discov, 3(4), 2006, 268-274.
  • [50] C. Ferrante, G. Zengin, L. Menghini, A. Diuzheva, J. Jekő, Z. Cziáky, L. Recinella, A. Chiavaroli, S. Leone, L. Brunetti, D. Lobine, I. Senkardes, M.F. Mohomoodally, Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L., Process, 7, 2019, 522.
  • [51] R.T. Greenlee, T. Murray, S. Bolden, P.A. Wingo, Cancer statistics, CA CA: A Cancer J Clin, 50(1): 2000, p. 7-33.
  • [52] R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, Cancer Statistics, 2021, CA: A Cancer J Clin, 71(1), 2021,7-33.
  • [53] B. Domingues, J.M. Lopes, P. Soares, H. Populo, Melanoma treatment in review, Immuno Targets Ther, 7, 2018, p. 35-49.
  • [54] A.R. Rao, H.N. Sindhuja, S.M. Dharmesh, K.U. Sankar, R. Sarada, G.A. Ravishankar,. Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis, J Agric Food Chem, 61(16), 2013, 3842-51.
  • [55] J. Ferlay, E. Steliarova-Foucher, J. Lortet-Tieulent, S. Rosso, J.W. Coebergh, H. Comber, D. Forman, F. Bray, Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012, Eur J Cancer, 49(6), 2013, p. 1374-403.
  • [56] H. Hardardottir, S. Jonsson, O. Gunnarsson, B. Hilmarsdottir, J. Asmundsson, I. Gudmundsdottir, V.Y. Saevarsdottir, S. Hansdottir, P. Hannesson, T. Gudbjartsson, Advances in lung cancer diagnosis and treatment- a review, Laeknabladid, 108 (1), 2022, 17-29.
  • [57] S. Aggarwal, G. Shailendra, D.M. Ribnicky, D. Burk, N. Karki, M.S.Q.X. Wang, An extract of Artemisia dracunculus L. stimulates insulin secretion from beta cells, activates AMPK and suppresses inflammation, J Ethnopharmacol, 170, 2015, 98-105.
  • [58] K. Safinejad, A. Mohebifar, H. Tolouei, P. Monfared, A. Razmjou, Comparative study on the toxicity of mentha piperita L. and Artemisia dracunculus L. hydroalcoholic extracts on human breast cancer cell lines, Int J Biology Biotechnol, 18(2), 2021, 253-261.
  • [59] H. Safari, G. Anani-Sarab, M. Naseri, Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model, Nutr Neurosci, 24(11), 2021, 843-849.

Year 2023, Volume: 5 Issue: 1, 1 - 10, 30.06.2023

Zehra Can Elif Ayazoglu Demir Zeynep Akar Yakup Kara Betül Gıdık

https://doi.org/10.51435/turkjac.1246389

Abstract

Keywords

Artemisia dracunculus Artemisia dracunculoides acetylcholinesterase lung carcinoma human melanoma

Project Number

BAP-AGAM project No. 2021/69001-01-06

References

  • [1] M. Willcox, Artemisia species: from traditional medicines to modern antimalarials-and back again J Altern Complem Med, 15, 2009, 101–109.
  • [2] B. Koul, P, Taak, The Artemisia genus: a review on traditional uses, phytochemical constituents, pharmacological properties and germplasm conservation. JGL. 7(1):1000142. 2017.
  • [3] H. Ekiert, J. Swiatkowska, E. Knut, P. Klin, A. Rzepiela, M. Tomczyk, A. Szopa, Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Frontiers in Pharacol, 14. 2021.
  • [4] R. Phillips, N. Foy, Herbs. Pan Books Ltd., London, pp. 1990, 171–178.
  • [5] G. Haghi, F. Ghasian, J. Safaei-Ghomi, Determination of the essential oil from root and aerial parts of Artemisia dracunculus L. cultivated in central Iran, J Essential Oil Res, 22, 2010, 294–296.
  • [6] E.M. Suleimenov, A.V. Tkachev, S.M. Adekenov, Essential oil from Kazakhstan Artemisia species. Chem, Nat Compd, 46(1), 2010, 135–139.
  • [7] I. Tak, D. Mohiuddin, B.A. Ganai, M.Z. Chishti, F. Ahmad, J.S. Dar, Phytochemical studies on the extract and essential oils of Artemisia dracunculus L. (tarragon), Afr J Plant Sci, 8(10), 2014, 72–75.
  • [8] S. Weinoehrl, B. Feistel, I. Pischel, B. Kopp, V. Butterweck, Comparative evaluation of two different Artemisia dracunculus L. cultivars for blood sugar lowering effects in rats, Phytother Res, 26, 2012, 625–629.
  • [9] T. Daly, M.A. Jiwan, N.M. O’Brien, S.A. Aherne, Carotenoid content of commonly consumed herbs and assessment of their bioaccessibility using an in vitro digestion model, Plant Food Hum Nutr, 65, 2010, 164–169.
  • [10] D. Obolskiy, I. Pischel, B. Feistel, N. Glotov, M. Heinrich, Artemisia dracunculus L. (tarragon): A critical review of its traditional use, chemical composition, pharmacology, and safety, J Agric Food Chem, 59, 2011, 11367–11384.
  • [11] G. ZawiĞlak, K. Dzida, Composition of essentials oils and content of macronutrients in herbage of tarragon (Artemisia dracunculus L.) grown in south-eastern Poland, J Elementol, 4, 2012, 721–729.
  • [12] A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, M.J. Thun, Cancer Statistics, CA Cancer J Clin, 58(2), 2008, 71–96.
  • [13] R.T. Skeel, Handbook of cancer chemotherapy. Lippincott Williams and Wilkins, Philadelphia, 2003.
  • [14] S. Duangmano, P. Sae-Lim, A. Suksamrarn, F.E. Domann, P. Patmasiriwat, B. Cucurbitacin, Inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation, BMC Complement Medicine Ther, 12, 2012,185.
  • [15] A. Trendafilova, L.M. Moujir, P.M.C. Sousa, A.M.L. Seca, Research advances on health effects of edible Artemisia species and some sesquiterpene lactones constituents, Foods, 10(1),2021,65.
  • [16] K. Slinkard, V.L. Singleton, Total phenol analysis: Automation and comparison with manual methods, Am J Enol Vitic, 28, 1997,49–55.
  • [17] L.R. Fukumoto, G. Mazza, Assessing antioxidant and prooxidant activities of phenolic compounds, J Agric Food Chem, 48, 2000, 3597–3604.
  • [18] W. Brand-Williams, M.E. Cuvelier, C. Berset, Use of a free radical method to evaluate antioxidant activity, LWT-Food Sci Technol, 28,1995,25–30.
  • [19] Z. Akar, M. Kucuk, H. Doğan, A new colorimetric DPPH• scavenging activity method with no need for a spectrophotometer applied on synthetic and natural antioxidants and medicinal herbs, J Enzyme Inhib Med Chem, 32 (1), 2017, 640–47.
  • [20] Z. Iskefiyeli, PhD. Thesis, Karadeniz Technical University, The Graduate School of Natural and Applied Sciences, Chemistry Graduate Program, Trabzon, Türkiye. 2014.
  • [21] I.F.F. Benzie, J.J. Strain, The ferric reducing ability of plasma (FRAP) as a measure of ‘’antioxidant power’’: The FRAP assay, Anal Biochem, 239, 1996,70–6.
  • [22] R. Apak, K. Guclu, M. Ozyurek, S.E. Karademir, Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method, J Agric Food Chem, 52, 2004,7970–81.
  • [23] Z. Akar, Chemical compositions by using LC–MS/MS and GC–MS and antioxidant activities of methanolic extracts from leaf and flower parts of Scabiosa columbaria subsp. columbaria var. columbaria L., Saudi J Biol Sci, 28(11), 2021, 6639–6644.
  • [24] Z. Can, N. Baltas, Bioactivity and enzyme inhibition properties of Stevia rebaudiana, Current Enzyme Inhib, 12(2), 2016, 188–194.
  • [25] G.L. Ellman, K.D. Courtney, JrV. Andres, R.M. Featherstone. A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol, 7(2), 1961, 88–95.
  • [26] N. Baltas, O. Yildiz, S. Kolayli, Inhibition properties of propolis extracts to some clinically important enzymes, J Enzyme Inhib Med Chem, 31(sup1), 2016, 52–55.
  • [27] E. Demir-Ayazoğlu, S. Demir, Y. Aliyazicioğlu, In vitro Cytotoxic Effect of Ethanol and Dimethyl Sulfoxide on Various. Human Cell Lines, KSU J Agric Natur, 23(5): p. 2020, 1119–1124.
  • [28] E. Demir-Ayazoğlu, A. Colak, S. Celik-Uzuner, O. Bekircan, 2021. Cytotoxic effect of a 3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazole derivative compound in human melanoma cells, Inter J Biol Chem, 14, (1), 2021, 139–48.
  • [29] T. Mosmann, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65(1–2), 1983, 55–63.
  • [30] M.J. Abad, L.M. Bedoya, L. Apaza, P. Bermejo, The Artemisia L. genus: a review of bioactive essential oils, Molecules, 17(3), 2012, 2542–2566.
  • [31] T.S. Cid-Pérez, R. Ávila-Sosa, C.E. Ochoa-Velasco, B.E. RiveraChavira, G.V. Nevárez-Moorillón, Antioxidant and antimicrobial activity of mexican oregano (Poliomintha longiflora) essential oil, hydrosol and extracts fromwaste solid residues, Plants 8 (1),2019.
  • [32] J. Arias, J. Mejía, Y. Córdoba, J.R. Martínez, E. Stashenko, J.M. del Valle, Optimization of flavonoids extraction from Lippia graveolens and Lippia origanoides chemotypes with ethanol-modified supercritical CO2 after steam distillation, Ind Crops Prod, 146, 2020, 112170.
  • [33] I. Bautista-Hernández, C.N. Aguilar, G.C. Martínez-Ávila, A. Ilina, C. Torres-León, D.K. Verma, M.L. Chávez-González, Phenolic compounds and antioxidant activity of Lippia graveolens Kunth residual leaves fermented by two filamentous fungal strains in solid-state process, Food Bioprod Process, 136, 2022, 24–35.
  • [34] H. Mumivand, M. Babalar, L. Tabrizi, L.E. Craker, M. Shokrpour, J. Hadian, Antioxidant properties and principal phenolic phytochemicals of Iranian tarragon (Artemisia dracunculus L.) accessions, Hortic Environ Biote, 58(4), 2017,414–422.
  • [35] A. Ismail, E.S. Abdalla, F.A. Khalil, E.M. El-Hadidy, Effect of Tarragon (Artemisia dracunculus L.) and its ethanolic extracts on chronic liver disease in male albino rats. Inter J Food Sci, 4(2), 2021, 46–59.
  • [36] Z. Akar, N.A. Burnaz, A new colorimetric method for CUPRAC assay with using of TLC plate, LWT - Food Sci Technol, 112,2019, 108212.
  • [37] B.A. Behbahani, F. Shahidi, F.T. Yazdi, S.A. Mortazavi, M. Mohebbi, Antioxidant activity and antimicrobial effect of tarragon (Artemisia dracunculus) extract and chemical composition of its essential oil, J Food Meas Charact, 11(2), 2017, 847–863.
  • [38] N. Sahakyan, P. Andreoletti, M. Cherkaoui‐Malki, M. Petrosyan, A. Trchounian, Artemisia dracunculus L. essential oil phytochemical components trigger the activity of cellular antioxidant enzymes, J Food Biochem, 45(4) 2021, e13691.
  • [39] I.S. Carvalho, T. Cavaco, M. Brodelius, Phenolic composition and antioxidant capacity of six Artemisia species, Ind Crop Prod, 33(2), 2011, 382–388.
  • [40] J.A. Ross, C.M. Kasum, Dietary flavonoids: Bioavailability, metabolic effects, and safety, Annu Rev Nutr, 22, 2002,19–34.
  • [41] B. Deng, S. Fang, X. Shang, X. Fu, W.Yang, Influence of genotypes and environmental factors on leaf triterpenoid content and growth of Cyclocarya paliurus, J Forest Res, 30 (3), 2019, 789–798.
  • [42] S. Logendra, D.M. Ribnicky, H. Yang, A. Poulev, Ma J. E.J. Kennelly, I. Raskın, Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus, Phytochem, 67(14), 2006, 1539-1546.
  • [43] D. Govorko, S. Logendra, Y. Wang, D. Esposito, S. Komarnytsky, D. Ribnicky, A. Poulev, Z. Wang, T.C. William, I. Raskin, Polyphenolic compounds fromArtemisia dracunculus L.inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line, Am J Physiol Endocrinol, 293 (6), 2007, E1503–E1510.
  • [44] L.Z. Lin, J.M. Harnly, LC-PDA-ESI/MS Identification of the phenolic components of three compositae spices: Chamomile, tarragon, and mexican arnica, Nat Prod Commun, 7(6), 2012,749-752.
  • [45] Y.J. Lee, M. Thiruvengadam, I.M. Chung, P. Nagella, Polyphenol composition and antioxidant activity from the vegetable plant Artemisia absinthium L, Aust J Crop Sci, 7(12), 2013,1921-1926.
  • [46] D. Melguizo, E. Diaz-de-Cerio, R. Quirantes-Piné, J. Švarc-Gajić, A. Segura-Carretero, The potential of Artemisia vulgaris leaves as a source of antioxidant phenolic compounds, J Funct Foods, 2014,192-200.
  • [47] A. Farah, M. Monteiro, C.M. Donangelo, S. Lafay, Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans, J Nutr, 138(12), 2008, 2309-2315.
  • [48] C.A. Curcio, T. Kemper, Nucleus rape dorsalis in dementia of the Alzheimer type: Neurofibrillary changes and neuronal packing density, J Neuropathol Exp, 43 (4),1984, 359–368.
  • [49] G. Orhan, I. Orhan, B. Sener, Recent developments in natural and synthetic drug research for Alzheimer's disease, Lett Drug Des Discov, 3(4), 2006, 268-274.
  • [50] C. Ferrante, G. Zengin, L. Menghini, A. Diuzheva, J. Jekő, Z. Cziáky, L. Recinella, A. Chiavaroli, S. Leone, L. Brunetti, D. Lobine, I. Senkardes, M.F. Mohomoodally, Qualitative Fingerprint Analysis and Multidirectional Assessment of Different Crude Extracts and Essential Oil from Wild Artemisia santonicum L., Process, 7, 2019, 522.
  • [51] R.T. Greenlee, T. Murray, S. Bolden, P.A. Wingo, Cancer statistics, CA CA: A Cancer J Clin, 50(1): 2000, p. 7-33.
  • [52] R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, Cancer Statistics, 2021, CA: A Cancer J Clin, 71(1), 2021,7-33.
  • [53] B. Domingues, J.M. Lopes, P. Soares, H. Populo, Melanoma treatment in review, Immuno Targets Ther, 7, 2018, p. 35-49.
  • [54] A.R. Rao, H.N. Sindhuja, S.M. Dharmesh, K.U. Sankar, R. Sarada, G.A. Ravishankar,. Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis, J Agric Food Chem, 61(16), 2013, 3842-51.
  • [55] J. Ferlay, E. Steliarova-Foucher, J. Lortet-Tieulent, S. Rosso, J.W. Coebergh, H. Comber, D. Forman, F. Bray, Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012, Eur J Cancer, 49(6), 2013, p. 1374-403.
  • [56] H. Hardardottir, S. Jonsson, O. Gunnarsson, B. Hilmarsdottir, J. Asmundsson, I. Gudmundsdottir, V.Y. Saevarsdottir, S. Hansdottir, P. Hannesson, T. Gudbjartsson, Advances in lung cancer diagnosis and treatment- a review, Laeknabladid, 108 (1), 2022, 17-29.
  • [57] S. Aggarwal, G. Shailendra, D.M. Ribnicky, D. Burk, N. Karki, M.S.Q.X. Wang, An extract of Artemisia dracunculus L. stimulates insulin secretion from beta cells, activates AMPK and suppresses inflammation, J Ethnopharmacol, 170, 2015, 98-105.
  • [58] K. Safinejad, A. Mohebifar, H. Tolouei, P. Monfared, A. Razmjou, Comparative study on the toxicity of mentha piperita L. and Artemisia dracunculus L. hydroalcoholic extracts on human breast cancer cell lines, Int J Biology Biotechnol, 18(2), 2021, 253-261.
  • [59] H. Safari, G. Anani-Sarab, M. Naseri, Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model, Nutr Neurosci, 24(11), 2021, 843-849.
There are 59 citations in total.

Details

Primary Language English
Subjects Analytical Chemistry
Journal Section Research Articles
Authors

Zehra Can 0000-0002-9366-5110

Elif Ayazoglu Demir 0000-0001-7188-2176

Zeynep Akar 0000-0001-9262-8070

Yakup Kara 0000-0003-3121-5023

Betül Gıdık 0000-0002-3617-899X

Project Number BAP-AGAM project No. 2021/69001-01-06
Publication Date June 30, 2023
Submission Date February 1, 2023
Acceptance Date March 12, 2023
Published in Issue Year 2023 Volume: 5 Issue: 1

Cite

APA Can, Z., Ayazoglu Demir, E., Akar, Z., Kara, Y., et al. (2023). Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp. Turkish Journal of Analytical Chemistry, 5(1), 1-10. https://doi.org/10.51435/turkjac.1246389
AMA Can Z, Ayazoglu Demir E, Akar Z, Kara Y, Gıdık B. Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp. TurkJAC. June 2023;5(1):1-10. doi:10.51435/turkjac.1246389
Chicago Can, Zehra, Elif Ayazoglu Demir, Zeynep Akar, Yakup Kara, and Betül Gıdık. “ Anti-Acetylcholinesterase and Antioxidant Activity of Some Medicinal Artemisia Spp”. Turkish Journal of Analytical Chemistry 5, no. 1 (June 2023): 1-10. https://doi.org/10.51435/turkjac.1246389.
EndNote Can Z, Ayazoglu Demir E, Akar Z, Kara Y, Gıdık B (June 1, 2023) Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp. Turkish Journal of Analytical Chemistry 5 1 1–10.
IEEE Z. Can, E. Ayazoglu Demir, Z. Akar, Y. Kara, and B. Gıdık, “ anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp”., TurkJAC, vol. 5, no. 1, pp. 1–10, 2023, doi: 10.51435/turkjac.1246389.
ISNAD Can, Zehra et al. “ Anti-Acetylcholinesterase and Antioxidant Activity of Some Medicinal Artemisia Spp”. Turkish Journal of Analytical Chemistry 5/1 (June 2023), 1-10. https://doi.org/10.51435/turkjac.1246389.
JAMA Can Z, Ayazoglu Demir E, Akar Z, Kara Y, Gıdık B. Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp. TurkJAC. 2023;5:1–10.
MLA Can, Zehra et al. “ Anti-Acetylcholinesterase and Antioxidant Activity of Some Medicinal Artemisia Spp”. Turkish Journal of Analytical Chemistry, vol. 5, no. 1, 2023, pp. 1-10, doi:10.51435/turkjac.1246389.
Vancouver Can Z, Ayazoglu Demir E, Akar Z, Kara Y, Gıdık B. Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp. TurkJAC. 2023;5(1):1-10.
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