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MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 224 - 224, 16.02.2017

Abstract

Melatonin is one
of well-known antioxidants that prevents from many diseases. There is no
evidence belong to in vivo studies that melatonin is pro-oxidant. In lots of in
vivo investigations indicate that melatonin is antioxidant even at high
concentrations. On the contrary, it has been revealed that it may have
pro-oxidant effects in some normal and cancer cells.  Melatonin shows this impact with producing
reactive oxygen species (ROS). High dose melatonin administration to normal
cells such as human liver cell line (HepG2) and melanoma cells, ovine embryos
lead to ROS generation and inhibition of cell proliferation, respectively.
Hence, melatonin can be considered as cytotoxic in high concentrations. Giving
high dosages of melatonin to cancer cells such as human leukemia cells
containing Jurkat cells, MOLT-4 and CMK cells, hematopoietic tumor cell lines
were resulted with decrease in cell viability and ROS production. But this
situation is an advantage for ceasing the tumorigenesis. In one of the
experiment with normal and tumor leucocytes the similar responses to the same
concentrations of melatonin were evaluated. Identical pro-radical effect was
observed in both cells. On the other hand, their viability and proliferation
were not affected.

It can be
summarized that these function of melatonin in both healthy and cancer cells is
challenging for tissue-specific cancer investigations. Due to the same
effectiveness with melatonin both in normal and cancer proliferation may not
seem advantageous.





 

References

  • Dilşad ÖZERKAN
  • Kastamonu University, Faculty of Engineering and Architecture, Department of Genetic and Bioengineering, Kastamonu 37100 TURKEY
Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 224 - 224, 16.02.2017

Abstract

References

  • Dilşad ÖZERKAN
  • Kastamonu University, Faculty of Engineering and Architecture, Department of Genetic and Bioengineering, Kastamonu 37100 TURKEY
There are 2 citations in total.

Details

Journal Section Articles
Authors

Dilşad Özerkan

Publication Date February 16, 2017
Published in Issue Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology

Cite

APA Özerkan, D. (2017). MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Volume 2(İssue 1 (1), 224-224.
AMA Özerkan D. MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?. turjoem. February 2017;Volume 2(İssue 1 (1):224-224.
Chicago Özerkan, Dilşad. “MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?”. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2, no. İssue 1 (1) (February 2017): 224-24.
EndNote Özerkan D (February 1, 2017) MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2 İssue 1 (1) 224–224.
IEEE D. Özerkan, “MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?”, turjoem, vol. Volume 2, no. İssue 1 (1), pp. 224–224, 2017.
ISNAD Özerkan, Dilşad. “MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?”. The Turkish Journal Of Occupational / Environmental Medicine and Safety VOLUME 2/İssue 1 (1) (February 2017), 224-224.
JAMA Özerkan D. MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?. turjoem. 2017;Volume 2:224–224.
MLA Özerkan, Dilşad. “MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, vol. Volume 2, no. İssue 1 (1), 2017, pp. 224-.
Vancouver Özerkan D. MELATONIN’S PRO-OXIDANT EFFECT IS AN ADVANTAGE OR DISADVANTAGE FOR NORMAL AND CANCER CELLS?. turjoem. 2017;Volume 2(İssue 1 (1):224-.