BibTex RIS Cite

DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS

Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 185 - 185, 16.02.2017

Abstract

Chronic kidney
disease (CKD) is an important and growing health problem. Hypertension (HT) is
a generally risk factor for progression of renal disease. In this study, we
investigated to determine the possible role of HT on DNA damage by comet assay
in maintenance hemodialysis patients with chronic kidney disease. Effects of
other factors such as the levels of hemoglobin (HB), ferritin (FER), age, sex
and duration of hemodialysis were also examined. No significant difference was
found on DNA damage between the hypertensive (n=9) and non-hypertensive (n=44),
those with hemoglobin levels below (n=40) and above 12 (g/dL) (n=13), those
with ferritin levels below (n=36) and above 500 ng/ml (n=17), those with a
duration of dialysis treatment below (n=34) and above 5 (n=19) years, those
younger (n=20) and older (n=33) than 50, and between males (n=17) and females
(n=36) in CKD patients. There was a negative correlation between the serum ferritin
level and comet tail length (r=-0.310, p=0.024), however no correlation was
observed in tail intensity. Moreover, there was no correlation between the DNA
damage and the duration of hemodialysis treatment and age among CKD patients.
As a result, age, sex, duration of hemodialysis treatment as well as HT, HB and
FER values did not affect the primary DNA damage.



 

References

  • Sevcan MAMUR, Deniz YÜZBAŞIOĞLU, Fatma ÜNAL, Kadriye ALTOK, Serpil Müge DEĞER
  • Department of Biology, Polatlı Art and Science Faculty, Gazi University, Ankara, Turkey Genetic Toxicology Laboratory, Department of Biology, Science Faculty, Gazi University, Ankara, Turkey Department of Nephrology, Medical Faculty, Gazi University, Ankara, Turkey
Year 2017, Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 185 - 185, 16.02.2017

Abstract

References

  • Sevcan MAMUR, Deniz YÜZBAŞIOĞLU, Fatma ÜNAL, Kadriye ALTOK, Serpil Müge DEĞER
  • Department of Biology, Polatlı Art and Science Faculty, Gazi University, Ankara, Turkey Genetic Toxicology Laboratory, Department of Biology, Science Faculty, Gazi University, Ankara, Turkey Department of Nephrology, Medical Faculty, Gazi University, Ankara, Turkey
There are 2 citations in total.

Details

Journal Section Articles
Authors

Sevcan Mamur

Deniz Yüzbaşıoğlu This is me

Fatma Ünal This is me

Kadriye Altok This is me

Serpil Müge Değer This is me

Publication Date February 16, 2017
Published in Issue Year 2017 Volume: Volume 2 Issue: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology

Cite

APA Mamur, S., Yüzbaşıoğlu, D., Ünal, F., Altok, K., et al. (2017). DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS. The Turkish Journal Of Occupational / Environmental Medicine and Safety, Volume 2(İssue 1 (1), 185-185.
AMA Mamur S, Yüzbaşıoğlu D, Ünal F, Altok K, Değer SM. DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS. turjoem. February 2017;Volume 2(İssue 1 (1):185-185.
Chicago Mamur, Sevcan, Deniz Yüzbaşıoğlu, Fatma Ünal, Kadriye Altok, and Serpil Müge Değer. “DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2, no. İssue 1 (1) (February 2017): 185-85.
EndNote Mamur S, Yüzbaşıoğlu D, Ünal F, Altok K, Değer SM (February 1, 2017) DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS. The Turkish Journal Of Occupational / Environmental Medicine and Safety Volume 2 İssue 1 (1) 185–185.
IEEE S. Mamur, D. Yüzbaşıoğlu, F. Ünal, K. Altok, and S. M. Değer, “DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS”, turjoem, vol. Volume 2, no. İssue 1 (1), pp. 185–185, 2017.
ISNAD Mamur, Sevcan et al. “DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety VOLUME 2/İssue 1 (1) (February 2017), 185-185.
JAMA Mamur S, Yüzbaşıoğlu D, Ünal F, Altok K, Değer SM. DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS. turjoem. 2017;Volume 2:185–185.
MLA Mamur, Sevcan et al. “DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS”. The Turkish Journal Of Occupational / Environmental Medicine and Safety, vol. Volume 2, no. İssue 1 (1), 2017, pp. 185-.
Vancouver Mamur S, Yüzbaşıoğlu D, Ünal F, Altok K, Değer SM. DETERMINATION OF THE INFLUENCE OF HYPERTENSION, HEMOGLOBIN, AND FERRITIN LEVELS ON DNA DAMAGE BY COMET ASSAY IN HEMODIALYSIS PATIENTS. turjoem. 2017;Volume 2(İssue 1 (1):185-.