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Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Year 2023, Volume: 7 Issue: 1, 81 - 91, 28.04.2023

Hümeyra Başkent Nazlı Nur Aslan Çin Taner Bayraktaroğlu Figen Barut

https://doi.org/10.25048/tudod.1250627

Abstract

Tüm dünya sorunu olan obezitenin tedavisinde güncel olarak terapötik stratejiler geliştirilmektedir. Memelilerde, işlevleri ve morfolojileri
bakımından farklılık gösteren farklı iki tip adipoz doku mevcuttur. Bunlar, embriyogenez sırasında ortaya çıkan kahverengi adipoz
doku (KAD); ve doğum sonrası gelişen beyaz adipoz dokudur (BAD). KAD’nun hacmi, enerji harcaması ile pozitif ilişkili olduğu ve
obez kişilerde zayıf bireylere göre önemli ölçüde düşük olduğu bilinmektedir. KAD indüksiyonunu ve/veya aktivasyonunu hedefleyen
stratejiler, obezite tedavisinde potansiyel olarak faydalı olabileceği düşünülmektedir. Son yıllarda yapılan araştırmalar, KAD aktivasyonu
ve BAD kahverengileşmesi ile ilgili mekanizmalar üzerine olan ilgiyi önemli ölçüde artırmaktadır. Bu mekanizmaları amaçlayan kimyasal
bileşiklerin yanı sıra çeşitli farmakolojik olmayan bazı müdahale yaklaşımları bulunmaktadır. Bu derlemede, KAD aktivasyonu ve BAD
kahverengileşmesi sürecindeki potansiyel terapötik hedefler ve bunları amaçlayan mevcut stratejilere ilişkin kavramlar özetlenmiştir

Keywords

Kahverengi adipoz doku beyaz adipoz doku adipoz doku kahverengileşmesi termogenez obezite

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Adipose Tissue Browning in Obesity Management

Year 2023, Volume: 7 Issue: 1, 81 - 91, 28.04.2023

Hümeyra Başkent Nazlı Nur Aslan Çin Taner Bayraktaroğlu Figen Barut

https://doi.org/10.25048/tudod.1250627

Abstract

Recently, therapeutic strategies have been developed for the treatment of obesity, which is a worldwide problem. There are two different
types of adipose tissue in mammals that differ in their function and morphology. These are brown adipose tissue (BAT), which develops
during embryogenesis and white adipose tissue (WAT), which develops after postnatal. It is known that the volume of BAT is positively
associated with energy discharge and is significantly lower in obese individuals than in slim individuals. Strategies targeting the BAT
induction and/or activation are considered potentially useful in the treatment of obesity. Recent research initiatives have significantly
attracted the interest in the mechanisms associated with the BAT activation and WAT browning. In addition to the chemical compounds
focusing on these mechanisms, there are various non-pharmacological intervention approaches. In this review, potential therapeutic
targets in BAT activation and WAT browning process as well as the concepts related to the strategies targeting them are summarized

Keywords

Brown adipose tissue white adipose tissue adipose tissue browning thermogenesis obesity

References

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  • 2. Catenacci VA, Hill JO, Wyatt HR. The obesity epidemic. Clin Chest Med. 2009;30(3):415-444, vii.
  • 3. Cannon B, Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol Rev. 2004;84(1):277-359.
  • 4. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30.
  • 5. Contreras C, Nogueiras R, Diéguez C, Medina-Gómez G, López M. Hypothalamus and thermogenesis: Heating the BAT, browning the WAT. Mol Cell Endocrinol. 2016;438:107-115.
  • 6. Kuryłowicz A, Puzianowska-Kuźnicka M. Induction of Adipose Tissue Browning as a Strategy to Combat Obesity. Int J Mol Sci. 2020;21(17):6241.
  • 7. Concha F, Prado G, Quezada J, Ramirez A, Bravo N, Flores C, Herrera JJ, Lopez N, Uribe D, Duarte-Silva L, Lopez-Legarrea P, Garcia-Diaz DF. Nutritional and non-nutritional agents that stimulate white adipose tissue browning. Rev Endocr Metab Disord. 2019;20(2):161-171.
  • 8. Schulz TJ, Tseng YH. Brown adipose tissue: Development, metabolism and beyond. Biochem J. 2013;453(2):167-78.
  • 9. Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: A mini-review. Gerontology. 2012;58(1):15-23. 10. Medina-Gómez G. Mitochondria and endocrine function of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2012;26(6):791-804.
  • 11. Mermer M, Nilüfer A. Adipoz doku ve enerji metabolizması üzerine etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2017;8(3): 40-46.
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  • 18. Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest. 2011;121(6):2094-2101.
  • 19. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509- 1517.
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  • 21. Kiefer FW. Browning and thermogenic programing of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2016;30(4):479- 485.
  • 22. Altuntuzcu Ş. 18-FDG PET/CT ile belirlenen kahverengi yağ dokusu glukoz uptake’i ile açlık kan glukozunun ilişkisi. Turk Diab Obes. 2019;3(3): 145-148.
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  • 24. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006;4(4):263-273.
  • 25. Montanari T, Pošćić N, Colitti M. Factors involved in whiteto- brown adipose tissue conversion and in thermogenesis: A review. Obes Rev. 2017;18(5):495-513.
  • 26. Crichton PG, Lee Y, Kunji ER. The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie. 2017;134:35-50.
  • 27. Rosell M, Kaforou M, Frontini A, Okolo A, Chan YW, Nikolopoulou E, Millership S, Fenech ME, MacIntyre D, Turner JO, Moore JD, Blackburn E, Gullick WJ, Cinti S, Montana G, Parker MG, Christian M. Brown and white adipose tissues: Intrinsic differences in gene expression and response to cold exposure in mice. Am J Physiol Endocrinol Metab. 2014;306(8):E945-964.
  • 28. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92(6):829-839.
  • 29. Kern PA, Finlin BS, Zhu B, Rasouli N, McGehee RE Jr, Westgate PM, Dupont-Versteegden EE. The effects of temperature and seasons on subcutaneous white adipose tissue in humans: Evidence for thermogenic gene induction. J Clin Endocrinol Metab. 2014;99(12):E2772-2779.
  • 30. Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Agerelated decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring). 2011;19(9):1755-1760.
  • 31. Shimizu Y, Nikami H, Saito M. Sympathetic activation of glucose utilization in brown adipose tissue in rats. J Biochem. 1991;110(5):688-692.
  • 32. Murano I, Barbatelli G, Giordano A, Cinti S. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J Anat. 2009;214(1):171-178.
  • 33. Aldiss P, Betts J, Sale C, Pope M, Budge H, Symonds ME. Exercise-induced ‘browning’ of adipose tissues. Metabolism. 2018;81:63-70.
  • 34. Crujeiras AB, Pardo M, Casanueva FF. Irisin: ‘fat’ or artefact. Clin Endocrinol (Oxf). 2015;82(4):467-474.
  • 35. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-468.
  • 36. Aslıhan İ, Ünübol Aypak S. İrisin ve metabolik etkileri. Turkiye Klinikleri J Endocrin. 2016;11(1):15-21.
  • 37. Aslan NN, Yardımcı H. Obezite üzerine etkili yeni bir hormon: İrisin. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2017;6(3):176-183.
  • 38. Yoneshiro T, Matsushita M, Saito M. Translational aspects of brown fat activation by food-derived stimulants, in Brown Adipose Tissue, Springer, 2018:359-379.
  • 39. Baskaran P, Krishnan V, Ren J, Thyagarajan B. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. Br J Pharmacol. 2016;173(15):2369-2389.
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There are 66 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Collection
Authors

Hümeyra Başkent 0000-0002-9580-6706

Nazlı Nur Aslan Çin 0000-0002-4458-8817

Taner Bayraktaroğlu 0000-0003-3159-6663

Figen Barut 0000-0003-2084-1678

Publication Date April 28, 2023
Acceptance Date April 26, 2023
Published in Issue Year 2023 Volume: 7 Issue: 1

Cite

APA Başkent, H., Aslan Çin, N. N., Bayraktaroğlu, T., Barut, F. (2023). Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet Ve Obezite Dergisi, 7(1), 81-91. https://doi.org/10.25048/tudod.1250627
AMA Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. April 2023;7(1):81-91. doi:10.25048/tudod.1250627
Chicago Başkent, Hümeyra, Nazlı Nur Aslan Çin, Taner Bayraktaroğlu, and Figen Barut. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet Ve Obezite Dergisi 7, no. 1 (April 2023): 81-91. https://doi.org/10.25048/tudod.1250627.
EndNote Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F (April 1, 2023) Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi 7 1 81–91.
IEEE H. Başkent, N. N. Aslan Çin, T. Bayraktaroğlu, and F. Barut, “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”, Turk J Diab Obes, vol. 7, no. 1, pp. 81–91, 2023, doi: 10.25048/tudod.1250627.
ISNAD Başkent, Hümeyra et al. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet ve Obezite Dergisi 7/1 (April 2023), 81-91. https://doi.org/10.25048/tudod.1250627.
JAMA Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. 2023;7:81–91.
MLA Başkent, Hümeyra et al. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet Ve Obezite Dergisi, vol. 7, no. 1, 2023, pp. 81-91, doi:10.25048/tudod.1250627.
Vancouver Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. 2023;7(1):81-9.
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Turkish Journal of Diabetes and Obesity (Turk J Diab Obes) is a scientific publication of Zonguldak Bulent Ecevit University Obesity and Diabetes Research and Application Center.

This is a refereed journal, which is published in printed and electronic forms. It aims at achieving free knowledge to the related national and international organizations and individuals.

This journal is published annually three times (in April, August and December).

The publication language of the journal is Turkish and English.