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A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature

Year 2024, Volume: 24 Issue: 1, 34 - 39, 30.04.2024

Savcı Bekir Telek Harika Yumru Çeliksoy İnci Kızıldağ Yırgın Hamdullah Sözen Samet Topuz

Abstract

Objective: The growing teratoma syndrome (GTS) defined as the growth of a benign tumor after removal of a germ cell tumor or after chemotherapy. There is no reached consensus managing GTS.
Case: A patient had undergone surgery for an adnexial mass at the age of 14 and diagnosed with immature teratoma. 13 years after the last operation she underwent a fourth time tumor free fertility sparing operation with partial resection of the right liver lobe, partial resection of the peritoneum of diaphragm and cyst removal from right ovary. Pathology result was compatible with mature teratoma having no immature characteristics. To our knowledge, this is the first case reported in the literature that reoccured such a long time after the last GTS surgery such as 13 years and having benign features on histopathological examination.
Conclusion: GTS has an unpredictable behavior and could reoccur even after a very long time and several surgeries.

Keywords

Immature Teratoma Growing Teratoma Syndrome Germ Cell Tumor Delbulking Surgery Fertility Sparing Surgery

Supporting Institution

None

Project Number

None

Thanks

None

References

  • Lai CH, Chang TC, Hsueh S, Wu TI, Chao A, Chou HH, et al. Outcome and prognostic factors in ovarian germ cell malignancies. Gynecol Oncol. 2005;96:784-91.
  • Chen CH, Yang MJ, Cheng MH, Yen MS, Lai CR, Wang PH. Fertility preservation with treatment of immature teratoma of the ovary. J Chin Med Assoc. 2007;70:218-21..
  • Zagamé L, Pautier P, Duvillard P, Castaigne D, Patte C, Lhommé C. Growing teratoma syndrome after ovarian germ cell tumors. Obstet Gynecol. 2006;108:509-514.
  • Gorbatiy V, Spiess PE, Pisters LL. The growing teratoma syndrome: Current review of the literature. Indian J Urol. 2009;25:186-189.
  • André F, Fizazi K, Culine S, Droz J, Taupin P, Lhommé C et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36:1389-1394.
  • Logothetis CJ, Samuels ML, Trindade A, Johnson DE. The growing teratoma syndrome. Cancer. 1982;50:1629-1635.
  • Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C. The growing teratoma syndrome: a case report and a review of the literature. Int J Gynecol Cancer. 2006;1:384-390.
  • DiSaia PJ, Saltz A, Kagan AR, Morrow CP. Chemotherapeutic retroconversion of immature teratoma of the ovary. Obstet Gynecol. 1977;49:346-350.
  • Bentivegna E, Azaïs H, Uzan C, Leary A, Pautier P, Gonthier C. Surgical Outcomes After Debulking Surgery for Intraabdominal Ovarian Growing Teratoma Syndrome: Analysis of 38 Cases. Ann Surg Oncol. 2015;22:S964-970.
  • Li S, Liu Z, Dong C, Long F, Liu Q, Sun D. Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl: A Case Report and Literature Review. Medicine. 2016;95:e2647.
  • Tzortzatos G, Sioutas A, Schedvins K. Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. Fertil Steril. 2009;91:936.e931-933.
  • Tangir J, Zelterman D, Ma W, Schwartz PE. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101:251-257.
  • Nishio S, Ushijima K, Fukui A, Fujiyoshi N, Kawano K, Komai K. Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary. J Obstet Gynaecol Res. 2006;32:416-421.
  • Nimkin K, Gupta P, McCauley R, Gilchrist BF, Lessin MS. The growing teratoma syndrome. Pediatr Radiol. 2004;34:259-262.
  • Djordjevic B, Euscher ED, Malpica A. Growing teratoma syndrome of the ovary: review of literature and first report of a carcinoid tumor arising in a growing teratoma of the ovary. Am J Surg Pathol. 2007;31:1913-1918.

Nadir bir Growing Teratom Sendromu olgusu; 13 yıl sonra karaciğer metastazı ile üçüncü nüksü; bir olgu sunumu ve literatürün gözden geçirilmesi

Year 2024, Volume: 24 Issue: 1, 34 - 39, 30.04.2024

Savcı Bekir Telek Harika Yumru Çeliksoy İnci Kızıldağ Yırgın Hamdullah Sözen Samet Topuz

Abstract

Amaç: Büyüyen teratom sendromu (BTS) germ hücreli tümor için gerçekleştirilen ameliyat ya da kemoterapi sonrasında benign karakterde tümöral büyüme olarak tanımlanmıştır. BTS tedavisi için bir uzlaşı bulunmamaktadır.
Vaka: 14 yaşında kız hasta adneksiyel kitle nedeni ile opere olup immatür teratom tanısı almıştır. Bu operasyondan 13 yıl sonra gerçekleşen dordüncü operasyonda hastaya batında tümör bırakılmadan sağ karaciğer lobunun parsiyel rezeksiyonu, diafram peritonunun parsiyel rezeksiyonu ve sağ over kist eksizyonu fertilite koruyucu yaklaşımla gerçekleştirlmiştir. Patoloji sonucu immatür karakterde tümör içermeyen matür teratom olarak gelmiştir. İlk operasyondan 13 yıl sonra ve benign natürde nüks eden hasta, literatürde bu denli uzun süre sonra iyi huylu olarak nüks gerçekleşen ilk BTS hastası niteliğindedir.
Sonuç: BTS prognozunu öngörmek oldukça zordur, uzun zaman ve tekrarlayan cerrahiler sonrasında dahi nüksler görülebilir.

Keywords

İmmatür Teratom Büyüyen Teratom Sendromu Germ Hücreli Tümör Sitoredüktif Cerrahi

Project Number

None

References

  • Lai CH, Chang TC, Hsueh S, Wu TI, Chao A, Chou HH, et al. Outcome and prognostic factors in ovarian germ cell malignancies. Gynecol Oncol. 2005;96:784-91.
  • Chen CH, Yang MJ, Cheng MH, Yen MS, Lai CR, Wang PH. Fertility preservation with treatment of immature teratoma of the ovary. J Chin Med Assoc. 2007;70:218-21..
  • Zagamé L, Pautier P, Duvillard P, Castaigne D, Patte C, Lhommé C. Growing teratoma syndrome after ovarian germ cell tumors. Obstet Gynecol. 2006;108:509-514.
  • Gorbatiy V, Spiess PE, Pisters LL. The growing teratoma syndrome: Current review of the literature. Indian J Urol. 2009;25:186-189.
  • André F, Fizazi K, Culine S, Droz J, Taupin P, Lhommé C et al. The growing teratoma syndrome: results of therapy and long-term follow-up of 33 patients. Eur J Cancer. 2000;36:1389-1394.
  • Logothetis CJ, Samuels ML, Trindade A, Johnson DE. The growing teratoma syndrome. Cancer. 1982;50:1629-1635.
  • Tangjitgamol S, Manusirivithaya S, Leelahakorn S, Thawaramara T, Suekwatana P, Sheanakul C. The growing teratoma syndrome: a case report and a review of the literature. Int J Gynecol Cancer. 2006;1:384-390.
  • DiSaia PJ, Saltz A, Kagan AR, Morrow CP. Chemotherapeutic retroconversion of immature teratoma of the ovary. Obstet Gynecol. 1977;49:346-350.
  • Bentivegna E, Azaïs H, Uzan C, Leary A, Pautier P, Gonthier C. Surgical Outcomes After Debulking Surgery for Intraabdominal Ovarian Growing Teratoma Syndrome: Analysis of 38 Cases. Ann Surg Oncol. 2015;22:S964-970.
  • Li S, Liu Z, Dong C, Long F, Liu Q, Sun D. Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl: A Case Report and Literature Review. Medicine. 2016;95:e2647.
  • Tzortzatos G, Sioutas A, Schedvins K. Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. Fertil Steril. 2009;91:936.e931-933.
  • Tangir J, Zelterman D, Ma W, Schwartz PE. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101:251-257.
  • Nishio S, Ushijima K, Fukui A, Fujiyoshi N, Kawano K, Komai K. Fertility-preserving treatment for patients with malignant germ cell tumors of the ovary. J Obstet Gynaecol Res. 2006;32:416-421.
  • Nimkin K, Gupta P, McCauley R, Gilchrist BF, Lessin MS. The growing teratoma syndrome. Pediatr Radiol. 2004;34:259-262.
  • Djordjevic B, Euscher ED, Malpica A. Growing teratoma syndrome of the ovary: review of literature and first report of a carcinoid tumor arising in a growing teratoma of the ovary. Am J Surg Pathol. 2007;31:1913-1918.
There are 15 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Collection
Authors

Savcı Bekir Telek

Harika Yumru Çeliksoy

İnci Kızıldağ Yırgın

Hamdullah Sözen

Samet Topuz

Project Number None
Early Pub Date April 30, 2024
Publication Date April 30, 2024
Submission Date May 7, 2023
Published in Issue Year 2024 Volume: 24 Issue: 1

Cite

APA Telek, S. B., Yumru Çeliksoy, H., Kızıldağ Yırgın, İ., Sözen, H., et al. (2024). A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature. Türk Jinekolojik Onkoloji Dergisi, 24(1), 34-39.
AMA Telek SB, Yumru Çeliksoy H, Kızıldağ Yırgın İ, Sözen H, Topuz S. A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature. TRSGO Dergisi. April 2024;24(1):34-39.
Chicago Telek, Savcı Bekir, Harika Yumru Çeliksoy, İnci Kızıldağ Yırgın, Hamdullah Sözen, and Samet Topuz. “A Rare Case of Growing Teratoma Syndrome ; Third Recurrence After 13 Years With Liver Metastases ; A Case Report and Review of the Literature”. Türk Jinekolojik Onkoloji Dergisi 24, no. 1 (April 2024): 34-39.
EndNote Telek SB, Yumru Çeliksoy H, Kızıldağ Yırgın İ, Sözen H, Topuz S (April 1, 2024) A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature. Türk Jinekolojik Onkoloji Dergisi 24 1 34–39.
IEEE S. B. Telek, H. Yumru Çeliksoy, İ. Kızıldağ Yırgın, H. Sözen, and S. Topuz, “A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature”, TRSGO Dergisi, vol. 24, no. 1, pp. 34–39, 2024.
ISNAD Telek, Savcı Bekir et al. “A Rare Case of Growing Teratoma Syndrome ; Third Recurrence After 13 Years With Liver Metastases ; A Case Report and Review of the Literature”. Türk Jinekolojik Onkoloji Dergisi 24/1 (April 2024), 34-39.
JAMA Telek SB, Yumru Çeliksoy H, Kızıldağ Yırgın İ, Sözen H, Topuz S. A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature. TRSGO Dergisi. 2024;24:34–39.
MLA Telek, Savcı Bekir et al. “A Rare Case of Growing Teratoma Syndrome ; Third Recurrence After 13 Years With Liver Metastases ; A Case Report and Review of the Literature”. Türk Jinekolojik Onkoloji Dergisi, vol. 24, no. 1, 2024, pp. 34-39.
Vancouver Telek SB, Yumru Çeliksoy H, Kızıldağ Yırgın İ, Sözen H, Topuz S. A rare case of Growing Teratoma Syndrome ; third recurrence after 13 years with liver metastases ; a case report and review of the literature. TRSGO Dergisi. 2024;24(1):34-9.
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