Research Article
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HPV TEST OUTCOMES OF PATIENTS WITH CERVICAL CANCER OR CERVICAL INTRAEPITHELIAL NEOPLASIA

Year 2016, Volume: 19 Issue: 4, 151 - 154, 22.05.2018

Abstract

Aim: Human Papilloma Virüs (HPV) is the essential factor for cervical cancer. Frequency and distribution of HPV types differ among
countries. In the present study, we aim to find the proportion of HPV 16/18 and also other high risk types (hrHPV) in patients with cervical
intraepitelial neoplasia (CIN) and cervical cancer.
Material and Methods: We reviewed clinical and pathological features of patients who had undergone colposcopic biopsy at Baskent
University Hospital in Ankara between 2007-2015. Patients with the diagnosis of CIN and cervical cancer were included in the study if
they had HPV test. Patients were grouped according to their HPV result. We expressed the frequencies of HPV groups based on histologic
diagnosis of CIN and cervical cancer.
Results: 229 patients were included in the present study. CIN 1, CIN 2, CIN 3 and cervical cancer were present in 80 (34.9 % ), 112 (48.9 %
), 30 (13.1 % ), 7 (3.1 % ) of the patients, respectively. Among 149 patients with ≥ CIN 2; HPV 16/18 was present in 77 (51.7 % ), other hrHPV
types were present in 37 (24.8 % ) patients. Both HPV 16/18 and other hrHPV types were present in 18 patients (12.1% ).
Conclusion: 51 % of the patients with CIN or cervical cancer have at least HPV 16 or HPV 18. This ratio was 45 % for other hrHPV types.

References

  • 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011: 61; 69-90.
  • 2. Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence worldwide in 2012: http://globocan.iarc. fr/Default.aspx
  • 3. Walboomers M, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189(1):12-9.
  • 4. Kitchener HC, Almonte, Th omson C, et al. HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial. Lancet Oncol 2009; 10: 672-82.
  • 5. Munoz N, Bosch FX, Sanjose SD, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518-27.
  • 6. Cliff ord GM, Smith JS, Plummer M, et al. Worlwide distrubition of humanpapilloma virus types in cytologically normal women in the international Agency for research on Cancer HPV prevalance surveys: a pooled analysis. Lancet. 2005;366:991-8.
  • 7. Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 2017; 141: 664-670.
  • 8. Bruni L, Diaz M, Castellsagué M, Ferrer E, Bosch FX, de Sanjosé S. Cervical human papillomavirus prevalance in 5 continents: meta-analysis of 1 million women with normal cytologic findings. J. Infect. Dis. 2010; 202 (12): 1789- 99.
  • 9. Cliff ord GM, Smith JS, Aguado T, Et al. Comparision of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta analysis. Br J Cancer 2003;89:101- 5
  • 10. Bian ML, Cheng JY, Cong X, Liu J, Chen Y, Chen XI. Evaluation of the detection of 14 high-risk human papillomaviruses with HPV 16 and HPV 18 genotyping for cervical cancer screening. Exp Th er Med 2013;6:1332–6.
  • 11. De Sanjose Silvia, Quint WGV, Alemany L, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 2010; 11: 1048-56.
  • 12. Hooi DJ, Lissenberg-Witte BI, Konig MNC, et al. High prevalance of high-risk HPV genotypes other than 16 and 18 in cervical cancers of Curacao: implications for choice of prophylactic HPV vaccine. Sex Transm Infec 2017; 0: 1-5.
  • 13. Chen W, Zhang X, Molijn A, Jenkins D, Shi JF, Quint W, et al. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control 2009; 20(9):1705-13.
  • 14. Zhang R, Velicer C, Chen W, Liaw K-L, Wu E-Q, Liu B, et al. Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grades 1 or worse among 4215 Chinese women in a population-based study. Cancer Epidemiol 2013; 37: 939-45.
  • 15. Xu XX, Zhou J-S, Yuan S-H, Yu H, Lou H-M. Distribution of HPV Genotype in Invasive Cervical Carcinoma and Cervical Intraepithelial Neoplasia in Zheijiang Province, Southeast China: Establishing the Baseline for Sueveillance. Int J Environ Res Public Health 2015: 12; 10794- 10805.
  • 16. Phoolcharoen N, Kantathavorn N, Sricharunrat T, Saeloo S, Krongthong W. A population-based study of cervical cytology findings and human papillomavirus infection in a suburban area of Th ailand. Gynecol Oncol Rep 2017; 21: 73-77

SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI

Year 2016, Volume: 19 Issue: 4, 151 - 154, 22.05.2018

Abstract

Amaç: Serviks kanserinin oluşumunda gerekli olan temel faktör Human Papilloma Virüs’ün (HPV) sıklığı ve dağılımı ülkelerarası toplumsal
farklılıklar gösterebilmektedir. Biz bu çalışmamızda serviks kanseri ve servikal intraepithelial neoplazi (CIN) saptanan hastalarda HPV 16,
18 ve diğer hrHPV (yüksek riskli HPV) tiplerinin sıklığını ortaya koymayı amaçladık.
Materyal ve Method: 2007-2015 yıllarında Başkent Üniversitesi Tıp Fakültesi Ankara Hastanesi Jinekolojik Onkoloji Cerrahisi poliklini-
ğinde kolposkopik biyopsi yapılan olgular taranmıştır. Servikal intraepitelial neoplazi (CIN) ve serviks kanseri saptanan ve HPV Testi ile
değerlendirilen hastalar çalışma kapsamında değerlendirilmiştir. HPV test sonucuna göre hastalar gruplandırılmıştır. CIN ve serviks kanseri
saptanan hastalarda tanımlanan HPV gruplarının sayısal dağılımı gösterilmiştir.
Bulgular: 229 hasta çalışma kapsamında değerlendirilmiştir. 80 (% 34.9) hastada CIN 1, 112 (% 48.9) hastada CIN 2, 30 (% 13.1) hastada
CIN 3, 7 (% 3.1) hastada serviks kanseri saptanmıştır. Kolposkopik biyopsi sonucuna göre ≥ CIN 2 lezyon saptanan 149 hastadan 77’sinde
(% 51.7) HPV 16/18 +, 37’ sinde (% 24.8) diğer hrHPV + tespit edilmiş olup 18 hastada (% 12.1) hem HPV 16/18 hem de diğer hrHPV tespit
edilmiştir.
Sonuç: CIN veya serviks kanseri olan hastaların % 51’ i en azından HPV 16 ya da 18’den birini taşımakta olup bu oran diğer hrHPV tipleri
için % 45’ dir.

References

  • 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011: 61; 69-90.
  • 2. Globocan 2012: Estimated Cancer Incidence, Mortality and Prevalence worldwide in 2012: http://globocan.iarc. fr/Default.aspx
  • 3. Walboomers M, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189(1):12-9.
  • 4. Kitchener HC, Almonte, Th omson C, et al. HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial. Lancet Oncol 2009; 10: 672-82.
  • 5. Munoz N, Bosch FX, Sanjose SD, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518-27.
  • 6. Cliff ord GM, Smith JS, Plummer M, et al. Worlwide distrubition of humanpapilloma virus types in cytologically normal women in the international Agency for research on Cancer HPV prevalance surveys: a pooled analysis. Lancet. 2005;366:991-8.
  • 7. Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 2017; 141: 664-670.
  • 8. Bruni L, Diaz M, Castellsagué M, Ferrer E, Bosch FX, de Sanjosé S. Cervical human papillomavirus prevalance in 5 continents: meta-analysis of 1 million women with normal cytologic findings. J. Infect. Dis. 2010; 202 (12): 1789- 99.
  • 9. Cliff ord GM, Smith JS, Aguado T, Et al. Comparision of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta analysis. Br J Cancer 2003;89:101- 5
  • 10. Bian ML, Cheng JY, Cong X, Liu J, Chen Y, Chen XI. Evaluation of the detection of 14 high-risk human papillomaviruses with HPV 16 and HPV 18 genotyping for cervical cancer screening. Exp Th er Med 2013;6:1332–6.
  • 11. De Sanjose Silvia, Quint WGV, Alemany L, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 2010; 11: 1048-56.
  • 12. Hooi DJ, Lissenberg-Witte BI, Konig MNC, et al. High prevalance of high-risk HPV genotypes other than 16 and 18 in cervical cancers of Curacao: implications for choice of prophylactic HPV vaccine. Sex Transm Infec 2017; 0: 1-5.
  • 13. Chen W, Zhang X, Molijn A, Jenkins D, Shi JF, Quint W, et al. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control 2009; 20(9):1705-13.
  • 14. Zhang R, Velicer C, Chen W, Liaw K-L, Wu E-Q, Liu B, et al. Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grades 1 or worse among 4215 Chinese women in a population-based study. Cancer Epidemiol 2013; 37: 939-45.
  • 15. Xu XX, Zhou J-S, Yuan S-H, Yu H, Lou H-M. Distribution of HPV Genotype in Invasive Cervical Carcinoma and Cervical Intraepithelial Neoplasia in Zheijiang Province, Southeast China: Establishing the Baseline for Sueveillance. Int J Environ Res Public Health 2015: 12; 10794- 10805.
  • 16. Phoolcharoen N, Kantathavorn N, Sricharunrat T, Saeloo S, Krongthong W. A population-based study of cervical cytology findings and human papillomavirus infection in a suburban area of Th ailand. Gynecol Oncol Rep 2017; 21: 73-77
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Surgery
Journal Section Research Article
Authors

Aykut Tuncer

Ali Ayhan

Publication Date May 22, 2018
Submission Date December 7, 2017
Published in Issue Year 2016 Volume: 19 Issue: 4

Cite

APA Tuncer, A., & Ayhan, A. (2018). SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI. Türk Jinekolojik Onkoloji Dergisi, 19(4), 151-154.
AMA Tuncer A, Ayhan A. SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI. TRSGO Dergisi. May 2018;19(4):151-154.
Chicago Tuncer, Aykut, and Ali Ayhan. “SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI”. Türk Jinekolojik Onkoloji Dergisi 19, no. 4 (May 2018): 151-54.
EndNote Tuncer A, Ayhan A (May 1, 2018) SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI. Türk Jinekolojik Onkoloji Dergisi 19 4 151–154.
IEEE A. Tuncer and A. Ayhan, “SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI”, TRSGO Dergisi, vol. 19, no. 4, pp. 151–154, 2018.
ISNAD Tuncer, Aykut - Ayhan, Ali. “SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI”. Türk Jinekolojik Onkoloji Dergisi 19/4 (May 2018), 151-154.
JAMA Tuncer A, Ayhan A. SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI. TRSGO Dergisi. 2018;19:151–154.
MLA Tuncer, Aykut and Ali Ayhan. “SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI”. Türk Jinekolojik Onkoloji Dergisi, vol. 19, no. 4, 2018, pp. 151-4.
Vancouver Tuncer A, Ayhan A. SERVİKS KANSERİ YA DA SERVİKAL İNTRAEPİTHELİAL NEOPLAZİ SAPTANAN HASTALARIN HPV TEST SONUÇLARI. TRSGO Dergisi. 2018;19(4):151-4.