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Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome

Year 2015, Volume: 22 Issue: 2, 78 - 80, 09.12.2015

Deniz Anuk İnce Şahin Takcı Buket Altıntaş

Abstract

Abstract

Aim: Meconium aspiration syndrome is usually seen in full-term and post-term infants and may cause complications including respiratory failure, pulmonary air leaks, and persistent pulmonary hypertension. The aim of this study was to determine risk factors of meconium aspiration syndrome and assess the clinical course of the disease.

Material and Methods: Fourteen of 508 infants diagnosed with meconium aspiration syndrome between January 2013 and April 2014 were retrospectively analyzed. The risk factors including the first and fifth minute Apgar scores, the mode of delivery, need for advanced intervention and deep tracheal aspiration in the delivery room, and the presence of perinatal asphyxia were recorded and patients were classified according to the severity of disease. The clinical features and complications of the disease were also recorded.

Results: Fourteen infants with a mean gestational age of 38.7±2.1 weeks and mean birth weight of 2828±810 grams enrolled in the study. Two patients had perinatal asphyxia, three pulmonary hypertension, and one of our patients developed pneumothorax. During the follow-up, nine patients needed mechanical ventilation support while five patients received surfactant therapy. In our study, one infant had mild, ten infants had moderate, and three infants had severe meconium aspiration syndrome. All patients responded well to the treatment.

Conclusion: Meconium aspiration syndrome is an important problem with high morbidity and mortality rates. The determination of risk factors and close follow-up during perinatal and neonatal period may prevent the disease and decrease morbidity and mortality rates.

Key Words: Meconium Aspiration Syndrome; Risk Factor; Complications.

Keywords

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References

  • Stensen BJ, Smith CL. Management of meconium aspiration syndrome. Paediatrics and Child Health 2009;19:174-7.
  • Mazor M, Hershkovitz R, Bashiri A, Maymon E, Schreiber R, Dukler D, et al. Meconium stained amniotic fluid in preterm delivery is an independent risk factor for perinatal complications. Eur J Obstet Gynecol Reprod Biol 1998;81:9–13.
  • Scott H,WalkerM, Gruslin A. Significance of meconium-stained amniotic fluid in the preterm population. J Perinatol 2001;21:174–7.
  • Dargaville PA, Copnell B. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics 2006;117:1712–21.
  • Yurdakök M. Meconium aspiration syndrome: do we know? Turk J Pediatr 2011;5:121-9.
  • Hankins GD, Speer M. Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy. Obstet Gynecol 2003;102:628-36.
  • Fanaroff AA. Meconium aspiration syndrome: historical aspects. J Perinatol 2008;3:3-7.
  • Cleary GM, Wiswell TE. Meconium-stained amniotic fluid and the meconium aspiration syndrome: an update. Pediatr Clin North Am 1998;45:511–29.
  • Swarnam K, Soraisham AS, Sivanandan S. Advances in the management of meconium aspiration syndrome. Int J Pediatr 2012;2012:1-7.
  • Vain NE, Szyld EG, Prudent LM, Aguilar AM. What (not) to do at and after delivery? Prevention and management of meconium aspiration syndrome. Early Hum Dev 2009;85:621-6.
  • Bhutani VK, Chima R, Sivieri EM. Innovative neonatal ventilation and meconium aspiration syndrome. Indian J Pediatr 2003;70:421–7.
  • Wiswell TE. Advances in the treatment of the meconium aspiration syndrome. Acta Paediatr 2001;90:28–30.
  • Engle WA, the Committee on fetus and newborn surfactant replacement therapy for respiratory distress in the preterm and term neonate. Pediatrics 2008;121:419–32.
  • Peng TC, Gutcher GR, Van Dorsten JP. A selective aggressive approach to the neonate exposed to meconium-stained amniotic fluid. Am J Obstet Gynecol 1996;175:296–301.
  • Hernandez C, Little BB, Dax JS, Gilstrap LC, Rosenfeld CR. Prediction of the severity of meconium aspiration syndrome. Am J Obstet Gynecol 1993;169:61–70.
  • Karatekin G, Kesim MD, Nuhoglu A. Risk factors for meconium aspiration syndrome. Int J Gynaecol Obstet 1999;65:295–7.
  • Dargaville PA, Copnell B; Australian and New Zealand Neonatal Network. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics 2006;117:1712-21.
  • Van Ierland Y, de Boer M, de Beaufort AJ. Meconium-stained amniotic fluid: discharge vigorous newborns. Arch Dis Child Fetal Neonatal Ed 2010;95:69-71.
  • Özdemir R, Akçay A, Dizdar EA, Oğuz ŞS, Yurttutan S, Yapar EG, et al. Mekonyum aspirasyon sendromu sıklığı ve prognostik faktörler: tek merkez deneyimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2011;54:211-5.

Mekonyum Aspirasyon Sendromunda Risk Faktörleri ve Klinik İzlem Bulguları

Year 2015, Volume: 22 Issue: 2, 78 - 80, 09.12.2015

Deniz Anuk İnce Şahin Takcı Buket Altıntaş

Abstract

Amaç: Mekonyum aspirasyon sendromu sıklıkla zamanında doğan veya postmatür bebeklerde görülen, solunum yetmezliği, pulmoner hava
kaçağı veya persistan pulmoner hipertansiyon gibi komplikasyonlara yol açan hayatı tehdit edebilen bir durumdur. Bu çalışmanın amacı
mekonyum aspirasyon sendromu için risk faktörlerinin belirlenmesi, hastalığın klinik seyri ve tedaviye yanıtın incelenmesidir.
Gereç ve Yöntemler: Bu çalışmada yenidoğan yoğun bakım ünitemizde Ocak 2013-Nisan 2014 tarihleri arasında izlenen 508 bebekten
mekonyum aspirasyon sendromu tanısı konulan 14 hastanın dosyaları geriye dönük olarak incelendi. Mekonyum aspirasyon sendromu için
risk faktörlerinden birinci ve beşinci dakika Apgar skoru, doğum şekli, doğum salonunda ileri girişim ve derin trakeal aspirasyon ihtiyacı,
perinatal asfiksi varlığı kaydedildi ve mekonyum aspirasyon sendromu şiddetine göre hastalar sınıflandırıldı. Bebeklerin klinik izlemi ve
gelişen komplikasyonlar kaydedildi.
Bulgular: Çalışmadaki 14 bebeğin gebelik yaşları ortalama 38.7±2.1 hafta, doğum ağırlıkları 2828±810 gr idi. Çalışmamızda 2 olguda
perinatal asfiksi, 3 olguda pulmoner hipertansiyon ve 1 olguda pnömotoraks görüldü. İzlemde 9 hastaya mekanik ventilasyon desteği verildi
ve 5 hastaya surfaktan uygulandı. Çalışmamızda bir bebekte hafif düzeyde MAS, 10 bebekte orta düzeyde MAS ve 3 bebekte ağır düzeyde
MAS görüldü. Komplikasyon görülen tüm hastalarda tedaviye iyi yanıt alındı.
Sonuç: Mekonyum aspirasyon sendromu yüksek morbidite, mortalite oranı nedeniyle günümüzde önemini koruyan bir sorundur. Mekonyum
aspirasyon sendromunun önlenmesi; morbidite ve mortalitenin azaltılmasında risk faktörlerinin bilinmesi, perinatal ve neonatal dönemde
bebeklerin yakın izlemi büyük önem taşımaktadır.

Keywords

Mekonyum Aspirasyon Sendromu Risk Faktörleri Komplikasyonlar

References

  • Stensen BJ, Smith CL. Management of meconium aspiration syndrome. Paediatrics and Child Health 2009;19:174-7.
  • Mazor M, Hershkovitz R, Bashiri A, Maymon E, Schreiber R, Dukler D, et al. Meconium stained amniotic fluid in preterm delivery is an independent risk factor for perinatal complications. Eur J Obstet Gynecol Reprod Biol 1998;81:9–13.
  • Scott H,WalkerM, Gruslin A. Significance of meconium-stained amniotic fluid in the preterm population. J Perinatol 2001;21:174–7.
  • Dargaville PA, Copnell B. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics 2006;117:1712–21.
  • Yurdakök M. Meconium aspiration syndrome: do we know? Turk J Pediatr 2011;5:121-9.
  • Hankins GD, Speer M. Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy. Obstet Gynecol 2003;102:628-36.
  • Fanaroff AA. Meconium aspiration syndrome: historical aspects. J Perinatol 2008;3:3-7.
  • Cleary GM, Wiswell TE. Meconium-stained amniotic fluid and the meconium aspiration syndrome: an update. Pediatr Clin North Am 1998;45:511–29.
  • Swarnam K, Soraisham AS, Sivanandan S. Advances in the management of meconium aspiration syndrome. Int J Pediatr 2012;2012:1-7.
  • Vain NE, Szyld EG, Prudent LM, Aguilar AM. What (not) to do at and after delivery? Prevention and management of meconium aspiration syndrome. Early Hum Dev 2009;85:621-6.
  • Bhutani VK, Chima R, Sivieri EM. Innovative neonatal ventilation and meconium aspiration syndrome. Indian J Pediatr 2003;70:421–7.
  • Wiswell TE. Advances in the treatment of the meconium aspiration syndrome. Acta Paediatr 2001;90:28–30.
  • Engle WA, the Committee on fetus and newborn surfactant replacement therapy for respiratory distress in the preterm and term neonate. Pediatrics 2008;121:419–32.
  • Peng TC, Gutcher GR, Van Dorsten JP. A selective aggressive approach to the neonate exposed to meconium-stained amniotic fluid. Am J Obstet Gynecol 1996;175:296–301.
  • Hernandez C, Little BB, Dax JS, Gilstrap LC, Rosenfeld CR. Prediction of the severity of meconium aspiration syndrome. Am J Obstet Gynecol 1993;169:61–70.
  • Karatekin G, Kesim MD, Nuhoglu A. Risk factors for meconium aspiration syndrome. Int J Gynaecol Obstet 1999;65:295–7.
  • Dargaville PA, Copnell B; Australian and New Zealand Neonatal Network. The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics 2006;117:1712-21.
  • Van Ierland Y, de Boer M, de Beaufort AJ. Meconium-stained amniotic fluid: discharge vigorous newborns. Arch Dis Child Fetal Neonatal Ed 2010;95:69-71.
  • Özdemir R, Akçay A, Dizdar EA, Oğuz ŞS, Yurttutan S, Yapar EG, et al. Mekonyum aspirasyon sendromu sıklığı ve prognostik faktörler: tek merkez deneyimi. Çocuk Sağlığı ve Hastalıkları Dergisi 2011;54:211-5.
There are 19 citations in total.

Details

Primary Language ingilizce
Journal Section Articles
Authors

Deniz Anuk İnce

Şahin Takcı This is me

Buket Altıntaş This is me

Publication Date December 9, 2015
Published in Issue Year 2015 Volume: 22 Issue: 2

Cite

APA Anuk İnce, D., Takcı, Ş., & Altıntaş, B. (2015). Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome. Journal of Turgut Ozal Medical Center, 22(2), 78-80.
AMA Anuk İnce D, Takcı Ş, Altıntaş B. Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome. J Turgut Ozal Med Cent. December 2015;22(2):78-80.
Chicago Anuk İnce, Deniz, Şahin Takcı, and Buket Altıntaş. “Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome”. Journal of Turgut Ozal Medical Center 22, no. 2 (December 2015): 78-80.
EndNote Anuk İnce D, Takcı Ş, Altıntaş B (December 1, 2015) Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome. Journal of Turgut Ozal Medical Center 22 2 78–80.
IEEE D. Anuk İnce, Ş. Takcı, and B. Altıntaş, “Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome”, J Turgut Ozal Med Cent, vol. 22, no. 2, pp. 78–80, 2015.
ISNAD Anuk İnce, Deniz et al. “Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome”. Journal of Turgut Ozal Medical Center 22/2 (December 2015), 78-80.
JAMA Anuk İnce D, Takcı Ş, Altıntaş B. Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome. J Turgut Ozal Med Cent. 2015;22:78–80.
MLA Anuk İnce, Deniz et al. “Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome”. Journal of Turgut Ozal Medical Center, vol. 22, no. 2, 2015, pp. 78-80.
Vancouver Anuk İnce D, Takcı Ş, Altıntaş B. Risk Factors and Clinical Follow-Up Features of Meconium Aspiration Syndrome. J Turgut Ozal Med Cent. 2015;22(2):78-80.
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