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Apoptosis in cancer

Year 2022, Volume: 6 Issue: 2, 85 - 95, 25.11.2022
https://doi.org/10.47748/tjvr.1121211

Abstract

Apoptosis is a programmed cell death mechanism, with its presence and absence, directs the progression of most diseases and is targeted in disease treatments. Many factors are influential in the cell's pathway to apoptosis. The defects in these pathways may transform the cell become malignant, and the organism may face a lethal outcome such as cancer. Understanding apoptosis will provide clues in guiding the pathogenesis of diseases. Two main pathway leading to apoptosis, intrinsic and extrinsic, take an active role. Another route is activated by enzymes and enzymes secreted by immune cells such as T and NK. With their initiator and enforcer roles, many caspase molecules are active at critical points in the cell's apoptosis process. In cancer treatments, activation of molecules in these pathways and repair of disrupted pathways are among the target approaches. This review discuss target strategies for inhibiting apoptotic pathways and molecules in cancer cells and the activation of these apoptotic pathways.

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References

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Year 2022, Volume: 6 Issue: 2, 85 - 95, 25.11.2022
https://doi.org/10.47748/tjvr.1121211

Abstract

Project Number

-

References

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  • Akl H, Vervloessem T, Kiviluoto S, et al. A Dual Role For The Anti-Apoptotic Bcl-2 Protein İn Cancer: Mitochondria Versus Endoplasmic Reticulum. Biochimica Et Biophysica Acta(Bba). 2014; 10(1843), 2240-2252.
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  • Blandino G, Agostino S. D. New Therapeutic Strategies To Treat Human Cancers Expressing Mutant P53 Proteins. J Exp Clin Cancer Res. 2018, 15;37(1):30.
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  • Campbell K. J, Tait S. W. G. Targeting Bcl-2 Regulated Apoptosis İn Cancer. Open Biol. 2018; 8(5), 180002. Carrasco R. A, Stamm N. B, Marcusson E, et al. Antisense inhibition of survivin expression as a cancer therapeutic. Mol Cancer Ther. 2011; 10(2), 221-232.
  • Chen Z, Chen J, Liu H, et al. The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma. Frontiers in pharmacology, 2018; 9, 1298.
  • Clemente N, Boggio E, Gigliotti C. L, et al. A Mutation İn Caspase-9 Decreases The Expression Of Baffr And Icos İn Patients With İmmunodeficiency And Lymphoproliferation. Genes & Immunity. 2015; (16), 151–161.
  • Cossu F, Milani M, Mastrangelo E, Lecis D. Targeting The BIR Domains Of Inhibitor Of Apoptosis (IAP) Proteins İn Cancer Treatment. Comput Struct Biotechnol J. 2019; (17),142-150.
  • Dagbay K. B, Hill, M. E, Barrett E, Hardy J. A. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. 2017; 29; 56(34), 4568–4577.
  • Dai X, Zhang J, Arfuso F, et al. Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy. Exp Biol Med (Maywood). 2015; 240(6),760-773.
  • Danial N. N, Hockenbery D. M. Chapter 18-Cell death. In Hematology, 7th ed.; Hoffman, R., Benz, E.J., Silberstein, L.E., Heslop, H.E., Weitz, J.I., Anastasi, J., Salama, M.E., Abutalib, S.A., Eds.; Elsevier: Amsterdam, The Netherlands, 2018; 186-196.
  • Donnelly O. G, Errington-Mais F, Steele L, et al. Measles virus causes immunogenic cell death in human melanoma. Gene Ther. 2013; 20(1),7-15.
  • Elkholi, R., Floros, K. V., Chipuk, J. E. The role of bh3-only proteins in tumor cell development, signaling and treatment. Genes Cancer. 2011; 2(5),523–537.
  • Elliott M. R, Chekeni F. B, Trampont P. C, et al. Nucleotides Released by Apoptotic Cells Act as a Find-Me Signal to Promote Phagocytic Clearance. Nature. 2009; 461(7261), 282-286. https://dx.doi.org/10.1038/nature08296.
  • Elmore S. Apoptosis: A Review Of Programmed Cell Death. Toxicol Pathol. 2007; 35(4), 495-516.
  • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998; 391(6662), 43-50.
  • Falschlehner C, Schaefer U, Walczak H. Following Traıl's Path in The Immune System. Immunology. 2009; 127 (2), 145-154.
  • Fleming J. B, Shen G. L, Holloway S. E, Davis M, Brekken R. A. Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: Justification for K-ras-directed therapy. Mol Cancer Res. 2005; 3, 413-423.
  • Fulda, S., Debatin, K. M. Caspase Activation in Cancer Therapy. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience. 2000-2013.
  • Fulda S, Debatin K. M. Extrinsic Versus İntrinsic Apoptosis Pathways İn Anticancer Chemotherapy. Oncogene. 2006; (25), 4798-4811.
  • Garg H, Suri P, Gupta J. C, Talwar G. P, Dubey S. Survivin: a unique target for tumor therapy. Cancer Cell Int. 2016; 23;16:49.
  • Giorgio M, Migliaccio E, Orsini F, et al. Electron Transfer Between Cytochrome C And P66shc Generates Reactive Oxygen Species That Trigger Mitochondrial Apoptosis. Cell. 2005; 122(2), 221-33.
  • Green D. R, Llambi F. Cell Death Signaling. Cold Spring Harb Perspect Biol. 2015; 12(3), A006080.
  • Hensley P, Mishra M, Kyprianou N. Targeting Caspases İn Cancer Therapeutics. Biol Chem. 2013; 394(7), 831-843. https://dx.doi.org/10.1515/hsz-2013-0128.
  • Humphreys L, Espona‐Fiedler M, Longley D. B. Flıp As A Therapeutic Target İn Cancer. Febs J. 2018; 285(22), 4104-4123.
  • Hyer M. L, Samuel T, Reed J. C. The Flıp-Side Of Fas Signaling Clinical Cancer Research. 2006; 15(12),5929-31. https://dx.doi.org/10.1158/1078-0432.CCR-06-2098.
  • Ivanov, V. N., Bhoumik, A., Ronai, Z. Death Receptors And Melanoma Resistance To Apoptosis. Oncogene. 2003; (22), 3152-3161.
  • Jan R, Chaudhry G. Understanding Apoptosis And Apoptotic Pathways Targeted Cancer Therapeutics. Adv Pharma Bull. 2019; 9(2), 205-218.
  • Jia L. T, Chen S. Y, Yang A. G. Cancer gene therapy targeting cellular apoptosis machinery. Cancer Treat Rev. 2012; 38, 868-876.
  • Johnstone R. W, Ruefli A. A, Lowe S. W. Apoptosis: A Link Between Cancer Genetics And Chemotherapy. Article History. 2002; 2(108), 153-164.
  • Kannan K, Jain S. Oxidative Stress And Apoptosis. Pathophysiology. 2000; 7(3), 153-163.
  • Karstedt S. V, Montinare A, Walczak H. Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nature Reviews Cancer. 2017; 17, 352-366.
  • Kerr J. F, Winterford C, Harmon B. Apoptosis. its Significance in Cancer and Cancer Therapy. Cancer. 1994; 15;73(8), 2013-2026.
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There are 101 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section 2022 Volume 6 Number 2
Authors

Melisa Beyhan Yılmaz 0000-0002-0769-8742

Dilek Muz 0000-0001-9358-8103

Project Number -
Early Pub Date November 21, 2022
Publication Date November 25, 2022
Submission Date May 25, 2022
Published in Issue Year 2022 Volume: 6 Issue: 2

Cite

APA Beyhan Yılmaz, M., & Muz, D. (2022). Apoptosis in cancer. Turkish Journal of Veterinary Research, 6(2), 85-95. https://doi.org/10.47748/tjvr.1121211
AMA Beyhan Yılmaz M, Muz D. Apoptosis in cancer. TJVR. November 2022;6(2):85-95. doi:10.47748/tjvr.1121211
Chicago Beyhan Yılmaz, Melisa, and Dilek Muz. “Apoptosis in Cancer”. Turkish Journal of Veterinary Research 6, no. 2 (November 2022): 85-95. https://doi.org/10.47748/tjvr.1121211.
EndNote Beyhan Yılmaz M, Muz D (November 1, 2022) Apoptosis in cancer. Turkish Journal of Veterinary Research 6 2 85–95.
IEEE M. Beyhan Yılmaz and D. Muz, “Apoptosis in cancer”, TJVR, vol. 6, no. 2, pp. 85–95, 2022, doi: 10.47748/tjvr.1121211.
ISNAD Beyhan Yılmaz, Melisa - Muz, Dilek. “Apoptosis in Cancer”. Turkish Journal of Veterinary Research 6/2 (November 2022), 85-95. https://doi.org/10.47748/tjvr.1121211.
JAMA Beyhan Yılmaz M, Muz D. Apoptosis in cancer. TJVR. 2022;6:85–95.
MLA Beyhan Yılmaz, Melisa and Dilek Muz. “Apoptosis in Cancer”. Turkish Journal of Veterinary Research, vol. 6, no. 2, 2022, pp. 85-95, doi:10.47748/tjvr.1121211.
Vancouver Beyhan Yılmaz M, Muz D. Apoptosis in cancer. TJVR. 2022;6(2):85-9.