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SARS KORONAVİRÜS-2 (SARS-CoV-2) VİROLOJİK ÖZELLİKLERİ VE DİĞER KORONAVİRÜSLERDEN FARKI

Year 2020, Volume: 1 Issue: Covid-19 Özel, 1 - 9, 07.10.2020

Abstract

Koronavirüsler, insanlarda ve hayvanlarda çeşitli derecelerde enterik, hepatik, respiratuvar ve sistemik tutulumlar yapabilen büyük bir virüs ailesidir. İnsanlarda enfeksiyona neden olduğu bilinen altı koronavirüsten dördü ( HCoV 229E, HCoV NL63, HCoV HKU1 ve HCoV OC43) immunkompetan bireylerde hafif üst solunum yolu enfeksiyonuna neden olmaktadır. SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) ve MERS-CoV (Middle East Respiratory Syndrome Coronavirus) zoonotik virüslerdir ve şiddetli alt solunum yolu enfeksiyonu ve hatta ölüme neden olabilmektedir. Çin’de 31 Aralık 2019’da etiyolojisi bilinmeyen pnömoni vakaları bildirilmiştir. Dünya Sağlık Örgütü (WHO) tarafından yeni tip koronavirüse bağlı pnömoni vakaları 11 Şubat 2020’de COVID-19 (Coronavirus Disease 2019) olarak adlandırılmıştır (WHO Report-1, 2020) Önceden 2019-nCov olarak bilinen virüs Koronavirüs Çalışma Grubu tarafından Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) olarak yeniden adlandırmıştır (Gorbalenya vd, 2020). Türkiye’de ilk COVID-19 vakası 11 Mart 2020’de bildirilmiştir. SARS-CoV-2’ nin Betacoronavirus olduğu ve yarasa kökenli bat-SL-CoVZC45 ve bat-SL-CoVZXC21 ile oldukça yakın ilişki gösterdiği tespit edilmiştir. Bu sonuç; yarasaların SARS-CoV-2 için olası rezervuar konakçılar olduğunu düşündürmektedir.

References

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  • Escors D, Ortego J, Laude H, Enjuanes L. (2001). ”The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability”, J Virol, 75(3),1312-24.
  • Fehr AR, Perlman S. (2015). “Coronaviruses: an overview of their replication and pathogenesis” Methods Mol Biol ,1282, 123.
  • Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, vd (2020). “The species Severe acute respiratory syndromerelated coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2” Nature Microbiol, 5, 536-44.
  • Haagmans BL, Al Dhahiry SH, Reusken CB, Raj VS, Galiano M, vd. (2014). “Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation”, Lancet Infect. Dis., 14, 140-5.
  • Hasöksüz M, Kılıç S, Saraç F. (2020). “Coronaviruses and SARS-COV-2”, Turk J Med Sci 50, 549-56.
  • Ji W, Wang W, Zhao X, Zai J, Li X. (2020). ” Cross‐species transmission of the newly identified coronavirus 2019‐nCoV”, J Med Virol, 92 (4), 433-40.
  • Kirchdoerfer RN, Cottrell CA, Wang N, Pallesen J, Yassine HM vd. (2016) “Pre-fusion structure of a human coronavirus spike protein”, Nature. 531(7592), 118-21.
  • Li X, Zai J, Zhao Q, Nie Q, Li Y vd. (2020) “ Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2”, J Med Virol, 92:602-11.
  • Lu R, Zhao X, Li J, Niu P, Yang B vd (2020). “Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”, The Lancet , 395(10224), 565-74.
  • Malik YA. (2020). “Properties of coronaviruses and SARS-CoV-2”, Malaysian J Pathol 42(1), 3-11.
  • McIntosh K, Peiris J. (2009) “Coronaviruses”, Richman D, Whitley R, Hayden F (Ed.), Clinical Virology, 3rd Edition, içinde (1155-1171), Washington, DC, USA, ASM Press.
  • Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF vd. (2011) “A structural analysis of M protein in coronavirus assembly and morphology”, J Struct Biol, 174(1),11-22.
  • Song HC, Seo M-Y, Stadler K, Yoo BJ, Choo Q-L vd. (2004) “ Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein”, J Virol, 78(19): 10328-35.
  • Velevan TP, Meyer CG. (2020). “The COVID-19 epidemic”, Trop Med Int Health, 25(3), 278-80.
  • Vennema H, Godeke G-J, Rossen J, Voorhout WF, Horzinek MC vd. (1996) “Nucleocapsid-independent assembly of coronaviruslike particles by co-expression of viral envelope protein genes” EMBO J, 15(8), 2020-8.
  • Venkatagopalan P, Daskalova SM, Lopez LA, Dolezal KA, Hogue BG. (2015). ” Coronavirus envelopeprotein remains at the site of assembl”, Virology, 478, 75-85.
  • Walls AC, Park Y, Tortorici MA, Wall A, McGuire AT vd. (2020). “Structure, function, and antigenicity of the SARSCoV-2 spike glycoprotein”, Cell, 180, 281-92.
  • Weston S, Frieman MB. (2020). “COVID-19: Knowns, Unknowns, and Questions”, mSphere, 5, e00203-20.
  • World Health Organization. Novel Coronavirus (2019-nCoV), Situation Report 1, 21 January 2020.
Year 2020, Volume: 1 Issue: Covid-19 Özel, 1 - 9, 07.10.2020

Abstract

References

  • Alekseev KP, Vlasova AN, Jung K, Hasoksuz M, Zhang X, vd. (2008). “ Bovine-like coronaviruses isolated from four species of captive wild ruminants are homologous to bovine coronaviruses, based on complete genomic sequences”, J Virol, 82 (24), 12422-31.
  • Belouzard, S, Chu, VC, Whittaker, GR (2009). ”Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites”, Proc. Natl. Acad. Sci. USA 106, 5871-6.
  • Chan JF, Kok KH, Zhu Z, Chu H, To KK, vd. (2020) “Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan”, Emerg. Microbes Infect., 9(1),221-36.
  • de Haan CA, Rottier PJ.(2005). ” Molecular interactions in the assembly of coronaviruses”, Adv Virus Res, (64),165–230.
  • de Wit E, van Doremalen N, Falzarano D, Munster VJ. (2016). “SARS and MERS: recent insights into emerging coronaviruses,. Nat Rev Microbiol, 14, 523–34.
  • Escors D, Ortego J, Laude H, Enjuanes L. (2001). ”The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability”, J Virol, 75(3),1312-24.
  • Fehr AR, Perlman S. (2015). “Coronaviruses: an overview of their replication and pathogenesis” Methods Mol Biol ,1282, 123.
  • Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, vd (2020). “The species Severe acute respiratory syndromerelated coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2” Nature Microbiol, 5, 536-44.
  • Haagmans BL, Al Dhahiry SH, Reusken CB, Raj VS, Galiano M, vd. (2014). “Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation”, Lancet Infect. Dis., 14, 140-5.
  • Hasöksüz M, Kılıç S, Saraç F. (2020). “Coronaviruses and SARS-COV-2”, Turk J Med Sci 50, 549-56.
  • Ji W, Wang W, Zhao X, Zai J, Li X. (2020). ” Cross‐species transmission of the newly identified coronavirus 2019‐nCoV”, J Med Virol, 92 (4), 433-40.
  • Kirchdoerfer RN, Cottrell CA, Wang N, Pallesen J, Yassine HM vd. (2016) “Pre-fusion structure of a human coronavirus spike protein”, Nature. 531(7592), 118-21.
  • Li X, Zai J, Zhao Q, Nie Q, Li Y vd. (2020) “ Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2”, J Med Virol, 92:602-11.
  • Lu R, Zhao X, Li J, Niu P, Yang B vd (2020). “Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”, The Lancet , 395(10224), 565-74.
  • Malik YA. (2020). “Properties of coronaviruses and SARS-CoV-2”, Malaysian J Pathol 42(1), 3-11.
  • McIntosh K, Peiris J. (2009) “Coronaviruses”, Richman D, Whitley R, Hayden F (Ed.), Clinical Virology, 3rd Edition, içinde (1155-1171), Washington, DC, USA, ASM Press.
  • Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF vd. (2011) “A structural analysis of M protein in coronavirus assembly and morphology”, J Struct Biol, 174(1),11-22.
  • Song HC, Seo M-Y, Stadler K, Yoo BJ, Choo Q-L vd. (2004) “ Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein”, J Virol, 78(19): 10328-35.
  • Velevan TP, Meyer CG. (2020). “The COVID-19 epidemic”, Trop Med Int Health, 25(3), 278-80.
  • Vennema H, Godeke G-J, Rossen J, Voorhout WF, Horzinek MC vd. (1996) “Nucleocapsid-independent assembly of coronaviruslike particles by co-expression of viral envelope protein genes” EMBO J, 15(8), 2020-8.
  • Venkatagopalan P, Daskalova SM, Lopez LA, Dolezal KA, Hogue BG. (2015). ” Coronavirus envelopeprotein remains at the site of assembl”, Virology, 478, 75-85.
  • Walls AC, Park Y, Tortorici MA, Wall A, McGuire AT vd. (2020). “Structure, function, and antigenicity of the SARSCoV-2 spike glycoprotein”, Cell, 180, 281-92.
  • Weston S, Frieman MB. (2020). “COVID-19: Knowns, Unknowns, and Questions”, mSphere, 5, e00203-20.
  • World Health Organization. Novel Coronavirus (2019-nCoV), Situation Report 1, 21 January 2020.
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review Articles
Authors

Ekin Eryılmaz This is me 0000-0002-0268-7542

Recep Keşli 0000-0002-2622-0760

Publication Date October 7, 2020
Submission Date July 10, 2020
Acceptance Date September 28, 2020
Published in Issue Year 2020 Volume: 1 Issue: Covid-19 Özel

Cite

APA Eryılmaz, E., & Keşli, R. (2020). SARS KORONAVİRÜS-2 (SARS-CoV-2) VİROLOJİK ÖZELLİKLERİ VE DİĞER KORONAVİRÜSLERDEN FARKI. Selçuk Sağlık Dergisi, 1(Covid-19 Özel), 1-9.