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PARAOXONASE AND ARYLESTERASE ACTIVITIES IN ADULTS WITH VITAMIN D DEFICIENCY

Year 2021, Volume: 11 Issue: 3, 571 - 575, 22.09.2021

Filiz Alkan Baylan Metin Kılınç Yeliz Doboğlu Hatice Sağer

https://doi.org/10.31832/smj.913255

Abstract

Objective: The aim of this study was to evaluate paraoxonase (PON-1) and arylesterase (ARE) enzyme activity and to evaluate the relationship between vitamin D level and serum lipids and Lipoprotein a (Lp (a)) in adults with vitamin D deficiency.
Materials and Methods: 43 patients with vitamin D deficiency and 37 healthy individuals with similar demographic characteristics were included in the study. A 25 (OH) D below 20 ng / mL was considered a vitamin D deficiency. PON-1, ARE enzyme activities, Lp (a) and serum I,ipid levels were compared between the groups.
Results: PON activity in patients with vitamin D deficiency was found to be lower than healthy control group. ARE activity and Lp (a) were similar between the groups. A positive correlation was observed between vitamin D and PON.
Conclusion: The vitamin D deficient group had lower PON-1 activity. It was thought that the increase in oxidative stress caused by vitamin D deficiency may be caused by the increase in LDL levels and the decrease in HDL levels together with the decrease in PON-1 activity.

Keywords

Vitamin D Paroxonase Arylesterase Lipoprotein a

References

  • 1. Palacios C, Gonzalez L. Is vitamin D deficiency a majör global public health problem? J Steroid Biochem Mol Biol 2014;144:138–145.
  • 2. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281.
  • 3. Wadhwa B, Relhan V, Goel K, Kochhar AM, Garg VK. Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015;81(4):344–355.
  • 4. Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46(4):1039–1059. doi:10.1016/j.ecl.2017.07.009.
  • 5. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vıtamın D: Metabolism, Molecular Mechanism of Action And Pleiotropıc Effects. Physiol Rev. 2016;96:365–408.
  • 6. Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res. 2011;50:303–312.
  • 7. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159–1165.
  • 8. Zittermann A, Gummert JF, Börgermann J. The role of vitamin D in dyslipidemia and cardiovascular disease. Curr Pharm Des. 2011;17:933–942.
  • 9. Dong J, Wong SL, Lau CW, Lee HK, Ng CF, Zhang L, et al. Calcitriol protects renovascular function in hypertension by downregulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J [Internet]. 2012;33(23):2980–2990. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22267242
  • 10. Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun [Internet]. 2015;460(1):53–71. Available from: http://dx.doi.org/10.1016/j. bbrc.2015.01.008.
  • 11. White CR, Anantharamaiah GM. Cholesterol Reduction and Macrophage Function: Role of Paraoxonases. Curr Opin Lipidol. 2017;28(5):397–402. doi:10.1097/MOL.0000000000000444.
  • 12. Kronenberg F. Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region. Clin Res Cardiol Suppl. 2019;14(S1):5-12. doi: 10.1007/s11789-019-00093-5.
  • 13. Katsiki N, Al-Rasadi K, Mikhailidis DP. Lipoprotein (a) and Cardiovascular Risk: The Show Must go on. Curr Med Chem. 2017;24(10):989-1006. doi: 10.2174/0929867324666170112111948.
  • 14. Orsó E, Schmitz G. Lipoprotein(a) and its role in inflammation, atherosclerosis and malignancies. Clin Res Cardiol Suppl. 2017;12:31–37.
  • 15. Kowalska K, Socha E, Milnerowicz M. Review: The role of paraoxonase in cardiovascular diseases. Ann Clin Lab Sci. Spring. 2015;45(2):226-233.
  • 16. Chistiakov, DA, Melnichenko, AA, Orekhov AN, & Bobryshev YV. Paraoxonase and atherosclerosis-related cardiovascular diseases. Biochimie. 2017;132:19–27. doi:10.1016/j.biochi.2016.10.010.
  • 17. Azarsiz E, Kayikcioglu M, Payzin S, Yildirim Sözmen E. PON1 activities and oxidative markers of LDL in patients with angiographically proven coronary artery disease. Int J Cardiol. 2003;91(1):43–51.
  • 18. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94(10):4023-4030. doi: 10.1210/jc.2008-1212.
  • 19. Makariou SE, Elisaf M, Challa A, Tellis C, Tselepis AD, Liberopoulos EN. Effect of combined vitamin D administration plus dietary intervention on oxidative stress markers in patients with metabolic syndrome: A pilot randomized study. Clin Nutr ESPEN. 2019;29:198-202. doi:10.1016/j.clnesp.2018.10.004.
  • 20. Javanbakht MH, Mohammady H, Fooladsaz K, Razzaghi M, Zarei M, Djalali M. Are serum levels of F2-isoprostane and oxidized-LDL related to vitamin D status in type 2 diabetic patients? A case-control study. Rep Biochem Mol Biol. 2016;5:26-32.
  • 21. Kim MR, Jeong SJ. Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children. Metabolites. 2019 Jun 30;9(7):125.
  • 22. Yarparvar A, Elmadfa I, Djazayery A, Abdollahi Z, Salehi F. The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents. Nutrients. 2020;12(2):590. doi: 10.3390/nu12020590.
  • 23. Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Gharavi A, et al. Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med. 2011;9:125. doi: 10.1186/1741-7015-9-125.
  • 24. Ooi EM, Afzal S, Nordestgaard BG. Elevated remnant cholesterol in 25-hydroxyvitamin D deficiency in the general population: Mendelian randomization study. Circ Cardiovasc Genet. 2014;7(5):650-658.

D Vitamini Eksikliği Olan Yetişkinlerde Paraoksonaz ve Arilesteraz Aktiviteleri

Year 2021, Volume: 11 Issue: 3, 571 - 575, 22.09.2021

Filiz Alkan Baylan Metin Kılınç Yeliz Doboğlu Hatice Sağer

https://doi.org/10.31832/smj.913255

Abstract

Amaç: Bu çalışmanın amacı, D vitamini eksikliği olan erişkinlerde Paroksonaz (PON) ve Arilesteraz (ARE) enzim aktivitelerini araştırmak, D vitamini eksikliğinin oksidatif stres ve kardiyovasküler hastalıklar için risk belirteci olan PON-1, ARE ve Lp (a) üzerindeki etkilerini değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya D vitamini eksikliği olan 43 hasta ve benzer demografik özelliklere sahip olan 37 sağlıklı birey dahil edildi. 25 (OH) D'nin 20 ng/mL' nin altında olması D vitamini eksikliği olarak kabul edildi. Gruplar arasında PON-1, ARE enzim aktiviteleri, Lp (a) ve serum lipid düzeyleri karşılaştırıldı.
Bulgular: D vitamini eksikliği olan hastalarda PON aktivitesi sağlıklı kontrol grubuna göre düşük bulundu. Gruplar arasında ARE aktivitesi ve Lp (a) benzer düzeylerdeydi. D vitamini ile PON arasında pozitif yönde bir ilişki gözlemlendi.
Sonuç: D vitamini eksikliği olan grup daha düşük PON-1 aktivitesine sahipti. D vitamini eksikliğinin neden olduğu oksidatif stres artışına, LDL düzeylerindeki artış ve HDL düzeyindeki azalma ile birlikte PON-1 aktivitesinin düşüklüğünün neden olabileceği düşünüldü.

Keywords

D vitamini Paroksonaz Arilesteraz Lipoprotein a

References

  • 1. Palacios C, Gonzalez L. Is vitamin D deficiency a majör global public health problem? J Steroid Biochem Mol Biol 2014;144:138–145.
  • 2. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–281.
  • 3. Wadhwa B, Relhan V, Goel K, Kochhar AM, Garg VK. Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015;81(4):344–355.
  • 4. Rai V, Agrawal DK. Role of Vitamin D in Cardiovascular Diseases. Endocrinol Metab Clin North Am. 2017;46(4):1039–1059. doi:10.1016/j.ecl.2017.07.009.
  • 5. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vıtamın D: Metabolism, Molecular Mechanism of Action And Pleiotropıc Effects. Physiol Rev. 2016;96:365–408.
  • 6. Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res. 2011;50:303–312.
  • 7. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159–1165.
  • 8. Zittermann A, Gummert JF, Börgermann J. The role of vitamin D in dyslipidemia and cardiovascular disease. Curr Pharm Des. 2011;17:933–942.
  • 9. Dong J, Wong SL, Lau CW, Lee HK, Ng CF, Zhang L, et al. Calcitriol protects renovascular function in hypertension by downregulating angiotensin II type 1 receptors and reducing oxidative stress. Eur Heart J [Internet]. 2012;33(23):2980–2990. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22267242
  • 10. Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun [Internet]. 2015;460(1):53–71. Available from: http://dx.doi.org/10.1016/j. bbrc.2015.01.008.
  • 11. White CR, Anantharamaiah GM. Cholesterol Reduction and Macrophage Function: Role of Paraoxonases. Curr Opin Lipidol. 2017;28(5):397–402. doi:10.1097/MOL.0000000000000444.
  • 12. Kronenberg F. Prediction of cardiovascular risk by Lp(a) concentrations or genetic variants within the LPA gene region. Clin Res Cardiol Suppl. 2019;14(S1):5-12. doi: 10.1007/s11789-019-00093-5.
  • 13. Katsiki N, Al-Rasadi K, Mikhailidis DP. Lipoprotein (a) and Cardiovascular Risk: The Show Must go on. Curr Med Chem. 2017;24(10):989-1006. doi: 10.2174/0929867324666170112111948.
  • 14. Orsó E, Schmitz G. Lipoprotein(a) and its role in inflammation, atherosclerosis and malignancies. Clin Res Cardiol Suppl. 2017;12:31–37.
  • 15. Kowalska K, Socha E, Milnerowicz M. Review: The role of paraoxonase in cardiovascular diseases. Ann Clin Lab Sci. Spring. 2015;45(2):226-233.
  • 16. Chistiakov, DA, Melnichenko, AA, Orekhov AN, & Bobryshev YV. Paraoxonase and atherosclerosis-related cardiovascular diseases. Biochimie. 2017;132:19–27. doi:10.1016/j.biochi.2016.10.010.
  • 17. Azarsiz E, Kayikcioglu M, Payzin S, Yildirim Sözmen E. PON1 activities and oxidative markers of LDL in patients with angiographically proven coronary artery disease. Int J Cardiol. 2003;91(1):43–51.
  • 18. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94(10):4023-4030. doi: 10.1210/jc.2008-1212.
  • 19. Makariou SE, Elisaf M, Challa A, Tellis C, Tselepis AD, Liberopoulos EN. Effect of combined vitamin D administration plus dietary intervention on oxidative stress markers in patients with metabolic syndrome: A pilot randomized study. Clin Nutr ESPEN. 2019;29:198-202. doi:10.1016/j.clnesp.2018.10.004.
  • 20. Javanbakht MH, Mohammady H, Fooladsaz K, Razzaghi M, Zarei M, Djalali M. Are serum levels of F2-isoprostane and oxidized-LDL related to vitamin D status in type 2 diabetic patients? A case-control study. Rep Biochem Mol Biol. 2016;5:26-32.
  • 21. Kim MR, Jeong SJ. Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children. Metabolites. 2019 Jun 30;9(7):125.
  • 22. Yarparvar A, Elmadfa I, Djazayery A, Abdollahi Z, Salehi F. The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents. Nutrients. 2020;12(2):590. doi: 10.3390/nu12020590.
  • 23. Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Gharavi A, et al. Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med. 2011;9:125. doi: 10.1186/1741-7015-9-125.
  • 24. Ooi EM, Afzal S, Nordestgaard BG. Elevated remnant cholesterol in 25-hydroxyvitamin D deficiency in the general population: Mendelian randomization study. Circ Cardiovasc Genet. 2014;7(5):650-658.
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Filiz Alkan Baylan 0000-0003-3117-7768

Metin Kılınç 0000-0002-1623-0201

Yeliz Doboğlu 0000-0001-5874-0368

Hatice Sağer 0000-0002-5937-6884

Publication Date September 22, 2021
Submission Date April 12, 2021
Published in Issue Year 2021 Volume: 11 Issue: 3

Cite

AMA Alkan Baylan F, Kılınç M, Doboğlu Y, Sağer H. D Vitamini Eksikliği Olan Yetişkinlerde Paraoksonaz ve Arilesteraz Aktiviteleri. Sakarya Tıp Dergisi. September 2021;11(3):571-575. doi:10.31832/smj.913255

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