Abstract
Amaç
İnfertilite, reprodüktif dönemdeki çiftlerin herhangi doğum
kontrol yöntemi kullanmaksızın bir yıl düzenli cinsel
ilişkiye rağmen gebelik durumunun sağlanamamasıdır.
Bu çalışmada spontan gebe kalan fertil hastalar
ile infertilite tanısı nedeniyle tedavi gören infertil kadın
hastalar arasında kan gruplarının karşılaştırılması
amaçlanmıştır.
Gereç ve Yöntem
Çalışmamız, Ocak 2015-Ocak 2023 yılları arasında
Süleyman Demirel Üniversitesi Kadın Hastalıkları Doğum
Anabilim Dalı polikliniğine rutin gebelik takibi için
başvuran ve spontan gebe kalan 304 fertil hasta ile
infertilite tanısı alarak Süleyman Demirel Üniversitesi
Üremeye Yardımcı Tedavi (ÜYTE) Merkezi’nde tedavi
alan 304 infertil olmak üzere toplam 608 hastanın kan
grupları ve demografik verilerinin istatistiksel olarak
değerlendirilmesini içermektedir.
Bulgular
Fertil grupta yer alan gönüllülerin yaş ortalaması
30,68±4,70 hesaplanırken, infertil gruptaki gönüllülerin
yaş ortalaması ise 32,50±5,35 olarak hesaplanmıştır.
Fertil ve infertil grupta yer alan gönüllülerin kan grupları
A kan grubunun her iki grupta da baskın olduğu ve
bunu sırasıyla 0, B ve AB kan gruplarının izlediği tespit
edilmiştir. Gruplar eğitim durumlarına göre karşılaştırıldığında,
infertil gruptaki hastaların büyük çoğunluğunun
lisans veya lisansüstü seviyede eğitim aldığı tespit
edilmiştir. Gruplar arasındaki mesleki dağılımlara göre
gelir düzeylerine ait veriler ise düşük, orta ve yüksek
gelir düzeyi olmak üzere üç kategoride değerlendirilmiştir.
Buna göre her iki grupta da katılımcılarının büyük
çoğunluğunun düşük gelir düzeyine sahip olduğu
saptanmıştır.
Sonuç
İnfertilite genetik, çevre, yaşam tarzı ve sağlık gibi çeşitli
faktörlerin bir araya gelmesiyle ortaya çıkan çok
faktörlü bir durumdur. İnfertilite prevalansının yaşla
orantılı olarak arttığı ve kan grubu dağılımlarının infertilite
üzerinden doğrudan bir etkisinin olmadığı tespit
edilmiştir.
Project Number
YOK
References
- 1. Harlev A, Walfisch A, Oran E, Har‐Vardi I, Friger M, Lunenfeld E, et al. The effect of fertility treatment on adverse perinatal outcomes in women aged at least 40 years. Int J Gynaecol Obstet. 2018;140(1):98-104.
- 2. Altamimi SI, Snobar RO, Al-Fraihat, A, Albuarki M, Rizk D. Causes of infertility. Bahrain Med Bull. 2019;41(2):93-96.
- 3. Nejat EJ, Jindal S, Berger D, Buyuk E, Lalioti M, Pal L. Implications of blood type for ovarian reserve. Hum Reprod. 2011;26(9):2513-2517.
- 4. Lata I, Mishra P. To study the association of ABO blood group type with Ovarian reserve in infertile women. Int J Gynaecol Obstet. 2020;4(3):75-79.
- 5. Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, et al. Association between biomarkers of ovarian reserve and infertility among older women of reproductive age. Jama. 2017;318(14):1367-1376.
- 6. Yusuf I, Emokpae MA. Association between a marker of sperm DNA damage and sperm indices in infertile males in Benin City, Nigeria: A cross-sectional study. Int J Reprod Biomed. 2021;19(2):137-146.
- 7. Castleton PE, Deluao JC, Sharkey DJ, McPherson NO. Measuring reactive oxygen species in semen for male preconception care: A scientist perspective. Antioxidants. 2022;11(2):264.
- 8. Sharma G, Choudhary R, Bharti D. Studies showing the relationship between ABO blood groups and major types of cancers. Asian J Exp Sci. 2007;21(1):129-132.
- 9. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al. Genome- wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009;41(9):986–90.
- 10. Anstee DJ. The relationship between blood groups and disease. Blood; Am J Hematol. 2010;115(23):4635-43.
- 11. Gates MA, Wolpin BM, Cramer DW, et al. ABO blood group and incidence of epithelial ovarian cancer. Int J Cancer. 2010;128(2):482–486.
- 12. Wolpin BM, Kraft P, Gross M, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res. 2010;70(3):1015–23.
- 13. Xie J, Qureshi AA, Li Y, et al. ABO blood group and incidence of skin cancer. PLoS One. 2010;5(8):e11972.
- 14. Ganitha G, Bhumkar S, Bhuvaneswari J. Association of ABO blood groups and infertility. Int J. 2012;2(5):72-77.
- 15. Spitzer D, Corn C, Stadler J, Wirleitner B, Schuff M, Vanderzwalmen P, et al. Implications of blood type for ovarian reserve and infertility–impact on oocyte yield in IVF Patients. Geburtsh Frauenheilk. 2014;74(10):928-932.
- 16. Şengül Ö, Dilbaz B, Yerebasmaz N, Dede S, Altınbaş Ş, Erkaya S. Only female age, and not blood type, is associated with ovarian reserve. Int J Fertil Steril. 2014;8(2):143.
- 17. Dibby HJ. Blood group and infertility relationship. Med J Babylon. 2015;12(2):479-483.
- 18. Awartani K, Al Ghabshi R, Al Shankiti H, Al Dossari M, Coskun S. Association of blood groups with ovarian reserve and outcome of in vitro fertilization treatment. Ann Saudi Med. 2016;36(2):116-120.
- 19. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175- 191.
- 20. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-1160.
- 21. Amanak K, Karaöz B, Sevil Ü. Modern yaşamın infertilite üzerine etkisi. TAF Prev Med Bull. 2014;13(4):345-350.
- 22. Ünal S, Kargın M, Akyüz A. İnfertil kadınları psikolojik olarak etkileyen faktörler. TAF Prev Med Bull. 2010;9(5):481-486.
- 23. Natarajamani ST, Thiagarajamurthy D, Subramanian M, Moorthy JD, Bhargav A, Parameaswari PJ. Oocyte quality and ABO blood group system: are they connected? Int. J Reprod Contracept Obstet. 2015;4(3):736.
- 24. Khan MS, Ahmed Z, Hanif R, Zaman S, Ali I, Rahman JU. Relationship between blood groups and male infertility. J Ayub Med Coll Abbottabad. 2010;22(1):154-156.
Abstract
Objective
The aim is to compare blood groups between spontaneously
pregnant fertile patients and infertile female
patients undergoing treatment for infertility diagnosis
is defined as the failure to achieve pregnancy despite
regular unprotected sexual intercourse for one year
during the reproductive period without using any contraceptive
method.
Material and Method
Our study includes statistically evaluating the blood
groups and demographic data of a total of 608 patients,
including 304 fertile patients who presented for
routine pregnancy follow-up at the Department of Obstetrics
and Gynecology, Süleyman Demirel University,
between January 2015 and January 2023, and 304
infertile patients receiving treatment at the Süleyman
Demirel University Assisted Reproductive Techniques
(ART) Center.
Results
The mean age of the volunteers in the fertile group
was calculated as 30.68±4.70, while the mean age of
the volunteers in the infertile group was 32.50±5.35.
Blood group A was found to be dominant in both the
fertile and infertile groups, followed by blood groups
O, B, and AB. When compared based on education,
it was determined that the majority of patients in the
infertile group had received undergraduate or postgraduate
education. Income levels were categorized as
low, medium, and high income based on occupational
distributions in both groups, revealing that the majority
of participants in both groups had a low-income level.
Conclusion
Infertility is a multifactorial condition resulting from a
combination of various factors such as genetics, environment,
lifestyle, and health. The prevalence of infertility
increases with age, and blood group distribution
does not have a direct impact on infertility.
Supporting Institution
YOK
Project Number
YOK
Thanks
We would like to thank the staff of Süleyman Demirel University Department of Obstetrics and Gynecology for their support.
References
- 1. Harlev A, Walfisch A, Oran E, Har‐Vardi I, Friger M, Lunenfeld E, et al. The effect of fertility treatment on adverse perinatal outcomes in women aged at least 40 years. Int J Gynaecol Obstet. 2018;140(1):98-104.
- 2. Altamimi SI, Snobar RO, Al-Fraihat, A, Albuarki M, Rizk D. Causes of infertility. Bahrain Med Bull. 2019;41(2):93-96.
- 3. Nejat EJ, Jindal S, Berger D, Buyuk E, Lalioti M, Pal L. Implications of blood type for ovarian reserve. Hum Reprod. 2011;26(9):2513-2517.
- 4. Lata I, Mishra P. To study the association of ABO blood group type with Ovarian reserve in infertile women. Int J Gynaecol Obstet. 2020;4(3):75-79.
- 5. Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, et al. Association between biomarkers of ovarian reserve and infertility among older women of reproductive age. Jama. 2017;318(14):1367-1376.
- 6. Yusuf I, Emokpae MA. Association between a marker of sperm DNA damage and sperm indices in infertile males in Benin City, Nigeria: A cross-sectional study. Int J Reprod Biomed. 2021;19(2):137-146.
- 7. Castleton PE, Deluao JC, Sharkey DJ, McPherson NO. Measuring reactive oxygen species in semen for male preconception care: A scientist perspective. Antioxidants. 2022;11(2):264.
- 8. Sharma G, Choudhary R, Bharti D. Studies showing the relationship between ABO blood groups and major types of cancers. Asian J Exp Sci. 2007;21(1):129-132.
- 9. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al. Genome- wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009;41(9):986–90.
- 10. Anstee DJ. The relationship between blood groups and disease. Blood; Am J Hematol. 2010;115(23):4635-43.
- 11. Gates MA, Wolpin BM, Cramer DW, et al. ABO blood group and incidence of epithelial ovarian cancer. Int J Cancer. 2010;128(2):482–486.
- 12. Wolpin BM, Kraft P, Gross M, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res. 2010;70(3):1015–23.
- 13. Xie J, Qureshi AA, Li Y, et al. ABO blood group and incidence of skin cancer. PLoS One. 2010;5(8):e11972.
- 14. Ganitha G, Bhumkar S, Bhuvaneswari J. Association of ABO blood groups and infertility. Int J. 2012;2(5):72-77.
- 15. Spitzer D, Corn C, Stadler J, Wirleitner B, Schuff M, Vanderzwalmen P, et al. Implications of blood type for ovarian reserve and infertility–impact on oocyte yield in IVF Patients. Geburtsh Frauenheilk. 2014;74(10):928-932.
- 16. Şengül Ö, Dilbaz B, Yerebasmaz N, Dede S, Altınbaş Ş, Erkaya S. Only female age, and not blood type, is associated with ovarian reserve. Int J Fertil Steril. 2014;8(2):143.
- 17. Dibby HJ. Blood group and infertility relationship. Med J Babylon. 2015;12(2):479-483.
- 18. Awartani K, Al Ghabshi R, Al Shankiti H, Al Dossari M, Coskun S. Association of blood groups with ovarian reserve and outcome of in vitro fertilization treatment. Ann Saudi Med. 2016;36(2):116-120.
- 19. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175- 191.
- 20. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-1160.
- 21. Amanak K, Karaöz B, Sevil Ü. Modern yaşamın infertilite üzerine etkisi. TAF Prev Med Bull. 2014;13(4):345-350.
- 22. Ünal S, Kargın M, Akyüz A. İnfertil kadınları psikolojik olarak etkileyen faktörler. TAF Prev Med Bull. 2010;9(5):481-486.
- 23. Natarajamani ST, Thiagarajamurthy D, Subramanian M, Moorthy JD, Bhargav A, Parameaswari PJ. Oocyte quality and ABO blood group system: are they connected? Int. J Reprod Contracept Obstet. 2015;4(3):736.
- 24. Khan MS, Ahmed Z, Hanif R, Zaman S, Ali I, Rahman JU. Relationship between blood groups and male infertility. J Ayub Med Coll Abbottabad. 2010;22(1):154-156.
Details
| Primary Language | English |
|---|---|
| Subjects | Histology and Embryology |
| Journal Section | Araştırma Makaleleri |
| Authors | |
| Project Number | YOK |
| Publication Date | September 23, 2023 |
| Submission Date | August 14, 2023 |
| Acceptance Date | September 4, 2023 |
| Published in Issue | Year 2023 Volume: 30 Issue: 3 |
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.