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THE ROLE AND IMPORTANCE OF miRNA PROFILES IN PATIENTS WITH FIBROMYALGIA SYNDROME

Year 2021, Volume: 28 Issue: 3, 529 - 533, 13.09.2021
https://doi.org/10.17343/sdutfd.792825

Abstract

Fibromyalgia syndrome (FMS) is a chronic musculoskeletal
pain disorder associated with other symptoms.
It is mainly characterized by pain, fatigue, and sleep
disturbance. Many other genetic, immunological, and
hormonal factors play an important role in the etiology
of fibromyalgia. This pathological condition affects
approximately 3-10% of the population. The incidence
of the disease is more often in women. Women show
more severe symptoms and lower pain threshold than
men. Therefore, most of the research has focused on
female subjects.
MicroRNAs (miRNAs) regulate at least 30% of
human genes. In recent years, miRNAs have been
identified as important modulators of gene expression
in disease processes and physiological pathways.
However, each microRNA may be responsible for
regulation of hundreds of genes. miRNAs inhibit the
gene expression after transcription through inhibition
of translation or degradation of target messenger RNA.
The purpose of this review is to discuss the role of
miRNAs in FMS disease. According to the studies,
some miRNA expression levels were changed in FMS
patients. The presence of microRNAs in different
cellular compartments and their extracellular stability
make them interesting candidate biomarkers for better
understanding the etiology of complex diseases such
as FMS.

References

  • 1. D'Agnelli S, Arendt-Nielsen L, Gerra MC, et al. Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers. Mol Pain. 2019;15:1744806918819944.
  • 2. Clauw DJ. Fibromyalgia: A clinical review. JAMA.2014;311(15):1547-1555.
  • 3. Arnold LM, Bennett RM, Crofford LJ et al. AAPT diagnostic criteria for fibromyalgia. J Pain 2019;20:611–28.
  • 4. Jahan F, Nanji K, Qidwai W, Qasim R. Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management. Oman Med J. 2012;27(3):192‐195.
  • 5. Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3‐14.
  • 6. Gu W, Xu Y, Xie X, Wang T, Ko JH, Zhou T. The role of RNA structure at 5' untranslated region in microRNA-mediated gene regulation. RNA. 2014;20(9):1369‐1375.
  • 7. Yao Q, Chen, Y, Zhou X. The roles of microRNAs in epigenetic regulation. Curr. Opin. In Chem. Biol. 2019. 51, 11–17.
  • 8. Bjersing JL, Bokarewa MI, Mannerkorpi K. Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory study. Rheumatol. Int. 2015. 35, 635–642.
  • 9. He BS, Qu J, Zhao Q. Identifying and Exploiting Potential miRNA-Disease Associations With Neighborhood Regularized Logistic Matrix Factorization. Front Genet. 2018;9:303.
  • 10. Tüfekci KU, Oner MG, Johan Meuwissen RL, Genç S. The Role of MicroRNAs in Human Diseases. Methods Mol Biol. 2014;1107:15-31.
  • 11. Bjersing JL, Lundborg C, Bokarewa MI, Mannerkorpi K. Profile of cerebrospinal microRNAs in fibromyalgia. PLoS One. 2013;8(10):e78762.
  • 12. Cerdá-Olmedo G, Mena-Durán AV, Monsalve V, Oltra E. Identification of a microRNA signature for the diagnosis of fibromyalgia. PLoS One. 2015;10(3):e0121903.
  • 13. Masotti A, Baldassarre A, Guzzo MP, et al. Circulating microRNA Profiles as Liquid Biopsies for the Characterization and Diagnosis of Fibromyalgia Syndrome. Mol Neurobiol. 2017; 54(9):7129-7136.
  • 14. Chhabra R, Dubey R, Saini N. Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases. Mol Cancer. 2010;9:232.
  • 15. Wada Sh, Kato Y, Sawada Sh, et al. MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle. Pflugers Arch. Eur. J. Physiol. 2015 Feb;467(2):389-98.
  • 16. Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P. Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients. CNS Neurosci Ther. 2017;23(2):188‐189.
  • 17. Cordero MD. Oxidative Stress in Fibromyalgia : Pathophysiology and Clinical Implications. Reumatol Clin. 2011;7(5):281–283.
  • 18. Sánchez-Domínguez B, Bullón P, Román-Malo L, et al. Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia. Mitochondrion. 2015 Mar;21:69-75.
  • 19. Cordero MD, De Miguel M, Moreno Fernández AM, et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther. 2010;12(1):R17.
  • 20. Lin YH. MicroRNA Networks Modulate Oxidative Stress in Cancer. Int J Mol Sci. 2019;20(18):4497.
  • 21. Dando I, Cordani M, Pozza ED, Biondani G, Donadelli M, Palmieri M. “Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative medicine and cellular longevity 2015(10):1-13.
  • 22. Wang Z, Liu Y, Han N, et al. Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res. 2010 Jul 30;1346:14-25.
  • 23. Cosentino G, Plantamura I, Cataldo A, Iorio MV. MicroRNA and Oxidative Stress Interplay in the Context of Breast Cancer Pathogenesis. Int J Mol Sci. 2019;20(20):5143.

FİBROMİYALJİ SENDROMU OLAN HASTALARDA miRNA PROFİLLERİNİN ROLÜ VE ÖNEMİ

Year 2021, Volume: 28 Issue: 3, 529 - 533, 13.09.2021
https://doi.org/10.17343/sdutfd.792825

Abstract

Fibromiyalji sendromu (FMS), diğer semptomlarla ilişkili
kronik kas-iskelet sistemi ağrı bozukluğudur. Esas
olarak ağrı, yorgunluk ve uyku bozukluğu ile karakterizedir.
Fibromiyaljinin etiyolojisinde genetik, immünolojik
ve hormonal birçok faktör önemli rol oynamaktadır.
Bu patolojik durum popülasyonun yaklaşık %3-10'unu
etkilemektedir. Görülme sıklığı açısından, kadınlarda
erkeklerden daha fazla görülmektedir. Kadınlar erkeklerden
daha şiddetli belirtiler ve daha düşük ağrı eşiği
göstermektedir. Bu yüzden araştırmaların çoğu kadın
deneklere odaklanmıştır.
MikroRNA'lar (miRNA), insan genlerinin en az %30'
unu düzenlemektedirler. Son yıllarda miRNA’lar hastalık
süreçlerinde ve fizyolojik yolaklarda gen ekspresyonunun
önemli modülatörleri olarak tanımlanmıştır.
Bununla birlikte her miRNA yüzlerce genin regülasyonundan
sorumlu olabilir. miRNA’lar translasyonun
engellenmesi veya hedef haberci RNA'nın yıkımı yoluyla
transkripsiyon sonrası gen ekspresyonunu inhibe
ederler.
Bu derlemenin amacı miRNA’ların FMS hastalığındaki
rolünü tartışmaktır. Yapılan çalışmalara göre, FMS
hastalarında bazı miRNA ekspresyon düzeylerinin
değiştiği saptanmıştır. Farklı hücresel bölmelerdeki
miRNA'ların varlığı ve hücre dışı ortamdaki kararlılıkları,
FMS gibi karmaşık hastalıkların etiyolojisini daha
iyi anlamak için onları ilgi çekici aday biyobelirteçler
yapmaktadır.

References

  • 1. D'Agnelli S, Arendt-Nielsen L, Gerra MC, et al. Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers. Mol Pain. 2019;15:1744806918819944.
  • 2. Clauw DJ. Fibromyalgia: A clinical review. JAMA.2014;311(15):1547-1555.
  • 3. Arnold LM, Bennett RM, Crofford LJ et al. AAPT diagnostic criteria for fibromyalgia. J Pain 2019;20:611–28.
  • 4. Jahan F, Nanji K, Qidwai W, Qasim R. Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management. Oman Med J. 2012;27(3):192‐195.
  • 5. Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3‐14.
  • 6. Gu W, Xu Y, Xie X, Wang T, Ko JH, Zhou T. The role of RNA structure at 5' untranslated region in microRNA-mediated gene regulation. RNA. 2014;20(9):1369‐1375.
  • 7. Yao Q, Chen, Y, Zhou X. The roles of microRNAs in epigenetic regulation. Curr. Opin. In Chem. Biol. 2019. 51, 11–17.
  • 8. Bjersing JL, Bokarewa MI, Mannerkorpi K. Profile of circulating microRNAs in fibromyalgia and their relation to symptom severity: an exploratory study. Rheumatol. Int. 2015. 35, 635–642.
  • 9. He BS, Qu J, Zhao Q. Identifying and Exploiting Potential miRNA-Disease Associations With Neighborhood Regularized Logistic Matrix Factorization. Front Genet. 2018;9:303.
  • 10. Tüfekci KU, Oner MG, Johan Meuwissen RL, Genç S. The Role of MicroRNAs in Human Diseases. Methods Mol Biol. 2014;1107:15-31.
  • 11. Bjersing JL, Lundborg C, Bokarewa MI, Mannerkorpi K. Profile of cerebrospinal microRNAs in fibromyalgia. PLoS One. 2013;8(10):e78762.
  • 12. Cerdá-Olmedo G, Mena-Durán AV, Monsalve V, Oltra E. Identification of a microRNA signature for the diagnosis of fibromyalgia. PLoS One. 2015;10(3):e0121903.
  • 13. Masotti A, Baldassarre A, Guzzo MP, et al. Circulating microRNA Profiles as Liquid Biopsies for the Characterization and Diagnosis of Fibromyalgia Syndrome. Mol Neurobiol. 2017; 54(9):7129-7136.
  • 14. Chhabra R, Dubey R, Saini N. Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases. Mol Cancer. 2010;9:232.
  • 15. Wada Sh, Kato Y, Sawada Sh, et al. MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle. Pflugers Arch. Eur. J. Physiol. 2015 Feb;467(2):389-98.
  • 16. Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P. Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients. CNS Neurosci Ther. 2017;23(2):188‐189.
  • 17. Cordero MD. Oxidative Stress in Fibromyalgia : Pathophysiology and Clinical Implications. Reumatol Clin. 2011;7(5):281–283.
  • 18. Sánchez-Domínguez B, Bullón P, Román-Malo L, et al. Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia. Mitochondrion. 2015 Mar;21:69-75.
  • 19. Cordero MD, De Miguel M, Moreno Fernández AM, et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther. 2010;12(1):R17.
  • 20. Lin YH. MicroRNA Networks Modulate Oxidative Stress in Cancer. Int J Mol Sci. 2019;20(18):4497.
  • 21. Dando I, Cordani M, Pozza ED, Biondani G, Donadelli M, Palmieri M. “Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative medicine and cellular longevity 2015(10):1-13.
  • 22. Wang Z, Liu Y, Han N, et al. Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res. 2010 Jul 30;1346:14-25.
  • 23. Cosentino G, Plantamura I, Cataldo A, Iorio MV. MicroRNA and Oxidative Stress Interplay in the Context of Breast Cancer Pathogenesis. Int J Mol Sci. 2019;20(20):5143.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Reviews
Authors

Khayala Rasulova 0000-0001-9773-3240

Melek Pehlivan 0000-0001-8755-4812

Banu Dilek 0000-0002-5451-0757

Sefa Kızıldağ 0000-0001-7939-5153

Publication Date September 13, 2021
Submission Date September 14, 2020
Acceptance Date November 19, 2020
Published in Issue Year 2021 Volume: 28 Issue: 3

Cite

Vancouver Rasulova K, Pehlivan M, Dilek B, Kızıldağ S. FİBROMİYALJİ SENDROMU OLAN HASTALARDA miRNA PROFİLLERİNİN ROLÜ VE ÖNEMİ. Med J SDU. 2021;28(3):529-33.

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