Research Article
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Oxidative stress markers in breast cancer

Year 2024, Volume: 17 Issue: 3, 2 - 2

Özge Fenercioğlu Giray Bozkaya Nuriye Uzuncan Baha Zengel

https://doi.org/10.31362/patd.1388561

Abstract

Purpose: Oxidative stress is thought to play a role in the etiology of breast cancer. The aim of this study was to compare serum Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) and Ischemia Modified Albumin (IMA) levels in breast cancer patients and healthy women and to determine whether there is a relationship between oxidative stress markers and breast cancer.
Materials and methods: Newly diagnosed 106 breast cancer patients at the Bozyaka Training and Research Hospital General Surgery Clinic and 30 healthy women were included in the study. Serum levels of IMA, TAS, TOS were analyzed by spectrophotometric methods.
Results: IMA, TOS and OSI values were found significantly higher in the breast cancer group. Although the TAS values in patients with breast cancer were lower than the control group, the difference was not statistically significant.
Conclusions: In our study, it was seen that oxidative stress levels increased in breast cancer patients due to decreased TAS, significantly increased IMA, TOS and OSI results. Therefore, we think that increased oxidative stress may be related to breast cancer and that IMA, TOS and OSI can be used as markers of oxidative stress to differentiate breast cancer patients from healthy women.
Keywords: breast cancer, cancer, biomarkers, ischemia-modified albumin, oxidative stress

Keywords

breast cancer cancer biomarkers ischemia-modified albumin oxidative stress

References

  • 1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics 2000. CA Cancer J Clin 2000;50:7-33. https://doi.org/10.3322/canjclin.50.1.7
  • 2. Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneityof breast cancer: molecular mechanism and potential therapeutic targets. Semin Cancer Biol 2020;60:14-27. https://doi.org/10.1016/j.semcancer.2019.08.012
  • 3. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem. 2006;97:1634-1658. https://doi.org/10.1111/j.1471-4159.2006.03907.x
  • 4. Ozcan O, Erdal H, Cakırca G, Yönden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest. 2015;6:331-336. https://doi.org/10.5799/ahinjs.01.2015.03.0545
  • 5. Schulz JB, Lindenau J, Seyfried J, Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 2000;267:4904-4911. https://doi.org/10.1046/j.1432-1327.2000.01595.x
  • 6. Cobanoğlu U, Demir H, Duran M. Erytrocyte catalase and carbonic anhydrase activities in lung cancer. Asian Pac J Cancer Prev 2010;11:1377-1382.
  • 7. Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxidative Med Cell Longev 2016;3164734:23. https://doi.org/10.1155/2016/3164734
  • 8. Yokuş B. Çakır DÜ. Invivo oksidatif DNA damage biomarker; 8Hydroxy-2’-deoxyguanosine. T Klin J Med Sci 2012;5:535-543.
  • 9. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • 10. Yilmaz N, Erel O, Hazer M, Bagci C, Namiduru E, Gül E. Biochemical assessments of retinol, alpha-tocopherol, pyridoxal--5-phosphate oxidative stress index and total antioxidant status in adolescent professional basketball players and sedentary controls. Int J Adolesc Med Health 2007;19:177-186. https://doi.org/10.1515/IJAMH.2007.19.2.177
  • 11. Bar Or D, Curtis G, Rao N, Bampos N, Lau E. Characterization of the Co+2 and Ni+2 binding amino-acid residues of the N-terminus of human albumin. Eur J Biochem 2001;268:42-48. https://doi.org/10.1046/j.1432-1327.2001.01846.x
  • 12. Lippi G, Montagnana M, Guidi Gc. Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia? Int J Cardiol 2006;108:410-411. https://doi.org/10.1016/j.ijcard.2005.03.040
  • 13. Bar Or D, Winkler Jv, Vanbenthuysen K, Harris L, Lau E, Hetzel Fw. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J 2001;141:985-991. https://doi.org/10.1067/mhj.2001.114800
  • 14. Bar Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia a preliminary report. J Emerg Med 2000;19:311-315. https://doi.org/10.1016/S0736-4679(00)00255-9
  • 15. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Standardization of ischemia-modified albumin testing: adjustment for serum albumin. Clin Chem Lab Med 2007;45:261-262. https://doi.org/10.1515/CCLM.2007.039
  • 16. Feng JF, Lu L, Zeng P, et al. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. Int J Clin Oncol 2012;17:575-583. https://doi.org/10.1007/s10147-011-0327-y
  • 17. Mill CP, Chester JA, Riese DJ. EGFR may couple moderate alcohol consumption to increased breast cancer risk. Breast Cancer (Dove Med Press) 2009;1:31-38. https://doi.org/10.2147/BCTT.S6254
  • 18. Jackson AL, Loeb LA. The Contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res 2001;477:7-21. https://doi.org/10.1016/S0027-5107(01)00091-4
  • 19. Leung EY, Crozier JE, Talwar D, et al. Vitamin antioxidants, lipidperoxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Int J Cancer 2008;123:2460-2464. https://doi.org/10.1002/ijc.23811
  • 20. Lim SH, Fan SH, Say YH. Plasma total antioxidant capacity (TAC) in obese Malaysian subjects. Malays J Nutr 2012;18:345-354.
  • 21. Goswami S, Philippar U, Sun D, et al. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2009;26:153-159. https://doi.org/10.1007/s10585-008-9225-8
  • 22. Feng JF, Lu L, Dai CM, et al. Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages. Clin Biochem 2016;49:692-698. https://doi.org/10.1016/j.clinbiochem.2016.02.005
  • 23. Bilgili S, Uğurlu Ö, Bozkaya G, Uzuncan N, Zengel B. Ischemia modified albumin levels in invasive ductal carcinoma and fibroadenoma patients. Türk Klinik Biyokimya Derg 2019;17:134-139
  • 24. Kosova F, Abusoglu S, Beksac OK, et al. Meme kanseri olan hastalarda serum homoarjinin ve iskemi modifiye albumin düzeyleri. Future Biochemistry and Bioscience 2020;1:1-5. https://doi.org/10.48086/ASD002
  • 25. Hunur U, Oruc Z, Ebinc S, Oruc I, Neselioglu S, Isikdogan A. Thiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast cancer. Journal of the College of Physicians and Surgeons 2022;32:1435-1440. https://doi.org/10.29271/jcpsp.2022.11.1435
  • 26. Kundaktepe BP, Sozer V, Durmus S, et al. The evaluation of oxidative stress parameters in breast and colon cancer. Medicine 2021;100:e25104(e1-12). https://doi.org/10.1097/MD.0000000000025104
  • 27. Kim SY, Kim JV, Ko YS, Koo JE, Chung HY, Lee Kim YC. Changes in lipid peroxidation and antioxidant trace elements in serum of women with cervical intraepithelial neoplasia and invasive cancer. Nutr Cancer 2003;47:126-130. https://doi.org/10.1207/s15327914nc4702_3
  • 28. Sener DE, Gonenç A, Akinci M, Torun M. Lipid peroxidation and total antioxidant status in patients with breast cancer. Cell Biochem Funct 2007;25:377-382. https://doi.org/10.1002/cbf.1308
  • 29. Pande D, Negi R, Khanna S, Khannai R, Khanna HR. Vascular endothelial growth factor levels in relation to oxidative damage and antioxidant status in patients with breast cancer. J Breast Cancer 2011;14:181-184. https://doi.org/10.4048/jbc.2011.14.3.181
  • 30. Zowczak Drabarczyk MM, Murawa D, Kaczmarek L, Połom K, Litwiniuk M. Total antioxidant status in plasma of breast cancer patients in relation to ERβ expression. Contemp Oncol (Pozn) 2013;17:499-503. https://doi.org/10.5114/wo.2013.38782

Meme kanserinde oksidatif stress belirteçleri

Year 2024, Volume: 17 Issue: 3, 2 - 2

Özge Fenercioğlu Giray Bozkaya Nuriye Uzuncan Baha Zengel

https://doi.org/10.31362/patd.1388561

Abstract

Amaç: Oksidatif stresin meme kanseri etiyolojisinde rol oynadığı düşünülmektedir. Çalışmamızda oksidatif stres ile meme kanseri arasında ilişki olup olmadığını araştırmak için, meme kanseri hastalarında ve sağlıklı kadınlarda serumda Total Antioksidan Seviye (TAS), Total Oksidan Seviye (TOS), Oksidatif Stres İndeksi (OSİ) ve İskemi Modifiye Albumin (İMA) değerlerinin karşılaştırması amaçlandı.
Gereç ve yöntem: Bozyaka Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniği’nde yeni tanı almış ve henüz tedavi almamış 106 meme kanseri hastası ve sağlıklı 30 kadın çalışmaya alındı. Serum TAS, TOS ve İMA düzeyleri spektrofotometrik yöntemle analiz edildi.
Bulgular: Meme kanseri grubunda İMA, TOS ve OSİ düzeyleri, istatistiksel olarak anlamlı yüksek bulundu. TAS değerleri ise, meme kanserli hastalarda kontrol grubuna göre düşük olmasına rağmen, aradaki fark istatistiksel olarak anlamlı değildi.
Sonuç: Çalışmamızda meme kanseri hastalarında azalmış TAS, anlamlı derecede artmış İMA, TOS ve OSİ sonuçları sebebiyle oksidatif stres düzeylerinin arttığı anlaşılmaktadır. Bu nedenle artmış oksidatif stresin meme kanseri ile ilişkili olabileceğini ve meme kanseri hastalarını sağlıklı kadınlardan ayırmak için İMA, TOS ve OSİ’nin oksidatif stres belirteçleri olarak kullanılabileceğini düşünüyoruz.
Anahtar Kelimeler: iskemi modifiye albumin, meme kanseri, oksidatif stres, total antioksidan seviye, total oksidan seviye

Keywords

iskemi modifiye albumin meme kanseri oksidatif stress total antioksidan seviye total oksidan seviye

References

  • 1. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics 2000. CA Cancer J Clin 2000;50:7-33. https://doi.org/10.3322/canjclin.50.1.7
  • 2. Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneityof breast cancer: molecular mechanism and potential therapeutic targets. Semin Cancer Biol 2020;60:14-27. https://doi.org/10.1016/j.semcancer.2019.08.012
  • 3. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem. 2006;97:1634-1658. https://doi.org/10.1111/j.1471-4159.2006.03907.x
  • 4. Ozcan O, Erdal H, Cakırca G, Yönden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest. 2015;6:331-336. https://doi.org/10.5799/ahinjs.01.2015.03.0545
  • 5. Schulz JB, Lindenau J, Seyfried J, Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 2000;267:4904-4911. https://doi.org/10.1046/j.1432-1327.2000.01595.x
  • 6. Cobanoğlu U, Demir H, Duran M. Erytrocyte catalase and carbonic anhydrase activities in lung cancer. Asian Pac J Cancer Prev 2010;11:1377-1382.
  • 7. Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxidative Med Cell Longev 2016;3164734:23. https://doi.org/10.1155/2016/3164734
  • 8. Yokuş B. Çakır DÜ. Invivo oksidatif DNA damage biomarker; 8Hydroxy-2’-deoxyguanosine. T Klin J Med Sci 2012;5:535-543.
  • 9. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • 10. Yilmaz N, Erel O, Hazer M, Bagci C, Namiduru E, Gül E. Biochemical assessments of retinol, alpha-tocopherol, pyridoxal--5-phosphate oxidative stress index and total antioxidant status in adolescent professional basketball players and sedentary controls. Int J Adolesc Med Health 2007;19:177-186. https://doi.org/10.1515/IJAMH.2007.19.2.177
  • 11. Bar Or D, Curtis G, Rao N, Bampos N, Lau E. Characterization of the Co+2 and Ni+2 binding amino-acid residues of the N-terminus of human albumin. Eur J Biochem 2001;268:42-48. https://doi.org/10.1046/j.1432-1327.2001.01846.x
  • 12. Lippi G, Montagnana M, Guidi Gc. Albumin cobalt binding and ischemia modified albumin generation: an endogenous response to ischemia? Int J Cardiol 2006;108:410-411. https://doi.org/10.1016/j.ijcard.2005.03.040
  • 13. Bar Or D, Winkler Jv, Vanbenthuysen K, Harris L, Lau E, Hetzel Fw. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J 2001;141:985-991. https://doi.org/10.1067/mhj.2001.114800
  • 14. Bar Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia a preliminary report. J Emerg Med 2000;19:311-315. https://doi.org/10.1016/S0736-4679(00)00255-9
  • 15. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Standardization of ischemia-modified albumin testing: adjustment for serum albumin. Clin Chem Lab Med 2007;45:261-262. https://doi.org/10.1515/CCLM.2007.039
  • 16. Feng JF, Lu L, Zeng P, et al. Serum total oxidant/antioxidant status and trace element levels in breast cancer patients. Int J Clin Oncol 2012;17:575-583. https://doi.org/10.1007/s10147-011-0327-y
  • 17. Mill CP, Chester JA, Riese DJ. EGFR may couple moderate alcohol consumption to increased breast cancer risk. Breast Cancer (Dove Med Press) 2009;1:31-38. https://doi.org/10.2147/BCTT.S6254
  • 18. Jackson AL, Loeb LA. The Contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat Res 2001;477:7-21. https://doi.org/10.1016/S0027-5107(01)00091-4
  • 19. Leung EY, Crozier JE, Talwar D, et al. Vitamin antioxidants, lipidperoxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Int J Cancer 2008;123:2460-2464. https://doi.org/10.1002/ijc.23811
  • 20. Lim SH, Fan SH, Say YH. Plasma total antioxidant capacity (TAC) in obese Malaysian subjects. Malays J Nutr 2012;18:345-354.
  • 21. Goswami S, Philippar U, Sun D, et al. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2009;26:153-159. https://doi.org/10.1007/s10585-008-9225-8
  • 22. Feng JF, Lu L, Dai CM, et al. Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages. Clin Biochem 2016;49:692-698. https://doi.org/10.1016/j.clinbiochem.2016.02.005
  • 23. Bilgili S, Uğurlu Ö, Bozkaya G, Uzuncan N, Zengel B. Ischemia modified albumin levels in invasive ductal carcinoma and fibroadenoma patients. Türk Klinik Biyokimya Derg 2019;17:134-139
  • 24. Kosova F, Abusoglu S, Beksac OK, et al. Meme kanseri olan hastalarda serum homoarjinin ve iskemi modifiye albumin düzeyleri. Future Biochemistry and Bioscience 2020;1:1-5. https://doi.org/10.48086/ASD002
  • 25. Hunur U, Oruc Z, Ebinc S, Oruc I, Neselioglu S, Isikdogan A. Thiol-disulphide homeostasis and ischemia-modified albumin level and its relationship with clinicopathological features of breast cancer. Journal of the College of Physicians and Surgeons 2022;32:1435-1440. https://doi.org/10.29271/jcpsp.2022.11.1435
  • 26. Kundaktepe BP, Sozer V, Durmus S, et al. The evaluation of oxidative stress parameters in breast and colon cancer. Medicine 2021;100:e25104(e1-12). https://doi.org/10.1097/MD.0000000000025104
  • 27. Kim SY, Kim JV, Ko YS, Koo JE, Chung HY, Lee Kim YC. Changes in lipid peroxidation and antioxidant trace elements in serum of women with cervical intraepithelial neoplasia and invasive cancer. Nutr Cancer 2003;47:126-130. https://doi.org/10.1207/s15327914nc4702_3
  • 28. Sener DE, Gonenç A, Akinci M, Torun M. Lipid peroxidation and total antioxidant status in patients with breast cancer. Cell Biochem Funct 2007;25:377-382. https://doi.org/10.1002/cbf.1308
  • 29. Pande D, Negi R, Khanna S, Khannai R, Khanna HR. Vascular endothelial growth factor levels in relation to oxidative damage and antioxidant status in patients with breast cancer. J Breast Cancer 2011;14:181-184. https://doi.org/10.4048/jbc.2011.14.3.181
  • 30. Zowczak Drabarczyk MM, Murawa D, Kaczmarek L, Połom K, Litwiniuk M. Total antioxidant status in plasma of breast cancer patients in relation to ERβ expression. Contemp Oncol (Pozn) 2013;17:499-503. https://doi.org/10.5114/wo.2013.38782
There are 30 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Research Article
Authors

Özge Fenercioğlu 0000-0003-2524-1073

Giray Bozkaya 0000-0002-5756-5796

Nuriye Uzuncan 0000-0003-1872-0615

Baha Zengel 0000-0002-1812-6846

Early Pub Date February 29, 2024
Publication Date
Submission Date December 15, 2023
Acceptance Date February 27, 2024
Published in Issue Year 2024 Volume: 17 Issue: 3

Cite

APA Fenercioğlu, Ö., Bozkaya, G., Uzuncan, N., Zengel, B. (2024). Oxidative stress markers in breast cancer. Pamukkale Medical Journal, 17(3), 2-2. https://doi.org/10.31362/patd.1388561
AMA Fenercioğlu Ö, Bozkaya G, Uzuncan N, Zengel B. Oxidative stress markers in breast cancer. Pam Med J. February 2024;17(3):2-2. doi:10.31362/patd.1388561
Chicago Fenercioğlu, Özge, Giray Bozkaya, Nuriye Uzuncan, and Baha Zengel. “Oxidative Stress Markers in Breast Cancer”. Pamukkale Medical Journal 17, no. 3 (February 2024): 2-2. https://doi.org/10.31362/patd.1388561.
EndNote Fenercioğlu Ö, Bozkaya G, Uzuncan N, Zengel B (February 1, 2024) Oxidative stress markers in breast cancer. Pamukkale Medical Journal 17 3 2–2.
IEEE Ö. Fenercioğlu, G. Bozkaya, N. Uzuncan, and B. Zengel, “Oxidative stress markers in breast cancer”, Pam Med J, vol. 17, no. 3, pp. 2–2, 2024, doi: 10.31362/patd.1388561.
ISNAD Fenercioğlu, Özge et al. “Oxidative Stress Markers in Breast Cancer”. Pamukkale Medical Journal 17/3 (February 2024), 2-2. https://doi.org/10.31362/patd.1388561.
JAMA Fenercioğlu Ö, Bozkaya G, Uzuncan N, Zengel B. Oxidative stress markers in breast cancer. Pam Med J. 2024;17:2–2.
MLA Fenercioğlu, Özge et al. “Oxidative Stress Markers in Breast Cancer”. Pamukkale Medical Journal, vol. 17, no. 3, 2024, pp. 2-2, doi:10.31362/patd.1388561.
Vancouver Fenercioğlu Ö, Bozkaya G, Uzuncan N, Zengel B. Oxidative stress markers in breast cancer. Pam Med J. 2024;17(3):2-.

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