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Nötrofil lenfosit oranı evre 1 testis tümöründe okkült metastaz parametrelerinde belirteç olabilir mi?

Year 2021, Volume: 14 Issue: 3, 598 - 603, 01.07.2021
https://doi.org/10.31362/patd.809407

Abstract

Amaç: Nötrofil-Lenfosit ve Trombosit-Lenfosit oranı (NLR / PLR) karşılaştırması, bazı kanserlerin ve hastalıkların tanısında kullanımı kolay ve düşük maliyetli bir yöntemdir. Bu çalışmada, özellikle okkült metastazlı erken dönem testis malignitelerinin tanısında NLR / PLR oranı değerlendirmesinin kullanılıp kullanılamayacağını araştırmayı amaçladık.
Yöntem: 2015-2019 yılları arasında testis tümörü için radikal inguinal orşiektomi müdahalesi yapılan hastalar retrospektif olarak incelendi. Çalışmaya testis tümör evre-I olan 40 hasta ve herhangi bir testis şikayeti olmayan 43 hasta kontrol grubu olarak çalışmaya dahil edildi. Evre-I testis kanserinde okkült metastatik hastalık için patolojik risk faktörleri ile NLR-PLR değerleri arasındaki ilişki araştırıldı.
Bulgular: Hastaların yaş ortalaması 30.05 yıl idi ve gruplar arasında yaş bakımından anlamlı fark yoktu (p = 0.150). Tümör grubunun NLR ve PLR oranı değerleri testis tümörlü hastalarda kontrol grubuna göre belirgin olarak yüksekti (sırasıyla p = 0.001 ve 0.016). Evre-I testis kanseri ve NLR / PLR'de okkült metastatik hastalık için risk faktörleri arasındaki korelasyon analizinde sadece tümör boyutu açısından anlamlı bir korelasyon olduğunu bulduk.
Sonuç: Sonuç olarak, tüm testis tümörlerinde NLR' nin arttığı sonucuna vardık. Klinik uygulamada prognostik belirteç olarak daha yüksek NLR oranı değerlerinin kullanılabileceğini önermekteyiz.

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References

  • REFERENCES 1. Znaor A, Lortet-Tieulent J, Jemal A, Bray F. International variations and trends in testicular cancer incidence and mortality. Eur Urol. 2014;65:1095-1106. https://doi.org. 10.1016/j.eururo.2013.11.004
  • 2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225-249. https://doi.org. 10.3322/caac.20006
  • 3. Şahin A, Toprak T, Kutluhan MA, Vural Y, Ürkmez A, Verit A. Increased neutrophil/lymphocyte ratio in testicular cancer. Arch Ital Urol Androl. 2019;2;91(2). https://doi.org. 10.4081/aiua.2019.2.97
  • 4. Borghesi M, Brunocilla E, Schiavina R, Gentile G, Dababneh H, Della Mora L, et al. Role of testis sparing surgery in the conservative management of small testicular masses: oncological and functional perspectives. Actas Urol Esp.2015;39:57-62. https://doi.org. 10.1016/j.acuro.2014.02.020
  • 5. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436-444. https://doi.org. 10.1038/nature07205

Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?

Year 2021, Volume: 14 Issue: 3, 598 - 603, 01.07.2021
https://doi.org/10.31362/patd.809407

Abstract

Objective: Neutrophile-Lymphocyte (NLR) and Platelet-Lymphocyte ratio (PLR) comparison is an easy to use and cost-effective method in diagnosis of some cancers and diseases. In this study, we aimed to investigate if NLR / PLR ratio evaluation could be utilized in diagnosis of testicular malignencies especially in early-term with occult metastasis.
Methods: A total of 40 patients at stage-I, who have undergone radical inguinal orchiectomy intervention for testicular tumor between 2015 and 2019, and 43 control individuals without any testicular complaints were included in this retrospective study. The relationship between pathological risk factors for occult metastatic disease in Stage-I testicular cancer and NLR-PLR values were investigated.
Results: The average age was 30.05 years, and there was no significant difference between the groups by means of age (p=0.150). The NLR and PLR values of the tumor group were prominently higher in the patient group, when compared with the control group (p=0.001 and 0.016, respectively). In the correlation analysis between risk-factors for occult metastatic disease in Stage-I testicular cancer and NLR / PLR, we have found that only a significant correlation was present in terms of tumor size.
Conclusion: As a result, we have concluded that NLR increases in all types of testicular tumors. We suggest that higher NLR ratio values can be used as prognostic marker in clinical practice.

Project Number

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References

  • REFERENCES 1. Znaor A, Lortet-Tieulent J, Jemal A, Bray F. International variations and trends in testicular cancer incidence and mortality. Eur Urol. 2014;65:1095-1106. https://doi.org. 10.1016/j.eururo.2013.11.004
  • 2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225-249. https://doi.org. 10.3322/caac.20006
  • 3. Şahin A, Toprak T, Kutluhan MA, Vural Y, Ürkmez A, Verit A. Increased neutrophil/lymphocyte ratio in testicular cancer. Arch Ital Urol Androl. 2019;2;91(2). https://doi.org. 10.4081/aiua.2019.2.97
  • 4. Borghesi M, Brunocilla E, Schiavina R, Gentile G, Dababneh H, Della Mora L, et al. Role of testis sparing surgery in the conservative management of small testicular masses: oncological and functional perspectives. Actas Urol Esp.2015;39:57-62. https://doi.org. 10.1016/j.acuro.2014.02.020
  • 5. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454:436-444. https://doi.org. 10.1038/nature07205
There are 5 citations in total.

Details

Primary Language English
Subjects Urology
Journal Section Research Article
Authors

Aykut Başer 0000-0003-0457-512X

Bekir Aras 0000-0002-7020-8830

Project Number yok
Publication Date July 1, 2021
Submission Date October 12, 2020
Acceptance Date December 21, 2020
Published in Issue Year 2021 Volume: 14 Issue: 3

Cite

APA Başer, A., & Aras, B. (2021). Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?. Pamukkale Medical Journal, 14(3), 598-603. https://doi.org/10.31362/patd.809407
AMA Başer A, Aras B. Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?. Pam Med J. July 2021;14(3):598-603. doi:10.31362/patd.809407
Chicago Başer, Aykut, and Bekir Aras. “Can Neutrophil Lymphocyte Ratio Be a Marker in Stage 1 Testicular Tumor Occult Metastasis Parameters?”. Pamukkale Medical Journal 14, no. 3 (July 2021): 598-603. https://doi.org/10.31362/patd.809407.
EndNote Başer A, Aras B (July 1, 2021) Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?. Pamukkale Medical Journal 14 3 598–603.
IEEE A. Başer and B. Aras, “Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?”, Pam Med J, vol. 14, no. 3, pp. 598–603, 2021, doi: 10.31362/patd.809407.
ISNAD Başer, Aykut - Aras, Bekir. “Can Neutrophil Lymphocyte Ratio Be a Marker in Stage 1 Testicular Tumor Occult Metastasis Parameters?”. Pamukkale Medical Journal 14/3 (July 2021), 598-603. https://doi.org/10.31362/patd.809407.
JAMA Başer A, Aras B. Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?. Pam Med J. 2021;14:598–603.
MLA Başer, Aykut and Bekir Aras. “Can Neutrophil Lymphocyte Ratio Be a Marker in Stage 1 Testicular Tumor Occult Metastasis Parameters?”. Pamukkale Medical Journal, vol. 14, no. 3, 2021, pp. 598-03, doi:10.31362/patd.809407.
Vancouver Başer A, Aras B. Can neutrophil lymphocyte ratio be a marker in stage 1 testicular tumor occult metastasis parameters?. Pam Med J. 2021;14(3):598-603.

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