Research Article
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Year 2023, Volume: 40 Issue: 1, 72 - 75, 18.03.2023

Abstract

References

  • 1. Ağar M, Güngör K, Güngör ND, Kavrut M, Madenli AA. Vitamin D supplementation inhibits NF-kß signaling pathway in lean and obese women with PCOS. Eur Rev Med Pharmacol Sci 2022; 26: 3973-7.
  • 2. Güngör K, Güngör ND, Başar MM, Cengiz F, Erşahin SS, Çil K. Relationship between serum vitamin D levels semen parameters and sperm DNA damage in men with unexplained infertility. Eur Rev Med Pharmacol Sci 2022; 26: 499-505.
  • 3. Güngör K, Dokuzeylül Güngör N. First-trimester maternal vitamin d levels and risk for gestational diabetes mellitus. Ankara Med J 2021; 21: 339-49.
  • 4. Gokmen Karasu AF, Ates S, Gurbuz T, Sahin N, Takmaz T, Aydin S. A Clinico-pathological Study of Transvaginal Endometrial Thickness Measurement in Asymptomatic Postmenopausal Patients and Patients with Postmenopausal Bleeding. Gynecol Obstet Reprod Med 2019; 25: 85-8.
  • 5. Özgü E, Yılmaz N, Başer E, Güngör T, Erkaya S, Yakut Hİ. Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions? J Exp Ther Oncol 2016; 11: 177-80.
  • 6. Çakir AT, Ozten MA. Serum vitamin D levels in high-risk HPV infected patients, is there any relation? J Clin Med Kaz 2022; 19: 35-9.
  • 7. Buskwofie A, David-West G, Clare CA. A Review of Cervical Cancer: Incidence and Disparities. J Natl Med Assoc 2020; 112: 229-32.
  • 8. Alfaro K, Soler M, Maza M, et al. Cervical Cancer Prevention in El Salvador: Gains to Date and Challenges for the Future. Cancers (Basel) 2022; 14: 2776. 9. Small W Jr, Bacon MA, Bajaj A, et al. Cervical cancer: A global health crisis. Cancer 2017; 123: 2404-12.
  • 10. Tanaka S, Palmer M, Katanoda K. Trends in cervical cancer incidence and mortality of young and middle adults in Japan. Cancer Sci 2022; 113: 1801-7.
  • 11. Saleh HS. Can visual inspection with acetic acid be used as an alternative to Pap smear in screening cervical cancer? Middle East Fertility Society Journal. 2014;19(3):187-91.
  • 12. Chitra B, Kumar S. Recent advancement in cervical cancer diagnosis for automated screening: a detailed review. J Ambient Intell Humaniz Comput 2021; 1: 3.
  • 13. Devi NL, Thirumurugan P. A literature survey of automated detection of cervical cancer cell in Pap smear images. World Rev of Scie Techno and Sust Develop 2022; 18: 74-82.
  • 14. Dillner J, Sparén P, Andrae B, Strander B. Livmoderhalscancer ökar hos kvinnor med normalt cellprov - Skillnader mellan laboratorier tyder på att ökningen orsakas av faktorer som kan åtgärdas [Cervical cancer has increased in Sweden in women who had a normal cell sample]. Lakartidningen 2018; 115: E9FD.
  • 15. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-60. 16. Sintzel MB, Rametta M, Reder AT. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther 2018; 7: 59-85.
  • 17. Saponaro F, Marcocci C, Zucchi R. Vitamin D status and cardiovascular outcome. J Endocrinol Invest 2019; 42: 1285-90.
  • 18. Grant WB, Lahore H, McDonnell SL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020; 12: 988.
  • 19. Karampela I, Sakelliou A, Vallianou N, Christodoulatos GS, Magkos F, Dalamaga M. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep 2021; 10: 162-80.
  • 20. Chen J, Mei K, Xie L, et al. Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: A meta-analysis and GRADE assessment of cohort studies and RCTs. Nutr J 2021; 20: 1-10.
  • 21. Tan Q, Liu S, Chen D. Poor vitamin D status and the risk of maternal depression: a dose-response meta-analysis of observational studies. Public Health Nutr 2021; 24: 2161-70.
  • 22. Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. Gynecol Endocrinol 2020; 36: 1-5.
  • 23. Polzonetti V, Pucciarelli S, Vincenzetti S, Polidori P. Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis. Nutrients 2020; 12: 1743.
  • 24. Gürbüz T, Dokuzeylül Güngör N. Hiperemezis gravidarum etiyopatogenezinde vitamin D eksikliğinin rolü var mı ?. ADYÜ Sağlık Bilimleri Derg 2018; 4: 761-71.
  • 25. Sharif YH. Clinical correlation of cervical cancer screening using Pap smear test. J Popul Ther Clin Pharmacol 2022; 29: e1-e8.
  • 26. Sachan PL, Singh M, Patel ML, Sachan R. A Study on Cervical Cancer Screening Using Pap Smear Test and Clinical Correlation. Asia Pac J Oncol Nurs 2018; 5: 337-41.
  • 27. Ghosh S, Pattanshetty SM, Mallya SD, et al. Cervical cytology and associated factors among tribal women of Karnataka, India. PLoS One. 2021; 16: e0248963.
  • 28. Marconi C, Duarte MT, Silva DC, Silva MG. Prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern Brazil. Int J Gynaecol Obstet 2015; 131: 137-41.
  • 29. Bautista CT, Wurapa E, Sateren WB, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res 2016; 3: 4.
  • 30. Teixeira PM, Vital WC, Lima AA, Silva NNT, Carneiro CM, de Medeiros Teixeira LF, et al. Bacterial vaginosis: prevalence, risk profile and association with sexually transmitted infections. Revista de Epidemiologia e Controle de Infecção. 2020; 10(3).

What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?

Year 2023, Volume: 40 Issue: 1, 72 - 75, 18.03.2023

Abstract

This study aimed to determine the impact of vitamin D deficiency on Pap smear test results in women in the postmenopausal period. This cross-sectional study included 394 women who applied to İstanbul Medeniyet University, Göztepe Training and Research Hospital gynecology and obstetric clinic for routine Pap smear tests. This study was conducted between May 2019 and December 2020. Cases were divided into severe deficiency (<12 ng/ml), moderate deficiency (12-20 ng/ml), deficiency (21-30 ng/ml), and sufficiency (>30 ng/ml) according to the vitamin D levels measured in the postmenopausal period within the scope of check-up examinations. Pap smear test results compared with vitamin D levels. The mean age of the study group was 48.70±3.46 years. There was a statistically significant association between vitamin D values and Pap smear test results (p<0.05). Vitamin D greater than 20 ng/ml had a significant relationship with the normal cytology results. There was a statistically significant association between vitamin D lower than 20 ng/ml and cervicitis cytology results. The results showed that the serum vitamin D and the Pap smear test results had a significant association. It is recommended that physicians prescribe the use of vitamin D supplements in women in the high-risk group of cervical cancer.

References

  • 1. Ağar M, Güngör K, Güngör ND, Kavrut M, Madenli AA. Vitamin D supplementation inhibits NF-kß signaling pathway in lean and obese women with PCOS. Eur Rev Med Pharmacol Sci 2022; 26: 3973-7.
  • 2. Güngör K, Güngör ND, Başar MM, Cengiz F, Erşahin SS, Çil K. Relationship between serum vitamin D levels semen parameters and sperm DNA damage in men with unexplained infertility. Eur Rev Med Pharmacol Sci 2022; 26: 499-505.
  • 3. Güngör K, Dokuzeylül Güngör N. First-trimester maternal vitamin d levels and risk for gestational diabetes mellitus. Ankara Med J 2021; 21: 339-49.
  • 4. Gokmen Karasu AF, Ates S, Gurbuz T, Sahin N, Takmaz T, Aydin S. A Clinico-pathological Study of Transvaginal Endometrial Thickness Measurement in Asymptomatic Postmenopausal Patients and Patients with Postmenopausal Bleeding. Gynecol Obstet Reprod Med 2019; 25: 85-8.
  • 5. Özgü E, Yılmaz N, Başer E, Güngör T, Erkaya S, Yakut Hİ. Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions? J Exp Ther Oncol 2016; 11: 177-80.
  • 6. Çakir AT, Ozten MA. Serum vitamin D levels in high-risk HPV infected patients, is there any relation? J Clin Med Kaz 2022; 19: 35-9.
  • 7. Buskwofie A, David-West G, Clare CA. A Review of Cervical Cancer: Incidence and Disparities. J Natl Med Assoc 2020; 112: 229-32.
  • 8. Alfaro K, Soler M, Maza M, et al. Cervical Cancer Prevention in El Salvador: Gains to Date and Challenges for the Future. Cancers (Basel) 2022; 14: 2776. 9. Small W Jr, Bacon MA, Bajaj A, et al. Cervical cancer: A global health crisis. Cancer 2017; 123: 2404-12.
  • 10. Tanaka S, Palmer M, Katanoda K. Trends in cervical cancer incidence and mortality of young and middle adults in Japan. Cancer Sci 2022; 113: 1801-7.
  • 11. Saleh HS. Can visual inspection with acetic acid be used as an alternative to Pap smear in screening cervical cancer? Middle East Fertility Society Journal. 2014;19(3):187-91.
  • 12. Chitra B, Kumar S. Recent advancement in cervical cancer diagnosis for automated screening: a detailed review. J Ambient Intell Humaniz Comput 2021; 1: 3.
  • 13. Devi NL, Thirumurugan P. A literature survey of automated detection of cervical cancer cell in Pap smear images. World Rev of Scie Techno and Sust Develop 2022; 18: 74-82.
  • 14. Dillner J, Sparén P, Andrae B, Strander B. Livmoderhalscancer ökar hos kvinnor med normalt cellprov - Skillnader mellan laboratorier tyder på att ökningen orsakas av faktorer som kan åtgärdas [Cervical cancer has increased in Sweden in women who had a normal cell sample]. Lakartidningen 2018; 115: E9FD.
  • 15. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-60. 16. Sintzel MB, Rametta M, Reder AT. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther 2018; 7: 59-85.
  • 17. Saponaro F, Marcocci C, Zucchi R. Vitamin D status and cardiovascular outcome. J Endocrinol Invest 2019; 42: 1285-90.
  • 18. Grant WB, Lahore H, McDonnell SL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020; 12: 988.
  • 19. Karampela I, Sakelliou A, Vallianou N, Christodoulatos GS, Magkos F, Dalamaga M. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep 2021; 10: 162-80.
  • 20. Chen J, Mei K, Xie L, et al. Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: A meta-analysis and GRADE assessment of cohort studies and RCTs. Nutr J 2021; 20: 1-10.
  • 21. Tan Q, Liu S, Chen D. Poor vitamin D status and the risk of maternal depression: a dose-response meta-analysis of observational studies. Public Health Nutr 2021; 24: 2161-70.
  • 22. Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. Gynecol Endocrinol 2020; 36: 1-5.
  • 23. Polzonetti V, Pucciarelli S, Vincenzetti S, Polidori P. Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis. Nutrients 2020; 12: 1743.
  • 24. Gürbüz T, Dokuzeylül Güngör N. Hiperemezis gravidarum etiyopatogenezinde vitamin D eksikliğinin rolü var mı ?. ADYÜ Sağlık Bilimleri Derg 2018; 4: 761-71.
  • 25. Sharif YH. Clinical correlation of cervical cancer screening using Pap smear test. J Popul Ther Clin Pharmacol 2022; 29: e1-e8.
  • 26. Sachan PL, Singh M, Patel ML, Sachan R. A Study on Cervical Cancer Screening Using Pap Smear Test and Clinical Correlation. Asia Pac J Oncol Nurs 2018; 5: 337-41.
  • 27. Ghosh S, Pattanshetty SM, Mallya SD, et al. Cervical cytology and associated factors among tribal women of Karnataka, India. PLoS One. 2021; 16: e0248963.
  • 28. Marconi C, Duarte MT, Silva DC, Silva MG. Prevalence of and risk factors for bacterial vaginosis among women of reproductive age attending cervical screening in southeastern Brazil. Int J Gynaecol Obstet 2015; 131: 137-41.
  • 29. Bautista CT, Wurapa E, Sateren WB, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res 2016; 3: 4.
  • 30. Teixeira PM, Vital WC, Lima AA, Silva NNT, Carneiro CM, de Medeiros Teixeira LF, et al. Bacterial vaginosis: prevalence, risk profile and association with sexually transmitted infections. Revista de Epidemiologia e Controle de Infecção. 2020; 10(3).
There are 28 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Asena Ayar Madenli 0000-0003-0129-8710

İnci Öz 0000-0001-9160-2733

Ergül Demirçivi 0000-0002-4448-3863

Early Pub Date March 18, 2023
Publication Date March 18, 2023
Submission Date October 2, 2022
Acceptance Date January 2, 2023
Published in Issue Year 2023 Volume: 40 Issue: 1

Cite

APA Ayar Madenli, A., Öz, İ., & Demirçivi, E. (2023). What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?. Journal of Experimental and Clinical Medicine, 40(1), 72-75.
AMA Ayar Madenli A, Öz İ, Demirçivi E. What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?. J. Exp. Clin. Med. March 2023;40(1):72-75.
Chicago Ayar Madenli, Asena, İnci Öz, and Ergül Demirçivi. “What Is the Effect of Vitamin D Deficiency on Pap Smear Test Results in the Postmenopausal Period?”. Journal of Experimental and Clinical Medicine 40, no. 1 (March 2023): 72-75.
EndNote Ayar Madenli A, Öz İ, Demirçivi E (March 1, 2023) What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?. Journal of Experimental and Clinical Medicine 40 1 72–75.
IEEE A. Ayar Madenli, İ. Öz, and E. Demirçivi, “What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?”, J. Exp. Clin. Med., vol. 40, no. 1, pp. 72–75, 2023.
ISNAD Ayar Madenli, Asena et al. “What Is the Effect of Vitamin D Deficiency on Pap Smear Test Results in the Postmenopausal Period?”. Journal of Experimental and Clinical Medicine 40/1 (March 2023), 72-75.
JAMA Ayar Madenli A, Öz İ, Demirçivi E. What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?. J. Exp. Clin. Med. 2023;40:72–75.
MLA Ayar Madenli, Asena et al. “What Is the Effect of Vitamin D Deficiency on Pap Smear Test Results in the Postmenopausal Period?”. Journal of Experimental and Clinical Medicine, vol. 40, no. 1, 2023, pp. 72-75.
Vancouver Ayar Madenli A, Öz İ, Demirçivi E. What is the effect of vitamin D deficiency on Pap smear test results in the postmenopausal period?. J. Exp. Clin. Med. 2023;40(1):72-5.