Research Article
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Year 2021, Volume: 38 Issue: 4, 521 - 524, 09.10.2021

Abstract

References

  • Baum M, Yerushalmi GM, Maman E, Kedem A, Machtinger R, Hourvitz A, Dor J. Does local injury to the endometrium before IVF cycle really affect treatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28(12):933-936.
  • Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010; 63(1):17-21.
  • El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reproductive BioMedicine Online 2012; 25(4):345-354.
  • Fritz MA, Speroff L. Kadın İnfertilitesi. Fritz MA, Speroff L. Klinik Jinekolojik Endokrinoloji ve İnfertilite 8. Edisyon. Çeviri Editörü: G.Serdar Günalp. Güneş Tıp Kitabevleri, Ankara, 2013; s. 1137-1190.
  • Garcia JE, Acosta AA, Hsiu JG, Jones HW, Jr. Advanced endometrial maturation after ovulation induction with human menopausal gonadotropin/human chorionic gonadotropin for in vitro fertilization. Fertil Steril 1984; 41(1):31-35.
  • Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, Mor G, Dekel N. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010;94(6):2030-2036.
  • Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012;144(6):661-668.
  • Hatasaka H. New perspectives for unexplained infertility. Clin Obstet Gynecol 2011; 54(4):727-733.
  • Humphrey KW. The effects of some anti-oestrogens on the deciduoma reaction and delayed implantation in the mouse. J Reprod Fertil 1968; 16(2):201-209.
  • Jasper MJ, Tremellen KP, Robertson SA. Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12(5):301-308.
  • Kalma Y, Granot I, Gnainsky Y, Or Y, Czernobilsky B, Dekel N, Barash A. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91(4):1042-1049.
  • Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49(6):677-680.
  • Lensen, S., Sadler, L., & Farquhar, C. (2016). Endometrial scratching for subfertility: everyone's doing it. Human reproduction, 31(6), 1241-1244.
  • Loeb L. Ueber die experimentelle Erzeugung von Knoten von Deciduagewebe in dem Uterus des Meerschweinchens nach stattgefundener Copulation. Zbl Allg Path Anat 1907;18:563–565.
  • Mahey, R., Goel, T., Gupta, M., Kachhawa, G., & Kriplani, A. (2015). To evaluate the pregnancy rate after endometrial scratching in couples with unexplained infertility in ovulation induction and IUI cycles. Fertility and Sterility, 104(3), e343.
  • Mirkin S, Nikas G, Hsiu JG, Diaz J, Oehninger S. Gene expression profiles and structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles. The Journal of clinical endocrinology and metabolism 2004; 89(11):5742-5752.
  • Nahshon, C., Sagi‐Dain, L., & Dirnfeld, M. (2020). The impact of endometrial injury on reproductive outcomes: results of an updated meta‐analysis. Reproductive Medicine and Biology.
  • Nastri, C. O., Lensen, S. F., Gibreel, A., Raine‐Fenning, N., Ferriani, R. A., Bhattacharya, S., & Martins, W. P. (2015). Endometrial injury in women undergoing assisted reproductive techniques. Cochrane database of systematic reviews.
  • Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med 2001; 345(19):1400-1408.
  • Ray A, Shah A, Gudi A, Homburg R. Unexplained infertility: an update and review of practice. Reprod Biomed Online 2012; 24(6):591-602.
  • Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97(5):1028-1032.
  • Sharkey A. Cytokines and implantation. Reviews of reproduction 1998;3(1):52-61.
  • Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 2006;12(5):617-630.
  • Van Hoogenhuijze, N. E., Kasius, J. C., Broekmans, F. J. M., Bosteels, J., & Torrance, H. L. (2019). Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis. Human Reproduction Open, 2019(1), hoy025.
  • Vitagliano, A., Noventa, M., Saccone, G., Gizzo, S., Vitale, S. G., Lagana, A. S., ... & Sardo, A. D. S. (2018). Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility, 109(1), 84-96.
  • Vitagliano, A., Andrisani, A., Alviggi, C., Vitale, S. G., Valenti, G., Sapia, F., ... & Ambrosini, G. (2019). Endometrial scratching for infertile women undergoing a first embryo transfer: a systematic review and meta-analysis of published and unpublished data from randomized controlled trials. Fertility and sterility, 111(4), 734-746.
  • Wadhwa, L., Pritam, A., Gupta, T., Gupta, S., Arora, S., & Chandoke, R. (2015). Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle. Journal of Human Reproductive Sciences, 8(3), 151.
  • Weimar CHE, Post Uiterweer ED, Teklenburg G, Heijnen CJ, Macklon NS. Reprint of: In-vitro model systems for the study of human embryo-endometrium interactions. Reproductive BioMedicine Online 2013;27(6):673-688.
  • Zhou L, Li R, Wang R, Huang HX, Zhong K. Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril 2008; 89(5):1166-1176.

The effect of local endometrial injury on the success of intrauterine insemination

Year 2021, Volume: 38 Issue: 4, 521 - 524, 09.10.2021

Abstract

Purpose: To determine the effect of local endometrial injury on implantation success in patients diagnosed with unexplained infertility and undergoing intrauterine insemination (IUI) after ovulation induction with gonadotropins.
Material and methods: In this prospective randomized controlled trial, 82 infertile patients underwent IUI following ovulation induction with gonadotropin. In the study group (n:40), local endometrial injury (stratch) was performed to the posterior side of the endometrial cavity with a biopsy catheter between the 21-26th days of luteal phase of the cycle preceding ovarian stimulation.
Results: There was no statistically significant difference between the study and the control groups in terms of age of female, age of male, duration of infertility, BMI, serum FSH and LH levels, mean dose of gonadotropin and mean duration of ovulation induction (p>0.05). Clinical pregnancy was achieved in two patients (4.76%) in control group and four (10%) patients in the study group, with no significant difference between groups (p=0.18). All pregnancies achieved in the control and the study groups passed 12th gestational weeks and continued. Ectopic pregnancy, multiple pregnancy and abortion was not observed in any patient in both groups. In the study group, pain level immediately after endometrial biopsy procedure was evaluated with visual analog scale (VAS) and it was established that only one (2,5%) patient experienced severe pain after the procedure.
Conclusion: Although local endometrial damage in the menstural period before ovulation induction and IUI cycle increases clinical pregnancy rates in the infertile patients, this increase is not statistically significant. Multi-center randomized controlled studies are needed for local endometrial damage to be recommended routinely in clinical practice.

References

  • Baum M, Yerushalmi GM, Maman E, Kedem A, Machtinger R, Hourvitz A, Dor J. Does local injury to the endometrium before IVF cycle really affect treatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28(12):933-936.
  • Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010; 63(1):17-21.
  • El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reproductive BioMedicine Online 2012; 25(4):345-354.
  • Fritz MA, Speroff L. Kadın İnfertilitesi. Fritz MA, Speroff L. Klinik Jinekolojik Endokrinoloji ve İnfertilite 8. Edisyon. Çeviri Editörü: G.Serdar Günalp. Güneş Tıp Kitabevleri, Ankara, 2013; s. 1137-1190.
  • Garcia JE, Acosta AA, Hsiu JG, Jones HW, Jr. Advanced endometrial maturation after ovulation induction with human menopausal gonadotropin/human chorionic gonadotropin for in vitro fertilization. Fertil Steril 1984; 41(1):31-35.
  • Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, Mor G, Dekel N. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010;94(6):2030-2036.
  • Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012;144(6):661-668.
  • Hatasaka H. New perspectives for unexplained infertility. Clin Obstet Gynecol 2011; 54(4):727-733.
  • Humphrey KW. The effects of some anti-oestrogens on the deciduoma reaction and delayed implantation in the mouse. J Reprod Fertil 1968; 16(2):201-209.
  • Jasper MJ, Tremellen KP, Robertson SA. Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12(5):301-308.
  • Kalma Y, Granot I, Gnainsky Y, Or Y, Czernobilsky B, Dekel N, Barash A. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91(4):1042-1049.
  • Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49(6):677-680.
  • Lensen, S., Sadler, L., & Farquhar, C. (2016). Endometrial scratching for subfertility: everyone's doing it. Human reproduction, 31(6), 1241-1244.
  • Loeb L. Ueber die experimentelle Erzeugung von Knoten von Deciduagewebe in dem Uterus des Meerschweinchens nach stattgefundener Copulation. Zbl Allg Path Anat 1907;18:563–565.
  • Mahey, R., Goel, T., Gupta, M., Kachhawa, G., & Kriplani, A. (2015). To evaluate the pregnancy rate after endometrial scratching in couples with unexplained infertility in ovulation induction and IUI cycles. Fertility and Sterility, 104(3), e343.
  • Mirkin S, Nikas G, Hsiu JG, Diaz J, Oehninger S. Gene expression profiles and structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles. The Journal of clinical endocrinology and metabolism 2004; 89(11):5742-5752.
  • Nahshon, C., Sagi‐Dain, L., & Dirnfeld, M. (2020). The impact of endometrial injury on reproductive outcomes: results of an updated meta‐analysis. Reproductive Medicine and Biology.
  • Nastri, C. O., Lensen, S. F., Gibreel, A., Raine‐Fenning, N., Ferriani, R. A., Bhattacharya, S., & Martins, W. P. (2015). Endometrial injury in women undergoing assisted reproductive techniques. Cochrane database of systematic reviews.
  • Norwitz ER, Schust DJ, Fisher SJ. Implantation and the survival of early pregnancy. N Engl J Med 2001; 345(19):1400-1408.
  • Ray A, Shah A, Gudi A, Homburg R. Unexplained infertility: an update and review of practice. Reprod Biomed Online 2012; 24(6):591-602.
  • Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97(5):1028-1032.
  • Sharkey A. Cytokines and implantation. Reviews of reproduction 1998;3(1):52-61.
  • Strowitzki T, Germeyer A, Popovici R, von Wolff M. The human endometrium as a fertility-determining factor. Hum Reprod Update 2006;12(5):617-630.
  • Van Hoogenhuijze, N. E., Kasius, J. C., Broekmans, F. J. M., Bosteels, J., & Torrance, H. L. (2019). Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis. Human Reproduction Open, 2019(1), hoy025.
  • Vitagliano, A., Noventa, M., Saccone, G., Gizzo, S., Vitale, S. G., Lagana, A. S., ... & Sardo, A. D. S. (2018). Endometrial scratch injury before intrauterine insemination: is it time to re-evaluate its value? Evidence from a systematic review and meta-analysis of randomized controlled trials. Fertility and sterility, 109(1), 84-96.
  • Vitagliano, A., Andrisani, A., Alviggi, C., Vitale, S. G., Valenti, G., Sapia, F., ... & Ambrosini, G. (2019). Endometrial scratching for infertile women undergoing a first embryo transfer: a systematic review and meta-analysis of published and unpublished data from randomized controlled trials. Fertility and sterility, 111(4), 734-746.
  • Wadhwa, L., Pritam, A., Gupta, T., Gupta, S., Arora, S., & Chandoke, R. (2015). Effect of endometrial biopsy on intrauterine insemination outcome in controlled ovarian stimulation cycle. Journal of Human Reproductive Sciences, 8(3), 151.
  • Weimar CHE, Post Uiterweer ED, Teklenburg G, Heijnen CJ, Macklon NS. Reprint of: In-vitro model systems for the study of human embryo-endometrium interactions. Reproductive BioMedicine Online 2013;27(6):673-688.
  • Zhou L, Li R, Wang R, Huang HX, Zhong K. Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril 2008; 89(5):1166-1176.
There are 29 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Didar Kurt This is me 0000-0001-9895-8353

Gazi Yıldız 0000-0003-2546-009X

Emre Mat 0000-0002-3965-543X

Pınar Yıldız This is me 0000-0001-7624-3656

Publication Date October 9, 2021
Submission Date March 27, 2021
Acceptance Date April 23, 2021
Published in Issue Year 2021 Volume: 38 Issue: 4

Cite

APA Kurt, D., Yıldız, G., Mat, E., Yıldız, P. (2021). The effect of local endometrial injury on the success of intrauterine insemination. Journal of Experimental and Clinical Medicine, 38(4), 521-524.
AMA Kurt D, Yıldız G, Mat E, Yıldız P. The effect of local endometrial injury on the success of intrauterine insemination. J. Exp. Clin. Med. October 2021;38(4):521-524.
Chicago Kurt, Didar, Gazi Yıldız, Emre Mat, and Pınar Yıldız. “The Effect of Local Endometrial Injury on the Success of Intrauterine Insemination”. Journal of Experimental and Clinical Medicine 38, no. 4 (October 2021): 521-24.
EndNote Kurt D, Yıldız G, Mat E, Yıldız P (October 1, 2021) The effect of local endometrial injury on the success of intrauterine insemination. Journal of Experimental and Clinical Medicine 38 4 521–524.
IEEE D. Kurt, G. Yıldız, E. Mat, and P. Yıldız, “The effect of local endometrial injury on the success of intrauterine insemination”, J. Exp. Clin. Med., vol. 38, no. 4, pp. 521–524, 2021.
ISNAD Kurt, Didar et al. “The Effect of Local Endometrial Injury on the Success of Intrauterine Insemination”. Journal of Experimental and Clinical Medicine 38/4 (October 2021), 521-524.
JAMA Kurt D, Yıldız G, Mat E, Yıldız P. The effect of local endometrial injury on the success of intrauterine insemination. J. Exp. Clin. Med. 2021;38:521–524.
MLA Kurt, Didar et al. “The Effect of Local Endometrial Injury on the Success of Intrauterine Insemination”. Journal of Experimental and Clinical Medicine, vol. 38, no. 4, 2021, pp. 521-4.
Vancouver Kurt D, Yıldız G, Mat E, Yıldız P. The effect of local endometrial injury on the success of intrauterine insemination. J. Exp. Clin. Med. 2021;38(4):521-4.