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Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae

Year 2023, Volume: 5 Issue: 2, 267 - 277, 31.12.2023

Kemal Çetin Koray Şarkaya Berna Kavakcıoğlu Yardımcı

https://doi.org/10.47112/neufmbd.2023.24

Abstract

One of the most serious concerns in biomedical implant occlusion and deep wound healing is microbial infections caused by bacteria and fungi. Therefore, it is crucial to design materials with antimicrobial and antifungal properties to prevent or cure infections in the wound, its surroundings, and the site where the implant will be placed. Cryo-hydrogels, called cryogels, are a valuable option for wound healing materials. In this study, various polymers were synthesized using the cryopolymerization process in order to examine the changes in the antifungal effects of the materials when metal ion and amino acid are incorporated. Swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction investigations were performed to characterize the polymers synthesized using 2-hydroxyethyl methacrylate (HEMA) as main monomer. The antifungal actions of the cryogels were examined on the eukaryotic yeast cell model S. cerevisiae, also referred to as baker's yeast or brewer's yeast. HEMA-based polymers exhibit porous morphology. Results showed that copper ions play an essential role in the antifungal activity of the HEMA-based polymers while attachment of additional histidine causes the recovery of cell metabolic activity.

Keywords

Antifungal activity Cu(II) ions HEMA Histidine Polymers

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Bakır (II) İyonu ve Histidin İçeren Polimerlerin Saccharomyces cerevisiae Mayası Üzerindeki Antifungal Etkileri

Year 2023, Volume: 5 Issue: 2, 267 - 277, 31.12.2023

Kemal Çetin Koray Şarkaya Berna Kavakcıoğlu Yardımcı

https://doi.org/10.47112/neufmbd.2023.24

Abstract

Biyomedikal implant oklüzyonundaki ve derin yara iyileşmesindeki en ciddi endişelerden biri bakteri ve mantarların neden olduğu mikrobiyal enfeksiyonlardır. Bu nedenle, yarada, yaranın etrafında ve implantın yerleştirileceği bölgedeki enfeksiyonları önlemek veya tedavi etmek için antimikrobiyal ve antifungal özelliklere sahip malzemeler tasarlamak çok önemlidir. Kriyojel olarak adlandırılan kriyo-hidrojeller, yara iyileştirme malzemeleri için önemli bir seçenektir. Bu çalışmada, metal iyonu ve amino asit katıldığında malzemelerin antifungal etkilerindeki değişiklikleri incelemek amacıyla kriyopolimerizasyon işlemi kullanılarak çeşitli polimerler sentezlenmiştir. 2-Hidroksietil metakrilat’ın ana monomer olarak kullanılmasıyla sentezlenen polimerleri karakterize etmek için şişme testleri, Fourier dönüşümlü kızılötesi spektroskopisi, taramalı elektron mikroskobu ve X-ışını kırınımı incelemeleri yapılmıştır. Kriyojellerin antifungal aktiviteleri, fırıncı mayası veya bira mayası olarak da adlandırılan ökaryotik maya hücre modeli S. cerevisiae üzerinde incelenmiştir. 2-Hidroksietil metakrilat temelli polimerler gözenekli morfoloji sergilemektedir. Sonuçlar, bakır iyonlarının 2-Hidroksietil metakrilat temelli polimerlerin antifungal aktivitesinde önemli bir rol oynadığını, ek olarak histidin bağlanmasının ise hücresel metabolik aktivite yüzdelerinde artışa sebep olduğunu göstermiştir.

Keywords

Antifungal aktivite Cu(II) iyonları HEMA Histidin Polimerler

References

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  • Z. Gu, K. Huang, Y. Luo, L. Zhang, T. Kuang, Z. Chen, G. Liao, Double network hydrogel for tissue engineering, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 10 (2018), e1520. doi:10.1002/WNAN.1520.
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  • K. Çetin, A. Denizli, Polyethylenimine-functionalized microcryogels for controlled release of diclofenac sodium, Reactive and Functional Polymers. 170 (2022), 105125. doi:10.1016/J.REACTFUNCTPOLYM.2021.105125.
  • R. Kumar Saini, L. Prasad Bagri, A.K. Bajpai, Nano-silver hydroxyapatite based antibacterial 3D scaffolds of gelatin/alginate/poly (vinyl alcohol) for bone tissue engineering applications, Colloids and Surfaces B: Biointerfaces. 177 (2019), 211–218. doi:10.1016/J.COLSURFB.2019.01.064.
  • M. Rezaeeyazdi, T. Colombani, A. Memic, S. Bencherif, M. Rezaeeyazdi, T. Colombani, A. Memic, S.A. Bencherif, Injectable hyaluronic acid-co-gelatin cryogels for tissue-engineering applications, Materials. 11 (2018), 1374. doi:10.3390/ma11081374.
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  • S. Niyomdecha, W. Limbut, A. Numnuam, P. Asawatreratanakul, P. Kanatharana, P. Thavarungkul, A novel BOD biosensor based on entrapped activated sludge in a porous chitosan-albumin cryogel incorporated with graphene and methylene blue, Sensors and Actuators B: Chemical. 241 (2017), 473–481. doi:10.1016/j.snb.2016.10.102.
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  • A. Zumbuehl, L. Ferreira, D. Kuhn, A. Astashkina, L. Long, Y. Yeo, T. Iaconis, M. Ghannoum, G.R. Fink, R. Langer, D.S. Kohane, Antifungal hydrogels, Proceedings of the National Academy of Sciences of the United States of America. 104 (2007), 12994–12998. doi:10.1073/PNAS.0705250104.
  • X. Zhao, H. Wu, B. Guo, R. Dong, Y. Qiu, P.X. Ma, Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing, Biomaterials. 122 (2017), 34–47. doi:10.1016/J.BIOMATERIALS.2017.01.011.
  • F.A. Paskiabi, S. Bonakdar, M.A. Shokrgozar, M. Imani, Z. Jahanshiri, M. Shams-Ghahfarokhi, M. Razzaghi-Abyaneh, Terbinafine-loaded wound dressing for chronic superficial fungal infections, Materials Science and Engineering: C. 73 (2017), 130–136. doi:10.1016/J.MSEC.2016.12.078.
  • I. De Luca, P. Pedram, A. Moeini, P. Cerruti, G. Peluso, A. Di Salle, N. Germann, Nanotechnology development for formulating essential oils in wound dressing materials to promote the wound-healing process: A review, Applied Sciences 2021, Vol. 11, Page 1713. 11 (2021), 1713. doi:10.3390/APP11041713.
  • M.A. Matica, F.L. Aachmann, A. Tøndervik, H. Sletta, V. Ostafe, Chitosan as a wound dressing starting material: antimicrobial properties and mode of action, International Journal of Molecular Sciences 2019, Vol. 20, Page 5889. 20 (2019), 5889. doi:10.3390/IJMS20235889.
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There are 55 citations in total.

Details

Primary Language English
Subjects Biomaterials in Biomedical Engineering
Journal Section Articles
Authors

Kemal Çetin 0000-0002-7393-7377

Koray Şarkaya 0000-0003-0177-5134

Berna Kavakcıoğlu Yardımcı 0000-0003-0719-9094

Early Pub Date December 28, 2023
Publication Date December 31, 2023
Acceptance Date October 6, 2023
Published in Issue Year 2023 Volume: 5 Issue: 2

Cite

APA Çetin, K., Şarkaya, K., & Kavakcıoğlu Yardımcı, B. (2023). Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae. Necmettin Erbakan Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 5(2), 267-277. https://doi.org/10.47112/neufmbd.2023.24
AMA Çetin K, Şarkaya K, Kavakcıoğlu Yardımcı B. Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae. NEJSE. December 2023;5(2):267-277. doi:10.47112/neufmbd.2023.24
Chicago Çetin, Kemal, Koray Şarkaya, and Berna Kavakcıoğlu Yardımcı. “Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces Cerevisiae”. Necmettin Erbakan Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 5, no. 2 (December 2023): 267-77. https://doi.org/10.47112/neufmbd.2023.24.
EndNote Çetin K, Şarkaya K, Kavakcıoğlu Yardımcı B (December 1, 2023) Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae. Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi 5 2 267–277.
IEEE K. Çetin, K. Şarkaya, and B. Kavakcıoğlu Yardımcı, “Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae”, NEJSE, vol. 5, no. 2, pp. 267–277, 2023, doi: 10.47112/neufmbd.2023.24.
ISNAD Çetin, Kemal et al. “Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces Cerevisiae”. Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi 5/2 (December 2023), 267-277. https://doi.org/10.47112/neufmbd.2023.24.
JAMA Çetin K, Şarkaya K, Kavakcıoğlu Yardımcı B. Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae. NEJSE. 2023;5:267–277.
MLA Çetin, Kemal et al. “Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces Cerevisiae”. Necmettin Erbakan Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 5, no. 2, 2023, pp. 267-7, doi:10.47112/neufmbd.2023.24.
Vancouver Çetin K, Şarkaya K, Kavakcıoğlu Yardımcı B. Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae. NEJSE. 2023;5(2):267-7.
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