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Year 2021, Volume: 7 Issue: 1, 46 - 55, 30.06.2021

Nazan Demir Sıla Nezahat Daşdemir Alevcan Kaplan

https://doi.org/10.51477/mejs.933062

Abstract

Supporting Institution

Muğla Sıtkı Koçman Üniversitesi

References

  • [1] Willis, J., Amaryllidaceae. “In: Shaw A, editor. A dictionary of the flowering plants & ferns”. 8th ed. Cambridge Cambridge University Press; pp: 49-50, 1988.
  • [2] Nair, J.J., Bastida, J., Codina, C., Viladomat, F., Van Stadene, J., “Alkaloids of the South African Amaryllidaceae: a Review”, Natural Product Communications, 8(9):1335-1350, 2013.
  • [3] Tanrıverdi, F., “Çiçek üretim tekniği, (Sera ve açık alanlarda saksı, kesme ve bahçe çiçeği yetiştirme ilkeleri ders kitabı)”, İnkilâp kitabevi, İstanbul, 1993.
  • [4] Baytop, T., “Türkiye'de Bitkiler ile Tedavi”, 2.baskı, 480 sayfa, Nobel Tıp Kitabevleri, İstanbul, (ilk baskı 1984), 1999.
  • [5] Bastida, J., Lavilla, R., Viladomat, F., “Chemical and biological aspects of Narcissus alkaloids”. In: Cordell, G.A. (Ed.), The Alkaloids, vol. 63. Elsevier, Chicago, pp: 87-179, 2006.
  • [6] Bastida, J., Berkov, S., Torras, L., Pigni, N.B., de Andrade, J.P., Martínez, V., Codina,C., Viladomat, F., “Chemical and biological aspects of Amaryllidaceae alkaloids”, In: Mu˜noz-Torrero, D. (Ed.), Recent Advances in Pharmaceutical Sciences. Transword Research Network, Kerala, pp: 65-100, 2011.
  • [7] Jin, Z., “Amaryllidaceae and Sceletium alkaloids”, Natural Product Reports, 24, 886-905, 2007.
  • [8] Rezanka, T., Rezanka, P., Sigler, K., “Glycosides of benzodioxole-indole alkaloids from Narcissus having axial chirality”, Phytochemistry,71(2-3):301-306, 2010.
  • [9] Pigni, N.B., Rios-Ruiz, S., Martinez-Frances, V., Nair, J.J., Viladomat, F., Codina, C et. al., “Alkaloids from Narcissus serotinus”, Journal of Natural Product, 75(9):1643-1647,2012.
  • [10] Jin, Z., “Amaryllidaceae and sceletium alkaloids”, Natural Product Reports, 30(6):849-868, 2013.
  • [11] Buckingham. J., Baggaley, K.H., Roberts, A. D., Szabo, L.F., “Dictionary of alkaloids”, USA: CRC Press Taylor & Francis Group, 2010.
  • [12] Harvey, A.L., “The Pharmacology of galanthamine and its analogs”, Pharmacology & Therapeutics, 68(1):113-128, 1995.
  • [13] Weniger, B., Italiano, L., Beck, J.P., Bastida, J., Bergonon, S., Codina, C et. al., “Cytotoxic activity of Amaryllidaceae alkaloids”, Planta Medica, 61(1):77-79, 1995.
  • [14] Triana-Vidal, L.E., Carvajal-Varona, S.M., “Protective effect of galantamine against oxidative damage using human lymphocytes: A novel in vitro model”, Archives of Medical Research, 44(2):85-92, 2013.
  • [15] Feldman, H.H., Pirttila, T., Dartigues, J.F., Everitt, B., Van Baelen, B., Brashear, H.R et. al., “Analyses of mortality risk in patients with dementia treated with galantamine”, Acta Neurologica Scandinavica,119(1):22-31, 2009.
  • [16] Bradford, M.M., “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding”, Analytical Biochemistry, 72(1-2): 248-254, 1976.
  • [17] Rawdkuen, S., Vanabun, A., Benjakul, S., “Recovery of proteases from the viscera of farmed giant catfish (Pangasianodon gigas) by three-phase partitioning”, Process Biochemistry, 47: 2566-2569, 2012.
  • [18] Fadıloğlu, S., “Immobilization and characterization of ficin”. Die Nahrung [Food], 45(2):143-146, 2001.
  • [19] Gülçin, I., Alıcı, H. A., Cesur, M., “Determination of in vitro antioxidant and radical scavenging activities of propofol”, Chemical & Pharmaceutical Bulletin, 53(3): 281-285, 2005.
  • [20] Can, Z., Yildiz, O., Sahin, H., Turumtay, E.A., Silici, S., Kolayli, S., “An investigation of Turkish honeys:their physico-chemical properties, antioxidant capacities and phenolic profiles”, Food Chemistry, 180, 133-141, 2015.
  • [21] Lehninger, A.L., “Principles of biochemistry”, New York: Worth Pub-lishers Inc., 2013.
  • [22] Yapar, E.A., “Fitokozmetikler”, Türk Farmakope Dergisi, 3 (1): 110-116, 2018.
  • [23] Sova, M., “Antioxidant and antimicrobial activities of Cinnamic acid derivatives”, Mini-Reviews in Medicinal Chemistry, 12 (8): 749-767, 2012.
  • [24] Yrbas, M.A., Morucci, F., Alonso, R., Gorzalczany, S., “Pharmacological mechanism underlying the antinociceptive activity of vanillic acid”, Pharmacology Biochemistry and Behavior, 132, 88-95, 2015.
  • [25] Espíndola, K. M. M., Ferreira, R. G., Narvaez, L. E. M., Rosario, A. C. R. S., Silva, A. H. M., Silva, A. G. B., Vieira, A. P. O., Monteiro, M. C., “Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma”, Frontiers in Oncology, 21 June 2019 https://doi.org/10.3389/fonc.2019.00541. 2019.
  • [26] Srinivasulu, C., Ramgopal, M., Ramanjaneyulu, G., Anuradha, C. M., and Suresh, K. C., “Syringic acid (SA) ‒ A review of its occurrence, biosynthesis, pharmacological and industrial importance”, Biomedicine and Pharmacotherapy, https://doi.org/10.1016/j.biopha.2018.09.069, 2018.
  • [27] Zduńska, K., Dana, A., Kolodziejczak, A., Rotsztejn, H., “Antioxidant properties of ferulic acid and its possible application”, Skin Pharmacology and Physiology, 31:332-336, 2018.
  • [28] Sun, M.Y., Ye, Y., Xiao, L., Rahman, K., Xia, W., Zhang, H., “Daidzein: A review of pharmacologıcal effects”, African Journal of Traditional, Complementary and Alternative Medicines, 13(3):117-132, 2016.
  • [29] Lin, Y., Shi, R., Wang, X., Shen, H.M., “Luteolin, a flavonoid with potential for cancer prevention and therapy”, Current Cancer Drug Targets, 8(7):634-646, 2008.
  • [30] Bae, J., Kim, N., Shin, Y., Kim, S.Y. and Kim, Y.J., “Activity of catechins and their applications”, Biomedical Dermatology, 4(8): 1-10, 2020.
  • [31] Shay, J., Elbaz, H.A., Lee, I., Zielske, S. P., Malek, M. H. and Hüttemann, M., “Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer”, Oxidative Medicine and Cellular Longevity, 2015, Article ID 181260, 1- 13, doi.org/10.1155/2015/1812602015.

BIOCHEMICA INVESTIGATION OF THE PHARMACEUTICAL AND COSMETIC USE OF NARCISSUS (Narcissus tazetta L. subsp. tazetta L.) GROWING NATURALLY AROUND IN MUĞLA, TURKEY

Year 2021, Volume: 7 Issue: 1, 46 - 55, 30.06.2021

Nazan Demir Sıla Nezahat Daşdemir Alevcan Kaplan

https://doi.org/10.51477/mejs.933062

Abstract

Amaryllidaceae is a monocot plant family represented in the world with approximately 85 genera and 1100 species, which has a great economic value as an ornamental plant, as well as plants that are widely used in treatment [1,2]. Narcissus L. species, a member of the Amaryllidaceae family, are perennial, herbaceous plants with bulbs that bear fragrant flowers and up to 30 different species grow naturally in Western Europe, the Mediterranean Region, China and Japan [3,4].
Amaryllidaceous plants have biological activities of medical uses, and their alkaloids have wide applications worldwide [5, 6, 7]. These alkaloids are a group of secondary metabolites on which many studies have been carried out due to their biogenesis, pharmacological and physiological activities. Until today, more than 500 Amaryllidaceae alkaloids have been isolated from different plants of the family, and modern phytochemical studies have shown that these alkaloids are responsible for many pharmacological activities [5, 8, 9, 10]. Due to their similarity to morphine and codeine skeletons, they have high analgesic effects. Among the pharmacological activities, including anti-cholinesterasic, antifungal, anti-inflammatory, cytotoxic, anticancer, antiplatelet, antifeedantan, antiparasitic and antiviral [5, 11]. In the Narcissus genus, the alkaloids found are divided into eight groups according to their skeleton type. These groups, according to the name of the representing alkaloid; It is expressed as norbelladin, lycorine, homolicoline, hemantamine, narciclasin, tazettin, pancracin and galantamine [5]. Among these alkaloids, especially galantamine, analgesic [12], antiviral, cytotoxic [13], antimicrobial and antioxidant [14]. activities have been reported, and it is known to be used in the treatment of Alzheimer's due to its acetylcholinesterase inhibition effect [15]. Apart from these known therapeutic effects of the plant, it is a valuable main product in the cosmetic industry. In ancient times, in the Aegean region, it was grown and essence was obtained from its flowers [4].
The aim of this work was to perform collect the Narcissus flower, which grows naturally in Muğla and its surroundings in February-April and draws attention with its scent, to determine some of its bioactivities and to conduct research on the purification of the protease enzyme for pharmaceuticals effects, as well as to research the use of the plant in this field by making a perfume design for the cosmetic industry.

Keywords

Narcissus flower perfume phenolic compound protease enzyme three phase partitioning

References

  • [1] Willis, J., Amaryllidaceae. “In: Shaw A, editor. A dictionary of the flowering plants & ferns”. 8th ed. Cambridge Cambridge University Press; pp: 49-50, 1988.
  • [2] Nair, J.J., Bastida, J., Codina, C., Viladomat, F., Van Stadene, J., “Alkaloids of the South African Amaryllidaceae: a Review”, Natural Product Communications, 8(9):1335-1350, 2013.
  • [3] Tanrıverdi, F., “Çiçek üretim tekniği, (Sera ve açık alanlarda saksı, kesme ve bahçe çiçeği yetiştirme ilkeleri ders kitabı)”, İnkilâp kitabevi, İstanbul, 1993.
  • [4] Baytop, T., “Türkiye'de Bitkiler ile Tedavi”, 2.baskı, 480 sayfa, Nobel Tıp Kitabevleri, İstanbul, (ilk baskı 1984), 1999.
  • [5] Bastida, J., Lavilla, R., Viladomat, F., “Chemical and biological aspects of Narcissus alkaloids”. In: Cordell, G.A. (Ed.), The Alkaloids, vol. 63. Elsevier, Chicago, pp: 87-179, 2006.
  • [6] Bastida, J., Berkov, S., Torras, L., Pigni, N.B., de Andrade, J.P., Martínez, V., Codina,C., Viladomat, F., “Chemical and biological aspects of Amaryllidaceae alkaloids”, In: Mu˜noz-Torrero, D. (Ed.), Recent Advances in Pharmaceutical Sciences. Transword Research Network, Kerala, pp: 65-100, 2011.
  • [7] Jin, Z., “Amaryllidaceae and Sceletium alkaloids”, Natural Product Reports, 24, 886-905, 2007.
  • [8] Rezanka, T., Rezanka, P., Sigler, K., “Glycosides of benzodioxole-indole alkaloids from Narcissus having axial chirality”, Phytochemistry,71(2-3):301-306, 2010.
  • [9] Pigni, N.B., Rios-Ruiz, S., Martinez-Frances, V., Nair, J.J., Viladomat, F., Codina, C et. al., “Alkaloids from Narcissus serotinus”, Journal of Natural Product, 75(9):1643-1647,2012.
  • [10] Jin, Z., “Amaryllidaceae and sceletium alkaloids”, Natural Product Reports, 30(6):849-868, 2013.
  • [11] Buckingham. J., Baggaley, K.H., Roberts, A. D., Szabo, L.F., “Dictionary of alkaloids”, USA: CRC Press Taylor & Francis Group, 2010.
  • [12] Harvey, A.L., “The Pharmacology of galanthamine and its analogs”, Pharmacology & Therapeutics, 68(1):113-128, 1995.
  • [13] Weniger, B., Italiano, L., Beck, J.P., Bastida, J., Bergonon, S., Codina, C et. al., “Cytotoxic activity of Amaryllidaceae alkaloids”, Planta Medica, 61(1):77-79, 1995.
  • [14] Triana-Vidal, L.E., Carvajal-Varona, S.M., “Protective effect of galantamine against oxidative damage using human lymphocytes: A novel in vitro model”, Archives of Medical Research, 44(2):85-92, 2013.
  • [15] Feldman, H.H., Pirttila, T., Dartigues, J.F., Everitt, B., Van Baelen, B., Brashear, H.R et. al., “Analyses of mortality risk in patients with dementia treated with galantamine”, Acta Neurologica Scandinavica,119(1):22-31, 2009.
  • [16] Bradford, M.M., “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding”, Analytical Biochemistry, 72(1-2): 248-254, 1976.
  • [17] Rawdkuen, S., Vanabun, A., Benjakul, S., “Recovery of proteases from the viscera of farmed giant catfish (Pangasianodon gigas) by three-phase partitioning”, Process Biochemistry, 47: 2566-2569, 2012.
  • [18] Fadıloğlu, S., “Immobilization and characterization of ficin”. Die Nahrung [Food], 45(2):143-146, 2001.
  • [19] Gülçin, I., Alıcı, H. A., Cesur, M., “Determination of in vitro antioxidant and radical scavenging activities of propofol”, Chemical & Pharmaceutical Bulletin, 53(3): 281-285, 2005.
  • [20] Can, Z., Yildiz, O., Sahin, H., Turumtay, E.A., Silici, S., Kolayli, S., “An investigation of Turkish honeys:their physico-chemical properties, antioxidant capacities and phenolic profiles”, Food Chemistry, 180, 133-141, 2015.
  • [21] Lehninger, A.L., “Principles of biochemistry”, New York: Worth Pub-lishers Inc., 2013.
  • [22] Yapar, E.A., “Fitokozmetikler”, Türk Farmakope Dergisi, 3 (1): 110-116, 2018.
  • [23] Sova, M., “Antioxidant and antimicrobial activities of Cinnamic acid derivatives”, Mini-Reviews in Medicinal Chemistry, 12 (8): 749-767, 2012.
  • [24] Yrbas, M.A., Morucci, F., Alonso, R., Gorzalczany, S., “Pharmacological mechanism underlying the antinociceptive activity of vanillic acid”, Pharmacology Biochemistry and Behavior, 132, 88-95, 2015.
  • [25] Espíndola, K. M. M., Ferreira, R. G., Narvaez, L. E. M., Rosario, A. C. R. S., Silva, A. H. M., Silva, A. G. B., Vieira, A. P. O., Monteiro, M. C., “Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma”, Frontiers in Oncology, 21 June 2019 https://doi.org/10.3389/fonc.2019.00541. 2019.
  • [26] Srinivasulu, C., Ramgopal, M., Ramanjaneyulu, G., Anuradha, C. M., and Suresh, K. C., “Syringic acid (SA) ‒ A review of its occurrence, biosynthesis, pharmacological and industrial importance”, Biomedicine and Pharmacotherapy, https://doi.org/10.1016/j.biopha.2018.09.069, 2018.
  • [27] Zduńska, K., Dana, A., Kolodziejczak, A., Rotsztejn, H., “Antioxidant properties of ferulic acid and its possible application”, Skin Pharmacology and Physiology, 31:332-336, 2018.
  • [28] Sun, M.Y., Ye, Y., Xiao, L., Rahman, K., Xia, W., Zhang, H., “Daidzein: A review of pharmacologıcal effects”, African Journal of Traditional, Complementary and Alternative Medicines, 13(3):117-132, 2016.
  • [29] Lin, Y., Shi, R., Wang, X., Shen, H.M., “Luteolin, a flavonoid with potential for cancer prevention and therapy”, Current Cancer Drug Targets, 8(7):634-646, 2008.
  • [30] Bae, J., Kim, N., Shin, Y., Kim, S.Y. and Kim, Y.J., “Activity of catechins and their applications”, Biomedical Dermatology, 4(8): 1-10, 2020.
  • [31] Shay, J., Elbaz, H.A., Lee, I., Zielske, S. P., Malek, M. H. and Hüttemann, M., “Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer”, Oxidative Medicine and Cellular Longevity, 2015, Article ID 181260, 1- 13, doi.org/10.1155/2015/1812602015.
There are 31 citations in total.

Details

Primary Language English
Journal Section Article
Authors

Nazan Demir 0000-0002-2177-7260

Sıla Nezahat Daşdemir 0000-0001-6268-6472

Alevcan Kaplan 0000-0001-6738-7527

Publication Date June 30, 2021
Submission Date May 5, 2021
Acceptance Date June 22, 2021
Published in Issue Year 2021 Volume: 7 Issue: 1

Cite

IEEE N. Demir, S. N. Daşdemir, and A. Kaplan, “BIOCHEMICA INVESTIGATION OF THE PHARMACEUTICAL AND COSMETIC USE OF NARCISSUS (Narcissus tazetta L. subsp. tazetta L.) GROWING NATURALLY AROUND IN MUĞLA, TURKEY”, MEJS, vol. 7, no. 1, pp. 46–55, 2021, doi: 10.51477/mejs.933062.
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