Clinical Research
Year 2024,
Volume: 6 Issue: 2, 165 - 170, 16.05.2024
Abstract
Aim: The study aims to ascertain whether Anzer Propolis, a natural antioxidant compound, can protect the kidneys from iopromide.
Material and Method: This study was done in 2021. Four groups of 32 adult male Wistar albino rats, weighing between 250 and 300 g, were formed. Control (C) group contained eight rats. Intraperitoneal ethanol was administered to the Ethanol (E) group (n=8), 8 g/kg intraperitoneal iopromide to the contrast-induced nephropathy (CIN) group (n=8), and a 100 mg/kg dose of Anzer Propolis on the date of application to the Anzer Propolis group (AP) (n=8), as well as the prior day, by gastric gavage and then 8 g/kg iopromide was administered intraperitoneally. Termination was carried out at the 48th hour. Histopathological examination was performed for CIN in the right and left kidneys.
Results: Following has been examined as a part of the research: serum urea, creatinine, IL6, interleukin (IL)-1β, total oxidant status (TOS), tumor necrosis factor (TNF-α), total antioxidant status (TAS), myeloperoxidase (MPO). TAS had a statistically significant increase in AP, in comparison to CIN, C and E groups (p<0.05). The pathological examination showed, vacuolar degeneration formations in tubular epithelial cells, and increase in mononuclear cell infiltration areas in the interstitial region in CIN. CIN had significantly higher values in comparison to AP (p<0.05).
Conclusion: Propolis protects the kidney tissue against the toxicity caused by CIN and negative effects of free radicals; most likely due to the antioxidant and antitoxic properties. Propolis is a promising natural substance for preventing CIN. There is a need for further research on the properties of propolis.
Ethical Statement
Etik kurul onayı eklenmiştir.
Supporting Institution
yok
Project Number
proje değildir.
Thanks
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References
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- Pattharanitima P, Tasanarong A. Pharmacological strategies to prevent contrast-induced acute kidney injury. BioMed Res Int. 2014;2014:236930.
- Mehran R, Dangas GD, Weisbord SD. Contrast-associated acute kidney injury. N Engl J Med. 2019;380:2146-55.
- Heyman SN, Rosen S, Khamaisi M, et al. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol. 2010;45:188-95.
- Anjum SI, Ullah A, Khan KA, et al. Composition and functional properties of propolis (bee glue): a review. Saudi J Biol Sci. 2019;26:1695-703.
- Kocot J, Kiełczykowska M, Luchowska-Kocot D, et al. Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application. Oxid Med Cell Longev. 2018;2018:7074209.
- Wolska K, Gorska A, Antosik K, et al. Immunomodulatory effects of propolis and its components on basic immune cell functions. Indian J Pharm Sci. 2019;81:575-88.
- Chiu H-F, Han Y-C, Shen Y-C, et al. Chemopreventive and chemotherapeutic effect of propolis and its constituents: a mini-review. J Cancer Prev. 2020;25:70-8.
- Kurek-Górecka A, Rzepecka-Stojko A, Górecki M, et al. Structure and antioxidant activity of polyphenols derived from propolis. Molecules. 2014;19:78-101.
- Asgharpour F, Moghadamnia AA, Motallebnejad M, et al. Propolis attenuates lipopolysaccharide-induced inflammatory responses through intracellular ROS and NO levels along with downregulation of IL-1β and IL-6 expressions in murine RAW 264.7 macrophages. J Food Biochem. 2019;43:e12926.
- Song J-J, Lim HW, Kim K, et al. Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2012;76:675-9.
- Günday M, Saritaş ZK, Demirel HH, et al. Does anzer propolis have a protective effect on rabbit spinal cord ischemia/reperfusion injury?. Braz J Cardiovasc Surg. 2021;37:65-73.
- Finn WF. The clinical and renal consequences of contrast-induced nephropathy. Nephrol Dial Transplant. 2006;21:i2-10.
- Zhang F, Z Lu, F Wang. Advances in the pathogenesis and prevention of contrast-induced nephropathy. Life Sci. 2020;259:118379.
- Buyuklu M, Kandemir FM, Ozkaraca M, et al. Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis. Eur Rev Med Pharmacol Sci. 2014;18:461-70.
- Baykara M, Silici S, Özçelik M, et al. In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy. Diagn Interv Radiol. 2015;21:317-21.
- Eraslan G, Kanbur M, Silici S, et al. Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2018;57:453-60.
- Aksoy F, Baş HA, Bağcı A, Basri Savaş H. Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction. Rev Port Cardiol (Engl Ed). 2020;40:489-97.
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- Wang K, Ping S, Huang S, et al. Molecular mechanisms underlying the in vitro anti-inflammatory effects of a flavonoid-rich ethanol extract from Chinese propolis (poplar type). Evid Based Complement Alternat Med. 2013;2013:127672.
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- Hudzik B, Szkodzinski J, Danikiewicz A, et al. Serum interleukin-6 concentration predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention. Eur Cytokine Netw. 2010;21:129-35.
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- Saritemur M, Un H, Cadirci E, et al. Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy. Environ Toxicol Pharmacol. 2015;39:577-88.
- Di Paola R, Genovese T, Impellizzeri D, et al. The renal injury and inflammation caused by ischemia–reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment. Eur J Pharmacol. 2013;700:134-46.
- Banda J, Duarte R, Dix-Peek T, et al. Biomarkers for diagnosis and prediction of outcomes in contrast-induced nephropathy. Int J Nephrol. 2020;2020:8568139.
- Yamamoto Y, Yamamoto N, Kanematsu Y, et al. High white blood cell count is a risk factor for contrast-induced nephropathy following mechanical thrombectomy for acute ischemic stroke. Cerebrovasc Dis Extra. 2020;10:59-65.
- Xu J, Zhang M, Ni Y, et al. Impact of low hemoglobin on the development of contrast-induced nephropathy: a retrospective cohort study. Exp Ther Med. 2016;12:603-10.
- McCullough PA, Choi JP, Feghali GA, et al. Contrast-induced acute kidney injury. J Am College Cardiol. 2016;68:1465-73.
Year 2024,
Volume: 6 Issue: 2, 165 - 170, 16.05.2024
Abstract
Project Number
proje değildir.
References
- Kusirisin P, Chattipakorn SC, Chattipakorn N. Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches. J Transl Med. 2020;18:400.
- Pattharanitima P, Tasanarong A. Pharmacological strategies to prevent contrast-induced acute kidney injury. BioMed Res Int. 2014;2014:236930.
- Mehran R, Dangas GD, Weisbord SD. Contrast-associated acute kidney injury. N Engl J Med. 2019;380:2146-55.
- Heyman SN, Rosen S, Khamaisi M, et al. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest Radiol. 2010;45:188-95.
- Anjum SI, Ullah A, Khan KA, et al. Composition and functional properties of propolis (bee glue): a review. Saudi J Biol Sci. 2019;26:1695-703.
- Kocot J, Kiełczykowska M, Luchowska-Kocot D, et al. Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application. Oxid Med Cell Longev. 2018;2018:7074209.
- Wolska K, Gorska A, Antosik K, et al. Immunomodulatory effects of propolis and its components on basic immune cell functions. Indian J Pharm Sci. 2019;81:575-88.
- Chiu H-F, Han Y-C, Shen Y-C, et al. Chemopreventive and chemotherapeutic effect of propolis and its constituents: a mini-review. J Cancer Prev. 2020;25:70-8.
- Kurek-Górecka A, Rzepecka-Stojko A, Górecki M, et al. Structure and antioxidant activity of polyphenols derived from propolis. Molecules. 2014;19:78-101.
- Asgharpour F, Moghadamnia AA, Motallebnejad M, et al. Propolis attenuates lipopolysaccharide-induced inflammatory responses through intracellular ROS and NO levels along with downregulation of IL-1β and IL-6 expressions in murine RAW 264.7 macrophages. J Food Biochem. 2019;43:e12926.
- Song J-J, Lim HW, Kim K, et al. Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2012;76:675-9.
- Günday M, Saritaş ZK, Demirel HH, et al. Does anzer propolis have a protective effect on rabbit spinal cord ischemia/reperfusion injury?. Braz J Cardiovasc Surg. 2021;37:65-73.
- Finn WF. The clinical and renal consequences of contrast-induced nephropathy. Nephrol Dial Transplant. 2006;21:i2-10.
- Zhang F, Z Lu, F Wang. Advances in the pathogenesis and prevention of contrast-induced nephropathy. Life Sci. 2020;259:118379.
- Buyuklu M, Kandemir FM, Ozkaraca M, et al. Protective effect of curcumin against contrast induced nephropathy in rat kidney: what is happening to oxidative stress, inflammation, autophagy and apoptosis. Eur Rev Med Pharmacol Sci. 2014;18:461-70.
- Baykara M, Silici S, Özçelik M, et al. In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy. Diagn Interv Radiol. 2015;21:317-21.
- Eraslan G, Kanbur M, Silici S, et al. Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2018;57:453-60.
- Aksoy F, Baş HA, Bağcı A, Basri Savaş H. Predictive value of oxidant and antioxidant status for contrast-induced nephropathy after percutaneous coronary intervention for ST-segment elevation myocardial infarction. Rev Port Cardiol (Engl Ed). 2020;40:489-97.
- Oweis AO, Alshelleh SA, Daoud AK, et al. Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study. Int J Nephrol Renovasc Dis. 2018;11:211-5.
- Wang K, Ping S, Huang S, et al. Molecular mechanisms underlying the in vitro anti-inflammatory effects of a flavonoid-rich ethanol extract from Chinese propolis (poplar type). Evid Based Complement Alternat Med. 2013;2013:127672.
- Nechemia-Arbely Y, Barkan D, Pizov G, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;19:1106-15.
- Hudzik B, Szkodzinski J, Danikiewicz A, et al. Serum interleukin-6 concentration predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention. Eur Cytokine Netw. 2010;21:129-35.
- Al-Otaibi KE, Al Elaiwi AM, Tariq M, Al-Asmari AK. Simvastatin attenuates contrast-induced nephropathy through modulation of oxidative stress, proinflammatory myeloperoxidase, and nitric oxide. Oxid Med Cell Longev. 2012;2012:831748.
- Sela S, Shurtz-Swirski R, Cohen-Mazor M, et al. Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease. J Am Soc Nephrol. 2005;16:2431-8. Erratum in: J Am Soc Nephrol. 2005;16:2814.
- Saritemur M, Un H, Cadirci E, et al. Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy. Environ Toxicol Pharmacol. 2015;39:577-88.
- Di Paola R, Genovese T, Impellizzeri D, et al. The renal injury and inflammation caused by ischemia–reperfusion are reduced by genetic inhibition of TNF-αR1: a comparison with infliximab treatment. Eur J Pharmacol. 2013;700:134-46.
- Banda J, Duarte R, Dix-Peek T, et al. Biomarkers for diagnosis and prediction of outcomes in contrast-induced nephropathy. Int J Nephrol. 2020;2020:8568139.
- Yamamoto Y, Yamamoto N, Kanematsu Y, et al. High white blood cell count is a risk factor for contrast-induced nephropathy following mechanical thrombectomy for acute ischemic stroke. Cerebrovasc Dis Extra. 2020;10:59-65.
- Xu J, Zhang M, Ni Y, et al. Impact of low hemoglobin on the development of contrast-induced nephropathy: a retrospective cohort study. Exp Ther Med. 2016;12:603-10.
- McCullough PA, Choi JP, Feghali GA, et al. Contrast-induced acute kidney injury. J Am College Cardiol. 2016;68:1465-73.
There are 30 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Nefroloji |
| Journal Section | Original Articles |
| Authors | |
| Project Number | proje değildir. |
| Publication Date | May 16, 2024 |
| Submission Date | November 17, 2023 |
| Acceptance Date | February 9, 2024 |
| Published in Issue | Year 2024 Volume: 6 Issue: 2 |
Chief Editors
Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye
Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye
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