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Serum 25-hidroksivitamin D ve Kalsiyum Düzeyleri ile İdiyopatik Benign Paroksismal Pozisyonel Vertigo Arasındaki İlişki

Year 2022, Volume: 6 Issue: 2, 133 - 137, 20.08.2022
https://doi.org/10.30565/medalanya.1066381

Abstract

Amaç: Kliniğimize baş dönmesi şikâyeti ile başvurup idiopathic benign paroksismal pozisyonel vertigo (BPPV) tanısı alan hastalar ile baş dönmesi olmayan sağlıklı kontrol grubunun 25-hidroksi vitamin D (25-OH vitamin D) ve Ca2+ düzeylerinin karşılaştırılması Ca2+ ve 25-OH vitamin D’nin BPPV gelişimindeki rolünün araştırılmasıdır.

Gereç ve Yöntem: Çalışmamız geriye dönük vaka kontrol çalışması olup, 01.01.2018-01.08.2021 arası Alanya Egitim ve Araştırma Hastanesi Nöroloji polikliniğine başvuran İdiopatik BPPV tanısı alan 409 hasta ile kontrol grubu olarak kliniğimize başvuru öncesi son 1 yıl içerisinde vertigo, dizziness ya da dengesizlik nedeniyle hekim başvurusu olmayan serum D vitamini düzeyi ölçümü yapılmış 338 hasta seçilerek oluşturuldu. İstatiksel değerlendirmeler için ki-kare ve T testi testi kullanıldı.

Bulgular: Ortalama serum 25-OH vitamin D düzeyleri BPPV ve kontrol grubunda sırasıyla 15,74 ng/mL ve 17,91 ng/mL idi. Serum 25-OH vitamin D düzeyleri BPPV grubunda kontrol grubuna göre anlamlı derecede düşük bulundu (p=0,01, p<0,05). Ortalama serum Ca2+ düzeyleri BPPV ve kontrol grubunda anlamlı farklılık göstermedi.

Sonuç: Düşük 25-OH vitamin D serum seviyeleri BPPV gelişimi ile diğer anahtar belirteçlerden bağımsız olarak ilişkilidir.

References

  • 1. Bayındır T, Kalcıoğlu MT, Periferik Vertigo. İnönü Üniversitesi Tıp Fakültesi Dergisi.2010;17 (2) 155-163.
  • 2. Güler İ, Baklacı D, Kuzucu İ, Kum RO, Özcan M. Benign Paroksismal Pozisyonel Vertigolu Hastalarda Serum 25-Hidroksi Vitamin D Düzeylerinde Azalma. KBB-Forum. 2018;17(2) 35-39.
  • 3. Ding J, Liu L, Kong W, Chen X and Liu X. Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo. Bioscience Reports. 2019; 39(4):BSR20190142 doi: 10.1042/BSR20190142.
  • 4. Schuknecht HF. Cupulolithiasis. Arch Otolaryngol. 1969;90(6):765-78. doi: 10.1001/archotol.1969.00770030767020.
  • 5. Epley JM. Positional vertigo related to semicircular canalithiasis. Otolaryngol Head Neck Surg. 1995;112(1):154-61. doi: 10.1016/S0194-59989570315-2.
  • 6. Hall S, Ruby R, McClure J. The mechanics of benign paroxysmal vertigo. J Otolaryngol .1979;8(2):151-8. PMID: 430582.
  • 7. Walther LE, Blodow A, Buder J, Kniep R. Principles of calcite dissolution in human and artificial otoconia. PLoS One. 2014;9(7):e102516. doi: 10.1371/journal.pone.0102516
  • 8. Jeong S, Kim JS. Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. J Neurol Phys Ther. 2019;43 Suppl 2:S37-S41. doi: 10.1097/NPT.0000000000000273.
  • 9. Talaat HS, Abuhadied G, Talaat AS, Abdelaal MS. Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol. 2015;272(9):2249-53. doi: 10.1007/s00405-014-3175-3.
  • 10. Serrano MA. Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population. Sci Total Environ. 2018;619-620:545-51. doi: 10.1016/j.scitotenv.2017.11.036.
  • 11. Jeong SH, Kim JS, Shin JW, Kim S, Lee H, Lee AY et al. Decreased serum vitamin D in idiopathic benign paroxysmal positional vertigo. J Neurol. 2013;260(3):832-8. doi: 10.1007/s00415-012-6712-2.
  • 12. Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, Talaat AS. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx. 2016;43(3):237-41. doi: 10.1016/j.anl.2015.08.009.
  • 13. Yamauchi D, Raveendran NN, Pondugula SR, Kampalli SB, Sanneman JD, Harbidge DG et al. Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1353-7. doi: 10.1016/j.bbrc.2005.04.053.
  • 14. Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvälä H et al. Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. 2009;114(3-5):161-6. doi: 10.1016/j.jsbmb.2009.01.020.
  • 15. Sheikhzadeh M, Lotfi Y, Mousavi A, Heidari B, Bakhshi E. The effect of serum vitamin D normalization in preventing recurrences of benign paroxysmal positional vertigo: A case-control study. Caspian J Intern Med. 2016;7(3):173-7. PMID: 27757201.
  • 16. Büki B, Ecker M, Jünger H, Lundberg YW. Vitamin D deficiency and benign paroxysmal positioning vertigo. Med Hypotheses. 2013;80(2):201-4. doi: 10.1016/j.mehy.2012.11.029.
  • 17. Gu X, Dong F, Gu J. Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Exp Ther Med. 2018;15(3):2321-2326. doi: 10.3892/etm.2018.5699. PMID: 29456639.
  • 18. Vibert D, Kompis M, Häusler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol. 2003 Oct;112(10):885-9. doi: 10.1177/000348940311201010.
  • 19. Rhim GI. Serum vitamin D and recurrent benign paroxysmal positional vertigo. Laryngoscope Investig Otolaryngol. 2016 Oct 20;1(6):150-153. doi: 10.1002/lio2.35.
  • 20. Karataş A, Acar Yüceant G, Yüce T, Hacı C, Cebi IT, Salviz M. Association of Benign Paroxysmal Positional Vertigo with Osteoporosis and Vitamin D Deficiency: A Case Controlled Study. J Int Adv Otol. 2017 Aug;13(2):259-65. doi: 10.5152/iao.2016.2640.
  • 21. Sanyelbhaa H, Sanyelbhaa A. Vestibular-evoked myogenic potentials and subjective visual vertical testing in patients with vitamin D deficiency/insufficiency. Eur Arch Otorhinolaryngol. 2015;272(11):3233-9. doi: 10.1007/s00405-014-3395-6.
  • 22. Parham K, Leonard G, Feinn RS, Lafreniere D, Kenny AM. Prospective clinical investigation of the relationship between idiopathic benign paroxysmal positional vertigo and bone turnover: a pilot study. Laryngoscope. 2013 Nov;123(11):2834-9. doi: 10.1002/lary.24162.

The Relationship Between Serum 25-hydroxyvitamin D and Calcium Levels and Idiopathic Benign Paroxysmal Positional Vertigo

Year 2022, Volume: 6 Issue: 2, 133 - 137, 20.08.2022
https://doi.org/10.30565/medalanya.1066381

Abstract

Aim: We aimed to compare 25-hydroxy vitamin D (25-OH vitamin D) and Ca2+ levels of patients admitted to our clinic with the complaint of dizziness and diagnosed with idiopathic benign paroxysmal positional vertigo (BPPV) with those of healthy control group without dizziness and investigate the role of Ca2+ and 25-OH vitamin D in the development of BPPV.

Material and methods: This study is a retrospective case-control study. The study sample consisted of 409 patients admitted to Alanya Training and Research Hospital Neurology outpatient clinic and diagnosed with idiopathic BPPV between 01.01.2018 and 01.08.2021, and of 338 control patients without any physician consultation due to vertigo, dizziness or imbalance in the last 1 year before admission to our clinic and whose serum vitamin D levels were measured, the Chi-square and T-test were utilized for statistical analysis.

Results: Mean blood 25-OH vitamin D levels were 15.74 ng/mL and 17.91 ng/mL in BPPV and control groups, respectively. Serum 25-OH vitamin D levels were significantly lower in BPPV group than control group (p=0.01, p<0.05). Mean serum Ca2+ levels did not exhibit any difference in BPPV and control groups.

Conclusion: Decreased serum levels of 25-OH vitamin D have been associated with the occurrence of BPPV independently of other key markers.

References

  • 1. Bayındır T, Kalcıoğlu MT, Periferik Vertigo. İnönü Üniversitesi Tıp Fakültesi Dergisi.2010;17 (2) 155-163.
  • 2. Güler İ, Baklacı D, Kuzucu İ, Kum RO, Özcan M. Benign Paroksismal Pozisyonel Vertigolu Hastalarda Serum 25-Hidroksi Vitamin D Düzeylerinde Azalma. KBB-Forum. 2018;17(2) 35-39.
  • 3. Ding J, Liu L, Kong W, Chen X and Liu X. Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo. Bioscience Reports. 2019; 39(4):BSR20190142 doi: 10.1042/BSR20190142.
  • 4. Schuknecht HF. Cupulolithiasis. Arch Otolaryngol. 1969;90(6):765-78. doi: 10.1001/archotol.1969.00770030767020.
  • 5. Epley JM. Positional vertigo related to semicircular canalithiasis. Otolaryngol Head Neck Surg. 1995;112(1):154-61. doi: 10.1016/S0194-59989570315-2.
  • 6. Hall S, Ruby R, McClure J. The mechanics of benign paroxysmal vertigo. J Otolaryngol .1979;8(2):151-8. PMID: 430582.
  • 7. Walther LE, Blodow A, Buder J, Kniep R. Principles of calcite dissolution in human and artificial otoconia. PLoS One. 2014;9(7):e102516. doi: 10.1371/journal.pone.0102516
  • 8. Jeong S, Kim JS. Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. J Neurol Phys Ther. 2019;43 Suppl 2:S37-S41. doi: 10.1097/NPT.0000000000000273.
  • 9. Talaat HS, Abuhadied G, Talaat AS, Abdelaal MS. Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol. 2015;272(9):2249-53. doi: 10.1007/s00405-014-3175-3.
  • 10. Serrano MA. Contribution of sun exposure to the vitamin D dose received by various groups of the Spanish population. Sci Total Environ. 2018;619-620:545-51. doi: 10.1016/j.scitotenv.2017.11.036.
  • 11. Jeong SH, Kim JS, Shin JW, Kim S, Lee H, Lee AY et al. Decreased serum vitamin D in idiopathic benign paroxysmal positional vertigo. J Neurol. 2013;260(3):832-8. doi: 10.1007/s00415-012-6712-2.
  • 12. Talaat HS, Kabel AM, Khaliel LH, Abuhadied G, El-Naga HA, Talaat AS. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx. 2016;43(3):237-41. doi: 10.1016/j.anl.2015.08.009.
  • 13. Yamauchi D, Raveendran NN, Pondugula SR, Kampalli SB, Sanneman JD, Harbidge DG et al. Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1353-7. doi: 10.1016/j.bbrc.2005.04.053.
  • 14. Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvälä H et al. Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. 2009;114(3-5):161-6. doi: 10.1016/j.jsbmb.2009.01.020.
  • 15. Sheikhzadeh M, Lotfi Y, Mousavi A, Heidari B, Bakhshi E. The effect of serum vitamin D normalization in preventing recurrences of benign paroxysmal positional vertigo: A case-control study. Caspian J Intern Med. 2016;7(3):173-7. PMID: 27757201.
  • 16. Büki B, Ecker M, Jünger H, Lundberg YW. Vitamin D deficiency and benign paroxysmal positioning vertigo. Med Hypotheses. 2013;80(2):201-4. doi: 10.1016/j.mehy.2012.11.029.
  • 17. Gu X, Dong F, Gu J. Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. Exp Ther Med. 2018;15(3):2321-2326. doi: 10.3892/etm.2018.5699. PMID: 29456639.
  • 18. Vibert D, Kompis M, Häusler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol. 2003 Oct;112(10):885-9. doi: 10.1177/000348940311201010.
  • 19. Rhim GI. Serum vitamin D and recurrent benign paroxysmal positional vertigo. Laryngoscope Investig Otolaryngol. 2016 Oct 20;1(6):150-153. doi: 10.1002/lio2.35.
  • 20. Karataş A, Acar Yüceant G, Yüce T, Hacı C, Cebi IT, Salviz M. Association of Benign Paroxysmal Positional Vertigo with Osteoporosis and Vitamin D Deficiency: A Case Controlled Study. J Int Adv Otol. 2017 Aug;13(2):259-65. doi: 10.5152/iao.2016.2640.
  • 21. Sanyelbhaa H, Sanyelbhaa A. Vestibular-evoked myogenic potentials and subjective visual vertical testing in patients with vitamin D deficiency/insufficiency. Eur Arch Otorhinolaryngol. 2015;272(11):3233-9. doi: 10.1007/s00405-014-3395-6.
  • 22. Parham K, Leonard G, Feinn RS, Lafreniere D, Kenny AM. Prospective clinical investigation of the relationship between idiopathic benign paroxysmal positional vertigo and bone turnover: a pilot study. Laryngoscope. 2013 Nov;123(11):2834-9. doi: 10.1002/lary.24162.
There are 22 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Research Article
Authors

Ahmet Özşimşek 0000-0003-0696-6749

Ertan Karaçay 0000-0002-3851-8644

Early Pub Date August 20, 2022
Publication Date August 20, 2022
Submission Date February 15, 2022
Acceptance Date May 15, 2022
Published in Issue Year 2022 Volume: 6 Issue: 2

Cite

Vancouver Özşimşek A, Karaçay E. The Relationship Between Serum 25-hydroxyvitamin D and Calcium Levels and Idiopathic Benign Paroxysmal Positional Vertigo. Acta Med. Alanya. 2022;6(2):133-7.

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