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Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage

Year 2016, Volume: 20 Issue: 3, 243 - 251, 14.03.2016

Abstract

Valproic acid (2-n-propylpentanoic acid, VPA),the most widely used antiepileptic drug, has potential adverse effects and it can disrupt the oxidant and antioxidant balance. Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one, EDA) is a potent free radical scavenger. In this study, the effect of EDA on gingiva in VPA induced toxicity was investigated. Female Sprague Dawley rats were randomly divided into four groups: control group, EDA (30 mg/kg/day) given group, VPA (0.5 g/kg/day) given group,  and VPA+EDA (in same dose and time) given group. EDA and VPA were given intraperitoneally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and reduced glutathione (GSH) levels and catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), myeloperoxidase (MPO), alkaline phosphatase (ALP), acid phosphatase (ACP), sodium potassium ATPase (Na+/K+-ATPase) and tissue factor (TF) activities were determined in gingiva homogenates. The VPA-induced increases were statistically significant for MPO (p<0.01), ACP (p<0.01), Na+/K+-ATPase (p<0.05) and TF (p<0.01) activities, but not for LPO level and ALP activities.  EDA treatment markedly blunted all such elevated anomalies. Conclusively: VPA induced oxidative- and inflammatory-gingival tissue damage, reactions that were appreciably reversed by concurrent administration of EDA.

 

Key words: Gingiva, valproic acid, edaravone,  oxidative stress, inflammation

Year 2016, Volume: 20 Issue: 3, 243 - 251, 14.03.2016

Abstract

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Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Şehkar Oktay

Burcin Alev This is me

Leyla Koc Ozturk This is me

Sevim Tunali This is me

Sezin Demirel This is me

Ebru Emekli Alturfan

Tugba Tunali-akbay

Serap Akyuz This is me

Refiye Yanardag

Aysen Yarat

Publication Date March 14, 2016
Published in Issue Year 2016 Volume: 20 Issue: 3

Cite

APA Oktay, Ş., Alev, B., Koc Ozturk, L., Tunali, S., et al. (2016). Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharmaceutical Journal, 20(3), 243-251. https://doi.org/10.12991/mpj.20162096267
AMA Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharm J. May 2016;20(3):243-251. doi:10.12991/mpj.20162096267
Chicago Oktay, Şehkar, Burcin Alev, Leyla Koc Ozturk, Sevim Tunali, Sezin Demirel, Ebru Emekli Alturfan, Tugba Tunali-akbay, Serap Akyuz, Refiye Yanardag, and Aysen Yarat. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal 20, no. 3 (May 2016): 243-51. https://doi.org/10.12991/mpj.20162096267.
EndNote Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A (May 1, 2016) Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharmaceutical Journal 20 3 243–251.
IEEE Ş. Oktay, “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”, Marmara Pharm J, vol. 20, no. 3, pp. 243–251, 2016, doi: 10.12991/mpj.20162096267.
ISNAD Oktay, Şehkar et al. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal 20/3 (May 2016), 243-251. https://doi.org/10.12991/mpj.20162096267.
JAMA Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharm J. 2016;20:243–251.
MLA Oktay, Şehkar et al. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal, vol. 20, no. 3, 2016, pp. 243-51, doi:10.12991/mpj.20162096267.
Vancouver Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharm J. 2016;20(3):243-51.