Research Article
Year 2023,
Volume: 18 Issue: 3, 29 - 36, 20.11.2023
Abstract
Amaç: Amacımız obez ve normal kilolu bireylerde vaspin ve galanin düzeylerini karşılaştırmak, bu parametrelerin obezite ve diğer ilişkili parametrelerle ilişkili olup olmadığını ortaya çıkarmak.
Gereç ve Yöntemler: Çalışmaya obezitesi olan 40 hasta ve 40 kontrol alındı. Biyokimyasal parametreler hasta dosyalarından kaydedildi. Hastalardan alınan kan örneklerinin santrifüjlenmesi sonucu elde edilen örnekten galanin ve vaspin düzeyleri çalışıldı.
Bulgular: Gruplar cinsiyet ve yaş açısından birbirine benzerdi (p>0.05). Obezitesi olan grupta galanin düzeyleri kontrol grubuna göre daha yüksekti (p<0,001). Vaspin düzeyleri obezitesi olan grupta kontrol grubuna göre daha yüksekti ancak istatistiksel olarak anlamlı değildi (p>0.05). Hasta grubunda glukoz, insülin, trigliserit ve LDL-C düzeyleri kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksekti (p<0,001). TSH açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Sırasıyla galanin ve glukoz, insülin ve BMI ile istatistiksel olarak anlamlı bir pozitif korelasyon bulundu (p<0.001, r=0.401; p<0.001, r=0.519; p<0.001, r=0.714). Ayrıca vaspin ile insülin, vücut kitle indeksi (VKİ) arasında sırasıyla istatistiksel olarak anlamlı pozitif korelasyon vardı (p=0.05,r=0.222;p=0.03, r=0.238).
Sonuçlar: Sonuçlarımız, obez kişilerde yüksek serum galanin ve vaspin konsantrasyonlarının kilo alımının bir sonucu olabileceğini veya obezitenin patogenezinde rol oynayan birçok faktörden biri olabileceğini göstermektedir.
Keywords
Supporting Institution
Kahramanmaraş Sütçü İmam Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi
Project Number
2020/3-17 D
References
- Türkiye Endokrinoloji ve Metabolizma Derneği. Obezite Tanı, Tedavi ve İzlem Kılavuzu. 8. Basım,s. 11, BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti, Ankara, 2019.
- Eichelmann F, Rudovich N, Pfeiffer AF, Schulze MB, Giuseppe RD, Boeing H, et al. Novel adipokines: Methodological utility in human obesity research. Int. J. Obes. 2017;41:976–981.
- Jeong E, Youn BS, Kim DW, Kim EH, Park JW, Namkoong C. et al. Circadian rhythm of serum vaspin in healthy male volunteers: Relation to meals. J. Clin. Endocrinol. Metab. 2010;95:1869–1875.
- Leibowitz SF, Wortley KE. Hypothalamic control of energy balance: different peptides, different functions. Peptides. 2004;25:473–504.
- Lang R, Gundlach AL, Holmes FE, et al. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacol Rev. 2015;67:118–75.
- Fang P, Yu M, Guo L, et al. Galanin and its receptors: a novel strategy for appetite control and obesity therapy. Peptides. 2012;36:331–9.
- Lago F, Dieguez C, Gómez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol. 2007;3:716–724.
- Antuna-Puente B, Feve B, Fellahi S, Bastard JP. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab. 2008;34(1):2-11
- Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents, N Engl J Med. 2004;350:2362-2374.
- Nedvidkova J, Smitka K, Kopsky V, et al. Adiponectin, an adipocyte-derived protein. Physiol Res. 2005;54:133-40.
- Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clinical Endocrinology. 2006;64:355-365.
- Blüher M. Clinical relevance of adipokines. Diabetes Metab J. 2012;36:317-327.
- Szekely M, Petervari E, Balasko M, Thermoregulation, energy balance, regulatory peptides: recent developments. Front. Biosci. 2010;1:1009-1046.
- Szekely M, Balasko M, Soos S, Petervari E. Peptidergic regulation of food intake: changes related to age and body composition. Morrison JL (Ed.), Food Intake: Regulation, Assessing and Controlling. New York: Nova Science Publishers Inc, 2012; 83-104.
- Holmes A, Kinney JW, Wrenn CC, Li Q, Yang RJ, Ma L, et al. Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behav-ior specific to the elevated plus-maze. Neuropsychopharmacology. 2003;28(6):1031-1044.
- Wrenn CC, Kinney JW, Marriott LK, Holmes A, Harris AP, Saavedra MC, et al. Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. Eur J Neurosci. 2004;19:1384-1396.
- Lang R, Kofler B. The galanin peptide family in inflammation. Neuropeptides. 2011 Feb;45(1):1-8.
- Leibowitz SF, Akabayashi A, Wang J. Obesity On A High-Fat Diet, Role Of Hypothalamic Galanin in Neurons of the Anterior Paraventricular Nucleus Projecting to the Median Eminence. Journal of Neuroscience. 1998;18(7):2709-2719.
- Leibowitz SF Avena NM, Chang GQ, Karatayev O, Chau DT, Hoebel BG. Ethanol İntake İncreases Galanin Mrna in the Hypothalamus and Withdrawal Decreases it. Physiology Behavior. 2003;79(1):103-111.
- Zhang Z, Gu C, Fang P, Shi M, Wang Y, Peng Y, et al. Endogenous galanin as a novel biomarker to predict gestational diabetes mellitus. Peptides. 2014;54:186- 189.
- Crawley JN, Austin MC, Fiske SM, Martin B, Consolo S, Berthold M, et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J Neurosci. 1990;10(11): 3695-3700.
- Baranowska B, Radzikowska M, Wasilewska-Dziubínska E, Roguski K, Polonowski A. Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women. Menopause. 2000;7:149-55.
- Joseph L, Pilote L. Obesity and C‐Reactive Protein in Various Populations: A Systematic Review and Meta‐Analysis. Obesity Reviews. 2013; 14(3): 232-244.
- Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, et al. Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test. Sci Rep. 2016; 6: 31661-31665.
- Zhang Z, Fang P, Shi M, Gu C, Wang Y, Bo P, et al. Association between circulating levels of galanin and pre-pregnancy body mass index in patients with gestational diabetes mellitus. Eating Behaviors. 2015;19:57–60.
- Fang P, Bo P, Shi M, Yu M, Zhang Z. Circulating galanin levels are increased in patients with gestational diabetes mellitus. Clin Biochem. 2013; 46: 831-833.
- Fang P, Shi M, Zhu Y, Bo P, Zhang Z. Type 2 diabetes mellitus as a disorder of galanin resistance. Exp Gerontol. 2016;73:72-77.
- Acar S, Paketçi A, Küme T, Demir K, Çalan Ö, Böber E, Abacı A. Positive correlation of galanin with insulin resistance and triglyceride levels in obese children Turk J Med Sci. 2018 Jun 14;48(3):560-568.
- Fang P, Yu M, Gu X, Shi M, Zhu Y, Zhang Z, et al. Low levels of plasma galanin in obese subjects with hypertension. J Endocrinol Invest. 2017;40:63–68.
- Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-Quintela A, Martínez JA, et al. Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J Mol Sci. 2017 ;18(8):1770.
- Blüher M. Vaspin in obesity and diabetes: pathophysiological and clinical significance. Endocrine. 2012 Apr;41(2):176-82.
- Yang W, Li Y, Tian, T, Wang L, Lee P, Hua Q. Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications. BMC Endocrine Disorders. 2017;17(1):67.
- Klöting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön MR, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun. 2006;339(1):430-6.
- Auguet, T, Quintero Y, Riesco, et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Medical Genetics. 2011;1471; 6-12.
- Chang HM, Lee HJ, Park HS, Kang J. H, Kim K. S, Song YS, et al. Effects of weight reduction on serum vaspin concentrations in obese subjects: Modification by insulin resistance. Obesity. 2010;18(11): 2105–2110.
- Samad Akbarzadeh, Iraj Nabipour, Serum visfatin and vaspin levels in normoglycemic first-degree relatives of Iranian patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice. 2012;95:132-8.
- Liu S, Duan R, Wu Y, Du F, Zhang J, Li X. et al. Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms. Sci Rep. 2018;8:13542.
- Alghannam M A, Khalefa AA, Alaleem DIA, Ahmad AA. Plasma Vaspin Levels in Relation to Diet Induced Metabolic Disturbance in Rats. International Journal of Diabetes Research. 2013;6:112–122.
- Saboori S, Hosseinzadeh-Attar MJ, Yousefi Rad E, Hosseini M, Mirzaei K, Ahmadivand Z. The comparison of serum vaspin and visfatin concentrations in obese and normal weight women. Diabetes Metabolism Syndrome. 2015;9(4):320-323.
- Sathyaseelan AJ, Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome, Journal of Clinical and Diagnostic Research. 2016;10:7-10.
Year 2023,
Volume: 18 Issue: 3, 29 - 36, 20.11.2023
Abstract
Objective: Our aim was to compare vaspin and galanin in obese and normal weight individuals, to reveal whether these parameters are related to obesity and other related parameters.
Material and Methods: Forty patients with obesity and 40 control subjects were included in the study. Biochemical parameters were recorded from patient’s files. Galanin and vaspin levels were studied from the sample obtained as a result of centrifugation of blood samples taken from the patients.
Results: The groups were similar to each other in terms of gender and age (p>0.05). Galanine levels were higher in the group with obesity compared to the control group (p<0.001). Vaspin levels were higher in the group with obesity compared to the control group, but it was not statistically significant (p>0.05). Glucose, insulin, triglyceride and low-density lipoprotein cholesterol (LDL-C) levels were statistically significantly higher in the patient group than in the control group (p<0.001). There was no statistically significant difference in terms of thyroid stimulating hormone (TSH) (p>0.05). A statistically significant positive correlation was found with galanin, glucose, insulin, and body mass index (BMI), respectively (p<0.001, r=0.401; p <0.001, r=0.519; p <0.001, r=0.714). Also there was statistically significant positive correlation between vaspin and insulin, BMI, respectively (p=0.05, r=0.222; p=0.03, r=0.238).
Conclusion: Our results show that high serum concentrations of galanin and vaspin in obese subjects may be the result of weight gain or may be one of many factors involved in the pathogenesis of obesity.
Keywords
Project Number
2020/3-17 D
References
- Türkiye Endokrinoloji ve Metabolizma Derneği. Obezite Tanı, Tedavi ve İzlem Kılavuzu. 8. Basım,s. 11, BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti, Ankara, 2019.
- Eichelmann F, Rudovich N, Pfeiffer AF, Schulze MB, Giuseppe RD, Boeing H, et al. Novel adipokines: Methodological utility in human obesity research. Int. J. Obes. 2017;41:976–981.
- Jeong E, Youn BS, Kim DW, Kim EH, Park JW, Namkoong C. et al. Circadian rhythm of serum vaspin in healthy male volunteers: Relation to meals. J. Clin. Endocrinol. Metab. 2010;95:1869–1875.
- Leibowitz SF, Wortley KE. Hypothalamic control of energy balance: different peptides, different functions. Peptides. 2004;25:473–504.
- Lang R, Gundlach AL, Holmes FE, et al. Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity. Pharmacol Rev. 2015;67:118–75.
- Fang P, Yu M, Guo L, et al. Galanin and its receptors: a novel strategy for appetite control and obesity therapy. Peptides. 2012;36:331–9.
- Lago F, Dieguez C, Gómez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol. 2007;3:716–724.
- Antuna-Puente B, Feve B, Fellahi S, Bastard JP. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab. 2008;34(1):2-11
- Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents, N Engl J Med. 2004;350:2362-2374.
- Nedvidkova J, Smitka K, Kopsky V, et al. Adiponectin, an adipocyte-derived protein. Physiol Res. 2005;54:133-40.
- Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clinical Endocrinology. 2006;64:355-365.
- Blüher M. Clinical relevance of adipokines. Diabetes Metab J. 2012;36:317-327.
- Szekely M, Petervari E, Balasko M, Thermoregulation, energy balance, regulatory peptides: recent developments. Front. Biosci. 2010;1:1009-1046.
- Szekely M, Balasko M, Soos S, Petervari E. Peptidergic regulation of food intake: changes related to age and body composition. Morrison JL (Ed.), Food Intake: Regulation, Assessing and Controlling. New York: Nova Science Publishers Inc, 2012; 83-104.
- Holmes A, Kinney JW, Wrenn CC, Li Q, Yang RJ, Ma L, et al. Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behav-ior specific to the elevated plus-maze. Neuropsychopharmacology. 2003;28(6):1031-1044.
- Wrenn CC, Kinney JW, Marriott LK, Holmes A, Harris AP, Saavedra MC, et al. Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor. Eur J Neurosci. 2004;19:1384-1396.
- Lang R, Kofler B. The galanin peptide family in inflammation. Neuropeptides. 2011 Feb;45(1):1-8.
- Leibowitz SF, Akabayashi A, Wang J. Obesity On A High-Fat Diet, Role Of Hypothalamic Galanin in Neurons of the Anterior Paraventricular Nucleus Projecting to the Median Eminence. Journal of Neuroscience. 1998;18(7):2709-2719.
- Leibowitz SF Avena NM, Chang GQ, Karatayev O, Chau DT, Hoebel BG. Ethanol İntake İncreases Galanin Mrna in the Hypothalamus and Withdrawal Decreases it. Physiology Behavior. 2003;79(1):103-111.
- Zhang Z, Gu C, Fang P, Shi M, Wang Y, Peng Y, et al. Endogenous galanin as a novel biomarker to predict gestational diabetes mellitus. Peptides. 2014;54:186- 189.
- Crawley JN, Austin MC, Fiske SM, Martin B, Consolo S, Berthold M, et al. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. J Neurosci. 1990;10(11): 3695-3700.
- Baranowska B, Radzikowska M, Wasilewska-Dziubínska E, Roguski K, Polonowski A. Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women. Menopause. 2000;7:149-55.
- Joseph L, Pilote L. Obesity and C‐Reactive Protein in Various Populations: A Systematic Review and Meta‐Analysis. Obesity Reviews. 2013; 14(3): 232-244.
- Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, et al. Serum galanin levels in young healthy lean and obese non-diabetic men during an oral glucose tolerance test. Sci Rep. 2016; 6: 31661-31665.
- Zhang Z, Fang P, Shi M, Gu C, Wang Y, Bo P, et al. Association between circulating levels of galanin and pre-pregnancy body mass index in patients with gestational diabetes mellitus. Eating Behaviors. 2015;19:57–60.
- Fang P, Bo P, Shi M, Yu M, Zhang Z. Circulating galanin levels are increased in patients with gestational diabetes mellitus. Clin Biochem. 2013; 46: 831-833.
- Fang P, Shi M, Zhu Y, Bo P, Zhang Z. Type 2 diabetes mellitus as a disorder of galanin resistance. Exp Gerontol. 2016;73:72-77.
- Acar S, Paketçi A, Küme T, Demir K, Çalan Ö, Böber E, Abacı A. Positive correlation of galanin with insulin resistance and triglyceride levels in obese children Turk J Med Sci. 2018 Jun 14;48(3):560-568.
- Fang P, Yu M, Gu X, Shi M, Zhu Y, Zhang Z, et al. Low levels of plasma galanin in obese subjects with hypertension. J Endocrinol Invest. 2017;40:63–68.
- Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-Quintela A, Martínez JA, et al. Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J Mol Sci. 2017 ;18(8):1770.
- Blüher M. Vaspin in obesity and diabetes: pathophysiological and clinical significance. Endocrine. 2012 Apr;41(2):176-82.
- Yang W, Li Y, Tian, T, Wang L, Lee P, Hua Q. Serum vaspin concentration in elderly patients with type 2 diabetes mellitus and macrovascular complications. BMC Endocrine Disorders. 2017;17(1):67.
- Klöting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön MR, et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun. 2006;339(1):430-6.
- Auguet, T, Quintero Y, Riesco, et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Medical Genetics. 2011;1471; 6-12.
- Chang HM, Lee HJ, Park HS, Kang J. H, Kim K. S, Song YS, et al. Effects of weight reduction on serum vaspin concentrations in obese subjects: Modification by insulin resistance. Obesity. 2010;18(11): 2105–2110.
- Samad Akbarzadeh, Iraj Nabipour, Serum visfatin and vaspin levels in normoglycemic first-degree relatives of Iranian patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice. 2012;95:132-8.
- Liu S, Duan R, Wu Y, Du F, Zhang J, Li X. et al. Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms. Sci Rep. 2018;8:13542.
- Alghannam M A, Khalefa AA, Alaleem DIA, Ahmad AA. Plasma Vaspin Levels in Relation to Diet Induced Metabolic Disturbance in Rats. International Journal of Diabetes Research. 2013;6:112–122.
- Saboori S, Hosseinzadeh-Attar MJ, Yousefi Rad E, Hosseini M, Mirzaei K, Ahmadivand Z. The comparison of serum vaspin and visfatin concentrations in obese and normal weight women. Diabetes Metabolism Syndrome. 2015;9(4):320-323.
- Sathyaseelan AJ, Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome, Journal of Clinical and Diagnostic Research. 2016;10:7-10.
There are 40 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Araştırma Makaleleri |
| Authors | |
| Project Number | 2020/3-17 D |
| Early Pub Date | November 10, 2023 |
| Publication Date | November 20, 2023 |
| Submission Date | July 4, 2022 |
| Acceptance Date | October 11, 2022 |
| Published in Issue | Year 2023 Volume: 18 Issue: 3 |
