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Nutrient Composition and Functional Properties of Black Elderberry (Sambucus nigra L.)

Year 2021, Volume: 11 Issue: 2, 1140 - 1153, 01.06.2021
https://doi.org/10.21597/jist.765296

Abstract

Black elderberry (Sambucus nigra) is a plant species in the Adoxaceae family and native to Europe, Asia, North Africa and the USA. Black elderberry plant has the round-shaped, purple-black colored, 3-5 seeded, small fruits. The chemical structure of Sambucus species consists of major compounds, flavonoids, phenolic acids, anthocyanidols, triterpenes, lectins, cyanogenic heterosides and essential oils. Elderberry species contain significant amounts of lectins. Elderberry fruits show high antioxidant activity with rich anthocyanin content. It has therapeutic effects against many diseases like cold, flu, cancer, diabetes in human health, thanks to its antioxidant activity. In addition to its antioxidant properties; It also shows various activities such as antiviral, antidepressant, anti-inflammatory, and anticarcinogenic. Black elderberry, with all those properties, is a plant that has the potential to make an important contribution to the enrichment and/or development of modern food and medicinal products. This article reviews the studies on the nutritional content and functional properties of black elderberry fruit and aims to shed light on future studies.

References

  • Abuja P M, Murkovic M, Pfannhauser W, 1998. Antioxidant and Prooxidant Activities of Elderberry (Sambucus nigra) Extract in Low-density Lipoprotein Oxidation. Journal of Agricultural and Food Chemistry, 46: 4091-4096.
  • Ağalar HG, 2019. Elderberry (Sambucus nigra L.). In Nonvitamin and Nonmineral Nutritional Supplements. Academic Press, pp. 211-215. Anonim, 2020. United States Department of Agriculture USDA Food Composition Databases, https://fdc.nal.usda.gov/fdc-app.html#/food-details/171727/nutrients (Erişim Tarihi: 02.07.2020).
  • Antolak H, Czy˙zowska A, Kr˛egiel D, 2017. Antibacterial and Antiadhesive Activities of Extracts From Edible Plants Against Soft Drink Spoilage by Asaia spp.. Journal of Food Protection, 80, 25-34.
  • Arslanoğlu Ş F, Sert S, Özdemir M, 2019. Anadolu Coğrafyasında Yayılış Gösteren Sambucus nigra ve Sambucus ebulus’un tıbbi bitki olarak önemi, Haziran-Temmuz 2019, 58-62.
  • Atkinson, M, 1979. Herbs for Your Health. Dalesman Books, New York.
  • Barak V, Halperin T, Kalickman I, 2001. The Effect of Sambucol, A Black Elderberry-Based, Natural Product, on The Production of Human Cytokines, I. Inflammatory Cytokines. Europen Cytokine Network, 12 (2): 290–296.
  • Barbieri L, Battelli M G, Stirpe F, 1993. Ribosome-Inactivating Proteins from Plants. Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes, 1154 (3-4): 237-282.
  • Barbieri L, Ciani M, Girbes T, Liu W Y, Van Damme E J, Peumans W J, Stirpe F, 2004. Enzymatic Activity of Toxic and Non-Toxic Type 2 Ribosome Inactivating Proteins. FEBS Letters, 563: 219-222.
  • Bergner P, 1996. Elderberry (Sambucus nigra, canadensis). Medical Herbalism, Winter 1996-97, Vol. 8, No. 4, s. 1, 11-12.
  • Bhattacharya S, Christensen K B, Olsen L C, Christensen L P, Grevsen K, Færgeman N J, Kristiansen K, Young J F, Oksbjerg N, 2013. Bioactive Components From Flowers of Sambucus nigra L. Increase Glucose Uptake in Primary Porcine Myotube Cultures and Reduce Fat Accumulation in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 61 (46): 11033-11040.
  • Bolli R, 1994. Revision of The Genus Sambucus. Dissertationes Botanicae, 223: 1–227.
  • Brimer L, Cicalina A R, Federici F, Petruccioli M, 1998. Amygdalin Degradation by Mucor Circinelloides and Penicillium Aurantiogriseum, Mechanisms of Hydrolysis. Archives of Microbiology, 169: 106-112.
  • Charlebois D, Byers P L, Finn C E, Thomas A L, 2010. Elderberry: Botany, Horticulture, Potential. Horticultural Reviews, 37: 213–280.
  • Christensen L P, Kaack K, Frette X C, 2008. Selection of Elderberry (Sambucus nigra L.) Genotypes Best Suited for The Preparation of Elderflower Extracts Rich in Flavonoids and Phenolic Acids. European Food Research and Technology, 227: 293–305.
  • Christensen K B, Petersen R K, Kristiansen K, Christensen L P, 2010. Identification of Bioactive Compounds From Flowers of Black Elder (Sambucus nigra L.) That Activate The Human Peroxisome Proliferator‐Activated Receptor (PPAR) γ. Phytotherapy Research, 24 (2): 129-132.
  • Citores L, Iglesias R, Muñoz R, Ferreras J M, Jimenez P, Girbes T, 1994. Elderberry (Sambucus nigra L.) Seed Proteins Inhibit Protein Synthesis and Display Strong Immunore Activity with Rabbit Polyclonal Antibodies Raised Against The Type 2 Ribosome-Inactivating Protein Nigrin b. Journal of Experimental Botany, 45: 513–516.
  • Citores L, De Benito F M, Iglesias R, Ferreras J M, Jimenez P, Argueso P, Farias G, Mendez E, Girbes T, 1996. Isolation and Characterization of A New Non-Toxic Two-Chain Ribosome-Inactivating Protein From Fruits of Elder (Sambucus nigra L). Journal of Experimental Botany, 47: 1577–1585.
  • Corrado G, Bovi P D, Ciliento R, Gaudio L, Di Maro A, Aceto S, Lorito M, Rao R, 2005. Inducible Expression of A Phytolacca Heterotepala Ribosome-Inactivating Protein Leads to Enhanced Resistance Against Major Fungal Pathogens in Tobacco. Phytopathology, 95 (2): 206-215.
  • Costica N, Stratu A, Boz I, Gille E, 2019. Characteristics of Elderberry (Sambucus nigra L.) Fruit. Agriculturae Conspectus Scientificus, 84 (1): 115-122.
  • Dawidowicz AL, Wianowska D, Baraniak B, 2006. The Antioxidant Properties of Alcoholic Extracts From Sambucus nigra L. (Antioxidative Properties of Extracts). Journal of Food Science and Technology, 39 (3): 308–315.
  • De Benito F M, Citores L, Iglesias R, Ferreras J M, Camafeita E, Mendez E, Girbes T, 1997. Isolation and Partial Characterization of A Novel and Uncommon Two-Chain 64-kDa Ribosome-Inactivating Protein From The Bark of Elder (Sambucus nigra L.). FEBS Letters, 413: 85–91.
  • Dellagreca M, Fiorentino A, Monaco P, Previtera L, Simonet A M, 2000. Cyanogenic Glycosides From Sambucus nigra. Natural Product Letters, 14: 175–182.
  • Domínguez R, Zhang L, Rocchetti G, Lucini L, Pateiro M, Munekata PE, Lorenzo JM, 2020. Elderberry (Sambucus nigra L.) as Potential Source of Antioxidants. Characterization, Optimization of Extraction Parameters and Bioactive Properties. Food Chemistry, 330: 127266.
  • Donoghue M J, Bell C D, Winkworth R C, 2003. The Evolution of Reproductive Characters in Dipsacales. International Journal of Plant Sciences, 164: 453-464.
  • Dulf FV, Oroian I, Vodnar DC, Socaciu C, Pintea A, 2013. Lipid Classes and Fatty Acid Regiodistribution in Triacylglycerols of Seed Oils of Two Sambucus Species (S. nigra L. and S. ebulus L.). Molecules, 18 (10): 11768-11782.
  • Duymuş H G, 2010. Türkiye’de Yetişen Sambucus nigra Meyveleri Üzerinde Ön Kimyasal Araştırmalar. Anadolu Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi (Basılmış).
  • Dündar S, 2009. Sambucus L. Türleri Üzerinde Fitoterapötik Çalışmalar. Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi (Basılmış).
  • Fazio A, Plastina P, Meijerink J, Witkamp RF, Gabriele B, 2013. Comparative Analyses of Seeds of Wild Fruits of Rubus and Sambucus Species from Southern Italy: Fatty Acid Composition of the Oil, Total Phenolic Content, Antioxidant and Anti-Inflammatory Properties of the Methanolic Extracts. Food Chemistry, 140 (4): 817-824.
  • Ferreras J M, Citores L, Iglesias R, Jimenez P, Girbes T, 2011. Use of Ribosome Inactivating Proteins from Sambucus for The Construction of Immunotoxins and Conjugates for Cancer Therapy. Toxins, 3: 420-441.
  • Galić A, Dragović-Uzelac V, Levaj B, Bursać Kovačević D, Pliestić S, Arnautović S, 2009. The Polyphenols Stability, Enzyme Activity and Physico-Chemical Parameters During Producing Wild Elderberry Concentrated Juice. Agriculturae Conspectus Scientificus, 74 (3): 181-186.
  • Gilman E F, Watson D G, Klein R W, Koeser A K, Hilbert D R, McLean D C, 2018. Sambucus nigra ssp. Canadensis: Elderberry. UF/IFAS Extension, University of Florida, USA.
  • Girbes T, Citores L, De Benito F M, Inglesias R, Ferreras J M, 1996. A Non-Toxic Two-Chain Ribosome-Inactivating Protein Co-Exists with A Structure-Related Monomeric Lectin (SNA III) in Elder (Sambucus nigra) Fruits. Biochemical Journal, 315: 343.
  • Girbes T, Ferreras J M, Arias F J, Stirpe F, 2004. Description, Distribution, Activity and Phylogenetic Relationship of Ribosome-Inactivating Proteins in Plants, Fungi and Bacteria. Mini Reviews in Medicinal Chemistry, 4: 461–476.
  • Gorchakova T V, Suprun I V, Sobenin I A, Orekhov A N, 2007. Use of Natural Products in Anticytokine Therapy. Bulletin of Experimental Biology and Medicine, 143 (3): 316-319.
  • Goud NS, Prasad G, 2020. Antioxidant, Antimicrobial Activity and Total Phenol and Flavonoids Analysis of Sambucus nigra (Elderberry). International Journal of Current Pharmaceutical Research, 12: 35-37.
  • Guseinova Z N, 1965. The Chemical Composition of The Leaves of Grass and Black Elder of Azerbaidzhan Flora and Laxative Effect of Their Medicinal Forms and Preparations. Azerbaidzhanskii Meditsinskii Zhurnal, 42 (6): 29-35.
  • Hearst C, McCollum G, Nelson D, Ballard LM, Millar BC, Goldsmith CE, Rooney PJ, Loughrey A, Moore JE, Rao JR, 2010. Antibacterial Activity of Elder (Sambucus nigra L.) Flower or Berry Against Hospital Pathogens. Journal of Medicinal Plants Research, 4 (17): 1805-1809.
  • Herrera C M, 1987. Vertebrate-Dispersed Plants of The Iberian Peninsula: A Study of Fruit Characteristics. Ecological Monographs, 57: 305–331.
  • Iglesias R, Citores L, Ferreras J M, Pérez Y, Jiménez P, Gayoso M J, Olsnes S, Tamburino R, Di Maro A, Parente A, Girbés T, 2010. Sialic Acid-Binding Dwarf Elder Four-Chain Lectin Displays Nucleic Acid N-glycosidase Activity. Biochimie, 92 (1): 71-80.
  • Izzo AA, Di Carlo G, Biscardi D, De Fusco R, Mascolo N, Borrelli F, Capasso F, Fasulo MP, Autore G, 1995. Biological Screening of Italian Medicinal Plants for Antibacterial Activity. Phytotherapy Research, 9 (4): 281-286.
  • Janeway CA, Travers P, Walport M, Shlomchik MJ, 2001. Immuno Biology, The Immune System in Health and Disease. pp. 12-130, New York-USA.
  • Karpova I S, Lylo V V, Macewicz L L, Kotsarenko K V, Palchykovska L G, Ruban T O, Lukash L L, 2013. Lectins of Sambucus nigra as Biologically Active and DNA-Protective Substances. In I International Symposium on Elderberry, June 2013, 1061, pp. 93-102.
  • Kayabaşı N, Etikan S, 1998. Mürver (Sambucus nigra L.) Bitkisinden Elde Edilen Renkler ve Bu Renklerin Yün Halı İplikleri Üzerindeki Işık ve Sürtünme Haslıkları. Tarım Bilimleri Dergisi, 4 (3): 65-69.
  • Kilham C, 2000. Health Benefits Boost Elderberry. HerbalGram, American Botanical Council, 50: 55.
  • Kislichenko VS, Vel’ma VV, 2006. Amino-Acid Composition of Flowers, Leaves, and Extract of Sambucus nigra Flowers. Chemistry of Natural Compounds, 42 (1): 125-126.
  • Kültür Ş, 2007. Medicinal Plants Used in Kırklareli Province (Turkey). Journal of Ethnopharmacology, 111 (2): 341-364.
  • Künsch U, Temperli A, 1978. Changes in Free and Protein‐Bound Amino Acids in Elderberry Fruit (Sambucus nigra) During Maturation. Journal of the Science of Food and Agriculture, 29 (12): 1037-1040.
  • Mahmoudi M, Ebrahimzadeh MA, Dooshan A, Arimi A, Ghasemi N, Fathiazad F, 2014. Antidepressant Activities of Sambucus ebulus and Sambucus nigra. European Review for Medical and Pharmacological Sciences, 18 (22): 3350-3353.
  • Marczylo T H, Cooke D, Brown K, Steward W P, Gescher A J, 2009. Pharmacokinetics and Metabolism of The Putative Cancer Chemopreventive Agent Cyanidin-3-Glucoside in Mice. Cancer Chemotherapy and Pharmacology, 64 (6): 1261-1268.
  • Mikulic-Petkovsek M, Schmitzer V, Slatnar A, Todorovic B, Veberic R, Stampar F, Ivancic A, 2014. Investigation of Anthocyanin Profile of Four Elderberry Species and Interspecific Hybrids. Journal of Agricultural Food Chemistry, 62: 5573–80.
  • Mikulic-Petkovsek M, Ivancic A, Todorovic B, Veberic R, Stampar F, 2015. Fruit Phenolic Composition of Different Elderberry Species and Hybrids. Journal of Food Science, 80: 2180–2190.
  • Morag AM, Mumcuoglu M, Baybikov T, 1997. Inhibition of Sensitive and Acyclovir-Resistant HSV-1 Strains by an Elderberry Extract in Vitro. Z Phytother, 25: 97-98.
  • Netzel M, Strass G, Herbst M, Dietrich H, Bitsch I, Frank T, 2005. The Excretion and Biological Antioxidant Activity of Elderberry Antioxidants in Healthy Humans. Food Research International, 38: 905–910.
  • Ng T B, Wong J H, Wang H, 2010. Recent Progress in Research on Ribosome Inactivating Proteins. Current Protein and Peptide Science, 11: 37–53.
  • Nile SH, Park SW, 2014. Edible Berries: Bioactive Components and Their Effect on Human Health. Nutrition, 30 (2): 134-144.
  • Pieroni A, Quave C L, Villanelli M L, Mangino P, Sabbatini G, Santini L, Boccetti T, Profili M, Ciccioli T, Rampa L G, Antonini G, Girolamini C, Cecchi M, Tomasi M, 2004. Ethnopharmacognostic Survey on The Natural Ingredients Used in Folk Cosmetics, Cosmeceuticals and Remedies for Healing Skin Diseases in The Inland Marches, Central-Eastern Italy. Journal Ethnopharmacol, 91: 331-344.
  • Pliszka B, 2017. Polyphenolic Content, Antiradical Activity, Stability and Microbiological Quality of Elderberry (Sambucus nigra L.) Extracts. Acta Scientiarum Polonorum Technologia Alimentaria, 16 (4): 393-401.
  • Porter R S, Bode R F, 2017. A Review of The Antiviral Properties of Black Elder (Sambucus nigra L.) Products. Phytotherapy Research, 31 (4): 533-554.
  • Rodino S, Butu A, Butu M, Cornea PC, 2015. Comparative Studies on Antibacterial Activity of Licorice, Elderberry and Dandelion. Digest Journal of Nanomaterials and Biostructures, 10 (3): 947-955.
  • Rodriguez Mateos A, Heiss C, Borges G, Crozier A, 2014. Berry (Poly)phenols and Cardiovascular Health. Journal of Agricultural and Food Chemistry, 62: 3842–51.
  • Romero Rodriguez M A, Vazquez Oderiz M L, Lopez Hernandez J, Simal Lozano J, 1992. Studio Della Composizione Chimica, Caratteristiche Fisiche Ed Indici Di Maturazione Del Lauroceraso (Prunus laurocerasus L.) e Delle Bacche Di Sambuco (Sambucus nigra L.). Industrie Alimentari, 31: 911–917.
  • Roschek Jr B, Fink RC, McMichael MD, Li D, Alberte RS, 2009. Elderberry Flavonoids Bind to and Prevent H1N1 Infection in Vitro. Phytochemistry, 70 (10): 1255–1261.
  • Sahpira Nahor O, Zakay Rones Z, Mumcuoğlu M, 1995. The Effects of Sambucol ® on HIV Infection in Vitro. Ann Israel Congress Microbiol, February 6-7.
  • Salvador ÂMC, 2017. Chemical Characterization and Biological Evaluation of Sambucus nigra L. Berries and Flowers in View of Their Valorization. Universidade de Aveiro Portekiz, Doktora Tezi (Basılmış).
  • Schmeda‐Hirschmann G, Feresin G, Tapia A, Hilgert N, Theoduloz C, 2005. Proximate Composition and Free Radical Scavenging Activity of Edible Fruits From the Argentinian Yungas. Journal of the Science of Food and Agriculture, 85 (8): 1357-1364.
  • Sharon N, 2007. Lectins: Carbohydrate-Specific Reagents and Biological Recognition Molecules. Journal of Biological Chemistry, 282: 2753-2764.
  • Sole C, 1988. Els fruits silvestres. Laia, Barcelona.
  • Sorensen A E, 1981. Interactions Between Birds and Fruit in A Temperate Woodland. Oecologia, 50: 242–249.
  • Stirpe F, 2004. Ribosome-Inactivating Proteins. Toxicon, 44: 371–383.
  • Tejero J, Jiménez P, Quinto E J, Cordoba-Diaz D, Garrosa M, Cordoba-Diaz, M., Gayoso M J, Girbés T, 2015. Elderberries: A Source of Ribosome-Inactivating Proteins With Lectin Activity. Molecules, 20 (2): 2364-2387.
  • Thole J M, Kraft T F B, Sueiro L A, Kang Y H, Gills J J, Cuendet M, Pezzuto J M, Seigler D S, Lila M A, 2006. A Comparative Evaluation of The Anticancer Properties of European and American Elderberry Fruits. Journal of Medicinal Food, 9: 498-504.
  • Ulbricht C, Basch E, Cheung L, Goldberg H, Hammerness P, Isaac R, Khalsa K P, Romm A, Rychlik I, Varghese M, Weissner W, Windsor R C, Wortley J, 2014. An Evidence-Based Systematic Review of Elderberry and Elderflower (Sambucus nigra) by The Natural Standard Research Collaboration. Journal of Dietary Supplements, 11: 80-120.
  • Uncini M R, Zaccaro L, Tomei P E, 2005. Antiviral Activity in Vitro of Urtica Dioica L., Parietaria Diffusa M. et K. and Sambucus nigra L. Journal of Ethnopharmacology, 98 (3): 323.
  • Válles J, Bonet Á, Agelet A, 2004. Ethnobotany of Sambucus nigra L. in Catalonia (Iberian peninsula): The Integral Exploitation of A Natural Resource in Mountain Regions. The Society Economic Botany, 58 (3): 456-469.
  • Van Damme E J, Roy S, Barre A, Rougé P, Van Leuven F, Peumans W J, 1997. The Major Elderberry (Sambucus nigra) Fruit Protein is A Lectin Derived From A Truncated Type 2 Ribosome‐Inactivating Protein. The Plant Journal, 12 (6): 1251-1260.
  • Van Damme E J, Peumans W J, Pusztai A, Bardocz S, 1998. Handbook of Plant Lectins: Properties and Biomedical Applications, John Wiley & Sons.
  • Veberic R, Jakopic J, Stampar F, Smitzer F, 2009. European Elderberry (Sambucus nigra L.) Rish in Sugars, Organic acids, Anthocyanins and Selected Polyphenols. Food Chemistry, 114: 511-515.
  • Vetter J, 2000. Plant Cyanogenic Glycosides. Toxicon, 38: 11-36.
  • Vulić J J, Vračar L O, Šμmić Z O, 2008. Chemical Characteristics of Cultivated Elderberry Fruit. Acta Periodica Technologica, 39: 85-90.
  • Vurdu H, Olgun Ç, Özkan O E, 2012. Kastamonu’ da Yetişen Mürver Türlerinin Botanik ve Kullanım Özellikleri, Kastamon’ nun Doğal Zenginlikleri Sempozyumu, 16–17 Ekim, Kastamonu.
  • Youdim K A, Martin A, Joseph JA, 2000. Incorporation of Elderberry Anthocyanins by Endothelial Cells Increases Protection by Oxidative Stress. Free Radic Biology and Medicine, 29: 51-60.
  • Zafra Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson J A, Bagchi D, 2007. Berry Anthocyanins as Novel Antioxidants in Human Health and Disease Prevention. Molecular Nutrition Food Research, 51: 675–83.
  • Zagrobelny M, Bak S, Rasmussen A N, Jørgensen B, Naumann C M, Møller B L, 2004. Cyanogenic Glycosides and Plant-Insect Interactions. Phytochemistry, 65: 293-306.
  • Zakay Rones Z, Varsano N, Zlotnik M, 1995. Inhibition of Several Strains of Influenza Virus in Vitro and Reduction of Symptoms by an Elderberry Extract (Sambucus nigra L.) During an Outbreak of Influenza B Panama. Journal of Alternative and Complementary Medicine, 1 (4): 361–369.
  • Zakay-Rones Z, Thom E, Wollan T, Wadstein J, 2004. Randomized Study of The Efficacy and Safety of Oral Elderberry Extract in The Treatment of Influenza A and B Virus Infections. Journal of International Medical Research, 32 (2): 132-140.

Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri

Year 2021, Volume: 11 Issue: 2, 1140 - 1153, 01.06.2021
https://doi.org/10.21597/jist.765296

Abstract

Kara mürver (Sambucus nigra) Adoxaceae familyasında, Avrupa, Asya, Kuzey Afrika ve ABD’ye özgü bir bitki türüdür. Kara mürver bitkisi; yuvarlak şekilli, mor-siyah renkli, 3-5 çekirdekli, küçük meyvelere sahiptir. Sambucus türlerinin kimyasal yapısını; majör bileşikler, flavonoidler, fenolik asitler, antosiyanidoller, triterpenler, lektinler, siyanojenik heterozitler ve uçucu yağlar oluşturmaktadır. Mürver türleri önemli miktarda lektin içermektedirler. Mürver meyveleri zengin antosiyanin içerikleri ile yüksek antioksidan aktivite göstermektedir. Antioksidan aktivitesi sayesinde insan sağlığında soğuk algınlığı, grip, kanser, diyabet gibi birçok hastalığa karşı terapötik etkiye sahiptir. Antioksidan özelliğinin yanı sıra; antiviral, antidepresan, antienflamatuvar ve antikarsinojenik gibi çeşitli aktiviteler de göstermektedir. Kara mürver, tüm bu özellikleri ile modern gıda ve tıbbi ürünlerin zenginleştirilmesi ve/veya geliştirilmesinde önemli katkı sağlayabilme potansiyeline sahip bir bitkidir. Bu makale kara mürver meyvesinin besinsel içeriği ve fonksiyonel özellikleri ile ilgili yapılan çalışmaları derlemektedir ve gelecekte yapılabilecek çalışmalara ışık tutmayı amaçlamaktadır.

References

  • Abuja P M, Murkovic M, Pfannhauser W, 1998. Antioxidant and Prooxidant Activities of Elderberry (Sambucus nigra) Extract in Low-density Lipoprotein Oxidation. Journal of Agricultural and Food Chemistry, 46: 4091-4096.
  • Ağalar HG, 2019. Elderberry (Sambucus nigra L.). In Nonvitamin and Nonmineral Nutritional Supplements. Academic Press, pp. 211-215. Anonim, 2020. United States Department of Agriculture USDA Food Composition Databases, https://fdc.nal.usda.gov/fdc-app.html#/food-details/171727/nutrients (Erişim Tarihi: 02.07.2020).
  • Antolak H, Czy˙zowska A, Kr˛egiel D, 2017. Antibacterial and Antiadhesive Activities of Extracts From Edible Plants Against Soft Drink Spoilage by Asaia spp.. Journal of Food Protection, 80, 25-34.
  • Arslanoğlu Ş F, Sert S, Özdemir M, 2019. Anadolu Coğrafyasında Yayılış Gösteren Sambucus nigra ve Sambucus ebulus’un tıbbi bitki olarak önemi, Haziran-Temmuz 2019, 58-62.
  • Atkinson, M, 1979. Herbs for Your Health. Dalesman Books, New York.
  • Barak V, Halperin T, Kalickman I, 2001. The Effect of Sambucol, A Black Elderberry-Based, Natural Product, on The Production of Human Cytokines, I. Inflammatory Cytokines. Europen Cytokine Network, 12 (2): 290–296.
  • Barbieri L, Battelli M G, Stirpe F, 1993. Ribosome-Inactivating Proteins from Plants. Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes, 1154 (3-4): 237-282.
  • Barbieri L, Ciani M, Girbes T, Liu W Y, Van Damme E J, Peumans W J, Stirpe F, 2004. Enzymatic Activity of Toxic and Non-Toxic Type 2 Ribosome Inactivating Proteins. FEBS Letters, 563: 219-222.
  • Bergner P, 1996. Elderberry (Sambucus nigra, canadensis). Medical Herbalism, Winter 1996-97, Vol. 8, No. 4, s. 1, 11-12.
  • Bhattacharya S, Christensen K B, Olsen L C, Christensen L P, Grevsen K, Færgeman N J, Kristiansen K, Young J F, Oksbjerg N, 2013. Bioactive Components From Flowers of Sambucus nigra L. Increase Glucose Uptake in Primary Porcine Myotube Cultures and Reduce Fat Accumulation in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 61 (46): 11033-11040.
  • Bolli R, 1994. Revision of The Genus Sambucus. Dissertationes Botanicae, 223: 1–227.
  • Brimer L, Cicalina A R, Federici F, Petruccioli M, 1998. Amygdalin Degradation by Mucor Circinelloides and Penicillium Aurantiogriseum, Mechanisms of Hydrolysis. Archives of Microbiology, 169: 106-112.
  • Charlebois D, Byers P L, Finn C E, Thomas A L, 2010. Elderberry: Botany, Horticulture, Potential. Horticultural Reviews, 37: 213–280.
  • Christensen L P, Kaack K, Frette X C, 2008. Selection of Elderberry (Sambucus nigra L.) Genotypes Best Suited for The Preparation of Elderflower Extracts Rich in Flavonoids and Phenolic Acids. European Food Research and Technology, 227: 293–305.
  • Christensen K B, Petersen R K, Kristiansen K, Christensen L P, 2010. Identification of Bioactive Compounds From Flowers of Black Elder (Sambucus nigra L.) That Activate The Human Peroxisome Proliferator‐Activated Receptor (PPAR) γ. Phytotherapy Research, 24 (2): 129-132.
  • Citores L, Iglesias R, Muñoz R, Ferreras J M, Jimenez P, Girbes T, 1994. Elderberry (Sambucus nigra L.) Seed Proteins Inhibit Protein Synthesis and Display Strong Immunore Activity with Rabbit Polyclonal Antibodies Raised Against The Type 2 Ribosome-Inactivating Protein Nigrin b. Journal of Experimental Botany, 45: 513–516.
  • Citores L, De Benito F M, Iglesias R, Ferreras J M, Jimenez P, Argueso P, Farias G, Mendez E, Girbes T, 1996. Isolation and Characterization of A New Non-Toxic Two-Chain Ribosome-Inactivating Protein From Fruits of Elder (Sambucus nigra L). Journal of Experimental Botany, 47: 1577–1585.
  • Corrado G, Bovi P D, Ciliento R, Gaudio L, Di Maro A, Aceto S, Lorito M, Rao R, 2005. Inducible Expression of A Phytolacca Heterotepala Ribosome-Inactivating Protein Leads to Enhanced Resistance Against Major Fungal Pathogens in Tobacco. Phytopathology, 95 (2): 206-215.
  • Costica N, Stratu A, Boz I, Gille E, 2019. Characteristics of Elderberry (Sambucus nigra L.) Fruit. Agriculturae Conspectus Scientificus, 84 (1): 115-122.
  • Dawidowicz AL, Wianowska D, Baraniak B, 2006. The Antioxidant Properties of Alcoholic Extracts From Sambucus nigra L. (Antioxidative Properties of Extracts). Journal of Food Science and Technology, 39 (3): 308–315.
  • De Benito F M, Citores L, Iglesias R, Ferreras J M, Camafeita E, Mendez E, Girbes T, 1997. Isolation and Partial Characterization of A Novel and Uncommon Two-Chain 64-kDa Ribosome-Inactivating Protein From The Bark of Elder (Sambucus nigra L.). FEBS Letters, 413: 85–91.
  • Dellagreca M, Fiorentino A, Monaco P, Previtera L, Simonet A M, 2000. Cyanogenic Glycosides From Sambucus nigra. Natural Product Letters, 14: 175–182.
  • Domínguez R, Zhang L, Rocchetti G, Lucini L, Pateiro M, Munekata PE, Lorenzo JM, 2020. Elderberry (Sambucus nigra L.) as Potential Source of Antioxidants. Characterization, Optimization of Extraction Parameters and Bioactive Properties. Food Chemistry, 330: 127266.
  • Donoghue M J, Bell C D, Winkworth R C, 2003. The Evolution of Reproductive Characters in Dipsacales. International Journal of Plant Sciences, 164: 453-464.
  • Dulf FV, Oroian I, Vodnar DC, Socaciu C, Pintea A, 2013. Lipid Classes and Fatty Acid Regiodistribution in Triacylglycerols of Seed Oils of Two Sambucus Species (S. nigra L. and S. ebulus L.). Molecules, 18 (10): 11768-11782.
  • Duymuş H G, 2010. Türkiye’de Yetişen Sambucus nigra Meyveleri Üzerinde Ön Kimyasal Araştırmalar. Anadolu Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi (Basılmış).
  • Dündar S, 2009. Sambucus L. Türleri Üzerinde Fitoterapötik Çalışmalar. Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi (Basılmış).
  • Fazio A, Plastina P, Meijerink J, Witkamp RF, Gabriele B, 2013. Comparative Analyses of Seeds of Wild Fruits of Rubus and Sambucus Species from Southern Italy: Fatty Acid Composition of the Oil, Total Phenolic Content, Antioxidant and Anti-Inflammatory Properties of the Methanolic Extracts. Food Chemistry, 140 (4): 817-824.
  • Ferreras J M, Citores L, Iglesias R, Jimenez P, Girbes T, 2011. Use of Ribosome Inactivating Proteins from Sambucus for The Construction of Immunotoxins and Conjugates for Cancer Therapy. Toxins, 3: 420-441.
  • Galić A, Dragović-Uzelac V, Levaj B, Bursać Kovačević D, Pliestić S, Arnautović S, 2009. The Polyphenols Stability, Enzyme Activity and Physico-Chemical Parameters During Producing Wild Elderberry Concentrated Juice. Agriculturae Conspectus Scientificus, 74 (3): 181-186.
  • Gilman E F, Watson D G, Klein R W, Koeser A K, Hilbert D R, McLean D C, 2018. Sambucus nigra ssp. Canadensis: Elderberry. UF/IFAS Extension, University of Florida, USA.
  • Girbes T, Citores L, De Benito F M, Inglesias R, Ferreras J M, 1996. A Non-Toxic Two-Chain Ribosome-Inactivating Protein Co-Exists with A Structure-Related Monomeric Lectin (SNA III) in Elder (Sambucus nigra) Fruits. Biochemical Journal, 315: 343.
  • Girbes T, Ferreras J M, Arias F J, Stirpe F, 2004. Description, Distribution, Activity and Phylogenetic Relationship of Ribosome-Inactivating Proteins in Plants, Fungi and Bacteria. Mini Reviews in Medicinal Chemistry, 4: 461–476.
  • Gorchakova T V, Suprun I V, Sobenin I A, Orekhov A N, 2007. Use of Natural Products in Anticytokine Therapy. Bulletin of Experimental Biology and Medicine, 143 (3): 316-319.
  • Goud NS, Prasad G, 2020. Antioxidant, Antimicrobial Activity and Total Phenol and Flavonoids Analysis of Sambucus nigra (Elderberry). International Journal of Current Pharmaceutical Research, 12: 35-37.
  • Guseinova Z N, 1965. The Chemical Composition of The Leaves of Grass and Black Elder of Azerbaidzhan Flora and Laxative Effect of Their Medicinal Forms and Preparations. Azerbaidzhanskii Meditsinskii Zhurnal, 42 (6): 29-35.
  • Hearst C, McCollum G, Nelson D, Ballard LM, Millar BC, Goldsmith CE, Rooney PJ, Loughrey A, Moore JE, Rao JR, 2010. Antibacterial Activity of Elder (Sambucus nigra L.) Flower or Berry Against Hospital Pathogens. Journal of Medicinal Plants Research, 4 (17): 1805-1809.
  • Herrera C M, 1987. Vertebrate-Dispersed Plants of The Iberian Peninsula: A Study of Fruit Characteristics. Ecological Monographs, 57: 305–331.
  • Iglesias R, Citores L, Ferreras J M, Pérez Y, Jiménez P, Gayoso M J, Olsnes S, Tamburino R, Di Maro A, Parente A, Girbés T, 2010. Sialic Acid-Binding Dwarf Elder Four-Chain Lectin Displays Nucleic Acid N-glycosidase Activity. Biochimie, 92 (1): 71-80.
  • Izzo AA, Di Carlo G, Biscardi D, De Fusco R, Mascolo N, Borrelli F, Capasso F, Fasulo MP, Autore G, 1995. Biological Screening of Italian Medicinal Plants for Antibacterial Activity. Phytotherapy Research, 9 (4): 281-286.
  • Janeway CA, Travers P, Walport M, Shlomchik MJ, 2001. Immuno Biology, The Immune System in Health and Disease. pp. 12-130, New York-USA.
  • Karpova I S, Lylo V V, Macewicz L L, Kotsarenko K V, Palchykovska L G, Ruban T O, Lukash L L, 2013. Lectins of Sambucus nigra as Biologically Active and DNA-Protective Substances. In I International Symposium on Elderberry, June 2013, 1061, pp. 93-102.
  • Kayabaşı N, Etikan S, 1998. Mürver (Sambucus nigra L.) Bitkisinden Elde Edilen Renkler ve Bu Renklerin Yün Halı İplikleri Üzerindeki Işık ve Sürtünme Haslıkları. Tarım Bilimleri Dergisi, 4 (3): 65-69.
  • Kilham C, 2000. Health Benefits Boost Elderberry. HerbalGram, American Botanical Council, 50: 55.
  • Kislichenko VS, Vel’ma VV, 2006. Amino-Acid Composition of Flowers, Leaves, and Extract of Sambucus nigra Flowers. Chemistry of Natural Compounds, 42 (1): 125-126.
  • Kültür Ş, 2007. Medicinal Plants Used in Kırklareli Province (Turkey). Journal of Ethnopharmacology, 111 (2): 341-364.
  • Künsch U, Temperli A, 1978. Changes in Free and Protein‐Bound Amino Acids in Elderberry Fruit (Sambucus nigra) During Maturation. Journal of the Science of Food and Agriculture, 29 (12): 1037-1040.
  • Mahmoudi M, Ebrahimzadeh MA, Dooshan A, Arimi A, Ghasemi N, Fathiazad F, 2014. Antidepressant Activities of Sambucus ebulus and Sambucus nigra. European Review for Medical and Pharmacological Sciences, 18 (22): 3350-3353.
  • Marczylo T H, Cooke D, Brown K, Steward W P, Gescher A J, 2009. Pharmacokinetics and Metabolism of The Putative Cancer Chemopreventive Agent Cyanidin-3-Glucoside in Mice. Cancer Chemotherapy and Pharmacology, 64 (6): 1261-1268.
  • Mikulic-Petkovsek M, Schmitzer V, Slatnar A, Todorovic B, Veberic R, Stampar F, Ivancic A, 2014. Investigation of Anthocyanin Profile of Four Elderberry Species and Interspecific Hybrids. Journal of Agricultural Food Chemistry, 62: 5573–80.
  • Mikulic-Petkovsek M, Ivancic A, Todorovic B, Veberic R, Stampar F, 2015. Fruit Phenolic Composition of Different Elderberry Species and Hybrids. Journal of Food Science, 80: 2180–2190.
  • Morag AM, Mumcuoglu M, Baybikov T, 1997. Inhibition of Sensitive and Acyclovir-Resistant HSV-1 Strains by an Elderberry Extract in Vitro. Z Phytother, 25: 97-98.
  • Netzel M, Strass G, Herbst M, Dietrich H, Bitsch I, Frank T, 2005. The Excretion and Biological Antioxidant Activity of Elderberry Antioxidants in Healthy Humans. Food Research International, 38: 905–910.
  • Ng T B, Wong J H, Wang H, 2010. Recent Progress in Research on Ribosome Inactivating Proteins. Current Protein and Peptide Science, 11: 37–53.
  • Nile SH, Park SW, 2014. Edible Berries: Bioactive Components and Their Effect on Human Health. Nutrition, 30 (2): 134-144.
  • Pieroni A, Quave C L, Villanelli M L, Mangino P, Sabbatini G, Santini L, Boccetti T, Profili M, Ciccioli T, Rampa L G, Antonini G, Girolamini C, Cecchi M, Tomasi M, 2004. Ethnopharmacognostic Survey on The Natural Ingredients Used in Folk Cosmetics, Cosmeceuticals and Remedies for Healing Skin Diseases in The Inland Marches, Central-Eastern Italy. Journal Ethnopharmacol, 91: 331-344.
  • Pliszka B, 2017. Polyphenolic Content, Antiradical Activity, Stability and Microbiological Quality of Elderberry (Sambucus nigra L.) Extracts. Acta Scientiarum Polonorum Technologia Alimentaria, 16 (4): 393-401.
  • Porter R S, Bode R F, 2017. A Review of The Antiviral Properties of Black Elder (Sambucus nigra L.) Products. Phytotherapy Research, 31 (4): 533-554.
  • Rodino S, Butu A, Butu M, Cornea PC, 2015. Comparative Studies on Antibacterial Activity of Licorice, Elderberry and Dandelion. Digest Journal of Nanomaterials and Biostructures, 10 (3): 947-955.
  • Rodriguez Mateos A, Heiss C, Borges G, Crozier A, 2014. Berry (Poly)phenols and Cardiovascular Health. Journal of Agricultural and Food Chemistry, 62: 3842–51.
  • Romero Rodriguez M A, Vazquez Oderiz M L, Lopez Hernandez J, Simal Lozano J, 1992. Studio Della Composizione Chimica, Caratteristiche Fisiche Ed Indici Di Maturazione Del Lauroceraso (Prunus laurocerasus L.) e Delle Bacche Di Sambuco (Sambucus nigra L.). Industrie Alimentari, 31: 911–917.
  • Roschek Jr B, Fink RC, McMichael MD, Li D, Alberte RS, 2009. Elderberry Flavonoids Bind to and Prevent H1N1 Infection in Vitro. Phytochemistry, 70 (10): 1255–1261.
  • Sahpira Nahor O, Zakay Rones Z, Mumcuoğlu M, 1995. The Effects of Sambucol ® on HIV Infection in Vitro. Ann Israel Congress Microbiol, February 6-7.
  • Salvador ÂMC, 2017. Chemical Characterization and Biological Evaluation of Sambucus nigra L. Berries and Flowers in View of Their Valorization. Universidade de Aveiro Portekiz, Doktora Tezi (Basılmış).
  • Schmeda‐Hirschmann G, Feresin G, Tapia A, Hilgert N, Theoduloz C, 2005. Proximate Composition and Free Radical Scavenging Activity of Edible Fruits From the Argentinian Yungas. Journal of the Science of Food and Agriculture, 85 (8): 1357-1364.
  • Sharon N, 2007. Lectins: Carbohydrate-Specific Reagents and Biological Recognition Molecules. Journal of Biological Chemistry, 282: 2753-2764.
  • Sole C, 1988. Els fruits silvestres. Laia, Barcelona.
  • Sorensen A E, 1981. Interactions Between Birds and Fruit in A Temperate Woodland. Oecologia, 50: 242–249.
  • Stirpe F, 2004. Ribosome-Inactivating Proteins. Toxicon, 44: 371–383.
  • Tejero J, Jiménez P, Quinto E J, Cordoba-Diaz D, Garrosa M, Cordoba-Diaz, M., Gayoso M J, Girbés T, 2015. Elderberries: A Source of Ribosome-Inactivating Proteins With Lectin Activity. Molecules, 20 (2): 2364-2387.
  • Thole J M, Kraft T F B, Sueiro L A, Kang Y H, Gills J J, Cuendet M, Pezzuto J M, Seigler D S, Lila M A, 2006. A Comparative Evaluation of The Anticancer Properties of European and American Elderberry Fruits. Journal of Medicinal Food, 9: 498-504.
  • Ulbricht C, Basch E, Cheung L, Goldberg H, Hammerness P, Isaac R, Khalsa K P, Romm A, Rychlik I, Varghese M, Weissner W, Windsor R C, Wortley J, 2014. An Evidence-Based Systematic Review of Elderberry and Elderflower (Sambucus nigra) by The Natural Standard Research Collaboration. Journal of Dietary Supplements, 11: 80-120.
  • Uncini M R, Zaccaro L, Tomei P E, 2005. Antiviral Activity in Vitro of Urtica Dioica L., Parietaria Diffusa M. et K. and Sambucus nigra L. Journal of Ethnopharmacology, 98 (3): 323.
  • Válles J, Bonet Á, Agelet A, 2004. Ethnobotany of Sambucus nigra L. in Catalonia (Iberian peninsula): The Integral Exploitation of A Natural Resource in Mountain Regions. The Society Economic Botany, 58 (3): 456-469.
  • Van Damme E J, Roy S, Barre A, Rougé P, Van Leuven F, Peumans W J, 1997. The Major Elderberry (Sambucus nigra) Fruit Protein is A Lectin Derived From A Truncated Type 2 Ribosome‐Inactivating Protein. The Plant Journal, 12 (6): 1251-1260.
  • Van Damme E J, Peumans W J, Pusztai A, Bardocz S, 1998. Handbook of Plant Lectins: Properties and Biomedical Applications, John Wiley & Sons.
  • Veberic R, Jakopic J, Stampar F, Smitzer F, 2009. European Elderberry (Sambucus nigra L.) Rish in Sugars, Organic acids, Anthocyanins and Selected Polyphenols. Food Chemistry, 114: 511-515.
  • Vetter J, 2000. Plant Cyanogenic Glycosides. Toxicon, 38: 11-36.
  • Vulić J J, Vračar L O, Šμmić Z O, 2008. Chemical Characteristics of Cultivated Elderberry Fruit. Acta Periodica Technologica, 39: 85-90.
  • Vurdu H, Olgun Ç, Özkan O E, 2012. Kastamonu’ da Yetişen Mürver Türlerinin Botanik ve Kullanım Özellikleri, Kastamon’ nun Doğal Zenginlikleri Sempozyumu, 16–17 Ekim, Kastamonu.
  • Youdim K A, Martin A, Joseph JA, 2000. Incorporation of Elderberry Anthocyanins by Endothelial Cells Increases Protection by Oxidative Stress. Free Radic Biology and Medicine, 29: 51-60.
  • Zafra Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson J A, Bagchi D, 2007. Berry Anthocyanins as Novel Antioxidants in Human Health and Disease Prevention. Molecular Nutrition Food Research, 51: 675–83.
  • Zagrobelny M, Bak S, Rasmussen A N, Jørgensen B, Naumann C M, Møller B L, 2004. Cyanogenic Glycosides and Plant-Insect Interactions. Phytochemistry, 65: 293-306.
  • Zakay Rones Z, Varsano N, Zlotnik M, 1995. Inhibition of Several Strains of Influenza Virus in Vitro and Reduction of Symptoms by an Elderberry Extract (Sambucus nigra L.) During an Outbreak of Influenza B Panama. Journal of Alternative and Complementary Medicine, 1 (4): 361–369.
  • Zakay-Rones Z, Thom E, Wollan T, Wadstein J, 2004. Randomized Study of The Efficacy and Safety of Oral Elderberry Extract in The Treatment of Influenza A and B Virus Infections. Journal of International Medical Research, 32 (2): 132-140.
There are 85 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Gıda Mühendisliği / Food Engineering
Authors

Betül Alıç 0000-0003-3085-9986

Nezahat Olcay 0000-0003-3302-8969

Mustafa Kürşat Demir 0000-0002-4706-4170

Publication Date June 1, 2021
Submission Date July 7, 2020
Acceptance Date December 9, 2020
Published in Issue Year 2021 Volume: 11 Issue: 2

Cite

APA Alıç, B., Olcay, N., & Demir, M. K. (2021). Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri. Journal of the Institute of Science and Technology, 11(2), 1140-1153. https://doi.org/10.21597/jist.765296
AMA Alıç B, Olcay N, Demir MK. Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri. J. Inst. Sci. and Tech. June 2021;11(2):1140-1153. doi:10.21597/jist.765296
Chicago Alıç, Betül, Nezahat Olcay, and Mustafa Kürşat Demir. “Kara Mürverin (Sambucus Nigra L.) Besinsel İçeriği Ve Fonksiyonel Özellikleri”. Journal of the Institute of Science and Technology 11, no. 2 (June 2021): 1140-53. https://doi.org/10.21597/jist.765296.
EndNote Alıç B, Olcay N, Demir MK (June 1, 2021) Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri. Journal of the Institute of Science and Technology 11 2 1140–1153.
IEEE B. Alıç, N. Olcay, and M. K. Demir, “Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri”, J. Inst. Sci. and Tech., vol. 11, no. 2, pp. 1140–1153, 2021, doi: 10.21597/jist.765296.
ISNAD Alıç, Betül et al. “Kara Mürverin (Sambucus Nigra L.) Besinsel İçeriği Ve Fonksiyonel Özellikleri”. Journal of the Institute of Science and Technology 11/2 (June 2021), 1140-1153. https://doi.org/10.21597/jist.765296.
JAMA Alıç B, Olcay N, Demir MK. Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri. J. Inst. Sci. and Tech. 2021;11:1140–1153.
MLA Alıç, Betül et al. “Kara Mürverin (Sambucus Nigra L.) Besinsel İçeriği Ve Fonksiyonel Özellikleri”. Journal of the Institute of Science and Technology, vol. 11, no. 2, 2021, pp. 1140-53, doi:10.21597/jist.765296.
Vancouver Alıç B, Olcay N, Demir MK. Kara Mürverin (Sambucus nigra L.) Besinsel İçeriği ve Fonksiyonel Özellikleri. J. Inst. Sci. and Tech. 2021;11(2):1140-53.