Abstract
References
- Referans 1-Cornely FB, Cornely OA, Salmanton-Garcia J, et al. Attributable mortality of candidemia after introduction of echinocandins. Mycoses. 2020;63:1373-1381.
- Referans2-Ricotta EE, Lai YL, Babiker A, et al. Invasive candidiasis species distribution and trends, United States, 2009–2017. J Infect Dis. 2020.
- Referans3-Rolling, T.; Hohl, T.M.; Zhai, B. Minority report: The intestinal mycobiota in systemic infections.Curr. Opin. Microbiol. 2020, 56, 1–6.
- Referans4-Lortholary O., The French Mycosis Study Group, Renaudat C., Sitbon K., Madec Y., Denoeud-Ndam L., Wolff M. Worrisome trends in incidence and mortality of candidemia in intensive care units .Intensiv. Care Med. 2014, 40, 1303–1312.
- Referans5- Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis. 2003;3:685-702.
- Referans6 -Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med 2015;373(15):1445-56.
- Referans7- Marra AR, Camargo LFA, Pignatari ACC, Sukiennik T , Behar PRP, Medeiros EAS, Ribeiro J. et al. Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study.J. Clin. Microbiol. 2011 , 49 , 1866–1871.
- Referans8- Arastehfar A., Carvalho A., Van De Veerdonk F.L., Jenks J.D., Köhler P., Krause R., Cornely O.A. et al. COVID-19 Associated Pulmonary Aspergillosis- From Immunology to Treatment. J. Fungi 2020 Jun; 6(2): 91.
- Referans9- Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y. Et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020, 395, 507–513.
- Referans10-Testing ECoAS. Breakpoint tables for interpretation of MICs for antifungal agents, version 10.0. 2020. Accessed on May 26th 2020
- Referans11- Cox MJ, Loman N, Bogaert D, O’Grady J. Co-infections: potentially lethal and unexplored in COVID-19. Lancet Microbe 2020;1:e11.
- Referans12- Posteraro B, Torelli R, Vella A, Leone P.M., Angelis G.D., Carolis E.D., Ventura G. et al. Pan-echinocandin-resistant candida glabrata bloodstream infection complicating COVID-19: A fatal case report. J Fungi (Basel). 2020;6:163.
- Referans13- Vidal C.G., Sanjuan G., García E.M., Alcalde P.P., Pouton N.G., Chumbita M., Pittol M.F.et al. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin. Microbiol. Infect.2021 Jan;27(1):83-88.
- Referans14- White P L., Dhillon R., Cordey A., Hughes H., Faggian F., Soni S., Pandey M. Et al. A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU.Clin. Infect. Dis. Published online 2020 Aug.29. doi: 10.1093/cid/ciaa1298
- Referans15- Koehler P ., Arendrup MC., Arıkan-Akdağlı S ., Bassetti M ., Bretagne S ., Klingspor L., Lagrou K. et al. ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies . Mycoses, 2019, 62(10):920-927
- Referans16- A Cornely O ., Bassetti M ., Calandra T ., Garbino J ., Kullberg B ., Lortholary O., Meersseman W. et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.Clin. Microbiol. Infect. 2012 , 18 , 19–37.
- Referans17- Pappas, PG; Kauffman, CA; Andes, DR; Clancy, CJ; Marr, KA; Ostrosky-Zeichner, L .; Reboli, AC; Schuster, MG; Vazquez, JA; Walsh, TJ; et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clin. Infect. Dis. 2016 Feb 15;62(4):e1-50.
Abstract
Kandidemi, yüksek ölüm oranları ile dünya çapında sık görülen bir kan dolaşımı enfeksiyonudur. Hastalık, geniş spektrumlu antibiyotiklere, kortikosteroidlere ve diğer immünosupresif ajanlara maruz kalma, intravasküler kateterler, mekanik ventilasyon ve diyaliz gibi invaziv prosedürler dahil olmak üzere çeşitli kandidemi risk faktörleri ile özellikle yoğun bakım gerektiren ciddi rahatsızlıkları olan hastaları etkilemektedir. COVID-19 hastalarının önemli bir kısmında akut solunum sıkıntısı sendromu (ARDS) gelişir. Bu durum YBÜ'sine yatış ve mekanik ventilasyon gerektirir, bu da hastaları bakteriyel ve fungal enfeksiyonlara bağlı nozokomiyal enfeksiyonlara yatkın hale getirir. İkincil enfeksiyonlu COVID-19 hastalarının yükünü ve bunların etiyolojik ajanlarını anlamak, COVID-19 hastalarının optimal yönetimi için çok önemlidir. COVID-19 hastaları arasında, Candida'ya bağlı süper enfeksiyon insidansı şu anda bilinmemektedir. Candida süper enfeksiyonunun artmış mortaliteye yol açıp açmadığı veya yalnızca COVID-19 enfeksiyonunun ciddiyetinin bir göstergesi olup olmadığı da bilinmemektedir. Yüksek mortalite göz önüne alındığında, kandideminin erken tanınması ve uygun antifungal tedavi ihtiyacı, YBÜ'deki COVID-19 hastalarının sonuçlarını iyileştirmek için temel gerekliliklerdir. Bu yazıda COVİD-19 hastası olan ve Candida süperenfeksiyonu görülen 2 olgumuzu sunmayı amaçladık. Bu raporla, COVID-19 hastalarıyla ilişkili nozokomiyal enfeksiyonları tanımaya ,klinisyenlerin dikkatini çekmeyi hedefliyoruz.
Keywords
References
- Referans 1-Cornely FB, Cornely OA, Salmanton-Garcia J, et al. Attributable mortality of candidemia after introduction of echinocandins. Mycoses. 2020;63:1373-1381.
- Referans2-Ricotta EE, Lai YL, Babiker A, et al. Invasive candidiasis species distribution and trends, United States, 2009–2017. J Infect Dis. 2020.
- Referans3-Rolling, T.; Hohl, T.M.; Zhai, B. Minority report: The intestinal mycobiota in systemic infections.Curr. Opin. Microbiol. 2020, 56, 1–6.
- Referans4-Lortholary O., The French Mycosis Study Group, Renaudat C., Sitbon K., Madec Y., Denoeud-Ndam L., Wolff M. Worrisome trends in incidence and mortality of candidemia in intensive care units .Intensiv. Care Med. 2014, 40, 1303–1312.
- Referans5- Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect Dis. 2003;3:685-702.
- Referans6 -Kullberg BJ, Arendrup MC. Invasive Candidiasis. N Engl J Med 2015;373(15):1445-56.
- Referans7- Marra AR, Camargo LFA, Pignatari ACC, Sukiennik T , Behar PRP, Medeiros EAS, Ribeiro J. et al. Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study.J. Clin. Microbiol. 2011 , 49 , 1866–1871.
- Referans8- Arastehfar A., Carvalho A., Van De Veerdonk F.L., Jenks J.D., Köhler P., Krause R., Cornely O.A. et al. COVID-19 Associated Pulmonary Aspergillosis- From Immunology to Treatment. J. Fungi 2020 Jun; 6(2): 91.
- Referans9- Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y. Et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020, 395, 507–513.
- Referans10-Testing ECoAS. Breakpoint tables for interpretation of MICs for antifungal agents, version 10.0. 2020. Accessed on May 26th 2020
- Referans11- Cox MJ, Loman N, Bogaert D, O’Grady J. Co-infections: potentially lethal and unexplored in COVID-19. Lancet Microbe 2020;1:e11.
- Referans12- Posteraro B, Torelli R, Vella A, Leone P.M., Angelis G.D., Carolis E.D., Ventura G. et al. Pan-echinocandin-resistant candida glabrata bloodstream infection complicating COVID-19: A fatal case report. J Fungi (Basel). 2020;6:163.
- Referans13- Vidal C.G., Sanjuan G., García E.M., Alcalde P.P., Pouton N.G., Chumbita M., Pittol M.F.et al. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin. Microbiol. Infect.2021 Jan;27(1):83-88.
- Referans14- White P L., Dhillon R., Cordey A., Hughes H., Faggian F., Soni S., Pandey M. Et al. A national strategy to diagnose COVID-19 associated invasive fungal disease in the ICU.Clin. Infect. Dis. Published online 2020 Aug.29. doi: 10.1093/cid/ciaa1298
- Referans15- Koehler P ., Arendrup MC., Arıkan-Akdağlı S ., Bassetti M ., Bretagne S ., Klingspor L., Lagrou K. et al. ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies . Mycoses, 2019, 62(10):920-927
- Referans16- A Cornely O ., Bassetti M ., Calandra T ., Garbino J ., Kullberg B ., Lortholary O., Meersseman W. et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.Clin. Microbiol. Infect. 2012 , 18 , 19–37.
- Referans17- Pappas, PG; Kauffman, CA; Andes, DR; Clancy, CJ; Marr, KA; Ostrosky-Zeichner, L .; Reboli, AC; Schuster, MG; Vazquez, JA; Walsh, TJ; et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clin. Infect. Dis. 2016 Feb 15;62(4):e1-50.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | March 31, 2021 |
| Published in Issue | Year 2021 Volume: 6 Issue: 1 |
Cite
Creative Commons Attribution Non-Commercial License: The articles in the Journal of Immunology and Clinical Microbiology are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.