Abstract
Supporting Institution
Başkent üniversitesi
Project Number
KA21/439
References
- Yan ZP, Yang M, Lai CL. COVID-19 Vaccines: a review of the safety and efficacy of current clinical trials. Pharmaceuticals (Basel). 2021;14(5):406.
- Akinosoglou K, Tzivaki I, Marangos M. Covid-19 vaccine and autoimmunity: awakening the sleeping dragon. Clin Immunol. 2021;226:108721.
- Pujol A, Gómez LA, Gallegos C, et al. Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis. J Endocrinol Invest. 2022;45(4):875-882.
- Shoenfeld Y, Agmon-Levin N.’ ASIA’ - autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011;36(1):4-8.
- Paschou SA, Karalis V, Psaltopoulou T, et al. Patients with autoimmune thyroiditis present similar immunological response to COVID-19 BNT162b2 mRNA vaccine with healthy subjects, while vaccination may affect thyroid function: a clinical study. Front Endocrinol (Lausanne). 2022;13:840668.
- Lui DTW, Lee CH, Cheung CYY, et al. Effect of COVID-19 vaccines on thyroid function and autoimmunity and effect of thyroid autoimmunity on antibody response. J Clin Endocrinol Metab. 2022;107(9):e3781-e3789.
- Li L, Chen X, Li B, et al. Effect of inactivated SARS-CoV-2 vaccine on thyroid function and autoimmunity within 28 days after the second dose. Thyroid. 2022;32(9):1051-1058.
- Huang L, Jiang Z, Zhou J, Chen Y, Huang H. The Effect of inactivated SARS-CoV-2 Vaccines on TRAB in Graves' disease. Front Endocrinol (Lausanne). 2022;13:835880.
- WHO. Coronavirus (COVID-19) Dashboard. Available online: https://covid19.who.int/
- Caron P. Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management. Endocrine. 2022;78(3):406-417.
- Ruggeri RM, Giovanellla L, Campennì A. SARS-CoV-2 vaccine may trigger thyroid autoimmunity: real-life experience and review of the literature. J Endocrinol Invest. 2022;45(12):2283-2289.
- Huang L, Jiang Z, Zhou J, Chen Y, Huang H. The Effect of inactivated SARS-CoV-2 vaccines on TRAB in Graves' disease. Front Endocrinol (Lausanne). 2022;13:835880.
- Watad A, David P, Brown S, Shoenfeld Y. Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity. Front Endocrinol (Lausanne). 2017;7:150.
- Ruiz JT, Lujan L, Blank M, Shoenfeld Y. Adjuvants- and vaccines-induced autoimmunity: animal models. Immunol Res. 2017;65(1):55–65.
- Bragazzi NL, Hejly A, Watad A, Adawi M, Amital H, Shoenfeld Y. ASIA syndrome and endocrine autoimmune disorders. Best Pract Res Clin Endocrinol Metab. 2020;34(1):101412.
- Siegrist CA, Lewis EM, Eskola J, Evans SJ, Black SB. Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactions. Pediatr Infect Dis J. 2007;26(11):979-84.
- Yu O, Bohlke K, Hanson CA, et al. Hepatitis B vaccine and risk of autoimmune thyroid disease: a vaccine safety datalink study. Pharmacoepidemiol Drug Saf. 2007;16(7):736-745.
- Hernán Martinez J, Corder E, Uzcategui M, Garcia M, Sostre S, Garcia A. Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation. Bol Asoc Med P R. 2011;103(2):48-52.
- Dow CT. Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) associated autoimmune diseases. Microorganisms. 2020;8(2):212.
Abstract
Aims: There have been reports about various thyroid autoimmune events after SARS-CoV-2 vaccinations. There is limited data on the extent to which vaccines for COVID-19 are effective on thyroid autoimmunity. This study investigates how COVID-19 vaccination affects thyroid antibodies and functions in individuals without any thyroid disease history.
Methods: The study evaluated individuals aged 18-65 with no previous COVID-19 history or thyroid disease who had at least two COVID-19 vaccine doses (CoronaVac + Pfizer-BioNTech or Pfizer-BioNTech alone) between October 2021 and October 2022. All participants' thyroid hormone (free triiodothyronine, thyroid-stimulating hormone, and free thyroxine) and thyroid autoantibody (anti-thyroglobulin, antithyroid peroxidase, and TSH receptor antibody) levels were measured.
Results: The study included 92 individuals in total. Thyroid functions and antithyroid antibody levels were found to be in the normal range before the implementation of the SARS-CoV-2 vaccine. Of the study participants, 42 received the Sinovac + BioNTech vaccine, and 50 received the BioNTech vaccine alone. While a decrease in st4 value was observed only in the BioNTech group after vaccination (p=0.007), thyroid dysfunction was not observed in any participant. After vaccination, TRAB positivity was observed in one participant, ANTI-TPO positivity in six participants, and ANTI-TG positivity in eight participants. No statistically significant antibody positivity was detected. No participants with antibody positivity displayed thyroid dysfunction.
Conclusion: Although some positivity in terms of antithyroid antibodies was observed after COVID-19 vaccination, this antibody positivity did not have a statistically significant level, and thyroid dysfunction was not detected in any participant. The COVID-19 vaccine is safe for thyroid function and autoimmunity.
Project Number
KA21/439
References
- Yan ZP, Yang M, Lai CL. COVID-19 Vaccines: a review of the safety and efficacy of current clinical trials. Pharmaceuticals (Basel). 2021;14(5):406.
- Akinosoglou K, Tzivaki I, Marangos M. Covid-19 vaccine and autoimmunity: awakening the sleeping dragon. Clin Immunol. 2021;226:108721.
- Pujol A, Gómez LA, Gallegos C, et al. Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis. J Endocrinol Invest. 2022;45(4):875-882.
- Shoenfeld Y, Agmon-Levin N.’ ASIA’ - autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011;36(1):4-8.
- Paschou SA, Karalis V, Psaltopoulou T, et al. Patients with autoimmune thyroiditis present similar immunological response to COVID-19 BNT162b2 mRNA vaccine with healthy subjects, while vaccination may affect thyroid function: a clinical study. Front Endocrinol (Lausanne). 2022;13:840668.
- Lui DTW, Lee CH, Cheung CYY, et al. Effect of COVID-19 vaccines on thyroid function and autoimmunity and effect of thyroid autoimmunity on antibody response. J Clin Endocrinol Metab. 2022;107(9):e3781-e3789.
- Li L, Chen X, Li B, et al. Effect of inactivated SARS-CoV-2 vaccine on thyroid function and autoimmunity within 28 days after the second dose. Thyroid. 2022;32(9):1051-1058.
- Huang L, Jiang Z, Zhou J, Chen Y, Huang H. The Effect of inactivated SARS-CoV-2 Vaccines on TRAB in Graves' disease. Front Endocrinol (Lausanne). 2022;13:835880.
- WHO. Coronavirus (COVID-19) Dashboard. Available online: https://covid19.who.int/
- Caron P. Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management. Endocrine. 2022;78(3):406-417.
- Ruggeri RM, Giovanellla L, Campennì A. SARS-CoV-2 vaccine may trigger thyroid autoimmunity: real-life experience and review of the literature. J Endocrinol Invest. 2022;45(12):2283-2289.
- Huang L, Jiang Z, Zhou J, Chen Y, Huang H. The Effect of inactivated SARS-CoV-2 vaccines on TRAB in Graves' disease. Front Endocrinol (Lausanne). 2022;13:835880.
- Watad A, David P, Brown S, Shoenfeld Y. Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity. Front Endocrinol (Lausanne). 2017;7:150.
- Ruiz JT, Lujan L, Blank M, Shoenfeld Y. Adjuvants- and vaccines-induced autoimmunity: animal models. Immunol Res. 2017;65(1):55–65.
- Bragazzi NL, Hejly A, Watad A, Adawi M, Amital H, Shoenfeld Y. ASIA syndrome and endocrine autoimmune disorders. Best Pract Res Clin Endocrinol Metab. 2020;34(1):101412.
- Siegrist CA, Lewis EM, Eskola J, Evans SJ, Black SB. Human papilloma virus immunization in adolescent and young adults: a cohort study to illustrate what events might be mistaken for adverse reactions. Pediatr Infect Dis J. 2007;26(11):979-84.
- Yu O, Bohlke K, Hanson CA, et al. Hepatitis B vaccine and risk of autoimmune thyroid disease: a vaccine safety datalink study. Pharmacoepidemiol Drug Saf. 2007;16(7):736-745.
- Hernán Martinez J, Corder E, Uzcategui M, Garcia M, Sostre S, Garcia A. Subacute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation. Bol Asoc Med P R. 2011;103(2):48-52.
- Dow CT. Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) associated autoimmune diseases. Microorganisms. 2020;8(2):212.
Details
| Primary Language | English |
|---|---|
| Subjects | Endocrinology |
| Journal Section | Original Article |
| Authors | |
| Project Number | KA21/439 |
| Early Pub Date | September 26, 2023 |
| Publication Date | September 28, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 5 |
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