Abstract
Amaç : AB0 ve Rh kan grupları, çeşitli malignitelerle ilişkilendirilmiştir. Bu çalışmada AB0 kan grupları ile kondroid neoplazi arasındaki ilişkinin araştırılması amaçlanmıştır. 276 kondroid neoplazili hastayı retrospektif olarak değerlendirdik.
Gereç ve Yöntem : 2014-2019 yılları arasında ameliyat edilen hastaların kan grupları ve tümör lokalizasyonu kaydedildi. Kontrol grubunu 2019 yılında hastanemize kan bağışı yapan 129 hasta oluşturdu. Ki-kare testi ile hastaların demografik özelliklerini ve kan gruplarını kontrol grubu ile karşılaştırdık.
Bulgular : Ortalama yaş, enkondroma, kondrosarkom ve kontrol grubu için sırasıyla 52 ± 14.6, 49 ± 15.9 ve 37 ± 10.3 yıldı. Tümör hem enkondrom hem de kondrosarkom hastalarında çoğunlukla distal femurda lokalizeydi. Enkondroma ve kondrosarkomlu hastalarda 0Rh (+) kan grubu oranı daha yüksek ve B (Rh (+) kan grubu oranı kontrol grubuna göre daha düşük olmasına rağmen, bu fark istatistiksel olarak anlamlı değildi.
Sonuç : A ve AB kan grubu oranları AB0 kan grupları ile kondroid neoplazi arasında ilişki yoktu. Geniş hasta serilerinde farklı benign ve malign kemik tümörlerinin AB0 ve Rh kan grupları ile ilişkisini araştıran çalışmalara ihtiyaç vardır.
Keywords
References
- Hakim DN, Pelly T, Kulendran M, Caris JA. Benign tumours of the bone: A review. J Bone Oncol 2015; 4: 37-41.
- Mulligan ME. How to Diagnose Enchondroma, Bone Infarct, and Chondrosarcoma. CurrProbl Diagn Radiol 2019; 48: 262-73.
- Campanacci M. Bone and soft tissue tumors. Springer; 2013.
- Brien EW, Mirra JM, Kerr R. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. Skeletal Radiol 1997; 26: 325-53.
- Atalay İB, Yılmaz S, Şimşek MA, Ekşioğlu MF, Güngör BŞ. Chondrosarcomas of the phalanges of the hand. Jt Dis Relat Surg 2018; 29: 34-9.
- Öztürk R, Ulucaköy C, Atalay İB, Yapar A, Karakoç Y. Management and retrospective analysis of pelvic ramus tumors and tumor-like lesions: Evaluation with 31 cases. Jt Dis Relat Surg 2020; 31.
- Murphey MD, Flemming DJ, Boyea SR, Bojescul JA, Sweet DE, Temple HT. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics 1998; 18: 1213-37.
- Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur JCancer 2010; 46: 3345-50.
- Huang JY, Wang R, Gao Y-T, Yuan J-M. ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one 2017; 12.
- Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer I 2009; 101: 424-31.
- Marinaccio M, Traversa A, Carioggia E, et al. Blood groups of the ABO system and survival rate in gynecologic tumors. Minerva ginecologica 1995; 47: 69-76.
- Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol 2010; 172: 1280-5.
- Sun W, Wen C-P, Lin J, et al. ABO blood types and cancer risk—a cohort study of 339,432 subjects in Taiwan. Cancer Epidemiol 2015; 39: 150-6.
- Hsiao LT, Liu NJ, You SL, Hwang LC. ABO blood group and the risk of cancer among middle‐aged people in T aiwan. Asia‐Pac J Clin Oncol 2015; 11: 31-6.
- Labarriere N, Piau J, Otry C, et al. H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res 1994; 54: 6275-81.
- Pinkston JA, Cole P. ABO blood groups and salivary gland tumors (Alabama, United States). Cancer Cause Control 1996; 7: 572-4.
- Tursen U, Tiftik EN, Unal S, et al. Relationship between ABO blood groups and skin cancers. Dermatol Online J 2005; 11: 44.
- Utkan G, Urun Y, Cangir AK, et al. Clinicopathological features of patients with malignant mesothelioma in a multicenter, case-control study: no role for ABO-Rh blood groups. Asian Pac J Cancer P 2013; 14: 249-53.
- Jia D. Bone tumor and ABO blood type. Zhonghuazhongliu za zhi 1991; 13: 220-2.
- Hakomori S-i. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta (BBA)-General Subjects 1999; 1473: 247-66.
- Reid ME, Mohandas N. Red blood cell blood group antigens: structure and function. Semin Hematol 2004; 41: 93-117.
- Zhang S, Zhang HS, Cordon-Cardo C, Ragupathi G, Livingston PO. Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. Clin Cancer Res 1998; 4: 2669-76.
- Melzer D, Perry JR, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008; 4: e1000072.
Abstract
Aim : AB0 and Rh blood groups have been associated with various malignancies. This study aims to investigate the relationship between AB0/Rh blood groups and chondroid neoplasia.
Material and Methods : We evaluated 276 patients with chondroid neoplasia retrospectively. The blood groups and tumor localization of the patients who were operated between 2014-2019 were recorded. 129 patients who donated blood to our hospital in 2019 constituted the control group.We compared the demographic characteristics and blood groups of the patients with the control group using the chi-square test.
Results : The mean age was 52±14.6, 49±15.9, and 37±10.3 years, respectively, for enchondroma, chondrosarcoma and the control group. The tumor was mostly localized to the distal femur in both enchondroma and chondrosarcoma patients. Although the 0Rh (+) blood group rate was higher and the B (Rh (+) blood group rate was lower in patients with enchondroma and chondrosarcoma compared to the control group, this difference was not statistically significant. The A and AB blood group rates of the case and control groups were similar.
Conclusion : There was no relationship between AB0 blood groups and chondroid neoplasia. Studies investigating the relationship of different benign and malignant bone tumors with AB0 and Rh blood groups in large patient series are needed.
References
- Hakim DN, Pelly T, Kulendran M, Caris JA. Benign tumours of the bone: A review. J Bone Oncol 2015; 4: 37-41.
- Mulligan ME. How to Diagnose Enchondroma, Bone Infarct, and Chondrosarcoma. CurrProbl Diagn Radiol 2019; 48: 262-73.
- Campanacci M. Bone and soft tissue tumors. Springer; 2013.
- Brien EW, Mirra JM, Kerr R. Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. Skeletal Radiol 1997; 26: 325-53.
- Atalay İB, Yılmaz S, Şimşek MA, Ekşioğlu MF, Güngör BŞ. Chondrosarcomas of the phalanges of the hand. Jt Dis Relat Surg 2018; 29: 34-9.
- Öztürk R, Ulucaköy C, Atalay İB, Yapar A, Karakoç Y. Management and retrospective analysis of pelvic ramus tumors and tumor-like lesions: Evaluation with 31 cases. Jt Dis Relat Surg 2020; 31.
- Murphey MD, Flemming DJ, Boyea SR, Bojescul JA, Sweet DE, Temple HT. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics 1998; 18: 1213-37.
- Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. Eur JCancer 2010; 46: 3345-50.
- Huang JY, Wang R, Gao Y-T, Yuan J-M. ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one 2017; 12.
- Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer I 2009; 101: 424-31.
- Marinaccio M, Traversa A, Carioggia E, et al. Blood groups of the ABO system and survival rate in gynecologic tumors. Minerva ginecologica 1995; 47: 69-76.
- Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol 2010; 172: 1280-5.
- Sun W, Wen C-P, Lin J, et al. ABO blood types and cancer risk—a cohort study of 339,432 subjects in Taiwan. Cancer Epidemiol 2015; 39: 150-6.
- Hsiao LT, Liu NJ, You SL, Hwang LC. ABO blood group and the risk of cancer among middle‐aged people in T aiwan. Asia‐Pac J Clin Oncol 2015; 11: 31-6.
- Labarriere N, Piau J, Otry C, et al. H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res 1994; 54: 6275-81.
- Pinkston JA, Cole P. ABO blood groups and salivary gland tumors (Alabama, United States). Cancer Cause Control 1996; 7: 572-4.
- Tursen U, Tiftik EN, Unal S, et al. Relationship between ABO blood groups and skin cancers. Dermatol Online J 2005; 11: 44.
- Utkan G, Urun Y, Cangir AK, et al. Clinicopathological features of patients with malignant mesothelioma in a multicenter, case-control study: no role for ABO-Rh blood groups. Asian Pac J Cancer P 2013; 14: 249-53.
- Jia D. Bone tumor and ABO blood type. Zhonghuazhongliu za zhi 1991; 13: 220-2.
- Hakomori S-i. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta (BBA)-General Subjects 1999; 1473: 247-66.
- Reid ME, Mohandas N. Red blood cell blood group antigens: structure and function. Semin Hematol 2004; 41: 93-117.
- Zhang S, Zhang HS, Cordon-Cardo C, Ragupathi G, Livingston PO. Selection of tumor antigens as targets for immune attack using immunohistochemistry: protein antigens. Clin Cancer Res 1998; 4: 2669-76.
- Melzer D, Perry JR, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008; 4: e1000072.
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| Primary Language | English |
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| Subjects | Health Care Administration |
| Journal Section | Original Article |
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| Publication Date | October 22, 2020 |
| Published in Issue | Year 2020 Volume: 3 Issue: 4 |
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