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Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat

Year 2023, Volume: 53 Issue: 2, 166 - 176, 30.08.2023

Dilara Aşkın Tuğçe Demiröz Akbulut Sura Baykan Bayram Göçmen Shabana Khan Petek Ballar Kırmızıbayrak Ayşe Nalbantsoy

https://doi.org/10.26650/IstanbulJPharm.2023.1060622

Abstract

Background and Aims: Venom of Macrovipera lebetina obtusa (Viperidae), Turkey’s biggest viper, is highly toxic to humans and causes inflammation. In Anatolian traditional medicine, many Anthemis L. species are used in wound healing and against inflammatory diseases. In the present study, antioxidant, cytotoxic and anti-inflammatory activities of different endemic A. tricolor Boiss. extracts were evaluated by in vitro assays. Besides, the anti-inflammatory activities of chloroform extract against carrageenan and snake venom induced-edema were investigated in rats.
Methods: Antioxidant and anti-inflammatory activities were evaluated by DCFH-DA, iNOS, NF-κB inhibitions and NAG-1 gene activation, while WST-1 assay was preferred for cytotoxic activity. Besides, the hind paw edema test was used for in vivo studies.
Results: Chloroform extract exhibited the strongest NAG-1-inducing activity. In addition, this extract showed potent iNOS and NF-κB inhibition (IC50:14.0 and 10.75 µg/mL, respectively) and cytotoxic effect against human osteosarcoma (U2OS; IC50: 15.18 µg/mL) and human cervical cancer (HeLa; IC50: 18.3 µg/mL) cell lines. Moreover, chloroform extract had stronger anti-inflammatory effects against both carrageenan and snake venom induced-edema formation than indomethacin. Fifty and 100 mg/kg extracts reduced the paw edema to 1-3% at 4 h after the snake venom injection. On the other hand, 50, 25 and 12.5 mg/kg of the extract completely inhibited inflammation induced by carrageenan.
Conclusion: This is the first report on the antioxidant, cytotoxic and anti-inflammatory effects of endemic A. tricolor by in vitro studies and snake venom-induced paw edema in rats. The plant exhibits strong potential for treating local tissue damage in snake bites.

Keywords

Macrovipera lebetina obtusa Anthemis tricolor cytotoxicity antioxidant anti-inflammatory in vivo

Project Number

17-FEN-024

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  • Zhao, J., Khan, S. I., Wang, M., Vasquez, Y., Yang, M. H., Avula, B., . Khan, I. A. (2014). Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against in-flammation and metabolic disorder. Journal of Natural Products, 77, 509-515. https://doi.org/10.1021/np400780n google scholar

Year 2023, Volume: 53 Issue: 2, 166 - 176, 30.08.2023

Dilara Aşkın Tuğçe Demiröz Akbulut Sura Baykan Bayram Göçmen Shabana Khan Petek Ballar Kırmızıbayrak Ayşe Nalbantsoy

https://doi.org/10.26650/IstanbulJPharm.2023.1060622

Abstract

Supporting Institution

Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

17-FEN-024

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There are 86 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Original Article
Authors

Dilara Aşkın This is me 0000-0002-8458-5610

Tuğçe Demiröz Akbulut 0000-0002-7606-5316

Sura Baykan This is me 0000-0002-3624-4811

Bayram Göçmen This is me 0000-0003-0526-872X

Shabana Khan This is me 0000-0001-6429-7219

Petek Ballar Kırmızıbayrak This is me 0000-0002-6189-1818

Ayşe Nalbantsoy 0000-0002-9108-4451

Project Number 17-FEN-024
Publication Date August 30, 2023
Submission Date April 11, 2022
Published in Issue Year 2023 Volume: 53 Issue: 2

Cite

APA Aşkın, D., Demiröz Akbulut, T., Baykan, S., Göçmen, B., et al. (2023). Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat. İstanbul Journal of Pharmacy, 53(2), 166-176. https://doi.org/10.26650/IstanbulJPharm.2023.1060622
AMA Aşkın D, Demiröz Akbulut T, Baykan S, Göçmen B, Khan S, Ballar Kırmızıbayrak P, Nalbantsoy A. Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat. iujp. August 2023;53(2):166-176. doi:10.26650/IstanbulJPharm.2023.1060622
Chicago Aşkın, Dilara, Tuğçe Demiröz Akbulut, Sura Baykan, Bayram Göçmen, Shabana Khan, Petek Ballar Kırmızıbayrak, and Ayşe Nalbantsoy. “Antioxidant, Cytotoxic and Anti-Inflammatory Properties of Anthemis Tricolor Boiss. Through a Series of Cellular Assays and Inhibition of Turkish Macrovipera Lebetina Obtusa Venom Induced Inflammation in Rat”. İstanbul Journal of Pharmacy 53, no. 2 (August 2023): 166-76. https://doi.org/10.26650/IstanbulJPharm.2023.1060622.
EndNote Aşkın D, Demiröz Akbulut T, Baykan S, Göçmen B, Khan S, Ballar Kırmızıbayrak P, Nalbantsoy A (August 1, 2023) Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat. İstanbul Journal of Pharmacy 53 2 166–176.
IEEE D. Aşkın, “Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat”, iujp, vol. 53, no. 2, pp. 166–176, 2023, doi: 10.26650/IstanbulJPharm.2023.1060622.
ISNAD Aşkın, Dilara et al. “Antioxidant, Cytotoxic and Anti-Inflammatory Properties of Anthemis Tricolor Boiss. Through a Series of Cellular Assays and Inhibition of Turkish Macrovipera Lebetina Obtusa Venom Induced Inflammation in Rat”. İstanbul Journal of Pharmacy 53/2 (August 2023), 166-176. https://doi.org/10.26650/IstanbulJPharm.2023.1060622.
JAMA Aşkın D, Demiröz Akbulut T, Baykan S, Göçmen B, Khan S, Ballar Kırmızıbayrak P, Nalbantsoy A. Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat. iujp. 2023;53:166–176.
MLA Aşkın, Dilara et al. “Antioxidant, Cytotoxic and Anti-Inflammatory Properties of Anthemis Tricolor Boiss. Through a Series of Cellular Assays and Inhibition of Turkish Macrovipera Lebetina Obtusa Venom Induced Inflammation in Rat”. İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 166-7, doi:10.26650/IstanbulJPharm.2023.1060622.
Vancouver Aşkın D, Demiröz Akbulut T, Baykan S, Göçmen B, Khan S, Ballar Kırmızıbayrak P, Nalbantsoy A. Antioxidant, cytotoxic and anti-inflammatory properties of Anthemis tricolor Boiss. through a series of cellular assays and inhibition of Turkish Macrovipera lebetina obtusa venom induced inflammation in rat. iujp. 2023;53(2):166-7.
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