Research Article
EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS
Abstract
Chemerin is a new
chemotactic protein that recently joined the adipokines family. It has been
shown to play a role in adipogenesis and energy metabolism, including its role
on obesity, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome and
cardiovascular diseases. Probiotics may play role in the prevention of obesity
by various mechanisms and treatment of many diseases such as T2DM. In this
study, we aimed to evaluate the effects of probiotic supplementation of
chemerin adipokines on serum levels and obesity markers in obese animal models.
For this purpose 3 groups of experimental animals were formed. In the obtained
serum samples, the effects of probiotic supplementation on chemerin and leptin
level which are indicators of obesity will be examined. Weights of all the rats
in the groups were weighed each week to monitor the obesity. The weight gain in
the group fed with probiotic supplementation was 10,00±27,2 g for 4 weeks and
the weight gain for the group fed with high fat diet was 26,200±7,085 g
(p<0.05). After 8 weeks of feding the changes of BMI values of the rats were
found to be statistically significant (p<0.05). There was no significant
difference between the leptin values of the groups, but the difference between
the mean values of the chemerin values after 12 weeks of feeding was found to
be statistically significant (p <0.05). As a result; this study showed that
obese rats reduced the weight gain of probiotic supplementation without calorie
restriction, positive effects on BMI and chemerin adipokine serum levels.
References
- Booth, A., Magnuson, A., Fouts, J., Foster, M. Adipose tissue, obesity and adipokines: role in cancer promotion, Horm Mol Biol Clin Invest, 21(2015),1, pp. 57–74.
- Roh, S., Song, S., Choi, K., Katoh, K., Wittamer, V., Parmentier, M., Sasaki, S. Chemerin-A new adipokine that modulates adipogenesis via its own receptor, Biochemical and Biophysical Research Communications, 362 (2007), pp. 1013-18.
- Rourke, JL., Dranse, HJ., Sinal, CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease, Obes, 14 (2013),3, pp. 245-62.
- Dupont, J., Pollet-Villard, X., Reverchon, M., Mellouk, N., Levy, R. Adipokines in human reproduction, Horm Mol Biol Clin Invest, 24 (2015),1, pp. 11–24.
- Ernst, MC., Sinal, CJ. Chemerin: at the crossroads of inflammation and obesity, Trends in Endocrinology and Metabolism, 21 (2010),11.
- Goralski, KB., McCarthy, TC., Hanniman, EA. et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism, J Biol Chem, 282 (2007), 38, pp. 28175-88.
- Chang, SS., Eisenberg, D., Zhao, L. et al. Chemerin activation in human obesity, Obesity, 27 (2016), 7, pp. 1522-9.
- Bauer, S., Bala, M., Kopp, A. et al. Adipocyte chemerin release is induced by insulin without being translated to higher levels in vivo, Eur J Clin Invest, 42 (2012), 11, pp. 1213-20.
- Li, Y., Shi, B., Li, S. Association between serum chemerin concentrations and clinical indices in obesity or metabolic syndrome: a meta-analysis, PLoS One, 9 (2014), 12, e113915.
- Sánchez, B., Delgado, S., Blanco‐Míguez, A. et al. Probiotics, gut microbiota, and their influence on host health and disease, Molecular nutrition & food research, 61 (2017),1.
- Shin, J. H., Nam, M. H., Lee, H., Lee, J. S., Kim, H., Chung, M. J., & Seo, J. G. Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model, European Journal of Nutrition, 2017, pp. 1-10.
- Moya-Perez, A., Romo-Vaquero, M., Tomas-Barberan, F., Sanz, Y., & García-Conesa, M. T. Hepatic molecular responses to Bifidobacterium pseudocatenulatum CECT 7765 in a mouse model of diet-induced obesity. Nutrition, Metabolism and Cardiovascular Diseases, 24 (2014), 1, pp. 57-64.
- Ress, C., Tschoner, A., Engl, J., Klaus, A., Tilg, H., Ebenbichler, CF., Patsch, JR., Kaser, S. Effect of bariatric surgery on circulating chemerin levels, Eur J Clin Invest, 40 (2010), 3, pp. 277–80.
- Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, MR., Shang, E., Lohmann, T., Dreßler, M., Fasshauer, M., Stumvoll, M., Blüher, M. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity, Metabolism Clincal and Experimental, 61 (2012), pp. 706-14.
- Fatima, SS., Bozaoglu, K., Rehman, R., Alam, F., Memon, AS. Elevated Chemerin Levels in Pakistani Men: An Interrelation with Metabolic Syndrome Phenotypes, PLoS ONE, 8 (2013), 2, e57113.
- Thomas, S., Kratzsch, D., Schaab, M., Scholz, M., Grunewald, S., Thiery, J., Paasch, U., Kratzsch, J. Seminal plasma adipokine levels are correlated with functional characteristics of spermatozo, Fertil Steril, 99 (2013), pp. 1256–63.
- Kang, J. H., Yun, S. I., & Park, H. O. Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats, The Journal of Microbiology, 48 (2010),5, pp. 712-14.
- Kobyliak, N., Falalyeyeva, T., Beregova, T., & Spivak, M. Probiotics for experimental obesity prevention: focus on strain dependence and viability of composition, Endokrynologia Polska, (2015).
Year 2017,
Volume: 2 Issue: 2, 58 - 64, 22.12.2017
Abstract
References
- Booth, A., Magnuson, A., Fouts, J., Foster, M. Adipose tissue, obesity and adipokines: role in cancer promotion, Horm Mol Biol Clin Invest, 21(2015),1, pp. 57–74.
- Roh, S., Song, S., Choi, K., Katoh, K., Wittamer, V., Parmentier, M., Sasaki, S. Chemerin-A new adipokine that modulates adipogenesis via its own receptor, Biochemical and Biophysical Research Communications, 362 (2007), pp. 1013-18.
- Rourke, JL., Dranse, HJ., Sinal, CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease, Obes, 14 (2013),3, pp. 245-62.
- Dupont, J., Pollet-Villard, X., Reverchon, M., Mellouk, N., Levy, R. Adipokines in human reproduction, Horm Mol Biol Clin Invest, 24 (2015),1, pp. 11–24.
- Ernst, MC., Sinal, CJ. Chemerin: at the crossroads of inflammation and obesity, Trends in Endocrinology and Metabolism, 21 (2010),11.
- Goralski, KB., McCarthy, TC., Hanniman, EA. et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism, J Biol Chem, 282 (2007), 38, pp. 28175-88.
- Chang, SS., Eisenberg, D., Zhao, L. et al. Chemerin activation in human obesity, Obesity, 27 (2016), 7, pp. 1522-9.
- Bauer, S., Bala, M., Kopp, A. et al. Adipocyte chemerin release is induced by insulin without being translated to higher levels in vivo, Eur J Clin Invest, 42 (2012), 11, pp. 1213-20.
- Li, Y., Shi, B., Li, S. Association between serum chemerin concentrations and clinical indices in obesity or metabolic syndrome: a meta-analysis, PLoS One, 9 (2014), 12, e113915.
- Sánchez, B., Delgado, S., Blanco‐Míguez, A. et al. Probiotics, gut microbiota, and their influence on host health and disease, Molecular nutrition & food research, 61 (2017),1.
- Shin, J. H., Nam, M. H., Lee, H., Lee, J. S., Kim, H., Chung, M. J., & Seo, J. G. Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model, European Journal of Nutrition, 2017, pp. 1-10.
- Moya-Perez, A., Romo-Vaquero, M., Tomas-Barberan, F., Sanz, Y., & García-Conesa, M. T. Hepatic molecular responses to Bifidobacterium pseudocatenulatum CECT 7765 in a mouse model of diet-induced obesity. Nutrition, Metabolism and Cardiovascular Diseases, 24 (2014), 1, pp. 57-64.
- Ress, C., Tschoner, A., Engl, J., Klaus, A., Tilg, H., Ebenbichler, CF., Patsch, JR., Kaser, S. Effect of bariatric surgery on circulating chemerin levels, Eur J Clin Invest, 40 (2010), 3, pp. 277–80.
- Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, MR., Shang, E., Lohmann, T., Dreßler, M., Fasshauer, M., Stumvoll, M., Blüher, M. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity, Metabolism Clincal and Experimental, 61 (2012), pp. 706-14.
- Fatima, SS., Bozaoglu, K., Rehman, R., Alam, F., Memon, AS. Elevated Chemerin Levels in Pakistani Men: An Interrelation with Metabolic Syndrome Phenotypes, PLoS ONE, 8 (2013), 2, e57113.
- Thomas, S., Kratzsch, D., Schaab, M., Scholz, M., Grunewald, S., Thiery, J., Paasch, U., Kratzsch, J. Seminal plasma adipokine levels are correlated with functional characteristics of spermatozo, Fertil Steril, 99 (2013), pp. 1256–63.
- Kang, J. H., Yun, S. I., & Park, H. O. Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats, The Journal of Microbiology, 48 (2010),5, pp. 712-14.
- Kobyliak, N., Falalyeyeva, T., Beregova, T., & Spivak, M. Probiotics for experimental obesity prevention: focus on strain dependence and viability of composition, Endokrynologia Polska, (2015).
There are 18 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Article |
| Authors | |
| Publication Date | December 22, 2017 |
| Submission Date | November 13, 2017 |
| Acceptance Date | November 27, 2017 |
| Published in Issue | Year 2017 Volume: 2 Issue: 2 |
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