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Polymer – flufenamic acid delivery systems for injured skin

Year 2022, Volume: 6 Issue: 2, 114 - 121, 31.12.2022

Minodora Maria Marın Mihaela Violeta Ghıca Alpaslan Kaya Denisa Ioana Udeanu Madalina Albu Kaya Cristina-elena Dınu-pîrvu Lăcrămioara Popa Valentina Anuța Razvan Mihai Prısada

https://doi.org/10.32571/ijct.1135548

Abstract

Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.

Keywords

Collagen sponges microcapsules flufenamic acid kinetic release wound healing

Supporting Institution

UEFISCDI

Project Number

PED 160/03.01.2017,code PN-III-P2-2.1-PED-2016-0813

Thanks

This work was in the frame of PN-III-Experimental Demonstration Project

References

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  • Nessler, M.; Chrapusta, A. Leczenie Ran. 2013, 10, 47–52.
  • Markiewicz-Gospodarek, A.; Kozioł, M.; Tobiasz, M.; Baj, J.; Radzikowska-Büchner, E.; Przekora, A. Int. J. Environ. Res. Public Health, 2022, 19, 1338.
  • Albu, M.G.; Titorencu, I.; Ghica, M.V. Collagen-Based Drug Delivery Systems for Tissue Engineering. In Biomaterials Applications for Nanomedicine; InTech, 2011.
  • Harley, B.A.; Lynn, A.K.; Wissner-Gross, Z.; Bonfield, W.; Yannas, I. V.; Gibson, L.J. J. Biomed. Mater. Res. Part A, 2009, 9999A.
  • Healy, K.E.; Rezania, A.; Stile, R.A. Ann. N. Y. Acad. Sci., 1999, 875, 24–35.
  • Alipal, J.; Mohd Pu’ad, N.A.S.; Lee, T.C.; Nayan, N.H..; Sahari, N.; Basri, H.; Idris, M.I.; Abdullah, H.Z. Mater. Today Proc., 2021, 42, 240–250.
  • Kumosa, L.S.; Zetterberg, V.; Schouenborg, J. Acta Biomater.,2018, 65, 137–149.
  • Ma, K.; Cai, X.; Zhou, Y.; Wang, Y.; Jiang, T. Macromol. Biosci., 2017, 17, 1600130.
  • Sosnik, A. ISRN Pharm., 2014, 2014, 1–17.
  • Rinaudo, M. Polym. Int., 2008, 57, 397–430.
  • Smidsrod, O.; Skjakbrk, G.Trends Biotechnol., 1990, 8, 71–78.
  • Gasperini, L.; Mano, J.F.; Reis, R.L. J. R. Soc. Interface, 2014, 11, 20140817.
  • Choi, H.-G.; Kim, C.-K. J. Control. Release, 2000, 68, 397–404.
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  • Heinze, T.; Liebert, T.; Heublein, B.; Hornig, S. Functional Polymers Based on Dextran. In Polysaccharides II; Springer Berlin Heidelberg; pp. 199–291, 2006.
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  • Rahman, M.S.; Hasan, M.S.; Nitai, A.S.; Nam, S.; Karmakar, A.K.; Ahsan, M.S.; Shiddiky, M.J.A.; Ahmed, M.B. Polymers (Basel)., 2021, 13, 1345.
  • Shu, W.; Wang, Y.; Zhang, X.; Li, C.; Le, H.; Chang, F. Front. Bioeng. Biotechnol., 2021, 9.788461.
  • Malinovskaja-Gomez, K.; Labouta, H.I.; Schneider, M.; Hirvonen, J.; Laaksonen, T. Eur. J. Pharm. Sci., 2016, 89, 154–162.
  • Dinescu, S.; Ignat, S.; Lazar, A.; Marin, S.; Danilă, E.; Marin, M.M.; Udeanu, D.I.; Ghica, M.V.; Albu Kaya, M.G.; Costache, M. J. Immun. Res., 2019, 4513108.
  • Albu, M. G.Collagen Gels and Matrices for Biomedical Applications, Lambert Academic Publishing, Saarbrücken, 2011.
  • Ghica, M.V.; Albu, M.G.; Popa, L.; Moisescu, Ș., Pharmazie, 2013, 68(5), 340-348.
  • Marin, M.M.;Albu Kaya, M.G.;Ghica, M.V.;Dănilă, E.;Coară, G.;Popa, L.; Chelaru, C.;Kaya, D.A.;Anuța, V.; Dinu-Pîrvu, C.E.;Cristescu, I. Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration, Proceedings of the 8thInternationalConferenceonAdvancedMaterialsandSystems (ICAMS),Bucharest, 1-3 October 2020, p. 201-206, 2020.
  • Udeanu, D.I.; Albu Kaya, M.G.; Ghica, M.V.; Marin, S.; Marin, M.M.; Kaya, D.A.; Popa, L., Dinu-Pîrvu, C.E. Farmacia,2018, 66(5), 783-790.
  • Ghica, M.V.; Albu Kaya, M.G.; Udeanu, D.I.; Marin, M.M.; Marin, S.; Kaya, D.A.;Dinu-Pirvu, C.; Popa, L.; Danila, E. RO Patent 132850, October 29, 2021.

Year 2022, Volume: 6 Issue: 2, 114 - 121, 31.12.2022

Minodora Maria Marın Mihaela Violeta Ghıca Alpaslan Kaya Denisa Ioana Udeanu Madalina Albu Kaya Cristina-elena Dınu-pîrvu Lăcrămioara Popa Valentina Anuța Razvan Mihai Prısada

https://doi.org/10.32571/ijct.1135548

Abstract

Keywords

Collagen sponges microcapsules flufenamic acid kinetic release wound healing

Project Number

PED 160/03.01.2017,code PN-III-P2-2.1-PED-2016-0813

References

  • Greenhalgh, D.G. Management of Burns. N. Engl. J. Med., 2019, 380, 2349–2359.
  • Nessler, M.; Chrapusta, A. Leczenie Ran. 2013, 10, 47–52.
  • Markiewicz-Gospodarek, A.; Kozioł, M.; Tobiasz, M.; Baj, J.; Radzikowska-Büchner, E.; Przekora, A. Int. J. Environ. Res. Public Health, 2022, 19, 1338.
  • Albu, M.G.; Titorencu, I.; Ghica, M.V. Collagen-Based Drug Delivery Systems for Tissue Engineering. In Biomaterials Applications for Nanomedicine; InTech, 2011.
  • Harley, B.A.; Lynn, A.K.; Wissner-Gross, Z.; Bonfield, W.; Yannas, I. V.; Gibson, L.J. J. Biomed. Mater. Res. Part A, 2009, 9999A.
  • Healy, K.E.; Rezania, A.; Stile, R.A. Ann. N. Y. Acad. Sci., 1999, 875, 24–35.
  • Alipal, J.; Mohd Pu’ad, N.A.S.; Lee, T.C.; Nayan, N.H..; Sahari, N.; Basri, H.; Idris, M.I.; Abdullah, H.Z. Mater. Today Proc., 2021, 42, 240–250.
  • Kumosa, L.S.; Zetterberg, V.; Schouenborg, J. Acta Biomater.,2018, 65, 137–149.
  • Ma, K.; Cai, X.; Zhou, Y.; Wang, Y.; Jiang, T. Macromol. Biosci., 2017, 17, 1600130.
  • Sosnik, A. ISRN Pharm., 2014, 2014, 1–17.
  • Rinaudo, M. Polym. Int., 2008, 57, 397–430.
  • Smidsrod, O.; Skjakbrk, G.Trends Biotechnol., 1990, 8, 71–78.
  • Gasperini, L.; Mano, J.F.; Reis, R.L. J. R. Soc. Interface, 2014, 11, 20140817.
  • Choi, H.-G.; Kim, C.-K. J. Control. Release, 2000, 68, 397–404.
  • Díaz-Montes, E. Polysaccharides, 2021, 2, 554–565.
  • Heinze, T.; Liebert, T.; Heublein, B.; Hornig, S. Functional Polymers Based on Dextran. In Polysaccharides II; Springer Berlin Heidelberg; pp. 199–291, 2006.
  • Naessens, M.; Cerdobbel, A.; Soetaert, W.; Vandamme, E.J. J. Chem. Technol. Biotechnol., 2005, 80, 845–860.
  • Rahman, M.S.; Hasan, M.S.; Nitai, A.S.; Nam, S.; Karmakar, A.K.; Ahsan, M.S.; Shiddiky, M.J.A.; Ahmed, M.B. Polymers (Basel)., 2021, 13, 1345.
  • Shu, W.; Wang, Y.; Zhang, X.; Li, C.; Le, H.; Chang, F. Front. Bioeng. Biotechnol., 2021, 9.788461.
  • Malinovskaja-Gomez, K.; Labouta, H.I.; Schneider, M.; Hirvonen, J.; Laaksonen, T. Eur. J. Pharm. Sci., 2016, 89, 154–162.
  • Dinescu, S.; Ignat, S.; Lazar, A.; Marin, S.; Danilă, E.; Marin, M.M.; Udeanu, D.I.; Ghica, M.V.; Albu Kaya, M.G.; Costache, M. J. Immun. Res., 2019, 4513108.
  • Albu, M. G.Collagen Gels and Matrices for Biomedical Applications, Lambert Academic Publishing, Saarbrücken, 2011.
  • Ghica, M.V.; Albu, M.G.; Popa, L.; Moisescu, Ș., Pharmazie, 2013, 68(5), 340-348.
  • Marin, M.M.;Albu Kaya, M.G.;Ghica, M.V.;Dănilă, E.;Coară, G.;Popa, L.; Chelaru, C.;Kaya, D.A.;Anuța, V.; Dinu-Pîrvu, C.E.;Cristescu, I. Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration, Proceedings of the 8thInternationalConferenceonAdvancedMaterialsandSystems (ICAMS),Bucharest, 1-3 October 2020, p. 201-206, 2020.
  • Udeanu, D.I.; Albu Kaya, M.G.; Ghica, M.V.; Marin, S.; Marin, M.M.; Kaya, D.A.; Popa, L., Dinu-Pîrvu, C.E. Farmacia,2018, 66(5), 783-790.
  • Ghica, M.V.; Albu Kaya, M.G.; Udeanu, D.I.; Marin, M.M.; Marin, S.; Kaya, D.A.;Dinu-Pirvu, C.; Popa, L.; Danila, E. RO Patent 132850, October 29, 2021.
There are 26 citations in total.

Details

Primary Language English
Subjects Material Production Technologies
Journal Section Research Articles
Authors

Minodora Maria Marın This is me 0000-0001-8310-5075

Mihaela Violeta Ghıca This is me 0000-0001-6853-9203

Alpaslan Kaya 0000-0003-3544-9214

Denisa Ioana Udeanu This is me 0000-0001-5266-2530

Madalina Albu Kaya 0000-0001-9960-2244

Cristina-elena Dınu-pîrvu This is me 0000-0003-1704-7887

Lăcrămioara Popa This is me 0000-0002-3139-9865

Valentina Anuța This is me 0000-0003-1266-5862

Razvan Mihai Prısada This is me 0000-0001-9585-7717

Project Number PED 160/03.01.2017,code PN-III-P2-2.1-PED-2016-0813
Publication Date December 31, 2022
Published in Issue Year 2022 Volume: 6 Issue: 2

Cite

APA Marın, M. M., Ghıca, M. V., Kaya, A., Udeanu, D. I., et al. (2022). Polymer – flufenamic acid delivery systems for injured skin. International Journal of Chemistry and Technology, 6(2), 114-121. https://doi.org/10.32571/ijct.1135548
AMA Marın MM, Ghıca MV, Kaya A, Udeanu DI, Albu Kaya M, Dınu-pîrvu Ce, Popa L, Anuța V, Prısada RM. Polymer – flufenamic acid delivery systems for injured skin. Int. J. Chem. Technol. December 2022;6(2):114-121. doi:10.32571/ijct.1135548
Chicago Marın, Minodora Maria, Mihaela Violeta Ghıca, Alpaslan Kaya, Denisa Ioana Udeanu, Madalina Albu Kaya, Cristina-elena Dınu-pîrvu, Lăcrămioara Popa, Valentina Anuța, and Razvan Mihai Prısada. “Polymer – Flufenamic Acid Delivery Systems for Injured Skin”. International Journal of Chemistry and Technology 6, no. 2 (December 2022): 114-21. https://doi.org/10.32571/ijct.1135548.
EndNote Marın MM, Ghıca MV, Kaya A, Udeanu DI, Albu Kaya M, Dınu-pîrvu C-e, Popa L, Anuța V, Prısada RM (December 1, 2022) Polymer – flufenamic acid delivery systems for injured skin. International Journal of Chemistry and Technology 6 2 114–121.
IEEE M. M. Marın, “Polymer – flufenamic acid delivery systems for injured skin”, Int. J. Chem. Technol., vol. 6, no. 2, pp. 114–121, 2022, doi: 10.32571/ijct.1135548.
ISNAD Marın, Minodora Maria et al. “Polymer – Flufenamic Acid Delivery Systems for Injured Skin”. International Journal of Chemistry and Technology 6/2 (December 2022), 114-121. https://doi.org/10.32571/ijct.1135548.
JAMA Marın MM, Ghıca MV, Kaya A, Udeanu DI, Albu Kaya M, Dınu-pîrvu C-e, Popa L, Anuța V, Prısada RM. Polymer – flufenamic acid delivery systems for injured skin. Int. J. Chem. Technol. 2022;6:114–121.
MLA Marın, Minodora Maria et al. “Polymer – Flufenamic Acid Delivery Systems for Injured Skin”. International Journal of Chemistry and Technology, vol. 6, no. 2, 2022, pp. 114-21, doi:10.32571/ijct.1135548.
Vancouver Marın MM, Ghıca MV, Kaya A, Udeanu DI, Albu Kaya M, Dınu-pîrvu C-e, Popa L, Anuța V, Prısada RM. Polymer – flufenamic acid delivery systems for injured skin. Int. J. Chem. Technol. 2022;6(2):114-21.
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