Tip II Diyabetes Mellituslu Hastalarda Serum Ürik Asit Ve Gama Glutamil Transferaz Düzeyleri İle Koroner Arter Hastalığı Gelişimi Arasındaki İlişki
Abstract
Amaç: Çalışmamızda koroner arter hastalığının (KAH) eşlik ettiği tip 2 diyabetesmellituslu (DM) hastalarla
tip 2 DM tanısıyla takip edilen hastalar serum ürik asit (SÜA) ve gama glutamiltransferaz (GGT) düzeyleri
diğer metabolik parametreler ile birlikte incelenerek prospektif olarak karşılaştırılmış; diyabetik hastalarda
bu parametreler ile KAH gelişimi arasındaki ilişki ortaya koymak amaçlanmıştır.
Gereç ve Yöntem: Kahramanmaraş Necip Fazıl Şehir Hastanesi\'nde gerçekleştirilen bu çalışmaya,
kardiyoloji polikliniğine başvuran tip II DM'lI 118 hasta, KAH\'nın eşlik ettiği 222 adet tip 2 DM\'li hasta
dahil edildi.
Bulgular: Guruplar arasında SÜA düzeylerinde anlamlı farkın olmadığı (5.37±1.48 vs 5.27±1.51 mg/dl;
p=0.194), GGT düzeyinin ise tip II DM'nin eşlik ettiği KAH olan grupta sadece tip II DM olan gruba göre
istatistiki olarak anlamlı olarak daha yüksek olduğunu tespit ettik(23,0 (16,0-32,50) vs 25 (18,0-39,0) U/L; P
< 0,0001).
Sonuç: Çalışmamızda serum GGTdüzeyinin diyabetli hastalarda kardiyovasküler riskin artışını gösteren bir
prediktör olabileceğini gözlemledik. Ancak SÜAseviyesiyle tip II DM'li hastalarda KAH riski arasında ilişki
saptanamamıştır
References
- 1.Solberg LA, Enger SC, Hjermann I, et al. Risk factors for coronary and cerebral atherosclerosis in Oslo Study. In: Gotto AM, Smith LC, Allen B AD AL. Atherosclerosis V. New York, NY: Springer Verlag; 1980:57-62.
- 2.American Diabetes Association. Standards of medicalcare in diabetes-2008. Diabetes Care 2008;31 Suppl 1:12-54.
- 3.Stamler J, Caccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial (MRFIT). Diabetes Care 1993;16:434-44.
- 4.Ruttmann E, Brant LJ, Concin H ve ark.Vorarlberg health monitoring and promotion program study group. Gamma-glutamyl transferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrianadults. Circulation. 2005; 112: 2130-7.
- 5.Pompella A, Emdin M, Passino C et al. Thesignificance of serum gamma-glutamyl transferase in cardiovascular diseases. Clin Chem Lab Med. 2004; 42: 1085-91.
- 6.Meisinger C, Döring A, Schneider A. Serum gammaglutamyl transferase is a predictor of incident coronary events in apparently healthy men fromthe general population. Atherosclerosis 2006; 189: 297-302.
- 7.Turgut O, Yilmaz A, Yalta K ve ark. Gamma glutamyl transferase is a promising biomarker for cardiovascular risk. MedHypotheses 2006; 67: 1060-4.
- 8.Ndrepepa G, Braun S, Schunkert H, et al. Gammaglutamyl transferase and prognosis in patients with coronary artery disease. Clin Chim Acta. 2015 Nov 12;452:155-60.
- 9.Celik O, Cakmak HA, Satilmis S, Gungor B at al. The relationship between gamma-glutamyl transferase levels and coronary plaque burdens and plaque structures in young adults with coronary atherosclerosis. Clin Cardiol. 2014 Sep;37(9):552-7.
- 10.Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996;174:288-91.
- 11.Kato M, Hisatome I, Tomikura Yet al. Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol 2005;96:1576-8.
- 12.Biscaglia S, Ceconi C, Malagù M, Pavasini R, Ferrari R. Uric acid and coronary artery disease: An elusive link deserving further attention. Int J Cardiol. 2015 (15)30315- 6.
- 13.Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid tomortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141:637-44.
- 14.Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131:7-13.
- 15.Erdoğan D, Güllü H, Çalışkan M, et al. Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults. Int J Clin Pract 2005;59:1276-82.
- 16.Tavil Y, Kaya MG, Oktar SO et al. Uric acid level and its association with carotid intima-media thickness in patients with hypertension. Atherosclerosis 2008;197:159-63.
The Relationship Between Type 2 DM Patients With Serum Uric Acid And Gamma Glutamyl Transferase Levels and Development Coronary Artery Disease
Abstract
Objective: In this study we prospectively compared the patients with coronary artery disease (CAD)
accompanied type 2 diabetes mellitus (DM) and patients followed with type 2 diabetes in view of the serum
uric acid (SUA) and glutamil gamma transferase (GGT) levels furthermore metabolic parameters; it is
targeted to reveal the relationship between these parameters and CAD development risk in diabetic patients.
Materials-Methods: 118 patients with type ll DM and 222 type 2 DM patients with CAD who were applied
to the cardiology output clinic enrolled to the study.
Results: No significant difference was established between groups for SUAlevels (5.37 ± 1,48 vs 5.27±1,51
mg/dl; p=0,194) , while the GGT levels in CAD with type ll DM detected statistically significent higher than type II DM group(23.0 (16,0-32,50) vs 25 (18,0-39,0)U/L; P< 0,001).
Conclusion: We observed serum GGTlevels in DM patients are a predictor of the raising cardiovascular risk.
However, SUAlevels in type II DM are not have a relation with the risk of CAD.
References
- 1.Solberg LA, Enger SC, Hjermann I, et al. Risk factors for coronary and cerebral atherosclerosis in Oslo Study. In: Gotto AM, Smith LC, Allen B AD AL. Atherosclerosis V. New York, NY: Springer Verlag; 1980:57-62.
- 2.American Diabetes Association. Standards of medicalcare in diabetes-2008. Diabetes Care 2008;31 Suppl 1:12-54.
- 3.Stamler J, Caccaro O, Neaton JD, Wentworth D. Diabetes, other risk factors, and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial (MRFIT). Diabetes Care 1993;16:434-44.
- 4.Ruttmann E, Brant LJ, Concin H ve ark.Vorarlberg health monitoring and promotion program study group. Gamma-glutamyl transferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163,944 Austrianadults. Circulation. 2005; 112: 2130-7.
- 5.Pompella A, Emdin M, Passino C et al. Thesignificance of serum gamma-glutamyl transferase in cardiovascular diseases. Clin Chem Lab Med. 2004; 42: 1085-91.
- 6.Meisinger C, Döring A, Schneider A. Serum gammaglutamyl transferase is a predictor of incident coronary events in apparently healthy men fromthe general population. Atherosclerosis 2006; 189: 297-302.
- 7.Turgut O, Yilmaz A, Yalta K ve ark. Gamma glutamyl transferase is a promising biomarker for cardiovascular risk. MedHypotheses 2006; 67: 1060-4.
- 8.Ndrepepa G, Braun S, Schunkert H, et al. Gammaglutamyl transferase and prognosis in patients with coronary artery disease. Clin Chim Acta. 2015 Nov 12;452:155-60.
- 9.Celik O, Cakmak HA, Satilmis S, Gungor B at al. The relationship between gamma-glutamyl transferase levels and coronary plaque burdens and plaque structures in young adults with coronary atherosclerosis. Clin Cardiol. 2014 Sep;37(9):552-7.
- 10.Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol 1996;174:288-91.
- 11.Kato M, Hisatome I, Tomikura Yet al. Status of endothelial dependent vasodilation in patients with hyperuricemia. Am J Cardiol 2005;96:1576-8.
- 12.Biscaglia S, Ceconi C, Malagù M, Pavasini R, Ferrari R. Uric acid and coronary artery disease: An elusive link deserving further attention. Int J Cardiol. 2015 (15)30315- 6.
- 13.Freedman DS, Williamson DF, Gunter EW, Byers T. Relation of serum uric acid tomortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol 1995;141:637-44.
- 14.Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med 1999; 131:7-13.
- 15.Erdoğan D, Güllü H, Çalışkan M, et al. Relationship of serum uric acid to measures of endothelial function and atherosclerosis in healthy adults. Int J Clin Pract 2005;59:1276-82.
- 16.Tavil Y, Kaya MG, Oktar SO et al. Uric acid level and its association with carotid intima-media thickness in patients with hypertension. Atherosclerosis 2008;197:159-63.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 30, 2016 |
| Submission Date | April 16, 2016 |
| Acceptance Date | April 27, 2016 |
| Published in Issue | Year 2016 Volume: 13 Issue: 3 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty