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Coenzyme Q10: Biological Activitiy and Current Approach on the Effect on Health

Year 2019, Volume: 6 Issue: 2, 95 - 111, 29.08.2019
https://doi.org/10.21020/husbfd.450217

Abstract






















Coenzyme Q10
is an endogenously synthesized and lipid-soluble benzoquinone compound. To date
the role in mitochondrial energy production and its antioxidant properties are
the well-known activities of coenzyme Q10. In addition, it is stated
that coenzyme Q10 has important roles in cell growth and in the
control of apoptosis in the case of cellular redox, in which it functions in
cell signaling and gene expression. Because of these biological activities, it
is associated with a number of diseases such as high blood pressure, diabetes,
cancer and cardiovascular disease and also it is effective in the treatment of
some neurodegenerative diseases such as alzheimer and parkinson.
It has been reported that the
dietary intake of coenzyme
Q10, which decreases especially in
tissues with aging, is inadequate. Experimental and observational studies are
needed to understand the role of vitamin in the pathology of diseases and their
prevention. In this review article, it is aimed to evaluate the health effects
of coenzyme
Q10 according to current studies.

References

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  • Acosta, M.J., Fonseca, L.V., Desbats, M.A., Cerqua, C., Zordan, R., Trevisson, E., ve diğerleri. (2016). Coenzyme Q biosynthesis in health and disease. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1857(8), 1079-1085. doi:10.1016/j.bbabio.2016.03.036
  • Alcázar-Fabra, M., Navas, P., Brea-Calvo, G. (2016). Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1857(8), 1073-1078. doi:10.1016/j.bbabio.2016.03.010
  • Alcocer-Gómez, E., Cano-García, F.J., Cordero, M.D. (2013). Effect of coenzyme Q 10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: Four case reports and literature review. Nutrition, 29(11), 1422-1425. doi: 10.1016/j.nut.2013.05.005 Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Burón, M.I., López-Lluch, G., Navas P. (1997). Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. Journal of bioenergetics and biomembranes, 29(3), 259-267.
  • Baysal, A., Aksoy, M., Besler, H., Bozkurt, N., Keçecioğlu, S., Merdol, T., ve diğerleri. (2008). Diyet El Kitabı. 5. baskı. Ankara: Hatipoğlu Yayınevi.
  • Bello, R.I., Kagan, V.E., Tyurin, V., Navarro, F., Alcaín, F.J., Villalba, J.M. (2003). Regeneration of lipophilic antioxidants by NAD (P) H: quinone oxidoreductase 1. Protoplasma, 221(1), 129-135. doi:10.1007/s00709-002-0068-x
  • Bentinger, M., Tekle, M., Dallner, G. (2010). Coenzyme Q–biosynthesis and functions. Biochemical and biophysical research communications, 396(1), 74-79. doi:10.1016/j.bbrc.2010.02.147
  • Burke, B.E., Neuenschwander, R., Olson, R.D. (2001). Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Southern medical journal, 94(11), 1112-1117.
  • Butterfield, D.A. (2004). Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain. Brain research, 1000(1):1-7. doi:10.1016/j.brainres.2003.12.012
  • Cordero, M.D., Alcocer-Gómez, E., de Miguel, M., Culic, O., Carrión, A.M., Alvarez-Suarez, J.M., ve diğerleri. (2013). Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxidants & Redox Signaling, 19(2), 1356-1361. doi: 10.1089/ars.2013.5260
  • Cordero, M.D., Cotán, D., del-Pozo-Martín, Y., Carrión, A.M., de Miguel, M., Bullón, P., ve diğerleri. (2012). Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition, 28(11), 1200-1203. doi: 10.1016/j.nut.2012.03.018
  • Cordero, M.D., Díaz-Parrado, E., Carrión, A.M., Alfonsi, S., Sánchez-Alcazar, J.A., Bullón, P., ve diğerleri. (2013). Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia? Antioxidants & Redox Signaling, 18(7), 800-807. doi: 10.1089/ars.2012.4892
  • Crane, F.L. (2001). Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598. doi:10.1080/07315724.2001.10719063 Dallner, G., Sindelar, P.J. (2000). Regulation of ubiquinone metabolism. Free Radical Biology and Medicine, 29(3), 285-294. doi:10.1016/S0891-5849(00)00307-5
  • de Grey, A.D.N.J. (2001). A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion, 1(2), 129-139. doi:10.1016/S1567-7249(01)00008-3
  • Ernster, L., Dallner, G. (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1271(1):195-204.
  • Fan, L., Feng, Y., Chen, G.C., Qin, L.Q., Fu, C.l., Chen, L.H. (2017). Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacological research, 119(2017), 128-136. doi:10.1016/j.phrs.2017.01.032
  • Folkers, K., Vadhanavikit, S., Mortensen, S.A. (1985). Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proceedings of the National Academy of Sciences, 82(3), 901-904. doi:10.1073/pnas.82.3.901
  • Fotino, A.D., Thompson-Paul, A.M., Bazzano, L.A. (2012). Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. The American journal of clinical nutrition, 97(2), 268-275. doi:10.3945/ajcn.112.040741
  • Frei, B., Kim, M.C., Ames, B.N. (1990). Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences, 87(12), 4879-4883.
  • Gómez-Díaz, C., Rodríguez-Aguilera, J.C., Barroso, M.P., Villalba, J.M., Navarro, F., Crane, F.L., ve diğerleri. (1997). Antioxidant ascorbate is stabilized by NADH-coenzyme Q 10 reductase in the plasma membrane. Journal of bioenergetics and biomembranes, 29(3), 251-257.
  • González, R., Ferrín, G., Hidalgo, A.B., Ranchal, I., López-Cillero, P., Santos-Gónzalez, M., ve diğerleri. (2009). N-acetylcysteine, coenzyme Q 10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chemico-biological interactions, 181(1), 95-106. doi:10.1016/j.cbi.2009.06.003
  • Gvozdjáková, A., Kucharská, J., Dubravicky, J., Mojto, V., Singh, R.B. (2015).Coenzyme Q10, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility. Disease markers, 2015. doi: 10.1155/2015/827941
  • Hebert, L.E., Beckett, L.A., Scherr, P.A., Evans, D.A. (2001). Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Disease & Associated Disorders, 15(4), 169-173. doi:10.5014/ajot.2011.002634
  • Hershey, A.D., Powers, S.W., Vockell, A.L.B., LeCates, S.L., Ellinor, P.L., Segers, A., ve diğerleri. (2007). Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache: the journal of head and face pain, 47(1):73-80. doi:10.1111/j.1526-4610.2007.00652.x
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Koenzim Q10 : Biyolojik Aktivitesi ve Sağlık Üzerine Etkisine Güncel Bakış

Year 2019, Volume: 6 Issue: 2, 95 - 111, 29.08.2019
https://doi.org/10.21020/husbfd.450217

Abstract

Koenzim Q10, endojen olarak sentezlenen ve yağda
çözünen bir benzokinon bileşiğidir. Mitokondrial enerji üretimindeki görevi ve antioksidan özelliği koenzim
Q10’nin
bugüne kadar en iyi bilinen fonksiyonlarıdır
.
Ayrıca koenzim
Q10’nin
hücre sinyalizasyonunda ve gen ekspresyonunda görev aldığı, hücresel redoks
reaksiyonlarında,
hücre büyümesi ve
apoptozisin
kontrolünde de önemli görevleri olduğu belirtilmiştir.
Bu biyolojik aktiviteleri nedeniyle

kalp sağlığı, yüksek tansiyon,
diyabet ve kanser gibi hastalıkların tedavisinde yardımcı olarak kullanılmakta,
ayrıca alzheimer ve parkinson gibi bazı nörodejeneratif hastalıkların
tedavisinde de etkili olduğu bildirilmiştir. Özellikle yaşlanma ile beraber
dokularda azalan koenzim
Q10 miktarının diyetle birlikte alımının
yetersiz olduğu bildirilmiştir.
Hastalıkların
patolojisinde vitaminin rolü ve önlenmesine yönelik mekanizmaların anlaşılması
için deneysel ve gözlemsel çalışmalara ihtiyaç duyulmaktadır. Bu derleme yazıda koenzim Q10’nin
sağlık üzerine etkilerinin güncel çalışmalara göre değerlendirilmesi
amaçlanmıştır.  

References

  • Abdollahzad, H., Aghdashi, M.A., Jafarabadi, M.A., Alipour, B. (2015). Effects of Coenzyme Q 10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Archives of medical research, 46(7), 527-533. doi: 10.1016/j.arcmed.2015.08.006
  • Abdollahzad, H., Alipour, B., Aghdashi, M.A., Jafarabadi, M.A. (2015). Coenzyme Q 10 supplementation in patients with rheumatoid arthritis: Are there any effects on cardiovascular risk factors? European Journal of Integrative Medicine, 7(5):534-539. doi: 10.1016/j.eujim.2015.09.003
  • Acosta, M.J., Fonseca, L.V., Desbats, M.A., Cerqua, C., Zordan, R., Trevisson, E., ve diğerleri. (2016). Coenzyme Q biosynthesis in health and disease. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1857(8), 1079-1085. doi:10.1016/j.bbabio.2016.03.036
  • Alcázar-Fabra, M., Navas, P., Brea-Calvo, G. (2016). Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1857(8), 1073-1078. doi:10.1016/j.bbabio.2016.03.010
  • Alcocer-Gómez, E., Cano-García, F.J., Cordero, M.D. (2013). Effect of coenzyme Q 10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: Four case reports and literature review. Nutrition, 29(11), 1422-1425. doi: 10.1016/j.nut.2013.05.005 Barroso, M.P., Gómez-Díaz, C., Villalba, J.M., Burón, M.I., López-Lluch, G., Navas P. (1997). Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. Journal of bioenergetics and biomembranes, 29(3), 259-267.
  • Baysal, A., Aksoy, M., Besler, H., Bozkurt, N., Keçecioğlu, S., Merdol, T., ve diğerleri. (2008). Diyet El Kitabı. 5. baskı. Ankara: Hatipoğlu Yayınevi.
  • Bello, R.I., Kagan, V.E., Tyurin, V., Navarro, F., Alcaín, F.J., Villalba, J.M. (2003). Regeneration of lipophilic antioxidants by NAD (P) H: quinone oxidoreductase 1. Protoplasma, 221(1), 129-135. doi:10.1007/s00709-002-0068-x
  • Bentinger, M., Tekle, M., Dallner, G. (2010). Coenzyme Q–biosynthesis and functions. Biochemical and biophysical research communications, 396(1), 74-79. doi:10.1016/j.bbrc.2010.02.147
  • Burke, B.E., Neuenschwander, R., Olson, R.D. (2001). Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Southern medical journal, 94(11), 1112-1117.
  • Butterfield, D.A. (2004). Proteomics: a new approach to investigate oxidative stress in Alzheimer's disease brain. Brain research, 1000(1):1-7. doi:10.1016/j.brainres.2003.12.012
  • Cordero, M.D., Alcocer-Gómez, E., de Miguel, M., Culic, O., Carrión, A.M., Alvarez-Suarez, J.M., ve diğerleri. (2013). Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Antioxidants & Redox Signaling, 19(2), 1356-1361. doi: 10.1089/ars.2013.5260
  • Cordero, M.D., Cotán, D., del-Pozo-Martín, Y., Carrión, A.M., de Miguel, M., Bullón, P., ve diğerleri. (2012). Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Nutrition, 28(11), 1200-1203. doi: 10.1016/j.nut.2012.03.018
  • Cordero, M.D., Díaz-Parrado, E., Carrión, A.M., Alfonsi, S., Sánchez-Alcazar, J.A., Bullón, P., ve diğerleri. (2013). Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia? Antioxidants & Redox Signaling, 18(7), 800-807. doi: 10.1089/ars.2012.4892
  • Crane, F.L. (2001). Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598. doi:10.1080/07315724.2001.10719063 Dallner, G., Sindelar, P.J. (2000). Regulation of ubiquinone metabolism. Free Radical Biology and Medicine, 29(3), 285-294. doi:10.1016/S0891-5849(00)00307-5
  • de Grey, A.D.N.J. (2001). A proposed mechanism for the lowering of mitochondrial electron leak by caloric restriction. Mitochondrion, 1(2), 129-139. doi:10.1016/S1567-7249(01)00008-3
  • Ernster, L., Dallner, G. (1995). Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1271(1):195-204.
  • Fan, L., Feng, Y., Chen, G.C., Qin, L.Q., Fu, C.l., Chen, L.H. (2017). Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacological research, 119(2017), 128-136. doi:10.1016/j.phrs.2017.01.032
  • Folkers, K., Vadhanavikit, S., Mortensen, S.A. (1985). Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proceedings of the National Academy of Sciences, 82(3), 901-904. doi:10.1073/pnas.82.3.901
  • Fotino, A.D., Thompson-Paul, A.M., Bazzano, L.A. (2012). Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. The American journal of clinical nutrition, 97(2), 268-275. doi:10.3945/ajcn.112.040741
  • Frei, B., Kim, M.C., Ames, B.N. (1990). Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proceedings of the National Academy of Sciences, 87(12), 4879-4883.
  • Gómez-Díaz, C., Rodríguez-Aguilera, J.C., Barroso, M.P., Villalba, J.M., Navarro, F., Crane, F.L., ve diğerleri. (1997). Antioxidant ascorbate is stabilized by NADH-coenzyme Q 10 reductase in the plasma membrane. Journal of bioenergetics and biomembranes, 29(3), 251-257.
  • González, R., Ferrín, G., Hidalgo, A.B., Ranchal, I., López-Cillero, P., Santos-Gónzalez, M., ve diğerleri. (2009). N-acetylcysteine, coenzyme Q 10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chemico-biological interactions, 181(1), 95-106. doi:10.1016/j.cbi.2009.06.003
  • Gvozdjáková, A., Kucharská, J., Dubravicky, J., Mojto, V., Singh, R.B. (2015).Coenzyme Q10, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility. Disease markers, 2015. doi: 10.1155/2015/827941
  • Hebert, L.E., Beckett, L.A., Scherr, P.A., Evans, D.A. (2001). Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Disease & Associated Disorders, 15(4), 169-173. doi:10.5014/ajot.2011.002634
  • Hershey, A.D., Powers, S.W., Vockell, A.L.B., LeCates, S.L., Ellinor, P.L., Segers, A., ve diğerleri. (2007). Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache: the journal of head and face pain, 47(1):73-80. doi:10.1111/j.1526-4610.2007.00652.x
  • Hidaka, T., Fujii, K., Funahashi, I., Fukutomi, N., Hosoe, K. (2008). Safety assessment of coenzyme Q10 (CoQ10). Biofactors, 32(1-4):199-208. doi:10.1002/biof.5520320124
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There are 52 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Kadriye Toprak

Aylin Ayaz

Publication Date August 29, 2019
Submission Date August 1, 2018
Published in Issue Year 2019 Volume: 6 Issue: 2

Cite

APA Toprak, K., & Ayaz, A. (2019). Koenzim Q10 : Biyolojik Aktivitesi ve Sağlık Üzerine Etkisine Güncel Bakış. Hacettepe University Faculty of Health Sciences Journal, 6(2), 95-111. https://doi.org/10.21020/husbfd.450217