Research Article
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Year 2023, Volume: 10 Issue: 2, 99 - 116, 30.06.2023
https://doi.org/10.17350/HJSE19030000297

Abstract

Supporting Institution

Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

KÜ-BAP01/2019-3

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Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Year 2023, Volume: 10 Issue: 2, 99 - 116, 30.06.2023
https://doi.org/10.17350/HJSE19030000297

Abstract

In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.

Project Number

KÜ-BAP01/2019-3

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There are 92 citations in total.

Details

Primary Language English
Subjects Environmental and Sustainable Processes
Journal Section Research Article
Authors

Mahmut Gür 0000-0001-9942-6324

Merve Zurnacı 0000-0002-2928-3492

Eda Altınöz 0000-0003-1277-2019

Nesrin Şener 0000-0001-5370-6048

Çiğdem Şahin 0000-0002-3370-2434

Merve Şenturan 0000-0003-2700-7088

İzzet Şener 0000-0003-0540-7523

Muhammet Çavuş 0000-0002-3721-0883

Ergin Murat Altuner 0000-0001-5351-8071

Project Number KÜ-BAP01/2019-3
Publication Date June 30, 2023
Submission Date October 20, 2022
Published in Issue Year 2023 Volume: 10 Issue: 2

Cite

Vancouver Gür M, Zurnacı M, Altınöz E, Şener N, Şahin Ç, Şenturan M, Şener İ, Çavuş M, Altuner EM. Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite J Sci Eng. 2023;10(2):99-116.

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