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Most Known Citrus L. Species and Breast Cancer Relationship

Year 2024, Volume: 6 Issue: 1, 36 - 51, 30.04.2024

Ömer Faruk Yakıncı İpek Süntar

https://doi.org/10.59124/guhes.1407399

Abstract

The genus Citrus L. belongs to the Rutaceae family of flowering plants and shrubs. Citrus genus has valuable edible fruits such as oranges, lemons, grapefruits, pomelos, and limes. Australia, Melanesia, Southeast Asia, East Asia, and South Asia are the native habitats of the genus Citrus. Indigenous societies in these regions have long utilized and tamed various Citrus species. Citrus fruits and their secondary metabolites have been reported to be useful agents in numerous studies to possess anti-inflammatory, antioxidant, and anticancer properties. This review gives an overview of Citrus species and background information on the potential anticancer properties of the compounds identified, along with the related in vitro and in vivo research. Studies from the past have revealed a variety of biological functions that Citrus compounds can regulate, such as angiogenesis, apoptosis, metastasis, cell cycle regulation, and cell proliferation. These promising data call for more investigation into the chemopreventative activity of Citrus and phytoconstituents.

Keywords

breast cancer Citrus coumarin flavonoid rutaceae

References

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Year 2024, Volume: 6 Issue: 1, 36 - 51, 30.04.2024

Ömer Faruk Yakıncı İpek Süntar

https://doi.org/10.59124/guhes.1407399

Abstract

References

  • Agócs, A., Nagy, V., Szabó, Z., Márk, L., Ohmacht, R., & Deli, J. (2007). Comparative study on the carotenoid composition of the peel and the pulp of different citrus species. Innovative Food Science & Emerging Technologies, 8(3), 390-394. https://doi.org/10.1016/j.ifset.2007.03.012
  • Agouillal, F., Taher, Z. M., Moghrani, H., Nasrallah, N., & El Enshasy, H. (2017). A Review of Genetic Taxonomy, Biomolecules Chemistry and Bioactivities of Citrus hystrix DC. Biosciences Biotechnology Research Asia, 14(1), 285. https://doi.org/10.13005/bbra/2446
  • Al-Ataby, I. A., & Talib, W. H. (2022). Daily Consumption of Lemon and Ginger Herbal Infusion Caused Tumor Regression and Activation of the Immune System in a Mouse Model of Breast Cancer. Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.829101
  • Alquézar, B., Rodrigo, M. J., & Zacarías, L. (2008). Carotenoid biosynthesis and their regulation in citrus fruits. Tree and Forestry Science and Biotechnology, 2(1), 23-37.
  • Alshatwi, A. A., Shafi, G., Hasan, T. N., Al-Hazzani, A. A., Alsaif, M. A., Alfawaz, M. A., Lei, K., & Munshi, A. (2011). Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pacific Journal of Cancer Prevention, 12(6), 1555-1559.
  • Amalina, N., & Wahyuni, S. (2021). Cytotoxic effects of the synthesized Citrus aurantium peels extract nanoparticles against MDA-MB-231 breast cancer cells. Journal of Physics: Conference Series,
  • Ashrafizadeh, M., Ahmadi, Z., Mohammadinejad, R., Kaviyani, N., & Tavakol, S. (2020). Monoterpenes modulating autophagy: A review study. Basic & Clinical Pharmacology & Toxicology, 126(1), 9-20. https://doi.org/10.1111/bcpt.13282
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  • Bhuiyan, M. N. I., Begum, J., Sardar, P., & Rahman, M. (2009). Constituents of peel and leaf essential oils of Citrus medica L. Journal of Scientific Research, 1(2), 387-392. https://doi.org/10.3329/jsr.v1i2.1760
  • Cebadera-Miranda, L., Morales, P., & Cámara, M. (2020). Bioactive compounds in oranges from the Mediterranean climate area. In The Mediterranean Diet (pp. 293-309). Elsevier. https://doi.org/10.1016/B978-0-12-818649-7.00027-8
  • Chen, S., Wang, X., Cheng, Y., Gao, H., & Chen, X. (2023). A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids. Molecules, 28(13), 4982. https://doi.org/10.3390/molecules28134982
  • Chhikara, B. S., & Parang, K. (2023). Global Cancer Statistics 2022: the trends projection analysis. Chemical Biology Letters, 10(1), 451-451.
  • Cirmi, S., Ferlazzo, N., Lombardo, G. E., Maugeri, A., Calapai, G., Gangemi, S., & Navarra, M. (2016). Chemopreventive agents and inhibitors of cancer hallmarks: may citrus offer new perspectives? Nutrients, 8(11), 698. https://doi.org/10.3390/nu8110698
  • de Araújo, E. F., de Queiroz, L. P., & Machado, M. A. (2003). What is Citrus? Taxonomic implications from a study of cp-DNA evolution in the tribe Citreae (Rutaceae subfamily Aurantioideae). Organisms Diversity & Evolution, 3(1), 55-62. https://doi.org/10.1078/1439-6092-00058
  • Dugrand-Judek, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., & Bourgaud, F. (2015). The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways. PloS one, 10(11), e0142757. https://doi.org/10.1371/journal.pone.0142757
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Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Articles
Authors

Ömer Faruk Yakıncı 0000-0002-9628-9376

İpek Süntar 0000-0003-4201-1325

Publication Date April 30, 2024
Submission Date December 20, 2023
Acceptance Date January 12, 2024
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

APA Yakıncı, Ö. F., & Süntar, İ. (2024). Most Known Citrus L. Species and Breast Cancer Relationship. Journal of Gazi University Health Sciences Institute, 6(1), 36-51. https://doi.org/10.59124/guhes.1407399
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