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Nanopartiküllerin Genotoksik Etkileri

Year 2021, Volume: 2 Issue: 2, 19 - 38, 01.11.2021

Aleyna Halıcı Açelya Seyrek Kübra Aykan Fatma Ünal Deniz Yüzbaşıoğlu

https://doi.org/10.5281/zenodo.5734749

Abstract

Nanoteknolojinin amacı, nanopartikül (NP) olarak adlandırılan maddeleri endüstriyel amaçlarla tasarlamak ve sentezlemektir. Ebatları ˂100 nm olan nanopartiküller, küçük boyut ve geniş yüzey alanı, iletkenlik, güç, dayanıklılık ve reaktivite gibi yeni olağanüstü özellikler kazanır. Bu özelliklerinden dolayı NP'ler tıp, eczacılık, kozmetik, elektronik, tekstil, boya, endüstri ve gıda koruma gibi çeşitli alanlarda yaygın olarak kullanılmaktadır. Fakat bu tür özellikler, nanopartiküllerin biyolojik ve toksikolojik özelliklerini de etkilemektedir. NP'ler önemli biyolojik bariyerleri ve zarları kolayca geçebilir ve organlar, hücresel organeller ve genetik materyal ile etkileşime girebilir. NP'ler oksidatif strese, inflamasyona, sitotoksisiteye, genotoksisiteye ve apoptoza neden olabilir. Bu sebeple, nanopartiküllerin olası genotoksik etkileri, Kromozom Anormallikleri (KA), Kardeş Kromatid Değişimi (KKD), Mikronukleus (MN), kuyruklu yıldız/Komet ve Allium testleri kullanılarak incelenmektedir. Bu çalışmanın amacı, yukarıda adı geçen testlerle incelenmiş olan bakır oksit (CuO), çinko oksit (ZnO), demir oksit (Fe2O3), gümüş (Ag), kobalt-krom (CoCr), silikon dioksit (SiO2), titanyum dioksit (TiO2) ve tungsten oksit (WO3) nanopartiküllerinin insan lenfositlerinde ve bazı hücre hatlarında in vitro ve Allium cepa ve Vicia faba’daki in vivo genotoksik etkileri konusundaki bazı makaleleri derlemektir. Ayrıca, nanopartiküllerin genotoksik mekanizmaları konusunda ileri sürülen görüşleri derlemektir.

Keywords

Nanopartikül Genotoksik Etki İnsan Lenfositleri Allium cepa Vicia faba

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Year 2021, Volume: 2 Issue: 2, 19 - 38, 01.11.2021

Aleyna Halıcı Açelya Seyrek Kübra Aykan Fatma Ünal Deniz Yüzbaşıoğlu

https://doi.org/10.5281/zenodo.5734749

Abstract

References

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Details

Primary Language Turkish
Journal Section Derlemeler
Authors

Aleyna Halıcı This is me 0000-0002-0423-8441

Açelya Seyrek This is me 0000-0003-0334-5154

Kübra Aykan This is me 0000-0002-9412-8317

Fatma Ünal 0000-0002-7468-6186

Deniz Yüzbaşıoğlu 0000-0003-2756-7712

Publication Date November 1, 2021
Published in Issue Year 2021 Volume: 2 Issue: 2

Cite

APA Halıcı, A., Seyrek, A., Aykan, K., Ünal, F., et al. (2021). Nanopartiküllerin Genotoksik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi, 2(2), 19-38. https://doi.org/10.5281/zenodo.5734749
AMA Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. November 2021;2(2):19-38. doi:10.5281/zenodo.5734749
Chicago Halıcı, Aleyna, Açelya Seyrek, Kübra Aykan, Fatma Ünal, and Deniz Yüzbaşıoğlu. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 2, no. 2 (November 2021): 19-38. https://doi.org/10.5281/zenodo.5734749.
EndNote Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D (November 1, 2021) Nanopartiküllerin Genotoksik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi 2 2 19–38.
IEEE A. Halıcı, A. Seyrek, K. Aykan, F. Ünal, and D. Yüzbaşıoğlu, “Nanopartiküllerin Genotoksik Etkileri”, GÜFFD, vol. 2, no. 2, pp. 19–38, 2021, doi: 10.5281/zenodo.5734749.
ISNAD Halıcı, Aleyna et al. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 2/2 (November 2021), 19-38. https://doi.org/10.5281/zenodo.5734749.
JAMA Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. 2021;2:19–38.
MLA Halıcı, Aleyna et al. “Nanopartiküllerin Genotoksik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi, vol. 2, no. 2, 2021, pp. 19-38, doi:10.5281/zenodo.5734749.
Vancouver Halıcı A, Seyrek A, Aykan K, Ünal F, Yüzbaşıoğlu D. Nanopartiküllerin Genotoksik Etkileri. GÜFFD. 2021;2(2):19-38.
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