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Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child

Year 2014, Volume: 4 Issue: 1, 41 - 43, 27.07.2014

Vehbi Doğan Sema Taşkın Erhan Karaaslan Resul Yilmaz Nurşen Çakan

Abstract

Achondroplasia is the most common skeletal dysplasia in children. Achondroplasic patients often have respiratory problems associated with upper respiratory tract obstruction and craniofacial dysmorphology. Chronic hypoxemia in these patients can result in pulmonary hypertension. In this report an achondroplasic child with severe day-time pulmonary hypertension is presented.

 

 

Keywords

achondroplasia; sleep-disordered breathing; pulmonary hypertension; continous positive airway pressure (CPAP)

References

  • Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet 2007; 370:162–172
  • Zucconi M, Weber G, Castronovo V, Ferini-Strambi L, Russo F, Chiumello G, Smirne S. Sleep and upper airway obstruction in children with achondroplasia. J Pediatr. 1996;129(5):743-9
  • Mogayzel PJ Jr, Carroll JL, Loughlin GM, Hurko O, Francomano CA, Marcus CL. Sleep-disordered breathing in children with achondroplasia. J Pediatr. 1998;132:667-71.
  • Schlüter B, De Sousa G, Trowitzsch E, Andler W. Diagnostics and management of sleep-related respiratory disturbances in children with skeletal dysplasia caused by FGFR3 mutations (achondroplasia and hypochondroplasia). Georgian Med News. 2011;196-197:63-72
  • Apprill M, Weitzenblum E, Krieger J, Oswald M, Kurtz D. Frequency and mechanism of daytime pulmonary hypertension in patients with obstructive sleep apnea syndrome. Cor Vasa. 1991;33:42-9
  • Alchanatis M, Tourkohoriti G, Kakouros S, Kosmas E, Podaras S, Jordanoglou JB. Daytime pulmonary hypertension in patients with obstructive sleep apnea: the effect of continuous positive airway pressure in pulmonary hemodynamics. Respiration 2001;68:566-72.
  • Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis. 2009;51:363-70
  • Adegunsoye A, Ramachandran S. Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders. Pulm Med. 2012;2012:273591. doi: 10.1155/2012/273591. Epub 2012 Jul 11.
  • Ito T, Sawaishi Y, Ito Y, Sugawara A. Severe pulmonary hypertension in an infant with achondroplasia. Lancet 2001; 358:1062
  • Yıldırım SV, Durmaz C, Pourbagher MA, Erkan AN. A case of achondroplasia with severe pulmonary hypertension due to obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2006;263:775-7
  • Sisk EA, Heatley DG, Borowski BJ, Leverson GE, Pauli RM. Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. Otolaryngol Head Neck Surg. 1999;120:248-54

Akondroplazik Bir Çocukta Uykuda Solunum Bozukluğuna Bağlı Gelişen Ciddi Pulmoner Hipertansiyon

Year 2014, Volume: 4 Issue: 1, 41 - 43, 27.07.2014

Vehbi Doğan Sema Taşkın Erhan Karaaslan Resul Yilmaz Nurşen Çakan

Abstract

Akondroplazi çocuklarda en sık görülen iskelet displazisidir. Akondroplazik hastalarda üst solunum yollarının obstrüksiyonu ve kraniyofasiyal dismorfoloji nedeniyle solunum yolu yakınmaları sık görülmektedir. Bu hastalarda özellikle geceleri gelişen kronik hipoksemi pulmoner hipertansiyona yol açabilmektedir. Bu makalede ciddi gün içinde de devam eden pulmoner hipertansiyon gelişen akondroplazik bir çocuk sunulmuştur.

Keywords

akondroplazi uykuda solunum bozukluğu pulmoner hipertansiyon sürekli pozitif havayolu basıncı

References

  • Horton WA, Hall JG, Hecht JT. Achondroplasia. Lancet 2007; 370:162–172
  • Zucconi M, Weber G, Castronovo V, Ferini-Strambi L, Russo F, Chiumello G, Smirne S. Sleep and upper airway obstruction in children with achondroplasia. J Pediatr. 1996;129(5):743-9
  • Mogayzel PJ Jr, Carroll JL, Loughlin GM, Hurko O, Francomano CA, Marcus CL. Sleep-disordered breathing in children with achondroplasia. J Pediatr. 1998;132:667-71.
  • Schlüter B, De Sousa G, Trowitzsch E, Andler W. Diagnostics and management of sleep-related respiratory disturbances in children with skeletal dysplasia caused by FGFR3 mutations (achondroplasia and hypochondroplasia). Georgian Med News. 2011;196-197:63-72
  • Apprill M, Weitzenblum E, Krieger J, Oswald M, Kurtz D. Frequency and mechanism of daytime pulmonary hypertension in patients with obstructive sleep apnea syndrome. Cor Vasa. 1991;33:42-9
  • Alchanatis M, Tourkohoriti G, Kakouros S, Kosmas E, Podaras S, Jordanoglou JB. Daytime pulmonary hypertension in patients with obstructive sleep apnea: the effect of continuous positive airway pressure in pulmonary hemodynamics. Respiration 2001;68:566-72.
  • Sajkov D, McEvoy RD. Obstructive sleep apnea and pulmonary hypertension. Prog Cardiovasc Dis. 2009;51:363-70
  • Adegunsoye A, Ramachandran S. Etiopathogenetic mechanisms of pulmonary hypertension in sleep-related breathing disorders. Pulm Med. 2012;2012:273591. doi: 10.1155/2012/273591. Epub 2012 Jul 11.
  • Ito T, Sawaishi Y, Ito Y, Sugawara A. Severe pulmonary hypertension in an infant with achondroplasia. Lancet 2001; 358:1062
  • Yıldırım SV, Durmaz C, Pourbagher MA, Erkan AN. A case of achondroplasia with severe pulmonary hypertension due to obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2006;263:775-7
  • Sisk EA, Heatley DG, Borowski BJ, Leverson GE, Pauli RM. Obstructive sleep apnea in children with achondroplasia: surgical and anesthetic considerations. Otolaryngol Head Neck Surg. 1999;120:248-54
There are 11 citations in total.

Details

Primary Language English
Journal Section Case Report
Authors

Vehbi Doğan This is me

Sema Taşkın This is me

Erhan Karaaslan

Resul Yilmaz

Nurşen Çakan This is me

Publication Date July 27, 2014
Published in Issue Year 2014 Volume: 4 Issue: 1

Cite

APA Doğan, V., Taşkın, S., Karaaslan, E., Yilmaz, R., et al. (2014). Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child. Çağdaş Tıp Dergisi, 4(1), 41-43.
AMA Doğan V, Taşkın S, Karaaslan E, Yilmaz R, Çakan N. Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child. J Contemp Med. July 2014;4(1):41-43.
Chicago Doğan, Vehbi, Sema Taşkın, Erhan Karaaslan, Resul Yilmaz, and Nurşen Çakan. “Severe Pulmonary Hypertension Due to Sleep-Disordered Breathing in an Achondroplasic Child”. Çağdaş Tıp Dergisi 4, no. 1 (July 2014): 41-43.
EndNote Doğan V, Taşkın S, Karaaslan E, Yilmaz R, Çakan N (July 1, 2014) Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child. Çağdaş Tıp Dergisi 4 1 41–43.
IEEE V. Doğan, S. Taşkın, E. Karaaslan, R. Yilmaz, and N. Çakan, “Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child”, J Contemp Med, vol. 4, no. 1, pp. 41–43, 2014.
ISNAD Doğan, Vehbi et al. “Severe Pulmonary Hypertension Due to Sleep-Disordered Breathing in an Achondroplasic Child”. Çağdaş Tıp Dergisi 4/1 (July 2014), 41-43.
JAMA Doğan V, Taşkın S, Karaaslan E, Yilmaz R, Çakan N. Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child. J Contemp Med. 2014;4:41–43.
MLA Doğan, Vehbi et al. “Severe Pulmonary Hypertension Due to Sleep-Disordered Breathing in an Achondroplasic Child”. Çağdaş Tıp Dergisi, vol. 4, no. 1, 2014, pp. 41-43.
Vancouver Doğan V, Taşkın S, Karaaslan E, Yilmaz R, Çakan N. Severe pulmonary hypertension due to sleep-disordered breathing in an achondroplasic child. J Contemp Med. 2014;4(1):41-3.