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ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ

Year 2023, Volume: 48 Issue: 5, 972 - 980, 15.10.2023

Hülya Şen Arslan

https://doi.org/10.15237/gida.GD23070

Abstract

Araştırmada elma atıklarının (yaprak, kabuk, posa) ultrason destekli su banyosunda 40 °C, %50 (333W) güç ve 2 saat sürede metanol ile alınan özütlerinin toplam fenolik madde miktarı (TFMM), antioksidan akivitesi, E. faecalis ve S. mutans inhibisyonu ve kolon kanser hücresi üzerine etkisi araştırılmıştır. Özütler içinde TFMM bakımından en yüksek değer yaprağa (104.72 mg/g) aittir. Atıkların antioksidan aktivitesi hem DPPH hem de ABTS yöntemiyle değerlendirilmiş ve her iki yöntemde de özütlerin yüksek antioksidan aktiviteye sahip olduğu bulunmuştur. Özütlerin patojenler üzerine antimikrobiyal aktivitesi olduğu bulunmuştur. Ayrıca; yaprak ve kabuk özütlerinin E. faecalis’e karşı posaya göre daha fazla inhibisyon potansiyeli olduğu görülmüştür. S. mutans üzerine en yüksek etkiyi ise yaprak özütleri göstermiştir. Çalışmada kullanılan kolon kanser (HT-29) hücresini özütlerin baskıladığı sonucuna varılmıştır. Sonuçlar, elma atıklarından ultrason ile alınan özütlerin patojen mikroorganizmalar ve kolon kanser hücresi üzerine inhibisyon aktivitesini ortaya koymuştur.

Keywords

antikanserojen fenolik kabuk yaprak posa

References

  • Acosta-Estrada, B. A., Gutiérrez-Uribe, J. A., Serna-Saldívar, S. O. (2014). Bound phenolics in foods, a review. Food Chemistry, 152, 46–55.
  • Ameer, K., Shahbaz, H. M., Kwon, J.-H. (2017). Green extraction methods for polyphenols from plant matrices and their byproducts: A review. Comprehensive Reviews in Food Science and Food Safety, 16, 295–315.
  • Assefi, M., Lewandrowski, K. U., Nankali, S., Sharafshah, A. (2023). Antioxidants Sources.
  • Avhad, D. N., Niphadkar, S. S., Rathod, V. K. (2014). Ultrasound assisted three phase partitioning of a fibrinolytic enzyme. Ultrasonics Sonochemistry, 21(2), 628-633.
  • Barba, F. J., Parniakov, O., Pereira, S. A., Wiktor, A., Grimi, N., Boussetta, N., et al. (2015). Current applications and new opportunities for the use of pulsed electric fields in food science and industry. Food Research International, 77, 773–798.
  • Bayat, R., Akin, M., Yilmaz, B., Bekmezci, M., Bayrakci, M., Sen, F. (2023). Biogenic platinum based nanoparticles: Synthesis, characterization and their applications for cell cytotoxic, antibacterial effect, and direct alcohol fuel cells. Chemical Engineering Journal Advances, 14, 100471.
  • Bolis M.S., (1958). Antioxidant Determinations by the Use of a Stable Free Radical.
  • Boyer, J., Liu, R.H. (2004). Apple phytochemicals and their health benefits. Nutrition Journal, 3(1), 1-15.
  • Buvaneshwaran, M., Radhakrishnan, M., Natarajan, V. (2023). Influence of ultrasound‐assisted extraction techniques on the valorization of agro‐based industrial organic waste–A review. Journal of Food Process Engineering, 46(6), e14012.
  • Bujor, O. C., Ginies, C., Popa, V. I., & Dufour, C. (2018). Phenolic compounds and antioxidant activity of lingonberry (Vaccinium vitis-idaea L.) leaf, stem and fruit at different harvest periods. Food Chemistry, 252, 356-365.
  • Bujor, O. C., Le Bourvellec, C., Volf, I., Popa, V. I., & Dufour, C. (2016). Seasonal variations of the phenolic constituents in bilberry (Vaccinium myrtillus L.) leaves, stems and fruits, and their antioxidant activity. Food Chemistry, 213, 58-68.
  • Caballero-Valdés, E., Olivares-Miralles, A., Soto-Maldonado, C., & Zúñiga-Hansen, M. E. (2016). Advances in technologies for producing food-relevant polyphenols. In J. R.V.-S. J. R. Cuevas Valenzuela Jose, & Pérez-Correa (Eds.). Advances in Technologies for producing food-relevant polyphenols (pp. 63–78).
  • Carpes, S. T., Bertotto, C., Bilck, A. P., Yamashita, F., Anjos, O., Siddique, M. A. B., ... Brunton, N. P. (2021). Bio-based films prepared with apple pomace: Volatiles compound composition and mechanical, antioxidant and antibacterial properties. LWT, 144, 111241.
  • Didier, A. J., Stiene, J., Fang, L., Watkins, D., Dworkin, L. D., Creeden, J. F. (2023). Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E. Antioxidants, 12(3), 632.
  • Gao, Y., Guo, S., Zhao, Y., Ji, Q., Yun, C., Wang, S., ... Wang, H. (2023). Extraction and Preconcentration of the Main Target Polyphenols from Empetrum nigrum by Freeze-Ultrasonic Thawing Method Based on Synthetic Gemini Surfactant Aqueous Systems. Food and Bioprocess Technology, 16(4), 844-856.
  • He, X., Liu, R.H. (2007). Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. Journal of Agricultural and Food Chemistry, 55 (11):4366–4370.
  • İlbay, Z., Şahin, S. ve Kırbaşlar, Ş. İ. (2013). Optimisation of Ultrasound-Assisted Extraction of Rosehip (Rosa canina L.) with Response Surface Methodology. Journal of the Science of Food and Agriculture, 93(11), 2804-2809.
  • Kaur, C., Kapoor, H.C. (2001). Antioxidants in fruits and vegetables–the millennium’s health. International Journal of Food Science Technology, 36(7), 703-725.
  • Kruczek, M., Gumul, D., Korus, A., Buksa, K., Ziobro, R. (2023). Phenolic Compounds and Antioxidant Status of Cookies Supplemented with Apple Pomace. Antioxidants, 12(2), 324.
  • Liao, Y. H., Chou, W. Y., Chang, C. W., Lin, M. C., Wang, C. P., Lou, P. J., Chen, T. C. (2023). Chemoprevention of oral cancer: A review and future perspectives. Head & Neck, 45(4), 1045-1059.
  • Lyu, F., Luiz, S. F., Azeredo, D. R. P., Cruz, A. G., Ajlouni, S., Ranadheera, C. S. (2020). Apple pomace as a functional and healthy ingredient in food products: A review. Processes, 8, 319–333.
  • Maheshwari, S., Kumar, V., Bhadauria, G., Mishra, A. (2022). Immunomodulatory potential of phytochemicals and other bioactive compounds of fruits: A review. Food Frontiers, 3(2), 221-238.
  • Miller NJ., Rice-Evans C., Davies MJ., Gopinathan V., VE Milner A., (1993). A Novel Method for Measuring Antioxidant Capacity and Its Application to Monitoring the Antioxidant Status in Premature Neonates. Division of Biochemistry, UMDS-Guy's Campus, London, U.K.
  • Ozdemir, I.O., Tuncer, C., Solmaz, F.G., Ozturk, B. (2022). The impact of green shield bug (Palomena prasina [Hemiptera: Pentatomidae]) infestation on antioxidant enzyme activities in hazelnut (Corylus avellana L. cvs.‘Tombul,’ ‘Palaz’ and ‘Çakıldak’). Erwerbs-Obstbau, 65(1), 1-7.
  • Panadare, D. C., Rathod, V. K. (2017). Three phase partitioning for extraction of oil: A review. Trends in Food Science & Technology, 68, 145-151.
  • Putra, N. R., Rizkiyah, D. N., Abdul Aziz, A. H., Che Yunus, M. A., Veza, I., Harny, I., Tirta, A. (2023). Waste to Wealth of Apple Pomace Valorization by Past and Current Extraction Processes: A Review. Sustainability, 15(1), 830.
  • Riaz, A., Lei, S., Akhtar, H. M. S., Wan, P., Chen, D., Jabbar, S., et al. (2018). Preparation and characterization of chitosan-based antimicrobial active food packaging film incorporated with apple peel polyphenols. International Journal of Biological Macromolecules, 114, 547–555.
  • Sair, A. T., Li, Y., Zhao, W., Li, T., Liu, R. H. (2023). Anticancer activity of apple peel extracts against human breast cancer cells through insulin-like growth factor-1 signal transduction pathway. Journal of Agriculture and Food Research, 100507.
  • Samanta, S., Chakraborty, S., Bagchi, D. (2023). Pathogenesis of Neurodegenerative Diseases and the Protective Role of Natural Bioactive Components. Journal of the American Nutrition Association, 1-13.
  • Shahbazi, Y. (2017). Antibacterial and antioxidant properties of methanolic extracts of apple (Malus pumila), grape (Vitis vinifera), pomegranate (Punica granatum L.) and common fig (Ficus carica L.) fruits. Pharmaceutical Sciences, 23, 308–315.
  • Singleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 16(3).
  • Sun, J., Liu, R.H. (2008). Apple phytochemical extracts inhibit proliferation of estrogendependent and estrogen-independent human breast cancer cells through cell cycle modulation, Journal of Agricultural and Food Chemistry, 56 (24) (2008) 11661–11667.
  • Teshome, E., Teka, T. A., Nandasiri, R., Rout, J. R., Harouna, D. V., Astatkie, T., Urugo, M. M. (2023). Fruit By-Products and Their Industrial Applications for Nutritional Benefits and Health Promotion: A Comprehensive Review. Sustainability, 15(10), 7840.
  • Uğurlu, S., Bakkalbaşı, E. (2023). Yeşil Cevizlerden Ultrason Destekli Ekstraksiyon Yöntemiyle Fenolik Bileşiklerin Eldesi. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 28(1), 185-191.
  • Valicente, V. M., Peng, C. H., Pacheco, K. N., Lin, L., Kielb, E. I., Dawoodani, E., ... Mattes, R. D. (2023). Ultra-Processed Foods and Obesity Risk: A Critical Review of Reported Mechanisms. Advances in Nutrition.
  • Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry Cell Biology, 39(1), 44-84.
  • Vallée Marcotte, B., Verheyde, M., Pomerleau, S., Doyen, A., Couillard, C. (2022). Health benefits of apple juice consumption: A review of interventional trials on humans. Nutrients, 14(4), 821.
  • Wani, S. M., Masoodi, F. A., Mir, S. A., Khanday, F. A. (2023). Pullulan production by Aureobasidium pullulans MTCC 1991 from apple pomace and its characterization. Food Bioscience, 51, 102254.
  • Weichselbaum, E., Wyness, L., Stanner, S. (2010). Apple polyphenols and cardiovascular disease–a review of the evidence. Nutrition Bulletin, 35, 92–101.
  • Wolfe, K.L., Kang, X. He, X., Dong, M., Zhang, Q., Liu, R.H. (2008). Cellular antioxidant activity of common fruits, Journal of Agricultural and Food Chemistry, 56 (18): 8418–8426.
  • Wu, B., Gao, K., Guo, Y., Ma, Y., Qiu, C., Song, C., Ma, H. (2023). Research progress on extraction of active components from apple processing waste. Critical Reviews in Food Science and Nutrition, 1-15.
  • Yilmaz B., Bayraç A. T., Bayrakci M. (2020). Evaluation of anticancer activities of novel facile synthesized calix [n] arene sulfonamide analogs. Applied Biochemistry and Biotechnology, 190 (4): 1484-1497.
  • Yilmaz, B. (2022). Release of nifedipine, furosemide, and niclosamide drugs from the biocompatible poly (HEMA) hydrogel structures. Turkish Journal of Chemistry, 46(5), 1710-1722.
  • Yilmaz, B., Bayrac, A. T., Bayrakci, M. (2020). Evaluation of anticancer activities of novel facile synthesized calix [n] arene sulfonamide analogs. Applied Biochemistry and Biotechnology, 190, 1484-1497.
  • Zhang, T., Wei, X., Miao, Z., Hassan, H., Song, Y., Fan, M. (2016). Screening for antioxidant and antibacterial activities of phenolics from Golden Delicious apple pomace. Chemistry Central Journal, 10, 47–55.
  • Zhang, X. F., Wang, X., Luo, G. H. (2017). Ultrasound-assisted three phase partitioning of phycocyanin from Spirulina platensis. European Journal of Pure and Applied Chemistry Vol, 4(1).

SOME BIOACTIVE PROPERTIES OF ULTRASOUND SUPPORTED APPLE WASTE EXTRACTS

Year 2023, Volume: 48 Issue: 5, 972 - 980, 15.10.2023

Hülya Şen Arslan

https://doi.org/10.15237/gida.GD23070

Abstract

In the study, extracts of apple waste were taken in an ultrasound assisted water bath at 40 °C, 50% (333W) power and 2 hours with methanol. The total phenolic content (TFMM) and antioxidant activity of these extracts; E. faecalis and S. mutans inhibition and its effect on colon cancer were investigated. Among the extracts, the highest value in terms of TFMM belongs to the leaf (104.72 mg/g). The antioxidant activity of the wastes was evaluated by both DPPH and ABTS methods, and it was found that the extracts had high antioxidant activity in both methods. The extracts were found to have antimicrobial activity on pathogens. Moreover; It was observed that leaf and peel extracts had more inhibition potential against E. faecalis than pulp. Leaf extracts showed the highest effect on S. mutans. It was concluded that the extracts used in the study suppressed colon cancer (HT-29) cells.

Keywords

anticancer phenolic peel pulp leaf

References

  • Acosta-Estrada, B. A., Gutiérrez-Uribe, J. A., Serna-Saldívar, S. O. (2014). Bound phenolics in foods, a review. Food Chemistry, 152, 46–55.
  • Ameer, K., Shahbaz, H. M., Kwon, J.-H. (2017). Green extraction methods for polyphenols from plant matrices and their byproducts: A review. Comprehensive Reviews in Food Science and Food Safety, 16, 295–315.
  • Assefi, M., Lewandrowski, K. U., Nankali, S., Sharafshah, A. (2023). Antioxidants Sources.
  • Avhad, D. N., Niphadkar, S. S., Rathod, V. K. (2014). Ultrasound assisted three phase partitioning of a fibrinolytic enzyme. Ultrasonics Sonochemistry, 21(2), 628-633.
  • Barba, F. J., Parniakov, O., Pereira, S. A., Wiktor, A., Grimi, N., Boussetta, N., et al. (2015). Current applications and new opportunities for the use of pulsed electric fields in food science and industry. Food Research International, 77, 773–798.
  • Bayat, R., Akin, M., Yilmaz, B., Bekmezci, M., Bayrakci, M., Sen, F. (2023). Biogenic platinum based nanoparticles: Synthesis, characterization and their applications for cell cytotoxic, antibacterial effect, and direct alcohol fuel cells. Chemical Engineering Journal Advances, 14, 100471.
  • Bolis M.S., (1958). Antioxidant Determinations by the Use of a Stable Free Radical.
  • Boyer, J., Liu, R.H. (2004). Apple phytochemicals and their health benefits. Nutrition Journal, 3(1), 1-15.
  • Buvaneshwaran, M., Radhakrishnan, M., Natarajan, V. (2023). Influence of ultrasound‐assisted extraction techniques on the valorization of agro‐based industrial organic waste–A review. Journal of Food Process Engineering, 46(6), e14012.
  • Bujor, O. C., Ginies, C., Popa, V. I., & Dufour, C. (2018). Phenolic compounds and antioxidant activity of lingonberry (Vaccinium vitis-idaea L.) leaf, stem and fruit at different harvest periods. Food Chemistry, 252, 356-365.
  • Bujor, O. C., Le Bourvellec, C., Volf, I., Popa, V. I., & Dufour, C. (2016). Seasonal variations of the phenolic constituents in bilberry (Vaccinium myrtillus L.) leaves, stems and fruits, and their antioxidant activity. Food Chemistry, 213, 58-68.
  • Caballero-Valdés, E., Olivares-Miralles, A., Soto-Maldonado, C., & Zúñiga-Hansen, M. E. (2016). Advances in technologies for producing food-relevant polyphenols. In J. R.V.-S. J. R. Cuevas Valenzuela Jose, & Pérez-Correa (Eds.). Advances in Technologies for producing food-relevant polyphenols (pp. 63–78).
  • Carpes, S. T., Bertotto, C., Bilck, A. P., Yamashita, F., Anjos, O., Siddique, M. A. B., ... Brunton, N. P. (2021). Bio-based films prepared with apple pomace: Volatiles compound composition and mechanical, antioxidant and antibacterial properties. LWT, 144, 111241.
  • Didier, A. J., Stiene, J., Fang, L., Watkins, D., Dworkin, L. D., Creeden, J. F. (2023). Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E. Antioxidants, 12(3), 632.
  • Gao, Y., Guo, S., Zhao, Y., Ji, Q., Yun, C., Wang, S., ... Wang, H. (2023). Extraction and Preconcentration of the Main Target Polyphenols from Empetrum nigrum by Freeze-Ultrasonic Thawing Method Based on Synthetic Gemini Surfactant Aqueous Systems. Food and Bioprocess Technology, 16(4), 844-856.
  • He, X., Liu, R.H. (2007). Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. Journal of Agricultural and Food Chemistry, 55 (11):4366–4370.
  • İlbay, Z., Şahin, S. ve Kırbaşlar, Ş. İ. (2013). Optimisation of Ultrasound-Assisted Extraction of Rosehip (Rosa canina L.) with Response Surface Methodology. Journal of the Science of Food and Agriculture, 93(11), 2804-2809.
  • Kaur, C., Kapoor, H.C. (2001). Antioxidants in fruits and vegetables–the millennium’s health. International Journal of Food Science Technology, 36(7), 703-725.
  • Kruczek, M., Gumul, D., Korus, A., Buksa, K., Ziobro, R. (2023). Phenolic Compounds and Antioxidant Status of Cookies Supplemented with Apple Pomace. Antioxidants, 12(2), 324.
  • Liao, Y. H., Chou, W. Y., Chang, C. W., Lin, M. C., Wang, C. P., Lou, P. J., Chen, T. C. (2023). Chemoprevention of oral cancer: A review and future perspectives. Head & Neck, 45(4), 1045-1059.
  • Lyu, F., Luiz, S. F., Azeredo, D. R. P., Cruz, A. G., Ajlouni, S., Ranadheera, C. S. (2020). Apple pomace as a functional and healthy ingredient in food products: A review. Processes, 8, 319–333.
  • Maheshwari, S., Kumar, V., Bhadauria, G., Mishra, A. (2022). Immunomodulatory potential of phytochemicals and other bioactive compounds of fruits: A review. Food Frontiers, 3(2), 221-238.
  • Miller NJ., Rice-Evans C., Davies MJ., Gopinathan V., VE Milner A., (1993). A Novel Method for Measuring Antioxidant Capacity and Its Application to Monitoring the Antioxidant Status in Premature Neonates. Division of Biochemistry, UMDS-Guy's Campus, London, U.K.
  • Ozdemir, I.O., Tuncer, C., Solmaz, F.G., Ozturk, B. (2022). The impact of green shield bug (Palomena prasina [Hemiptera: Pentatomidae]) infestation on antioxidant enzyme activities in hazelnut (Corylus avellana L. cvs.‘Tombul,’ ‘Palaz’ and ‘Çakıldak’). Erwerbs-Obstbau, 65(1), 1-7.
  • Panadare, D. C., Rathod, V. K. (2017). Three phase partitioning for extraction of oil: A review. Trends in Food Science & Technology, 68, 145-151.
  • Putra, N. R., Rizkiyah, D. N., Abdul Aziz, A. H., Che Yunus, M. A., Veza, I., Harny, I., Tirta, A. (2023). Waste to Wealth of Apple Pomace Valorization by Past and Current Extraction Processes: A Review. Sustainability, 15(1), 830.
  • Riaz, A., Lei, S., Akhtar, H. M. S., Wan, P., Chen, D., Jabbar, S., et al. (2018). Preparation and characterization of chitosan-based antimicrobial active food packaging film incorporated with apple peel polyphenols. International Journal of Biological Macromolecules, 114, 547–555.
  • Sair, A. T., Li, Y., Zhao, W., Li, T., Liu, R. H. (2023). Anticancer activity of apple peel extracts against human breast cancer cells through insulin-like growth factor-1 signal transduction pathway. Journal of Agriculture and Food Research, 100507.
  • Samanta, S., Chakraborty, S., Bagchi, D. (2023). Pathogenesis of Neurodegenerative Diseases and the Protective Role of Natural Bioactive Components. Journal of the American Nutrition Association, 1-13.
  • Shahbazi, Y. (2017). Antibacterial and antioxidant properties of methanolic extracts of apple (Malus pumila), grape (Vitis vinifera), pomegranate (Punica granatum L.) and common fig (Ficus carica L.) fruits. Pharmaceutical Sciences, 23, 308–315.
  • Singleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. American Journal of Enology and Viticulture, 16(3).
  • Sun, J., Liu, R.H. (2008). Apple phytochemical extracts inhibit proliferation of estrogendependent and estrogen-independent human breast cancer cells through cell cycle modulation, Journal of Agricultural and Food Chemistry, 56 (24) (2008) 11661–11667.
  • Teshome, E., Teka, T. A., Nandasiri, R., Rout, J. R., Harouna, D. V., Astatkie, T., Urugo, M. M. (2023). Fruit By-Products and Their Industrial Applications for Nutritional Benefits and Health Promotion: A Comprehensive Review. Sustainability, 15(10), 7840.
  • Uğurlu, S., Bakkalbaşı, E. (2023). Yeşil Cevizlerden Ultrason Destekli Ekstraksiyon Yöntemiyle Fenolik Bileşiklerin Eldesi. Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 28(1), 185-191.
  • Valicente, V. M., Peng, C. H., Pacheco, K. N., Lin, L., Kielb, E. I., Dawoodani, E., ... Mattes, R. D. (2023). Ultra-Processed Foods and Obesity Risk: A Critical Review of Reported Mechanisms. Advances in Nutrition.
  • Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry Cell Biology, 39(1), 44-84.
  • Vallée Marcotte, B., Verheyde, M., Pomerleau, S., Doyen, A., Couillard, C. (2022). Health benefits of apple juice consumption: A review of interventional trials on humans. Nutrients, 14(4), 821.
  • Wani, S. M., Masoodi, F. A., Mir, S. A., Khanday, F. A. (2023). Pullulan production by Aureobasidium pullulans MTCC 1991 from apple pomace and its characterization. Food Bioscience, 51, 102254.
  • Weichselbaum, E., Wyness, L., Stanner, S. (2010). Apple polyphenols and cardiovascular disease–a review of the evidence. Nutrition Bulletin, 35, 92–101.
  • Wolfe, K.L., Kang, X. He, X., Dong, M., Zhang, Q., Liu, R.H. (2008). Cellular antioxidant activity of common fruits, Journal of Agricultural and Food Chemistry, 56 (18): 8418–8426.
  • Wu, B., Gao, K., Guo, Y., Ma, Y., Qiu, C., Song, C., Ma, H. (2023). Research progress on extraction of active components from apple processing waste. Critical Reviews in Food Science and Nutrition, 1-15.
  • Yilmaz B., Bayraç A. T., Bayrakci M. (2020). Evaluation of anticancer activities of novel facile synthesized calix [n] arene sulfonamide analogs. Applied Biochemistry and Biotechnology, 190 (4): 1484-1497.
  • Yilmaz, B. (2022). Release of nifedipine, furosemide, and niclosamide drugs from the biocompatible poly (HEMA) hydrogel structures. Turkish Journal of Chemistry, 46(5), 1710-1722.
  • Yilmaz, B., Bayrac, A. T., Bayrakci, M. (2020). Evaluation of anticancer activities of novel facile synthesized calix [n] arene sulfonamide analogs. Applied Biochemistry and Biotechnology, 190, 1484-1497.
  • Zhang, T., Wei, X., Miao, Z., Hassan, H., Song, Y., Fan, M. (2016). Screening for antioxidant and antibacterial activities of phenolics from Golden Delicious apple pomace. Chemistry Central Journal, 10, 47–55.
  • Zhang, X. F., Wang, X., Luo, G. H. (2017). Ultrasound-assisted three phase partitioning of phycocyanin from Spirulina platensis. European Journal of Pure and Applied Chemistry Vol, 4(1).
There are 46 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering, Food Microbiology
Journal Section Articles
Authors

Hülya Şen Arslan 0000-0003-0116-9062

Early Pub Date September 11, 2023
Publication Date October 15, 2023
Published in Issue Year 2023 Volume: 48 Issue: 5

Cite

APA Şen Arslan, H. (2023). ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ. Gıda, 48(5), 972-980. https://doi.org/10.15237/gida.GD23070
AMA Şen Arslan H. ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ. The Journal of Food. October 2023;48(5):972-980. doi:10.15237/gida.GD23070
Chicago Şen Arslan, Hülya. “ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ”. Gıda 48, no. 5 (October 2023): 972-80. https://doi.org/10.15237/gida.GD23070.
EndNote Şen Arslan H (October 1, 2023) ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ. Gıda 48 5 972–980.
IEEE H. Şen Arslan, “ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ”, The Journal of Food, vol. 48, no. 5, pp. 972–980, 2023, doi: 10.15237/gida.GD23070.
ISNAD Şen Arslan, Hülya. “ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ”. Gıda 48/5 (October 2023), 972-980. https://doi.org/10.15237/gida.GD23070.
JAMA Şen Arslan H. ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ. The Journal of Food. 2023;48:972–980.
MLA Şen Arslan, Hülya. “ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ”. Gıda, vol. 48, no. 5, 2023, pp. 972-80, doi:10.15237/gida.GD23070.
Vancouver Şen Arslan H. ULTRASON DESTEKLİ ELMA ATIK ÖZÜTLERİNİN BAZI BİYOAKTİF ÖZELLİKLERİ. The Journal of Food. 2023;48(5):972-80.
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